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1. 发明授权

US07429590B2 Antiprotozoal imidazopyridine compounds 有权
标题翻译：抗原虫咪唑并吡啶化合物
公开(公告)号：US07429590B2
公开(公告)日：2008-09-30
申请号：US10573363
申请日：2004-12-06
申请人： Tesfaye Biftu , Matthew J. Wyvratt , Louis L. Zuegner, III, legal representative
发明人： Michael H. Fisher
IPC分类号： C07D401/04 , C07D403/04 , C07D417/04 , A61K31/4188
CPC分类号： C07D471/04
摘要： Compounds described by the Formula (I) or (II): or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidieal agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria. African typanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s).
摘要翻译：由式（I）或（II）表示的化合物：或其药学上可接受的盐或N-氧化物。该化合物可用于治疗和预防哺乳动物和鸟类中的原生动物疾病。用于控制家禽中球虫病的方法包括单独施用有效量的化合物，或与一种或多种抗球虫剂组合施用。用于控制家禽中球虫病的组合物包含单独的化合物，或与一种或多种抗球虫剂组合。用于治疗和预防哺乳动物原生动物疾病的方法，例如弓形体病，疟疾。非洲typanosomias，恰加斯病和机会性感染包括单独施用化合物，或与一种或多种抗原虫剂组合施用。

2. 发明授权

US07326726B2 Biaryl substituted triazoles as sodium channel blockers 有权
标题翻译：二芳基取代三唑作为钠通道阻断剂
公开(公告)号：US07326726B2
公开(公告)日：2008-02-05
申请号：US10799230
申请日：2004-03-12
申请人： Prasun K. Chakravarty , Louis L. Zuegner III, legal representative , Brenda Palucki , Min K. Park , William H. Parsons , Bishan Zhou
发明人： Michael H. Fisher, deceased
IPC分类号： A61K31/41 , C07D249/08
CPC分类号： C07D249/08 , C07D249/10
摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.
摘要翻译：由式I，II或III表示的二芳基取代的三唑化合物或其药学上可接受的盐，以及制备这些化合物及其盐的方法。药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，癫痫，肠易激综合征，抑郁症，焦虑症，多发性硬化症和双相包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。

3. 发明授权

US07572822B2 Biaryl substituted triazoles as sodium channel blockers 有权
标题翻译：二芳基取代三唑作为钠通道阻断剂
公开(公告)号：US07572822B2
公开(公告)日：2009-08-11
申请号：US12011967
申请日：2008-01-30
申请人： Prasun K. Chakravarty , Louis L. Zuegner, III, legal representative , William H. Parsons , Brenda Palucki , Bishan Zhou , Min K. Park
发明人： Michael H. Fisher
IPC分类号： A61K31/4196 , A61K31/41 , C07D249/08
CPC分类号： C07D249/08 , C07D249/10
摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.
摘要翻译：由式I，II或III表示的二芳基取代的三唑化合物或其药学上可接受的盐，以及制备这些化合物及其盐的方法。药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，癫痫，肠易激综合征，抑郁症，焦虑症，多发性硬化症和双相包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。

4. 发明授权

US07459475B2 Substituted triazoles as sodium channel blockers 有权
标题翻译：取代的三唑作为钠通道阻断剂
公开(公告)号：US07459475B2
公开(公告)日：2008-12-02
申请号：US10985592
申请日：2004-11-10
申请人： Min K. Park , Prasun K. Chakravarty , Bishan Zhou , Edward Gonzalez , Hyun Ok , Brenda Palucki , William H. Parsons , Rosemary Sisco , Louis L. Zuegner, III, legal representative
发明人： Michael H. Fisher
IPC分类号： A61K31/41 , C07D249/08
CPC分类号： C07D249/10 , C07D403/10
摘要： Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.
摘要翻译：由式I，II或III表示的取代的三唑化合物或其药学上可接受的盐。药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，偏头痛，头痛，偏头痛，癫痫，肠易激综合征，糖尿病神经病，多发性硬化症，躁狂抑郁症和双相性精神障碍，包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。

5. 发明申请

US20090074890A1 Substituted Triazoles as Sodium Channel Blockers 审中-公开
标题翻译：取代三唑作为钠通道阻断剂
公开(公告)号：US20090074890A1
公开(公告)日：2009-03-19
申请号：US10578950
申请日：2004-11-05
申请人： Min K. Park , Prasun K. Chakravarty , Bishan Zhou , Edward Gonzalez , Hyun Ok , Brenda Palucki , William H. Parsons , Rosemary Sisco , Michael H. Fisher , Louis L. Zuegner, III
发明人： Min K. Park , Prasun K. Chakravarty , Bishan Zhou , Edward Gonzalez , Hyun Ok , Brenda Palucki , William H. Parsons , Rosemary Sisco , Michael H. Fisher , Louis L. Zuegner, III
IPC分类号： C07D249/08 , A61P29/00 , A61P9/00 , A61P25/00 , A61K33/00 , A61K31/4196 , A61P1/00 , A61P31/12 , A61P37/00
CPC分类号： C07D249/10 , C07D403/10
摘要： Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier (I), (II), (III).
摘要翻译：由式I，II或III表示的取代的三唑化合物或其药学上可接受的盐。药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，偏头痛，头痛，偏头痛，癫痫，肠易激综合征，糖尿病神经病，多发性硬化症，躁狂抑郁症和双相性精神障碍，包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体（I），（II），（III）。

6. 发明申请

US20080171777A1 Biaryl substituted triazoles as sodium channel blockers 有权
公开(公告)号：US20080171777A1
公开(公告)日：2008-07-17
申请号：US12011967
申请日：2008-01-30
申请人： Prasun K. Chakravarty , Michael H. Fisher , Louis L. Zuegner , William H. Parsons , Brenda Palucki , Bishan Zhou , Min K. Park
发明人： Prasun K. Chakravarty , Michael H. Fisher , Louis L. Zuegner , William H. Parsons , Brenda Palucki , Bishan Zhou , Min K. Park
IPC分类号： A61K31/4196 , C07D249/08 , A61P23/02 , A61P25/04
CPC分类号： C07D249/08 , C07D249/10
摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

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