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1. 发明申请

US20080063638A1 Mitotic kinesin-like protein-1, MKLP1, and uses therof priority 审中-公开
标题翻译：有丝分裂驱动蛋白样蛋白-1，MKLP1，并优先使用
公开(公告)号：US20080063638A1
公开(公告)日：2008-03-13
申请号：US11903942
申请日：2007-09-24
申请人： Paz Einat , Louis Deiss , Ruth Maya
发明人： Paz Einat , Louis Deiss , Ruth Maya
IPC分类号： A61K31/7088 , A61K38/02 , A61K39/395 , A61P43/00
CPC分类号： C07K16/18 , C12N9/14
摘要： The present invention discloses uses for the MKLP1 gene and/or polypeptide and/or modulators thereof in the diagnosis and treatment of apoptosis-related diseases.
摘要翻译：本发明公开了MKLP1基因和/或其多肽和/或其调节剂在凋亡相关疾病的诊断和治疗中的应用。

2. 发明申请

US20050272056A1 Gene identification method 审中-公开
标题翻译：基因鉴定方法
公开(公告)号：US20050272056A1
公开(公告)日：2005-12-08
申请号：US11031356
申请日：2005-01-07
申请人： Louis Deiss , Fruma Yehiely , Paz Einat
发明人： Louis Deiss , Fruma Yehiely , Paz Einat
IPC分类号： C12N15/74 , C12N15/867 , C12Q1/68
CPC分类号： C12N15/1079
摘要： A method for the identification of genes that are essential for the maintenance of specific cell phenotypes is disclosed. The method includes the initial step of identifying a cell type with a phenotype of interest. Gene inactivation is performed on an aliquot of cells of the cell type of interest. Positive selection is then performed to an aliquot of the cell culture to which gene inactivation has been applied. Cells which continue to maintain the phenotype following gene inactivation have not had the gene of interest inactivated whereas cells in which genes necessary for maintaining the phenotype have been inactivated have been lost. Utilizing subtraction analysis between treated and untreated aliquots the gene in the cells which has been inactivated that affects the phenotype of interest is identified. Genes that are identified by the method are also disclosed as well as antibodies directed against the gene product of the identified genes. Further a customized kit for the practice of the gene identification method is also disclosed.
摘要翻译：公开了用于鉴定对维持特定细胞表型必不可少的基因的方法。该方法包括鉴定具有感兴趣的表型的细胞类型的初始步骤。对感兴趣的细胞类型的细胞的等分试样进行基因灭活。然后对已应用基因失活的细胞培养物的等分试样进行阳性选择。在基因失活后继续保持表型的细胞没有使目的基因失活，而其中维持表型所必需的基因已被灭活的细胞已经丧失。鉴定了处理和未处理等分试样之间的减法分析，已经灭活的影响感兴趣的表型的细胞中的基因被鉴定出来。还公开了通过该方法鉴定的基因以及针对所鉴定的基因的基因产物的抗体。还公开了用于实施基因鉴定方法的定制试剂盒。

3. 发明申请

US20080300208A1 Isociatrate dehydrogenase and uses therof 审中-公开
标题翻译：联合脱氢酶并使用
公开(公告)号：US20080300208A1
公开(公告)日：2008-12-04
申请号：US12069188
申请日：2008-02-07
申请人： Paz Einat , Louis Deiss , Ruth Maya
发明人： Paz Einat , Louis Deiss , Ruth Maya
IPC分类号： A61K31/7088 , C07H21/04 , C12N15/85 , C12N5/08 , C12N5/06
CPC分类号： C07K16/40 , A61K2039/505
摘要： The present invention discloses uses for the IDH gene and/or polypeptide and/or modulators thereof in the diagnosis and treatment of apoptosis-related diseases.
摘要翻译：本发明公开了IDH基因和/或多肽和/或其调节剂在凋亡相关疾病的诊断和治疗中的用途。

4. 发明申请

US20070042418A1 Therapeutic modulation of the fas pathway 失效
标题翻译： fas途径的治疗调节
公开(公告)号：US20070042418A1
公开(公告)日：2007-02-22
申请号：US11586021
申请日：2006-10-24
申请人： Fruma Yehiely , Louis Deiss , Paz Einat
发明人： Fruma Yehiely , Louis Deiss , Paz Einat
IPC分类号： C12Q1/68
CPC分类号： A61K48/00
摘要： A method for the identification of genes that are essential for the maintenance of specific cell phenotypes is disclosed. The method includes the initial step of identifying a cell type with a phenotype of interest. Gene inactivation is performed on an aliquot of cells of the cell type of interest. Selection is then performed to an aliquot of the cell culture to which gene inactivation has been applied. Cells which continue to maintain the phenotype following gene inactivation have not had the gene of interest inactivated whereas cells in which genes necessary for maintaining the phenotype have been inactivated have been lost. Utilizing subtraction analysis between treated and untreated aliquots the gene in the cells which has been inactivated that affects the phenotype of interest is identified. Genes that are identified by the method are also disclosed as well as antibodies directed against the gene product of the identified genes. Further a customized kit for the practice of the gene identification method is also disclosed.
摘要翻译：公开了用于鉴定对维持特定细胞表型必不可少的基因的方法。该方法包括鉴定具有感兴趣的表型的细胞类型的初始步骤。对感兴趣的细胞类型的细胞的等分试样进行基因灭活。然后对已应用基因失活的细胞培养物的等分试样进行选择。在基因失活后继续保持表型的细胞没有使目的基因失活，而其中维持表型所必需的基因已被灭活的细胞已经丧失。鉴定了处理和未处理等分试样之间的减法分析，已经灭活的影响感兴趣的表型的细胞中的基因被鉴定出来。还公开了通过该方法鉴定的基因以及针对所鉴定的基因的基因产物的抗体。还公开了用于实施基因鉴定方法的定制试剂盒。

5. 发明授权

US07749977B2 Therapeutic modulation of the Fas pathway 失效
标题翻译： Fas途径的治疗调节
公开(公告)号：US07749977B2
公开(公告)日：2010-07-06
申请号：US11586021
申请日：2006-10-24
申请人： Fruma Yehiely , Louis Deiss , Paz Einat
发明人： Fruma Yehiely , Louis Deiss , Paz Einat
IPC分类号： A61K31/70 , C07H21/02
CPC分类号： A61K48/00
摘要： A method for the identification of genes that are essential for the maintenance of specific cell phenotypes is disclosed. The method includes the initial step of identifying a cell type with a phenotype of interest. Gene inactivation is performed on an aliquot of cells of the cell type of interest. Selection is then performed to an aliquot of the cell culture to which gene inactivation has been applied. Cells which continue to maintain the phenotype following gene inactivation have not had the gene of interest inactivated whereas cells in which genes necessary for maintaining the phenotype have been inactivated have been lost. Utilizing subtraction analysis between treated and untreated aliquots the gene in the cells which has been inactivated that affects the phenotype of interest is identified. Genes that are identified by the method are also disclosed as well as antibodies directed against the gene product of the identified genes. Further a customized kit for the practice of the gene identification method is also disclosed.
摘要翻译：公开了用于鉴定对维持特定细胞表型必不可少的基因的方法。该方法包括鉴定具有感兴趣的表型的细胞类型的初始步骤。对感兴趣的细胞类型的细胞的等分试样进行基因灭活。然后对已应用基因失活的细胞培养物的等分试样进行选择。在基因失活后继续保持表型的细胞没有使目的基因失活，而其中维持表型所必需的基因已被灭活的细胞已经丧失。鉴定了处理和未处理等分试样之间的减法分析，已经灭活的影响感兴趣的表型的细胞中的基因被鉴定出来。还公开了通过该方法鉴定的基因以及针对所鉴定的基因的基因产物的抗体。还公开了用于实施基因鉴定方法的定制试剂盒。

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