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1. 发明申请

US20070154900A1 Methods for determining protein and peptide terminal sequences 有权
标题翻译：确定蛋白质和肽末端序列的方法
公开(公告)号：US20070154900A1
公开(公告)日：2007-07-05
申请号：US11444215
申请日：2006-05-30
申请人： Luke Schneider , Michael Hall , Robert Petesch
发明人： Luke Schneider , Michael Hall , Robert Petesch
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G01N33/6848 , C12Q1/6872 , H01J49/0045 , Y10T436/105831 , Y10T436/143333 , Y10T436/24 , Y10T436/25125
摘要： Methods and apparatuses for deriving the sequence of an oligomer. In one exemplary method for deriving the sequence of a polypeptide, a predetermined set of mass/charge values for amino acid sequences is stored. An abundance value from mass spectrum data for each mass/charge value in the predetermined set is determined to produce a plurality of abundance values. A first ranking, based on the plurality of abundance values, is calculated for each sequence of a set of amino acid sequences having a first number of amino acids. A second ranking, based on the plurality of abundance values, for each sequence of a set of amino acid sequences having a second number of amino acids is calculated. A cumulative ranking, based on the first ranking and the second ranking, is calculated for each sequence of a set of amino acid sequences having at least the second number of amino acids.
摘要翻译：衍生寡聚物序列的方法和装置。在衍生多肽序列的一个示例性方法中，存储氨基酸序列的预定质量/电荷值集合。确定预定组中每个质量/电荷值的质谱数据的丰度值以产生多个丰度值。针对具有第一数目的氨基酸的一组氨基酸序列的每个序列计算基于多个丰度值的第一等级。计算出具有第二数量氨基酸的一组氨基酸序列的每个序列的基于多个丰度值的第二等级。针对具有至少第二数量氨基酸的一组氨基酸序列的每个序列计算基于第一等级和第二等级的累积排名。

2. 发明申请

US20050153346A1 Methods for conducting metabolic analyses 失效
标题翻译：进行代谢分析的方法
公开(公告)号：US20050153346A1
公开(公告)日：2005-07-14
申请号：US11018871
申请日：2004-12-20
申请人： Luke Schneider
发明人： Luke Schneider
IPC分类号： B65G59/06 , G01N27/447 , C12Q1/68 , A61K49/00 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： G01N33/6848 , B65G59/066 , G01N27/44717 , G01N27/44726 , G01N27/44773 , G01N27/44782 , G01N27/44795 , Y10S435/968 , Y10S435/973
摘要： The present invention provides methods and apparatus for purifying metabolites of interest and conducting metabolic analyses. The methods generally involve determining metabolic flux values for a plurality of target analytes by monitoring the relative isotope abundance of a stable isotope in a substrate labeled with the stable isotope and/or one or more target metabolites formed through metabolism of the labeled substrate. Certain methods utilize multiple electrophoretic methods to separate the target analytes from other components within the sample being analyzed. The methods can be used in a variety of applications including screens to identify metabolites that are correlated with certain diseases and diagnostic screens for identifying individuals having, or susceptible to, a disease.
摘要翻译：本发明提供了用于纯化目的代谢物和进行代谢分析的方法和装置。所述方法通常涉及通过监测用稳定同位素标记的底物和/或通过标记的底物代谢形成的一种或多种目标代谢物来监测稳定同位素的相对同位素丰度来确定多种目标分析物的代谢通量值。某些方法利用多种电泳方法将目标分析物与正在分析的样品中的其他组分分离。所述方法可用于各种应用，包括筛选鉴定与某些疾病相关的代谢物和用于识别具有或易感染疾病的个体的诊断筛选的筛选。

3. 发明申请

US20060120961A1 Glycan analysis using deuterated glucose 审中-公开
标题翻译：使用氘化葡萄糖进行糖苷分析
公开(公告)号：US20060120961A1
公开(公告)日：2006-06-08
申请号：US11262311
申请日：2005-10-28
申请人： Luke Schneider , Michael Hall
发明人： Luke Schneider , Michael Hall
IPC分类号： A61K49/00 , G01N33/00
CPC分类号： G01N33/58 , A61K49/0004 , A61K51/0491 , G01N33/574 , G01N33/6848 , G01N2400/00
摘要： Novel methods and apparatuses are provided for use in identifying glucose metabolic products and determining metabolic flux by administering D7-glucose to a subject.
摘要翻译：提供新的方法和装置用于鉴定葡萄糖代谢产物并通过向受试者施用D 7 - 葡萄糖来测定代谢通量。

4. 发明申请

US20050089930A1 Polypeptide fingerprinting methods 失效
标题翻译：多肽指纹法
公开(公告)号：US20050089930A1
公开(公告)日：2005-04-28
申请号：US10721047
申请日：2003-11-21
申请人： Luke Schneider , Michael Hall , Robert Petesch , Jeffrey Peterson
发明人： Luke Schneider , Michael Hall , Robert Petesch , Jeffrey Peterson
IPC分类号： B65G59/06 , G01N27/447 , G01N33/53 , G01N33/557
CPC分类号： G01N33/6848 , B65G59/066 , G01N27/44726 , G01N27/44773 , G01N27/44782 , G01N27/44795 , Y10T436/24 , Y10T436/25125
摘要： The invention provides methods, compositions, apparatus, and a computer data retrieval system for conducting proteomics.
摘要翻译：本发明提供了用于进行蛋白质组学的方法，组合物，装置和计算机数据检索系统。

5. 发明申请

US20060219897A1 METHOD FOR INCREASING IONIZATION EFFICIENCY IN MASS SPECTROSCOPY 有权
标题翻译：在大量光谱中增加离子化效率的方法
公开(公告)号：US20060219897A1
公开(公告)日：2006-10-05
申请号：US11381516
申请日：2006-05-03
申请人： Luke Schneider
发明人： Luke Schneider
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/165 , H01J49/164
摘要： A mass spectrometry ionization method in which electrospray droplets or solid sample matrices are exposed to an ion beam thereby increasing the unbalanced charge of the analyte is provided. In another embodiment, a mass spectrometry ionization method in which ionization of the sample is achieved by directing an ion beam at a liquid or solid sample matrix containing analyte thereby ionizing and adding unbalanced charge to the analyte is provided.
摘要翻译：提供了一种质谱电离法，其中电喷雾液滴或固体样品基质暴露于离子束，从而增加分析物的不平衡电荷。在另一个实施方案中，提供了质谱离子化方法，其中通过将离子束引导到含有分析物的液体或固体样品基质，从而进行离子化并向分析物添加不平衡电荷来实现样品的离子化。

6. 发明申请

US20050001162A1 Method for increasing ionization efficiency in mass spectroscopy 有权
标题翻译：在质谱中提高电离效率的方法
公开(公告)号：US20050001162A1
公开(公告)日：2005-01-06
申请号：US10696549
申请日：2003-10-28
申请人： Luke Schneider
发明人： Luke Schneider
IPC分类号： G01N20060101 , G01N1/00 , G01N30/72 , G01N37/00 , H01J49/00 , H01J49/04 , H01J49/26
CPC分类号： H01J49/165 , H01J49/164
摘要： A mass spectrometry ionization method in which electrospray droplets or solid sample matrices are exposed to an ion beam thereby increasing the unbalanced charge of the analyte is provided. In another embodiment, a mass spectrometry ionization method in which ionization of the sample is achieved by directing an ion beam at a liquid or solid sample matrix containing analyte thereby ionizing and adding unbalanced charge to the analyte is provided.
摘要翻译：提供了一种质谱电离法，其中电喷雾液滴或固体样品基质暴露于离子束，从而增加分析物的不平衡电荷。在另一个实施方案中，提供了质谱离子化方法，其中通过将离子束引导到含有分析物的液体或固体样品基质，从而进行离子化并向分析物添加不平衡电荷来实现样品的离子化。

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