专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08603478B2 Anti-RON antibodies 失效
标题翻译：抗RON抗体
公开(公告)号：US08603478B2
公开(公告)日：2013-12-10
申请号：US13177071
申请日：2011-07-06
申请人： Kerry Whalen , Steve Bottega , Andrea Boudrow , Lyne Breault , Ting Chen , James Gifford , May Han , Jinwei Jiang , Lorena Lerner , Qing Liu , Kristan Meetze , Sylvie Vincent , Solly Weiler , William M. Winston, Jr. , Jeno Gyuris
发明人： Kerry Whalen , Steve Bottega , Andrea Boudrow , Lyne Breault , Ting Chen , James Gifford , May Han , Jinwei Jiang , Lorena Lerner , Qing Liu , Kristan Meetze , Sylvie Vincent , Solly Weiler , William M. Winston, Jr. , Jeno Gyuris
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d' Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON.
摘要翻译：公开了结合并抑制人RON（Recepteur d'Origine Nantais）活化的单克隆抗体。抗体可用于治疗与RON活化相关的特定形式的癌症。

2. 发明申请

US20120027773A1 ANTI-RON ANTIBODIES 失效
标题翻译：抗体抗体
公开(公告)号：US20120027773A1
公开(公告)日：2012-02-02
申请号：US13177071
申请日：2011-07-06
申请人： Kerry Whalen , Steve Botega , Andrea Boudrow , Lyne Breault , Ting Chen , James Gifford , May Han , Jinwei Jiang , Lorena Lerner , Qing Liu , Kristan Meetze , Sylvie Vincent , Solly Weiler , William M. Winston, JR. , Jeno Gyuris
发明人： Kerry Whalen , Steve Botega , Andrea Boudrow , Lyne Breault , Ting Chen , James Gifford , May Han , Jinwei Jiang , Lorena Lerner , Qing Liu , Kristan Meetze , Sylvie Vincent , Solly Weiler , William M. Winston, JR. , Jeno Gyuris
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , A61P35/00 , C12N1/21 , C12P21/00 , C12N5/09 , C07K16/40 , C12N5/10
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of human RON (Recepteur d' Origine Nantais) are disclosed. The antibodies can be used to treat certain forms of cancer that are associated with activation of RON.
摘要翻译：公开了结合并抑制人RON（Recepteur d'Origine Nantais）活化的单克隆抗体。抗体可用于治疗与RON活化相关的特定形式的癌症。

3. 发明授权

US07556796B2 Directed complementation 失效
标题翻译：导向互补
公开(公告)号：US07556796B2
公开(公告)日：2009-07-07
申请号：US11398171
申请日：2006-04-05
申请人： Murray Robinson , Ronan O'Hagan , Karuppiah Kannan , Ti Cai , Maria Isabel Chiu , Lorena Lerner , Jie Lin , Yinghui Zhou
发明人： Murray Robinson , Ronan O'Hagan , Karuppiah Kannan , Ti Cai , Maria Isabel Chiu , Lorena Lerner , Jie Lin , Yinghui Zhou
IPC分类号： A61K49/00 , A61K35/12
CPC分类号： A01K67/0271 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C12N15/8509 , C12N2830/002
摘要： A method of producing a tumorigenic mouse cell, the tumorigenicity of which depends on a recombinant gene of interest is disclosed. The method involves: (a) providing a conditionally tumorigenic mouse cell containing a recombinant oncogene operably linked to an inducible promoter, wherein (i) expression of the recombinant oncogene is necessary and sufficient for the tumorigenicity of the tumorigenic mouse cell, and (ii) the inducible promoter is in the uninduced state; and (b) introducing into the cell a recombinant gene of interest that functionally complements the oncogene, thereby restoring tumorigenicity without expression of the inducible recombinant oncogene. Also disclosed is a method of testing a compound for anti-tumor effects. The method includes producing tumorigenic mouse cells the tumorigenicity depends on expression of a recombinant gene of interest, implanting the cells in mice and obtaining tumors from the implanted cells, administering test compounds to the mice, and determining anti-tumor effects, if any, of the compounds.
摘要翻译：公开了一种致瘤性小鼠细胞的产生方法取决于感兴趣的重组基因的方法。该方法包括：（a）提供含有可操作地连接到诱导型启动子的重组癌基因的条件致瘤小鼠细胞，其中（i）重组癌基因的表达对于致瘤性小鼠细胞的致瘤性是必要和足够的，以及（ii）诱导型启动子处于未诱导状态; 和（b）在细胞中引入功能上补充致癌基因的重组基因，从而恢复致瘤性而不表达可诱导的重组癌基因。还公开了测试化合物抗肿瘤作用的方法。该方法包括产生致瘤性小鼠细胞，其致瘤性取决于感兴趣的重组基因的表达，将细胞植入小鼠中并从植入的细胞中获得肿瘤，向小鼠施用测试化合物，并测定抗肿瘤作用（如果有的话）化合物。

4. 发明申请

US20060228302A1 Directed complementation 失效
公开(公告)号：US20060228302A1
公开(公告)日：2006-10-12
申请号：US11398171
申请日：2006-04-05
申请人： Murray Robinson , Ronan O'Hagan , Karuppiah Kannan , Ti Cai , Maria Chiu , Lorena Lerner , Jie Lin , Yinghui Zhou
发明人： Murray Robinson , Ronan O'Hagan , Karuppiah Kannan , Ti Cai , Maria Chiu , Lorena Lerner , Jie Lin , Yinghui Zhou
IPC分类号： A61K49/00 , C12N5/06 , C12N15/09
CPC分类号： A01K67/0271 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C12N15/8509 , C12N2830/002
摘要： A method of producing a tumorigenic mouse cell, the tumorigenicity of which depends on a recombinant gene of interest is disclosed. The method involves: (a) providing a conditionally tumorigenic mouse cell containing a recombinant oncogene operably linked to an inducible promoter, wherein (i) expression of the recombinant oncogene is necessary and sufficient for the tumorigenicity of the tumorigenic mouse cell, and (ii) the inducible promoter is in the uninduced state; and (b) introducing into the cell a recombinant gene of interest that functionally complements the oncogene, thereby restoring tumorigenicity without expression of the inducible recombinant oncogene. Also disclosed is a method of testing a compound for anti-tumor effects. The method includes producing tumorigenic mouse cells the tumorigenicity depends on expression of a recombinant gene of interest, implanting the cells in mice and obtaining tumors from the implanted cells, administering test compounds to the mice, and determining anti-tumor effects, if any, of the compounds.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式