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1. 发明申请

US20090239819A1 PERITONEAL DIALYSIS SOLUTION TEST METHOD 审中-公开
标题翻译： PERITONEAL DIALYSIS解决方案测试方法
公开(公告)号：US20090239819A1
公开(公告)日：2009-09-24
申请号：US12052446
申请日：2008-03-20
申请人： Run Wang , Cliff Holmes , Line Skoufos , John Lamela
发明人： Run Wang , Cliff Holmes , Line Skoufos , John Lamela
IPC分类号： A61K31/715 , G01N33/53 , C12Q1/54
CPC分类号： G01N33/56911 , C12Q1/04 , G01N33/5047 , G01N2333/4722 , G01N2333/5412
摘要： A method of testing a glucose polymer or a glucose polymer derivative includes providing a sample of the glucose polymer or glucose polymer derivative. The sample is filtered at a specified molecular weight cutoff to obtain a retentate portion and a filtrate portion. The retentate portion is added to a first assay. The filtrate portion is added to a second assay. A reagent is added to each of the first assay and the second assay. The reagent produces a proinflammatory response. The proinflammatory response of each of the first assay and the second assay is measured. The proinflammatory response of the first assay is compared to the proinflammatory response of the second assay to determine if the glucose polymer or glucose polymer derivative is suitable for use in a patient.
摘要翻译：测定葡萄糖聚合物或葡萄糖聚合物衍生物的方法包括提供葡萄糖聚合物或葡萄糖聚合物衍生物的样品。将样品以规定的分子量截留值过滤，得到滞留物部分和滤液部分。将滞留物部分加入到第一测定中。将滤液部分加入到第二次测定中。在第一测定和第二测定中的每一个中加入试剂。试剂产生促炎反应。测量第一测定和第二测定中的每一个的促炎反应。将第一测定的促炎反应与第二测定的促炎响应进行比较，以确定葡萄糖聚合物或葡萄糖聚合物衍生物是否适合用于患者。

2. 发明申请

US20090239238A1 METHODS FOR MEASURING PRO-INFLAMMATORY SUBSTANCE LEVELS IN DIALYSIS SOLUTIONS AND DIALYSIS COMPONENTS 审中-公开
标题翻译：用于测量DIALYSIS解决方案和透析组件中的预防性物质水平的方法
公开(公告)号：US20090239238A1
公开(公告)日：2009-09-24
申请号：US12052477
申请日：2008-03-20
申请人： Run Wang , Cliff Holmes , Line Skoufos , Pat Hyla
发明人： Run Wang , Cliff Holmes , Line Skoufos , Pat Hyla
IPC分类号： G01N33/53
CPC分类号： C12Q1/04 , G01N33/5047 , G01N33/56911 , G01N33/6869 , G01N2333/4722 , G01N2333/5412
摘要： Methods of measuring levels of pro-inflammatory substances in dialysis solutions or specific dialysis components used to manufacture dialysis solutions are provided. In a general embodiment, the method comprises determining an IL-6 response versus a pro-inflammatory substance concentration of a reference standard containing a pro-inflammatory substance and establishing a dose-response curve of the IL-6 responses as a function of different pro-inflammatory substance concentrations of the reference standard. An IL-6 response of a test sample of a dialysis solution is determined. The corresponding pro-inflammatory substance concentration of the dialysis solution is then calculated using the dose-response curve. The IL-6 response of the reference standards and the dialysis solution can be determined using a high sensitivity PBMC IL-6 assay.
摘要翻译：提供测量用于制造透析溶液的透析溶液或特定透析组分中促炎物质水平的方法。在一般实施方案中，该方法包括测定IL-6应答与含有促炎物质的参考标准物的促炎物质浓度，并建立IL-6应答的剂量 - 反应曲线作为不同的pro - 炎性物质浓度参考标准。确定透析溶液的测试样品的IL-6应答。然后使用剂量 - 反应曲线计算透析溶液的相应的促炎物质浓度。参考标准和透析溶液的IL-6反应可以使用高灵敏度PBMC IL-6测定来确定。

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