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1. 发明申请

WO2007149030A1 NOVEL HETEROARYL SUBSTITUTED BENZOXAZOLES 审中-公开
标题翻译：新型取代苯并噻唑
公开(公告)号：WO2007149030A1
公开(公告)日：2007-12-27
申请号：PCT/SE2007/000591
申请日：2007-06-18
申请人： ASTRAZENECA AB , MALMSTRÖM, Jonas , PYRING, David , SLIVO, Can , SOHN, Daniel , SWAHN, Britt-Marie , WENSBO, David
发明人： MALMSTRÖM, Jonas , PYRING, David , SLIVO, Can , SOHN, Daniel , SWAHN, Britt-Marie , WENSBO, David
IPC分类号： C07D413/04 , A61K31/4439 , A61K31/506 , A61P25/28
CPC分类号： C07D413/04
摘要： The present invention relates to novel heteroaryl substituted benzoxazole derivatives and therapeutic uses for such compounds, having the structural formula (Ia) below: [Chemical formula should be inserted here. Please see paper copy] and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted benzoxazole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measureing clinical efficacy of Alzheimer's disease therapeutic agents.
摘要翻译：本发明涉及新颖的杂芳基取代的苯并恶唑衍生物和具有以下结构式（Ia）的这类化合物的治疗用途：[化学式应在此插入。请参阅纸本]及其药学上可接受的盐，组合物和使用方法。此外，本发明涉及适用于在活体患者中成像淀粉样蛋白沉积物的新型杂芳基取代的苯并恶唑衍生物，其组合物，使用方法和制备此类化合物的方法。更具体地说，本发明涉及在体内淀粉样蛋白沉积物在体内成像以使阿尔茨海默病的抗原异常诊断以及阿尔茨海默病治疗剂的临床疗效的测定方法。

2. 发明申请

WO2011002405A1 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774 审中-公开
标题翻译： 2-羧酰胺-7-哌嗪基苯并呋喃衍生物774
公开(公告)号：WO2011002405A1
公开(公告)日：2011-01-06
申请号：PCT/SE2010/050747
申请日：2010-06-29
申请人： ASTRAZENECA AB , ANDERSSON, Johan , GYBÄCK, Helena , JOHANSSON, Anh , LINDE, Christian, Erik , MALMSTRÖM, Jonas , NORDVALL, Gunnar , TERP, Gitte , WEIGELT, Tatjana
发明人： ANDERSSON, Johan , GYBÄCK, Helena , JOHANSSON, Anh , LINDE, Christian, Erik , MALMSTRÖM, Jonas , NORDVALL, Gunnar , TERP, Gitte , WEIGELT, Tatjana
IPC分类号： C07D405/14 , A61K31/443 , A61K31/444 , A61P25/00 , C07D307/82 , C07D405/12 , C07D417/14
CPC分类号： C07D405/12 , C07D307/84 , C07D307/85 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to compounds of formula (I), wherein R 1 is heteroaryl or heterocyclyl, optionally substituted R 2 is C 1-4 alkyl, heterocyclyl, C 1-4 alkylaryl, C 1-4 alkylheteroaryl, carbocyclyl, C 1- 4 alkylheterocyclyl, heterocyclylheteroaryl, arylheterocyclyl, carbocyclylheteroaryl, heterocyclylaryl, optionally substituted R 3 is hydrogen or C 1-4 alkyl, or R 2 and R 3 may together with the nitrogen atom, form a saturated ring system containing 4, 5 or 6 ring forming atoms, and optionally substituted R 4 is hydrogen, halogen, methyl or methoxy to pharmaceutical composition containing said compounds and to the use of said compounds in therapy, for instance in treating cognitive disorders. The present invention further relates to new intermediates useful in the preparation thereof.
摘要翻译：本发明涉及式（I）化合物，其中R 1是杂芳基或杂环基，任选取代的R 2是C 1-4烷基，杂环基，C 1-4烷基芳基，C 1-4烷基杂芳基，碳环基，C 1-4烷基杂环基，杂环基杂芳基，芳基杂环基，碳环基杂芳基，杂环基，任选取代的R 3是氢或C 1-4烷基，或者R 2和R 3可以与氮原子一起形成含有4,5或6个成环原子的饱和环系，任选取代的R 4是氢，卤素，甲基或甲氧基，含有所述化合物的药物组合物和所述化合物在治疗中的用途，例如用于治疗认知障碍。本发明还涉及可用于其制备的新中间体。

3. 发明申请

WO2005082884A3 2-PYRIDIN-2YL-PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF GASTRO-ESOPHAGEA L REFLUX DISEASE 审中-公开
公开(公告)号：WO2005082884A3
公开(公告)日：2005-09-09
申请号：PCT/US2005/004751
申请日：2005-02-15
申请人： ASTRAZENECA AB , NPS PHARMACEUTICALS, INC. , JOHANSSON, Martin , MALMSTRÖM, Jonas , MINIDIS, Alexander , NILSSON, Karolina , WENSBO, David , WÅLLBERG, Andreas , ÖSTERLUND, Krister
发明人： JOHANSSON, Martin , MALMSTRÖM, Jonas , MINIDIS, Alexander , NILSSON, Karolina , WENSBO, David , WÅLLBERG, Andreas , ÖSTERLUND, Krister
IPC分类号： C07D401/04
摘要： The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

4. 发明申请

WO2008091195A1 NOVEL HETEROARYL SUBSTITUTED IMIDAZO [1,2 -A] PYRIDINE DERIVATIVES 审中-公开
标题翻译：新戊酰基取代的咪唑并[1,2-A]吡啶衍生物
公开(公告)号：WO2008091195A1
公开(公告)日：2008-07-31
申请号：PCT/SE2008/000045
申请日：2008-01-21
申请人： ASTRAZENECA AB , EDIN, Michaela , MALMSTRÖM, Jonas , PYRING, David , SLIVO, Can , WENSBO, David
发明人： EDIN, Michaela , MALMSTRÖM, Jonas , PYRING, David , SLIVO, Can , WENSBO, David
IPC分类号： C07D471/04 , A61K31/437 , A61K51/00 , A61P25/28 , A61K101/00
CPC分类号： C07D471/04 , A61K49/10 , A61K51/041 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0463
摘要： The present invention relates to novel heteroaryl substituted imidazopyridine derivatives, precursors thereof, and therapeutic uses of such compounds, having the structural formula (Ia) and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted imidazopyridine derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measureing clinical efficacy of Alzheimer's disease therapeutic agents.
摘要翻译：本发明涉及新颖的杂芳基取代的咪唑并吡啶衍生物，其前体和具有结构式（Ia）的这类化合物及其药学上可接受的盐，组合物和使用方法的治疗用途。此外，本发明涉及适用于在活体患者中成像淀粉样蛋白沉积物的新型杂芳基取代的咪唑并吡啶衍生物，其组合物，使用方法和制备此类化合物的方法。更具体地说，本发明涉及在体内淀粉样蛋白沉积物在体内成像以使阿尔茨海默病的抗原异常诊断以及阿尔茨海默病治疗剂的临床疗效的测定方法。

5. 发明申请

WO2005088731A1 THIN FILM SOLAR CELL AND MANUFACTURING METHOD 审中-公开
标题翻译：薄膜太阳能电池和制造方法
公开(公告)号：WO2005088731A1
公开(公告)日：2005-09-22
申请号：PCT/SE2005/000321
申请日：2005-03-03
申请人： SOLIBRO AB , MALMSTRÖM, Jonas , STOLT, Lars
发明人： MALMSTRÖM, Jonas , STOLT, Lars
IPC分类号： H01L31/0248
CPC分类号： H01L31/0322 , H01L31/022425 , H01L31/056 , Y02E10/52 , Y02E10/541 , Y02P70/521
摘要： The present invention relates to a thin film solar cell and a method of manufacturing such cells. In particular the invention relates to the use of a composite back contact (314) in Cu(In,Ga)Se 2 (CIGS) based thin film solar cells with thin absorber layers. The composite back contact (314) is provided between the substrate (105) and the absorber (115) and comprises: a back reflector layer (311) that enhance the reflectance at the absorber/composite back contact interface; and at least a contact layer that contact layer (310, 313) that ensures suitable electrical properties of the back contact with respect to the absorber; and/or a conductance layer (312) that ensures low sheet resistance for the in-plane current flow.
摘要翻译：本发明涉及一种薄膜太阳能电池及其制造方法。特别地，本发明涉及在具有薄吸收层的Cu（In，Ga）Se2（CIGS））薄膜太阳能电池中使用复合背接触（314）。所述复合背接触件（314）设置在所述基底（105）和所述吸收体（115）之间，并包括：增强所述吸收体/复合背接触界面处的反射率的后反射层（311）以及至少接触层，其接触层（310,313）确保所述背接触件相对于所述吸收体的适合的电特性; 和/或电导层（312），其确保面内电流的低的薄层电阻。

6. 发明申请

WO2003068754A1 THERAPEUTIC SUBSTITUTED INDAZOLE DERIVATIVES 审中-公开
标题翻译：治疗替代的吲哚酚衍生物
公开(公告)号：WO2003068754A1
公开(公告)日：2003-08-21
申请号：PCT/SE2003/000227
申请日：2003-02-11
申请人： ASTRAZENECA AB , MALMSTRÖM, Jonas , SWAHN, Britt-Marie
发明人： MALMSTRÖM, Jonas , SWAHN, Britt-Marie
IPC分类号： C07D231/56
CPC分类号： C07D231/56 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/04
摘要： The invention provides a compound of Formula I Formula I wherein R 1 is aryl or heteroaryl each of which is optionally substituted with one or more of the following R 3 , -OR 3 , -OCOR 3 , -COOR 3 , -COR 3 , -CONR 3 R 4 , -NHCOR 3 , -NR 3 R 4 , -NHSO 2 R 3 , -SO 2 R 3 , -SO 2 NR 3 R 4 , -SR 3 , CN, halogeno or NO 2 ; R 2 is NO 2 , NH 2 , -NR 5 R 6 or -NR 6 R 7 ; as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译：本发明提供了式I的式I化合物，其中R 1是芳基或杂芳基，其各自任选被一个或多个下列R 3，-OR 3，-OCOR 3，-COOR 3，-COR 3，-CONR 3 R 4，-NHCOR 3， NR 3 R 4，-NHSO 2 R 3，-SO 2 R 3，-SO 2 NR 3 R 4，-SR 3，CN，卤代或NO 2; R2是NO2，NH2，-NR5R6或-NR6R7; 作为其盐的游离碱或其药学上可接受的盐，溶剂化物或溶剂合物，其制备方法，含有所述化合物的药物制剂以及所述化合物在治疗中的用途。

7. 发明申请

WO2012087229A1 2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURAN DERIVATIVE 审中-公开
标题翻译： 2-羧酰胺-4-哌嗪基苯并呋喃衍生物
公开(公告)号：WO2012087229A1
公开(公告)日：2012-06-28
申请号：PCT/SE2011/051535
申请日：2011-12-19
申请人： ASTRAZENECA AB , GYBÄCK, Helena , MALMSTRÖM, Jonas , TERP, Elgaard, Gitte
发明人： GYBÄCK, Helena , MALMSTRÖM, Jonas , TERP, Elgaard, Gitte
IPC分类号： C07D405/12 , A61K31/4709 , A61P25/00 , A61P25/24 , A61P25/28
CPC分类号： C07D405/12 , C07D215/227 , C07D307/85
摘要： The present invention relates to a compound of formula (I), and to pharmaceutical compositions containing said compound and to the use of said compound in therapy, for instance in treating cognitive disorders, as well as to intermediates useful in the preparation thereof.
摘要翻译：本发明涉及式（I）化合物，以及含有所述化合物的药物组合物和所述化合物在治疗中的用途，例如治疗认知障碍，以及可用于其制备的中间体。

8. 发明申请

WO2007086800A1 NOVEL HETEROARYL SUBSTITUTED BENZOTHIAZOLES 审中-公开
标题翻译：新型异氟醚取代苯并噻唑
公开(公告)号：WO2007086800A1
公开(公告)日：2007-08-02
申请号：PCT/SE2007/000068
申请日：2007-01-25
申请人： ASTRAZENECA AB , GRAVENFORS, Ylva , JONASSON, Catrin , MALMSTRÖM, Jonas , NORDVALL, Gunnar , PYRING, David , SLIVO, Can , SOHN, Daniel , STRÖM, Peter , WENSBO, David
发明人： GRAVENFORS, Ylva , JONASSON, Catrin , MALMSTRÖM, Jonas , NORDVALL, Gunnar , PYRING, David , SLIVO, Can , SOHN, Daniel , STRÖM, Peter , WENSBO, David
IPC分类号： C07D417/04 , A61K31/4436 , A61K31/496 , A61P25/28 , C07D417/14 , C07D513/04
CPC分类号： C07D417/04 , C07B59/002 , C07D513/04
摘要： The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below: [Chemical formula should be inserted here. Please see paper copy] and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted benzothiazole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measureing clinical efficacy of Alzheimer's disease therapeutic agents.
摘要翻译：本发明涉及新颖的杂芳基取代的苯并噻唑衍生物，其前体，以及具有以下结构式（I）的化合物的治疗用途：[化学式应在此插入。请参阅纸本]及其药学上可接受的盐，组合物和使用方法。此外，本发明涉及适用于在活体患者中成像淀粉样蛋白沉积物的新型杂芳基取代的苯并噻唑衍生物，其组合物，使用方法和制备此类化合物的方法。更具体地说，本发明涉及在体内淀粉样蛋白沉积物在体内成像以使阿尔茨海默氏病的止血诊断以及测量阿尔茨海默病治疗剂的临床疗效的方法。

9. 发明申请

WO2006004507A2 NEW COMPOUNDS USEFUL FOR TREATING CNS DISORDERS 审中-公开
标题翻译：用于治疗CNS病症的新化合物
公开(公告)号：WO2006004507A2
公开(公告)日：2006-01-12
申请号：PCT/SE2005/001033
申请日：2005-06-29
申请人： ASTRAZENECA AB , MALMSTRÖM, Jonas , VIKLUND, Jenny
发明人： MALMSTRÖM, Jonas , VIKLUND, Jenny
IPC分类号： C07D20060101
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention provides new compounds of formula (I) as well as a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
摘要翻译：本发明提供新的式（I）化合物及其制备方法和其中使用的新中间体，含有所述治疗活性化合物的药物制剂和所述活性化合物在治疗中的用途。

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