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1. 发明申请

US20070224683A1 Raman spectroscopic test strip systems 失效
标题翻译：拉曼光谱测试条系统
公开(公告)号：US20070224683A1
公开(公告)日：2007-09-27
申请号：US11698084
申请日：2007-01-26
申请人： Richard Clarke , M. Womble
发明人： Richard Clarke , M. Womble
IPC分类号： G01N35/10 , G01J3/44
CPC分类号： G01N21/65 , G01N21/658 , G01N21/8483 , Y10T436/112499
摘要： The invention provides diagnostic apparatuses that are advantageously adapted for the Raman spectroscopic analysis of fluid samples, such as biological fluid samples, deposited on test strip substrates. The tests strips may be include a surface-enhanced Raman spectroscopy (SERS) surface for deposition and analysis of a sample and/or may be lateral flow binding assay type test strips.
摘要翻译：本发明提供了有利地适用于沉积在测试条基材上的流体样品（例如生物流体样品）的拉曼光谱分析的诊断装置。测试条可以包括用于样品沉积和分析的表面增强拉曼光谱（SERS）表面和/或可以是侧向流动结合测定型测试条。

2. 发明申请

US20080064120A1 Raman spectroscopic lateral flow test strip assays 审中-公开
标题翻译：拉曼光谱横向流动测试条测试
公开(公告)号：US20080064120A1
公开(公告)日：2008-03-13
申请号：US11698083
申请日：2007-01-26
申请人： Richard Clarke , M. Womble
发明人： Richard Clarke , M. Womble
IPC分类号： G01N33/558 , G01N21/65
CPC分类号： G01N33/558 , G01N21/658 , G01N33/54313 , G01N33/54373 , G01N33/585
摘要： The invention provides improved Raman spectroscopy-based methods and systems for the quantitative analysis of selected analytes using lateral flow binding assay test strips.
摘要翻译：本发明提供了改进的基于拉曼光谱的方法和系统，用于使用侧向流动结合测定试片对所选分析物进行定量分析。

3. 发明申请

US20060240401A1 Handheld raman body fluid analyzer 失效
标题翻译：手持式拉曼体液分析仪
公开(公告)号：US20060240401A1
公开(公告)日：2006-10-26
申请号：US11340712
申请日：2006-01-27
申请人： Richard Clarke , M. Womble
发明人： Richard Clarke , M. Womble
IPC分类号： C12Q1/00 , C12M1/34 , A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/0295 , G01N21/65 , G01N21/658 , G01N21/8483 , G01N33/52 , G01N2021/656
摘要： Methods and apparatus for in vitro detection of an analyte in a body fluid sample using low resolution Raman spectroscopy are disclosed. The body fluid analyzer includes a disposable strip for receiving a sample of body fluid on a target region, the target region including gold sol-gel to provide surface enhanced Raman scattering. A light source irradiates the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects at least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The results of the processed data are displayed on a screen to inform a user about an analyte within the body fluid sample.
摘要翻译：公开了使用低分辨率拉曼光谱法体外检测体液样品中分析物的方法和装置。体液分析仪包括用于接收目标区域上的体液样本的一次性条，所述目标区域包括金溶胶 - 凝胶以提供表面增强的拉曼散射。光源照射目标区域以产生由分散元件分离成不同波长分量的散射电磁辐射组成的拉曼光谱。检测阵列检测散射光的至少一些波长分量，并向处理器提供数据以处理数据。处理数据的结果显示在屏幕上以通知用户体液样品内的分析物。

4. 发明授权

US5360061A Blowout preventer with tubing shear rams 失效
标题翻译：防喷器用管剪剪
公开(公告)号：US5360061A
公开(公告)日：1994-11-01
申请号：US960690
申请日：1992-10-14
申请人： Lee M. Womble
发明人： Lee M. Womble
IPC分类号： E21B29/08 , E21B33/06
CPC分类号： E21B33/063 , E21B29/08
摘要： An improved shearing blowout preventer having improved shearing rams for shearing a tubing string extending through the bore of the preventer body. The shear rams include a shear ram having an upper shear blade and a ram having a lower shear blade. The upper shear blade includes a flat surface under the blade with a recess therein for a sealing element and a pair of surfaces spaced apart and below the flat surface under the blade and a tapered conical recess in the rear end of the blade to receive the fish that is sheared and to control the shape of the upper end of the sheared fish. The ram with the lower shear blade includes a tapered conical surface in the center portion of the blade and extending below the cutting edge of the blade. This recess coacts with the recess below the upper shear blade to shape the cut fish so that it does not flatten and to maintain a substantial opening in its upper end without exceeding maximum dimension. The shape of the two tapered conical recesses is such that they will receive a variety of sizes of tubing and function to maintain the opening of the upper end of the lower fish while preventing the transverse dimension from exceeding the preselected maximum dimension.
摘要翻译：一种改进的剪切防喷器，其具有改进的剪切柱塞，用于剪切延伸穿过预防器主体的孔的管柱。剪切冲击器包括具有上剪切刀片和具有较低剪切刀片的冲头的剪切柱塞。上剪切叶片包括在叶片下面的平坦表面，其中具有用于密封元件的凹部和在叶片下方的平坦表面下方间隔开并且在叶片下方的平坦表面下方的一对表面以及在叶片的后端中的锥形凹槽，以接收鱼剪切并控制剪切鱼的上端的形状。具有较低剪切刀片的冲头在叶片的中心部分包括锥形锥形表面，并且在叶片的切割边缘的下方延伸。该凹槽与上剪切刀片下方的凹部共同作用以使切割的鱼成形，使得其不变平，并且在其上端保持基本开口而不超过最大尺寸。两个锥形锥形凹部的形状使得它们将接收各种尺寸的管道并且用于保持下部鱼的上端的开口，同时防止横向尺寸超过预选的最大尺寸。

5. 发明申请

US20060176478A1 Raman spectroscopy with stabilized multi-mode lasers 审中-公开
标题翻译：具有稳定多模激光器的拉曼光谱
公开(公告)号：US20060176478A1
公开(公告)日：2006-08-10
申请号：US11054379
申请日：2005-02-09
申请人： Richard Clarke , M. Womble
发明人： Richard Clarke , M. Womble
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0218 , G01J3/0227 , G01J3/10 , G01N21/65 , G01N2021/651 , G01N2021/656 , G01N2021/8528 , G01N2201/08
摘要： Methods and apparatus for analysis of a sample using Raman spectroscopy, which employs a multi-mode radiation source and a spectral filter, are disclosed. The source radiation produces a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects a least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The resulting spectroscopic data has higher resolution and stability than conventional low-resolution Raman systems.
摘要翻译：公开了采用多模式辐射源和光谱滤波器的拉曼光谱分析样品的方法和装置。源辐射产生由散射电磁辐射组成的拉曼光谱，其通过分散元件分离成不同的波长分量。检测阵列检测散射光的至少一些波长分量，并向处理器提供数据以处理数据。所得到的光谱数据具有比常规低分辨率拉曼系统更高的分辨率和稳定性。

6. 发明授权

US5101839A Cigarette and smokable filler material therefor 失效
标题翻译：香烟和烟熏填料
公开(公告)号：US5101839A
公开(公告)日：1992-04-07
申请号：US567519
申请日：1990-08-15
申请人： Stephen W. Jakob , Michael D. Shannon , Olivia D. Furin , Paul F. Bernasek , Richard L. Blakley , Johnny L. Brooks , Karen M. Womble , Gary R. Shelar , James L. Resce
发明人： Stephen W. Jakob , Michael D. Shannon , Olivia D. Furin , Paul F. Bernasek , Richard L. Blakley , Johnny L. Brooks , Karen M. Womble , Gary R. Shelar , James L. Resce
IPC分类号： A24B15/14 , A24B15/16 , A24D1/00
CPC分类号： A24D1/00 , A24B15/14 , A24B15/165
摘要： A smokable filler material includes an aerosol forming material (e.g., propylene glycol and glycerin) and a binding agent (e.g., ammonium alginate). Tobacco extracts and/or pieces of tobacco laminae can be incorporated into the smokable filler material, and/or the smokable filler material can be blended with tobacco cut filler. The amount of aerosol forming material within the smokable filler material typically is at least about 20 percent, based on the weight of that smokable filler material. Cigarettes are provided by wrapping the smokable filler material in a paper wrapping material. A typical paper wrapping material has a porosity of less than about 5 CORESTA units. Cigarettes cn include two layers of circumscribing paper wrapping materials. Cigarettes also can include filter elements.
摘要翻译：可吸填料包括烟雾形成材料（例如丙二醇和甘油）和粘合剂（例如藻酸铵）。可以将烟草提取物和/或烟草片段加入到可吸收的填充材料中，和/或可吸收的填充材料可与烟草切割填料混合。可吸填充材料中的烟雾形成材料的量通常为至少约20％，基于该可吸填料的重量。通过将可吸入的填充材料包裹在纸包装材料中来提供香烟。典型的纸包装材料具有小于约5个CORESTA单位的孔隙率。香烟包括两层外接纸包装材料。香烟还可以包括过滤元件。

7. 发明授权

US4920990A Cigarette 失效
公开(公告)号：US4920990A
公开(公告)日：1990-05-01
申请号：US276161
申请日：1988-11-23
申请人： Brian M. Lawrence , Robert F. Moates , Thomas A. Perfetti , Renee M. Pogrow , Robert H. Powell , Jerry W. Redding , Cynthia A. Stewart , Karen M. Womble , Milly M. L. Wong
发明人： Brian M. Lawrence , Robert F. Moates , Thomas A. Perfetti , Renee M. Pogrow , Robert H. Powell , Jerry W. Redding , Cynthia A. Stewart , Karen M. Womble , Milly M. L. Wong
IPC分类号： A24B15/10 , A24B15/14 , A24B15/30 , A24B15/42 , A24D1/00 , A24D1/02
CPC分类号： A24B15/14 , A24B15/301 , A24B15/42 , A24D1/00 , A24D1/02
摘要： Cigarettes have a smokable filler blend comprising 60 to 75 percent tobacco cut filler and 25 to 40 percent of a second smokable cut filler consisting essentially of 50 to 70 percent calcium carbonate, 15 to 45 percent pyrolyzed cotton linters, and 7 to 12 percent polysaccharide binder. The blend is contained in a paper wrapper having a permeability from about 40 to about 75 CORESTA units. Cigarettes normally include a filter element and are air diluted to an air dilution level of from 40 to 65 percent. The smokable blend preferably is blended with a tobacco essence, and the nicotine content of the blend is greater than 2 percent. Cigarettes exhibit resistances to draw between 80 and 150 mm water pressure drop at 17.5 cc/sec. air flow. Cigarettes exhibit FTC "tar" to nicotine ratios less than 9.

8. 发明授权

US5598868A Cigarette and smokable filler material therefor material for use in smoking articles 失效
标题翻译：用于吸烟制品的香烟和可吸入的填充材料
公开(公告)号：US5598868A
公开(公告)日：1997-02-04
申请号：US346841
申请日：1994-11-30
申请人： Stephen W. Jakob , Michael D. Shannon , Olivia D. Furin , Paul F. Bernasek , Richard L. Blakley , Johnny L. Brooks , Karen M. Womble , Gary R. Shelar , James L. Resce
发明人： Stephen W. Jakob , Michael D. Shannon , Olivia D. Furin , Paul F. Bernasek , Richard L. Blakley , Johnny L. Brooks , Karen M. Womble , Gary R. Shelar , James L. Resce
IPC分类号： A24B15/14 , A24B15/16 , A24D1/00 , A24B15/00
CPC分类号： A24D1/00 , A24B15/14 , A24B15/165
摘要： A smokable filler material includes an aerosol forming material (e.g., glycerin) and as binding agent. Tobacco extracts and/or pieces of tobacco laminae can be incorporated into the smokable filler material, and/or the smokable filler material can be blended with tobacco cut filler. The amount of aerosol forming material within the smokable filler material typically is at least about 20 percent, based on the weight of that smokable filler material. Cigarettes are provided by wrapping the smokable filler material in a paper wrapping material. A typical paper wrapping material has a porosity of less than about 5 CORESTA units.
摘要翻译：可吸填料包括烟雾形成材料（例如甘油）和粘合剂。可以将烟草提取物和/或烟草片段加入到可吸收的填充材料中，和/或可吸收的填充材料可与烟草切割填料混合。可吸填充材料中的烟雾形成材料的量通常为至少约20％，基于该可吸填料的重量。通过将可吸入的填充材料包裹在纸包装材料中来提供香烟。典型的纸包装材料具有小于约5个CORESTA单位的孔隙率。

9. 发明申请

US20080262555A1 Percutaneous delivery of facet screws using depth control indicator 审中-公开
标题翻译：使用深度控制指示器经皮输送面螺钉
公开(公告)号：US20080262555A1
公开(公告)日：2008-10-23
申请号：US12008111
申请日：2008-01-07
申请人： Robert L. Assell , Thomas M. Womble
发明人： Robert L. Assell , Thomas M. Womble
IPC分类号： A61B17/68 , A61B17/58 , A61B17/32
CPC分类号： A61B17/86 , A61B17/1615 , A61B17/1637 , A61B17/1655 , A61B17/1671 , A61B17/7064 , A61B17/848 , A61B17/8605 , A61B17/8625 , A61B17/8635 , A61B90/94
摘要： Instrumentation systems that facilitate the reproducible deployment and placement of fixation device such as a screw, via an aligned, percutaneous access and approach, designed to relieve lower back pain and possibly improve disc health and prevent progression or transition of disease. Information about methods and equipment for accessing and preparing bone for subsequent delivery of a bone screw such as a facet screw across a facet joint. Some of the many teachings contained herein address a system of visual indicators may be used in connection with a bore cutter that operates around an anchored guide wire to avoid dislodging the anchored guide wire.
摘要翻译：仪器系统有助于通过对齐的经皮通道和方法促进固定装置（例如螺钉）的可再现部署和放置，设计用于缓解下背痛并可能改善椎间盘的健康并防止疾病的进展或转变。关于接近和准备骨骼的方法和设备的信息，用于随后传递诸如小平面螺钉的骨螺钉穿过小关节。本文所包含的许多教导中的一些涉及视觉指示器的系统可以与围绕锚定的导丝围绕操作的孔切割器一起使用以避免移除锚定的导丝。

10. 发明申请

US20060166302A1 Handheld raman blood analyzer 失效
公开(公告)号：US20060166302A1
公开(公告)日：2006-07-27
申请号：US10905956
申请日：2005-01-27
申请人： Richard Clarke , M. Womble
发明人： Richard Clarke , M. Womble
IPC分类号： G06F19/00 , C12Q1/26
CPC分类号： G01N21/65 , A61B5/14532 , A61B5/1455 , A61B2562/0295 , G01N21/658 , G01N21/8483 , G01N2021/656
摘要： Methods and apparatus for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy are disclosed. The blood analyzer includes a disposable strip for receiving a sample of blood on a target region, the target region including gold sol-gel to provide surface enhanced Raman scattering. A light source irradiates the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects a least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The results of the processed data are displayed on a screen to inform a user about an analyte within the blood sample.

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