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1. 发明授权

US5843863A Process for improving flow characteristics of crystalline ibuprofen 失效
标题翻译：改善结晶布洛芬流动特性的方法
公开(公告)号：US5843863A
公开(公告)日：1998-12-01
申请号：US115836
申请日：1993-09-03
申请人： Lloyd E. Goddard , George A. Knesel
发明人： Lloyd E. Goddard , George A. Knesel
IPC分类号： C07C51/43 , C07C57/30 , C07C51/42
CPC分类号： C07C51/43
摘要： A process for producing crystalline ibuprofen having a crystal habit characterized by a particle length larger than 75 microns average and a length to width aspect ratio of greater than about 4 to 1 to about 5 to 1. The process involves crystallizing ibuprofen from a saturated solution of ibuprofen in a liquid hydrocarbon solvent by seeding and cooling such solution to a temperature of about 0.degree. C. to about -20.degree. C. at a rate to retard primary nucleation and promote secondary nucleation. The crystalline ibuprofen is separated from the slurry produced from such cooling.
摘要翻译：具有结晶习性的结晶布洛芬的制造方法，其特征在于粒度长度大于75微米，长宽比大于约4至1至约5比1。该方法包括将布洛芬从饱和溶液布洛芬在液体烃溶剂中通过接种并将该溶液冷却至约0℃至约-20℃的温度，以延缓初级成核并促进二次成核。将结晶布洛芬与由这种冷却产生的浆料分离。

2. 发明授权

US3939215A Chemical process 失效
标题翻译：化学工艺
公开(公告)号：US3939215A
公开(公告)日：1976-02-17
申请号：US472352
申请日：1974-05-22
申请人： Lloyd E. Goddard
发明人： Lloyd E. Goddard
IPC分类号： C07C37/86 , C07C39/06 , C07C37/22
CPC分类号： C07C37/86
摘要： Aluminum is removed from sec-alkyl phenolic compositions containing aluminum in the form of a phenate by first adding aqueous alkali metal hydroxide in stoichiometric excess over said aluminum and then acidifying the mixture with a mineral acid and removing the acidic aqueous phase to leave a substantially aluminum-free sec-alkyl phenolic composition. The method is especially adapted to remove aluminum from the distillation bottoms remaining after distilling product from a sec-alkylation mixture formed by alkylating a phenol with a sec-alkyl precursor olefin using an aluminum phenate catalyst.
摘要翻译：通过首先在所述铝上加入化学计量过量的碱金属氢氧化物水溶液然后用无机酸酸化所述混合物并除去酸性水相以留下基本上铝，从而从含有酚形式的铝的仲烷基酚类组合物中除去铝 - 非仲烷基酚类组合物。该方法特别适用于从通过使用酚铝催化剂将仲烷基前体烯烃烷基化形成的仲烷基化混合物蒸馏产物后，从蒸馏塔底中除去铝。

3. 发明授权

US3933927A Phenol transalkylation process 失效
标题翻译：苯酚烷基转移法
公开(公告)号：US3933927A
公开(公告)日：1976-01-20
申请号：US351015
申请日：1973-04-13
申请人： Lloyd E. Goddard
发明人： Lloyd E. Goddard
IPC分类号： C07C37/48 , C07C37/66 , C07C39/06
CPC分类号： C07C37/66 , C07C37/48 , C07C41/30 , C07C2101/14
摘要： Phenols having an unsubstituted ortho position are transalkylated in the ortho position by mixing them with an ortho-alpha-branched alkylphenol (e.g., 2,6-di-sec-butylphenol) and an aluminum phenoxide catalyst and heating the mixture to 100.degree.-350.degree.C., preferably in a closed system and in the presence of olefin corresponding in structure to the ortho-alpha-branched alkyl group.
摘要翻译：具有未取代的邻位的酚通过将它们与邻α-支化烷基酚（例如2,6-二仲丁基苯酚）和苯酚氧化物催化剂混合在邻位进行烷基转移，并将混合物加热至100 -350℃ 优选在封闭体系中和存在烯烃的存在下，其结构相当于邻α-支链烷基。

4. 发明授权

US4994628A Phenolic antioxidant process 失效
标题翻译：酚类抗氧化过程
公开(公告)号：US4994628A
公开(公告)日：1991-02-19
申请号：US411631
申请日：1989-09-25
申请人： Lloyd E. Goddard , George L. Mina
发明人： Lloyd E. Goddard , George L. Mina
IPC分类号： C07C37/16 , C07C39/15
CPC分类号： C07C37/16
摘要： 3,5-dialkyl-4-hydroxybenzyl-substituted benzene compounds are made by reacting 2,6-dialkyl-4-methoxymethyl phenols with a benzene compound having an unsubstituted nuclear position in an inert solvent and in the presence of sulfuric acid catalyst while distilling methanol by-product from the reaction mixture as it forms.
摘要翻译： 3,5-二烷基-4-羟基苄基取代的苯化合物是通过使2,6-二烷基-4-甲氧基甲基苯酚与惰性溶剂中的具有未取代的核位置的苯化合物和在硫酸催化剂存在下进行蒸馏甲醇副产物从反应混合物中形成。

5. 发明授权

US5352823A Process for improving flow characteristics of crystalline ibuprofen 失效
标题翻译：改善结晶布洛芬流动特性的方法
公开(公告)号：US5352823A
公开(公告)日：1994-10-04
申请号：US963872
申请日：1992-10-20
申请人： Lloyd E. Goddard , George A. Knesel
发明人： Lloyd E. Goddard , George A. Knesel
IPC分类号： C07C51/43 , C07C57/30 , C07C51/42
CPC分类号： C07C51/43
摘要： A process for producing crystalline ibuprofen having a crystal habit characterized by a particle length larger than 75 microns average and a length to width aspect ratio of greater than about 4 to 1 to about 5 to 1. The process involves crystallizing ibuprofen from a saturated solution of ibuprofen in a liquid hydrocarbon solvent by seeding and cooling such solution to a temperature of about 0.degree. C. to about -20.degree. C. at a rate to retard primary nucleation and promote secondary nucleation. The crystalline ibuprofen is separated from the slurry produced from such cooling.
摘要翻译：具有结晶习性的结晶布洛芬的制造方法，其特征在于粒度长度大于75微米，长宽比大于约4至1至约5比1。该方法包括将布洛芬从饱和溶液布洛芬在液体烃溶剂中通过接种并将该溶液冷却至约0℃至约-20℃的温度，以延缓初级成核并促进二次成核。将结晶布洛芬与由这种冷却产生的浆料分离。

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