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1. 发明授权

US09150635B2 ILT3 polypeptides and uses thereof 有权
标题翻译： ILT3多肽及其用途
公开(公告)号：US09150635B2
公开(公告)日：2015-10-06
申请号：US13480421
申请日：2012-05-24
申请人： Nicole Suciu-Foca , Luigi Scotto , Seunghee Kim-Schulze , George Vlad , Raffaello Cortesini
发明人： Nicole Suciu-Foca , Luigi Scotto , Seunghee Kim-Schulze , George Vlad , Raffaello Cortesini
IPC分类号： A61K38/16 , C07K14/705
CPC分类号： C07K14/70503 , C07K2319/30
摘要： This invention provides a first polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water-soluble and does not comprise the Fc portion of an immunoglobulin. This invention also provides a second polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) the Fc portion of an immunoglobulin, wherein the Fc portion of the immunoglobulin comprises a function-enhancing mutation, and wherein the polypeptide is water-soluble. This invention further provides a third polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) a transmembrane domain. This invention further provides related nucleic acids, expression vectors, host vector systems, compositions, and articles of manufacture and therapeutic and prophylactic methods using the polypeptides of the invention.
摘要翻译：本发明提供了包含ILT3的全部或部分细胞外结构域的第一多肽，其中多肽是水溶性的并且不包含免疫球蛋白的Fc部分。本发明还提供了第二多肽，其包含（i）ILT3的全部或部分细胞外结构域可操作地附着于（ii）免疫球蛋白的Fc部分，其中所述免疫球蛋白的Fc部分包含功能增强突变，并且其中该多肽是水溶性的。本发明还提供了第三多肽，其包含（i）ILT3的全部或部分细胞外结构域可操作地固定于（ii）跨膜结构域。本发明还提供了使用本发明的多肽的相关核酸，表达载体，宿主载体系统，组合物和制品以及治疗和预防方法。

2. 发明授权

US08207110B2 ITL3 polypeptides and uses thereof 有权
标题翻译： ITL3多肽及其用途
公开(公告)号：US08207110B2
公开(公告)日：2012-06-26
申请号：US11661877
申请日：2005-09-01
申请人： Nicole Suciu-Foca , Luigi Scotto , Seunghee Kim-Schulze , George Vlad , Raffaello Cortesini
发明人： Nicole Suciu-Foca , Luigi Scotto , Seunghee Kim-Schulze , George Vlad , Raffaello Cortesini
IPC分类号： A61K38/00
CPC分类号： C07K14/70503 , C07K2319/30
摘要： This invention provides a first polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water-soluble and does not comprise the Fc portion of an immunoglobulin. This invention also provides a second polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) the Fc portion of an immunoglobulin, wherein the Fc portion of the immunoglobulin comprises a function-enhancing mutation, and wherein the polypeptide is water-soluble. This invention further provides a third polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) a transmembrane domain. This invention further provides related nucleic acids, expression vectors, host vector systems, compositions, and articles of manufacture and therapeutic and prophylactic methods using the polypeptides of the invention.
摘要翻译：本发明提供了包含ILT3的全部或部分细胞外结构域的第一多肽，其中多肽是水溶性的并且不包含免疫球蛋白的Fc部分。本发明还提供了第二多肽，其包含（i）ILT3的全部或部分细胞外结构域可操作地附着于（ii）免疫球蛋白的Fc部分，其中所述免疫球蛋白的Fc部分包含功能增强突变，并且其中该多肽是水溶性的。本发明还提供了第三多肽，其包含（i）ILT3的全部或部分细胞外结构域可操作地固定于（ii）跨膜结构域。本发明还提供了使用本发明的多肽的相关核酸，表达载体，宿主载体系统，组合物和制品以及治疗和预防方法。

3. 发明申请

US20120321623A1 ILT3 Polypeptides and Uses Thereof 有权
标题翻译： ILT3多肽及其用途
公开(公告)号：US20120321623A1
公开(公告)日：2012-12-20
申请号：US13480421
申请日：2012-05-24
申请人： Nicole Suciu-Foca , Luigi Scotto , Seunghee Kim-Schulze , George Vlad , Raffaello Cortesini
发明人： Nicole Suciu-Foca , Luigi Scotto , Seunghee Kim-Schulze , George Vlad , Raffaello Cortesini
IPC分类号： A61K38/17 , C07K19/00 , C12N5/0783 , A61P37/06 , A61K39/395
CPC分类号： C07K14/70503 , C07K2319/30
摘要： This invention provides a first polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water-soluble and does not comprise the Fc portion of an immunoglobulin. This invention also provides a second polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) the Fc portion of an immunoglobulin, wherein the Fc portion of the immunoglobulin comprises a function-enhancing mutation, and wherein the polypeptide is water-soluble. This invention further provides a third polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) a transmembrane domain. This invention further provides related nucleic acids, expression vectors, host vector systems, compositions, and articles of manufacture and therapeutic and prophylactic methods using the polypeptides of the invention.
摘要翻译：本发明提供了包含ILT3的全部或部分细胞外结构域的第一多肽，其中多肽是水溶性的并且不包含免疫球蛋白的Fc部分。本发明还提供了第二多肽，其包含（i）ILT3的全部或部分细胞外结构域可操作地附着于（ii）免疫球蛋白的Fc部分，其中所述免疫球蛋白的Fc部分包含功能增强突变，并且其中该多肽是水溶性的。本发明还提供了第三多肽，其包含（i）ILT3的全部或部分细胞外结构域可操作地固定于（ii）跨膜结构域。本发明还提供了使用本发明的多肽的相关核酸，表达载体，宿主载体系统，组合物和制品以及治疗和预防方法。

4. 发明申请

US20080311073A1 Ilt3 Polypeptides and Uses Thereof 有权
标题翻译： Ilt3多肽及其用途
公开(公告)号：US20080311073A1
公开(公告)日：2008-12-18
申请号：US11661877
申请日：2005-09-01
申请人： Nicole Suciu-Foca , Luigi Scotto , Seunghee Kim-Schulze , George Vlad , Raffaello Cortesini
发明人： Nicole Suciu-Foca , Luigi Scotto , Seunghee Kim-Schulze , George Vlad , Raffaello Cortesini
IPC分类号： A61K45/00 , C07K14/00 , C12N15/11 , C12N15/00 , A61P37/00 , A61K35/12 , C12N5/06 , C12P21/04
CPC分类号： C07K14/70503 , C07K2319/30
摘要： This invention provides a first polypeptide comprising all or a portion of the extracellular domain of ILT3, wherein the polypeptide is water-soluble and does not comprise the Fc portion of an immunoglobulin. This invention also provides a second polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) the Fc portion of an immunoglobulin, wherein the Fc portion of the immunoglobulin comprises a function-enhancing mutation, and wherein the polypeptide is water-soluble. This invention further provides a third polypeptide comprising (i) all or a portion of the extracellular domain of ILT3 operable affixed to (ii) a transmembrane domain. This invention further provides related nucleic acids, expression vectors, host vector systems, compositions, and articles of manufacture and therapeutic and prophylactic methods using the polypeptides of the invention.
摘要翻译：本发明提供了包含ILT3的全部或部分细胞外结构域的第一多肽，其中多肽是水溶性的并且不包含免疫球蛋白的Fc部分。本发明还提供了第二多肽，其包含（i）ILT3的全部或部分细胞外结构域可操作地附着于（ii）免疫球蛋白的Fc部分，其中所述免疫球蛋白的Fc部分包含功能增强突变，并且其中该多肽是水溶性的。本发明还提供了第三多肽，其包含（i）ILT3的全部或部分细胞外结构域可操作地固定于（ii）跨膜结构域。本发明还提供了使用本发明的多肽的相关核酸，表达载体，宿主载体系统，组合物和制品以及治疗和预防方法。

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