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1. 发明申请

US20050119228A1 METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF 失效
标题翻译：熔融杂环化合物化合物的制备方法及其模拟物
公开(公告)号：US20050119228A1
公开(公告)日：2005-06-02
申请号：US10024878
申请日：2001-12-19
申请人： Mark Salvati , Toomas Mitt , Ramesh Patel , Ronald Hanson , David Brzozowski , Animesh Goswami , Linda Chu , Wen-sen Li , James Simpson , Michael Totleben , Weixuan He
发明人： Mark Salvati , Toomas Mitt , Ramesh Patel , Ronald Hanson , David Brzozowski , Animesh Goswami , Linda Chu , Wen-sen Li , James Simpson , Michael Totleben , Weixuan He
IPC分类号： A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , C07D487/14
CPC分类号： C07D487/18 , A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译：稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。

2. 发明申请

US20060286646A1 STEREOSELECTIVE REDUCTION PROCESS FOR THE PREPARATION OF PYRROLOTRIAZINE COMPOUNDS 有权
标题翻译：用于制备吡咯啉化合物的选择性缩合方法
公开(公告)号：US20060286646A1
公开(公告)日：2006-12-21
申请号：US11421112
申请日：2006-05-31
申请人： Ramesh Patel , Linda Chu , Robert Johnson , Zhiwei Guo , Yijun Chen , Steven Goldberg , Ronald Hanson , Animesh Goswami , Kishta Katipally
发明人： Ramesh Patel , Linda Chu , Robert Johnson , Zhiwei Guo , Yijun Chen , Steven Goldberg , Ronald Hanson , Animesh Goswami , Kishta Katipally
IPC分类号： C12P17/16 , C07D487/04
CPC分类号： C12N9/0006 , C07D487/04 , C12P17/165
摘要： The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula Ib:
摘要翻译：本发明涉及一种用于酶促立构选择性还原酮化合物以提供手性醇的方法，例如式Ib化合物：

3. 发明授权

US07884644B1 Techniques for adjusting level shifted signals 有权
标题翻译：调整电平转换信号的技术
公开(公告)号：US07884644B1
公开(公告)日：2011-02-08
申请号：US12709492
申请日：2010-02-21
申请人： Luqiong Wu , Linda Chu , Toan D. Do , Jack Chui , Praveen Krishnanunni
发明人： Luqiong Wu , Linda Chu , Toan D. Do , Jack Chui , Praveen Krishnanunni
IPC分类号： H03K19/094
CPC分类号： H03K17/693 , H03K3/017 , H03K3/356113 , H03K5/1565 , H03K19/018521
摘要： A level shifter circuit includes first and second transistors that receive a first input signal at control inputs. A level shifted output signal is generated by the first and the second transistors. Third and fourth transistors receive a second input signal at control inputs. The first input signal is an inverse of the second input signal. A first multiplexer circuit is configurable to couple a control input of a fifth transistor to the first and the second transistors. A second multiplexer circuit is configurable to couple a control input of a sixth transistor to the third and the fourth transistors.
摘要翻译：电平移位器电路包括在控制输入端接收第一输入信号的第一和第二晶体管。电平移位的输出信号由第一和第二晶体管产生。第三和第四晶体管在控制输入端接收第二输入信号。第一输入信号是第二输入信号的倒数。第一多路复用器电路可配置为将第五晶体管的控制输入耦合到第一和第二晶体管。第二多路复用器电路可配置为将第六晶体管的控制输入耦合到第三和第四晶体管。

4. 发明授权

US07083973B2 Stereoselective reduction of substituted oxo-butanes 有权
标题翻译：取代的氧代 - 丁烷的立体选择性还原
公开(公告)号：US07083973B2
公开(公告)日：2006-08-01
申请号：US10661893
申请日：2003-09-12
申请人： Ramesh N. Patel , Linda Chu
发明人： Ramesh N. Patel , Linda Chu
IPC分类号： C12S13/00 , C12P7/04 , C12P7/22
CPC分类号： C12P13/001
摘要： The present invention relates to a process for the stereoselective enzymatic reduction of 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes utilizing certain species of Rhodococcus and Brevibacterium. The product 1-halo-2-hydroxy-3-(protected)amino-4-substituted-butanes, which are useful as intermediates in the synthesis of compounds that are inhibitors of ACE, renin and HIV proteases, are obtained in high yield and, particularly, in very high diastereomeric purity. The process is advantageously highly selective for the (3S,2R) enantiomer of the product.
摘要翻译：本发明涉及利用某些种红细菌和短杆菌的立体选择性还原1-卤代-2-氧代-3-（保护的）氨基-4-取代的丁烷的方法。在合成作为ACE，肾素和HIV蛋白酶抑制剂的化合物中有用的中间体产物1-卤代-2-羟基-3-（被保护的）氨基-4-取代的丁烷以高产率和特别是非常高的非对映纯度。该方法有利地对产物的（3S，2R）对映异构体具有高选择性。

5. 发明授权

US08013632B1 Integrated circuit with global hotsocket architecture 有权
标题翻译：具有全球热插槽架构的集成电路
公开(公告)号：US08013632B1
公开(公告)日：2011-09-06
申请号：US12638799
申请日：2009-12-15
申请人： Jack Chui , Linda Chu , Toan D. Do
发明人： Jack Chui , Linda Chu , Toan D. Do
IPC分类号： H03K19/0175
CPC分类号： H03K19/177
摘要： Integrated circuits such as programmable logic devices are provided with hotsocket detection circuitry. The hotsocket detection circuitry monitors signals on data pins and power supply voltages. If the data pins become active before the power supply voltages have reached appropriate levels, a hotsocket condition is identified. When a hotsocket condition is identified, driver circuitry on the integrated circuit can be disabled by a hotsocket signal. The integrated circuit may include multiple blocks of input-output circuitry, each of which includes a local hotsocket circuit that uses global hotsocket and power-on-reset signals in disabling input-output circuitry in that input-output block. A power supply circuit in each input-output block may ensure that the local hotsocket circuit in that input-output block is powered.
摘要翻译：诸如可编程逻辑器件的集成电路具有热插入检测电路。热插拔检测电路监视数据引脚和电源电压上的信号。如果数据引脚在电源电压达到适当的电平之前变为有效，则会识别热插条件。当识别出热封条件时，集成电路上的驱动电路可以通过热插拔信号禁用。集成电路可以包括多个输入 - 输出电路模块，每个模块包括本地热插拔电路，该电路使用全局热插拔和上电复位信号来禁用该输入 - 输出模块中的输入 - 输出电路。每个输入 - 输出块中的电源电路可以确保该输入 - 输出块中的本地热插拔电路被供电。

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