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1. 发明申请

US20050065331A1 Recombinant immunogens for the generation of antivenoms to the venom of scorpions of the genus Centruroides 有权
标题翻译：用于将毒死蜱产生到Centruroides蝎子毒液的重组免疫原
公开(公告)号：US20050065331A1
公开(公告)日：2005-03-24
申请号：US10721793
申请日：2003-11-26
申请人： Miguel Corona Villegas , Ma Garcia Rodriguez , Georgina Gurrola Briones , Norma Valdez Cruz , Baltazar Becerril Lujan , Lourival Possani Postay
发明人： Miguel Corona Villegas , Ma Garcia Rodriguez , Georgina Gurrola Briones , Norma Valdez Cruz , Baltazar Becerril Lujan , Lourival Possani Postay
IPC分类号： A61K38/00 , C07H21/02 , C07H21/04 , C07K14/435
CPC分类号： C07H21/02 , A61K38/00 , C07H21/04 , C07K14/43522
摘要： The invention concerns genes and fusion of genes that code for scorpion toxins and the corresponding polypeptides. The invention also concerns the use of the polypeptides as immunogens for the generation of antibodies that can recognize and neutralize components of scorpion venom as well as for vaccines to prevent envenomation from stings of scorpions of the genus Centruroides, and to immunogenic matrices for the purification of specific immunoglobulins.
摘要翻译：本发明涉及编码蝎毒素的基因和相应多肽的基因的融合。本发明还涉及多肽作为免疫原用于产生能够识别和中和蝎毒素组分的抗体以及用于预防针对Centruroides的蝎子引起刺激的疫苗的用途，以及免疫原性基质用于纯化特异性免疫球蛋白。

2. 发明授权

US5756454A Collagen-induced platelet aggregation inhibitor 失效
标题翻译：胶原诱导的血小板聚集抑制剂
公开(公告)号：US5756454A
公开(公告)日：1998-05-26
申请号：US206185
申请日：1994-03-07
申请人： Christiane Noeske-Jungblut , Bernard Haendler , Joern Reiner Kraetzschmar , Wolf-Dieter Schleuning , Alejandro Alagon , Lourival Possani , Delia Cuevas-Aguirre
发明人： Christiane Noeske-Jungblut , Bernard Haendler , Joern Reiner Kraetzschmar , Wolf-Dieter Schleuning , Alejandro Alagon , Lourival Possani , Delia Cuevas-Aguirre
IPC分类号： A61K38/00 , C07K14/435 , A23J1/00 , C07K1/00
CPC分类号： C07K14/43563 , A61K38/00
摘要： The invention provides a protein which inhibits collagen-induced platelet aggregation, derived from Triatoma pallidipennis, and derivatives thereof. The protein is useful for inhibition of collagen-induced human platelet aggregation or of cancer with metastatic tumor cells.
摘要翻译：本发明提供抑制胶原诱导的血小板聚集的蛋白质，其来源于苍白球菌（Triatoma pallidipennis）及其衍生物。该蛋白质可用于抑制胶原诱导的人血小板聚集或癌症与转移性肿瘤细胞。

3. 发明授权

US5723312A Collagen-induced platelet aggregation inhibitor 失效
标题翻译：胶原诱导的血小板聚集抑制剂
公开(公告)号：US5723312A
公开(公告)日：1998-03-03
申请号：US462894
申请日：1995-06-05
申请人： Christiane Noeske-Jungblut , Bernard Haendler , Joern Reiner Kraetzschmar , Wolf-Dieter Schleuning , Alejandro Alagon , Lourival Possani , Delia Cuevas-Aguirre
发明人： Christiane Noeske-Jungblut , Bernard Haendler , Joern Reiner Kraetzschmar , Wolf-Dieter Schleuning , Alejandro Alagon , Lourival Possani , Delia Cuevas-Aguirre
IPC分类号： A61K38/00 , C07K14/435 , C12P21/06 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C07K14/43563 , A61K38/00
摘要： The invention provides a protein which inhibits collagen-induced platelet aggregation, derived from Triatoma pallidipennis, and derivatives thereof. The protein is useful for inhibition of collagen-induced human platelet aggregation or of cancer with metastatic tumor cells.
摘要翻译：本发明提供抑制胶原诱导的血小板聚集的蛋白质，其来源于苍白球菌（Triatoma pallidipennis）及其衍生物。该蛋白质可用于抑制胶原诱导的人血小板聚集或具有转移性肿瘤细胞的癌症。

4. 发明申请

US20070071750A1 Human antibody variants that specifically recognize the toxin CN2 from Centruroides noxius scorpion venom 有权
标题翻译：人类抗体变异体，特异性识别来自Centruroides noxius蝎子毒液的毒素CN2
公开(公告)号：US20070071750A1
公开(公告)日：2007-03-29
申请号：US11404879
申请日：2006-04-17
申请人： Lidia Riano-Umbarila , Baltazar Becerril Lujan , Lourival Possani Postay
发明人： Lidia Riano-Umbarila , Baltazar Becerril Lujan , Lourival Possani Postay
IPC分类号： A61K39/395 , G01N33/53 , C07H21/04 , C12P21/06 , C12N9/00 , C12N1/21 , C07K16/40 , C07K14/435
CPC分类号： C07K16/18 , A61K39/39591 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention is directed to recombinant human antibodies specific for Cn2 toxin from C. noxius scorpion venom. The antibodies are able to recognize the toxin and preferably neutralize it as well as the whole venom of C. noxius scorpion. This invention is also directed to a human non-immune phage display library. One clone that specifically binds the Cn2 toxin was affinity matured by directed evolution. Three cycles of maturation were performed and several scFv clones were isolated which specifically recognize toxin Cn2 with increased Kd of 446 fold. All variants were monomeric and only variants 6009F, 6105F and 6103E showed to be capable of neutralizing toxin Cn2 and the whole venom. Variant 6009F recognizes a different epitope than that of BCF2, a murine monoclonal antibody raised against scorpion toxin Cn2 which is also capable of neutralizing both Cn2 toxin and the whole venom when tested in mice, as well as that of commercially available polyclonal antibody fragments antivenom from horse. The scFv 6009F is the first reported recombinant human antibody fragment capable of neutralizing a scorpion venom. These results pave the way for the generation of safer autologous recombinant neutralizing antivenom against scorpion stings. The antibodies of the present invention can be used as part of a composition to treat those in need of treatment including those already stung by one or more scorpions, particularly C. noxius scorpions.
摘要翻译：本发明涉及对来自C.noxius蝎毒素的Cn2毒素特异的重组人抗体。抗体能够识别毒素，并优选中和它以及C.noxius蝎子的全部毒液。本发明还涉及人类非免疫噬菌体展示文库。特异性结合Cn2毒素的一个克隆通过定向进化亲和成熟。进行三个成熟周期，并分离出几个scFv克隆，其特异性识别毒素Cn2，增加了446倍。所有变体都是单体的，只有变体6009F，6105F和6103E才能够中和毒素Cn2和全毒液。变体6009F识别与BCF2不同的表位，BCF2是针对蝎毒素Cn2产生的鼠单克隆抗体，其在小鼠中测试时也能够中和Cn2毒素和全毒液，以及可商购的多克隆抗体片段抗蛇毒素马。 scFv 6009F是能够中和蝎毒液的首次报道的重组人抗体片段。这些结果为针对蝎子蜇产生更安全的自体重组中和抗蛇毒剂铺平了道路。本发明的抗体可以用作组合物的一部分，以治疗需要治疗的组合物，包括已经被一种或多种蝎子，特别是C.noxius蝎子刺伤的那些。

5. 发明授权

US5876971A Thrombin inhibitor from the saliva of protostomia 失效
标题翻译：凝血酶抑制剂来自原肠the唾液
公开(公告)号：US5876971A
公开(公告)日：1999-03-02
申请号：US448438
申请日：1995-08-24
申请人： Christiane Noeske-Jungblut , Wolf-Dieter Schleuning , Alejandro Alagon , Lourival Possani , Delia Cuevas-Aguierre , Peter Donner , Bernard Haendler , Ulrike Hechler
发明人： Christiane Noeske-Jungblut , Wolf-Dieter Schleuning , Alejandro Alagon , Lourival Possani , Delia Cuevas-Aguierre , Peter Donner , Bernard Haendler , Ulrike Hechler
IPC分类号： C12N15/09 , A61K35/12 , A61K35/56 , A61K35/64 , A61K38/00 , A61K38/55 , A61K38/57 , A61P7/02 , A61P9/10 , C07H21/04 , C07K1/14 , C07K14/435 , C07K14/81 , C12N1/21 , C12N5/10 , C12N9/99 , C12N15/15 , C12P21/00 , C12P21/02 , A61K38/16 , C07K1/36
CPC分类号： C07K14/811 , A61K38/00
摘要： The invention relates to a natural protein or a protein that can be synthetically produced, which is a thrombin inhibitor and can be isolated from the saliva of insects which suck the blood of mammals. Preferred is the Triatoma pallidipennis insect. The protein is used for the treatment of thromboses or unstable angina or arteriosclerosis, or for the prevention of a reblockage of vessels after PTCA/PTA or for the prevention of blood clotting in hemodialysis.
摘要翻译： PCT No.PCT / DE93 / 01172 Sec。 371日期1995年8月24日 102（e）日期1995年8月24日PCT提交1993年12月3日PCT公布。公开号WO94 / 13807 日期1994年6月23日本发明涉及可以合成产生的天然蛋白质或蛋白质，其是凝血酶抑制剂，并且可以从吸入哺乳动物的血液的昆虫的唾液中分离出来。优选的是Triatoma pallidipennis昆虫。该蛋白质用于治疗血栓形成或不稳定性心绞痛或动脉硬化，或用于预防PTCA / PTA后血管再阻塞或用于预防血液透析中血液凝固。

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