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1. 发明申请

US20110212462A1 ULTRA-SENSITIVE DETECTION OF MOLECULES USING DUAL DETECTION METHODS 有权
标题翻译：使用双重检测方法进行超声检测分子
公开(公告)号：US20110212462A1
公开(公告)日：2011-09-01
申请号：US12731135
申请日：2010-03-24
申请人： David C. Duffy , David M. Rissin , David R. Walt , Linan Song , Lei Chang
发明人： David C. Duffy , David M. Rissin , David R. Walt , Linan Song , Lei Chang
IPC分类号： G01N33/53
CPC分类号： G01N33/54393 , G01N33/5306
摘要： Described herein are systems and methods for the detection of and/or determination of a measure of the concentration of analyte molecules or particles in a fluid sample. In some cases, the systems and methods employ techniques to reduce or limit the negative effects associated with non-specific binding events. Certain methods of the present invention involve associating the analyte molecules at least a first type of binding ligand and at least a second type of binding ligand, and spatially segregating the analyte molecules into a plurality of locations on a surface. The presence of an analyte molecule at or in a location may be determined by determining the presence of both the first type of binding ligand and the second type of binding ligand.
摘要翻译：本文描述了用于检测和/或确定流体样品中分析物分子或颗粒的浓度的测量的系统和方法。在某些情况下，系统和方法采用技术来减少或限制与非特异性结合事件相关的负面影响。本发明的某些方法包括将分析物分子与至少第一类型的结合配体和至少第二类型的结合配体相关联，并将分析物分子空间分离成表面上的多个位置。可以通过确定第一类型的结合配体和第二类型的结合配体的存在来确定在位置处或位置处的分析物分子的存在。

2. 发明授权

US09678068B2 Ultra-sensitive detection of molecules using dual detection methods 有权
公开(公告)号：US09678068B2
公开(公告)日：2017-06-13
申请号：US12731135
申请日：2010-03-24
申请人： David C. Duffy , David M. Rissin , David R. Walt , Linan Song , Lei Chang
发明人： David C. Duffy , David M. Rissin , David R. Walt , Linan Song , Lei Chang
IPC分类号： G01N33/543 , G01N33/53
CPC分类号： G01N33/54393 , G01N33/5306
摘要： Described herein are systems and methods for the detection of and/or determination of a measure of the concentration of analyte molecules or particles in a fluid sample. In some cases, the systems and methods employ techniques to reduce or limit the negative effects associated with non-specific binding events. Certain methods of the present invention involve associating the analyte molecules at least a first type of binding ligand and at least a second type of binding ligand, and spatially segregating the analyte molecules into a plurality of locations on a surface. The presence of an analyte molecule at or in a location may be determined by determining the presence of both the first type of binding ligand and the second type of binding ligand.

3. 发明申请

US20100075862A1 HIGH SENSITIVITY DETERMINATION OF THE CONCENTRATION OF ANALYTE MOLECULES OR PARTICLES IN A FLUID SAMPLE 审中-公开
标题翻译：分析物分子或颗粒在流体样品中的浓度的高灵敏度测定
公开(公告)号：US20100075862A1
公开(公告)日：2010-03-25
申请号：US12236484
申请日：2008-09-23
申请人： David C. Duffy , David M. Rissin , Linan Song , David R. Walt
发明人： David C. Duffy , David M. Rissin , Linan Song , David R. Walt
IPC分类号： C40B30/04 , C40B40/00
CPC分类号： G01N33/54366
摘要： The present invention relates to methods, systems, and kits for detecting, quantifying and/or analyzing a fluid sample comprising molecules or particles at low concentration. In certain embodiments, the methods for detection and/or quantifying analyte molecules in a sample comprise capturing a plurality of analyte molecules on a substrate (e.g., an array comprising a plurality of reaction vessels). The substrate may then be exposed to additional reaction components such as at least one binding ligand. The substrate may additionally be exposed to a precursor labeling agent molecule, wherein the precursor labeling agent molecule, in some cases, is converted to a labeling agent molecule, which may be detected, either directly or indirectly, which determination may be related to the presence of and/or may be employed to quantify the analyte molecules. Although the various aspects of the present invention may use a number of different assay formats, in one embodiment, the assays are conducted in a plurality of reaction vessels defined, at least in part, by the distal ends of fiber optic strands.
摘要翻译：本发明涉及用于检测，定量和/或分析低浓度分子或颗粒的流体样品的方法，系统和试剂盒。在某些实施方案中，用于检测和/或定量样品中的分析物分子的方法包括在基底上捕获多个分析物分子（例如，包括多个反应容器的阵列）。然后将底物暴露于另外的反应组分，例如至少一种结合配体。底物可以另外暴露于前体标记试剂分子，其中在某些情况下，前体标记试剂分子被转化成可直接或间接检测的标记试剂分子，该测定可能与存在和/或可以用于定量分析物分子。尽管本发明的各个方面可以使用多种不同的测定形式，但是在一个实施方案中，测定是在多个反应容器中进行的，所述多个反应容器至少部分由纤维束的远端限定。

4. 发明申请

US20140094386A1 METHODS OF DETERMINING A TREATMENT PROTOCOL FOR AND/OR A PROGNOSIS OF A PATIENT'S RECOVERY FROM A BRAIN INJURY RESULTING FROM A HYPOXIC EVENT 审中-公开
标题翻译：确定治疗方案和/或预防由高血压事件引起的脑损伤患者恢复的方法
公开(公告)号：US20140094386A1
公开(公告)日：2014-04-03
申请号：US14111331
申请日：2012-04-12
申请人： David Wilson , Linan Song
发明人： David Wilson , Linan Song
IPC分类号： G01N33/53
CPC分类号： G01N33/5306 , G01N33/6896 , G01N2333/4709 , G01N2800/28 , G01N2800/2871 , G01N2800/52
摘要： The present invention, in some embodiments, generally relates to methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury resulting from a hypoxic event. In some embodiments, methods are provided for determining a measure of the concentration of beta-amyloid peptide in a patient sample containing or suspected of containing beta-amyloid peptide.
摘要翻译：在一些实施方案中，本发明通常涉及确定患者从由缺氧事件引起的脑损伤恢复的治疗方案和/或预后的方法。在一些实施方案中，提供了用于确定含有或怀疑含有β-淀粉样蛋白肽的患者样品中β-淀粉样肽浓度测量的方法。

5. 发明申请

US20070251824A1 Multiplexed analyte quantitation by two-dimensional planar electrochromatography 审中-公开
标题翻译：通过二维平面电色谱法复用分析物定量
公开(公告)号：US20070251824A1
公开(公告)日：2007-11-01
申请号：US11657922
申请日：2007-01-24
申请人： Wayne Patton , Linan Song , Nancy Wilker
发明人： Wayne Patton , Linan Song , Nancy Wilker
IPC分类号： B01D57/02
CPC分类号： G01N33/6803 , G01N27/44782
摘要： The invention relates to methods for isolating an analyte of interest in a sample suspected of containing the analyte of interest using two-dimensional planar electrochromatography. The methods comprise treating at least a portion of the sample with a mobility modifier capable of modifying the mobility of the analyte of interest after the second dimension of planar electrochromatography. Kits and compositions are also disclosed.
摘要翻译：本发明涉及使用二维平面电色谱法分离怀疑含有感兴趣分析物的样品的感兴趣分析物的方法。所述方法包括使用能够在平面电色谱的第二维度之后改变目的分析物的迁移率的迁移率调节剂处理至少一部分样品。还公开了试剂盒和组合物。

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