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1. 发明授权

US5739004A Biological sterilization indication for use with or without test pack materials or devices 失效
标题翻译：用于或不与测试包材料或设备一起使用的生物灭菌指示
公开(公告)号：US5739004A
公开(公告)日：1998-04-14
申请号：US739277
申请日：1996-10-29
申请人： Lewis P. Woodson
发明人： Lewis P. Woodson
IPC分类号： C12Q1/22 , C12M1/40
CPC分类号： C12Q1/22 , Y10S435/81 , Y10S435/832 , Y10S435/839
摘要： A biological indicator which utilizes immobilization to increase the thermostability of the biomaterial (e.g., microorganism or enzyme) contained within the indicator. Due to the increased thermostability of the biomaterial, the indicator can be utilized to monitor sterilization with or without conventional test pack materials or devices.
摘要翻译：利用固定化以增加包含在指示剂内的生物材料（例如微生物或酶）的热稳定性的生物指示剂。由于生物材料的热稳定性增加，可以使用指示剂来监测具有或不具有常规测试包材料或装置的灭菌。

2. 发明授权

US06623955B2 Rapid read-out biological indicator 失效
标题翻译：快速读出生物指标
公开(公告)号：US06623955B2
公开(公告)日：2003-09-23
申请号：US08443820
申请日：1995-05-18
申请人： Richard R. Matner , William E. Foltz , Lewis P. Woodson
发明人： Richard R. Matner , William E. Foltz , Lewis P. Woodson
IPC分类号： C12M300
CPC分类号： C12Q1/22 , Y10S435/81
摘要： A rapid method of determining the efficacy of a sterilization cycle, and an indicator adapted to perform such method, comprising subjecting to the sterilization cycle a source of active enzyme having activity which correlates with the viability of a microorganism commonly used to monitor sterilization, and incubating the enzyme source, following the completion of the sterilization cycle, with an effective amount of a substrate system capable of reacting with any residual active enzyme to produce a detectable enzyme-modified product.
摘要翻译：确定灭菌循环功效的快速方法，以及适于进行这种方法的指示剂，包括对灭菌周期进行活性酶源，该酶活性与通常用于监测灭菌的微生物的活力相关，并且孵育在灭菌周期完成之后，酶源与有效量的能够与任何残留活性酶反应以产生可检测酶修饰产物的底物系统。

3. 发明授权

US5073488A Rapid method for determining efficacy of a sterilization cycle and rapid read-out biological indicator 失效
标题翻译：用于确定灭菌循环和快速释放生物指示剂的功效的快速方法
公开(公告)号：US5073488A
公开(公告)日：1991-12-17
申请号：US277305
申请日：1988-11-29
申请人： Richard R. Matner , William E. Foltz , Lewis P. Woodson
发明人： Richard R. Matner , William E. Foltz , Lewis P. Woodson
IPC分类号： A61L2/26 , C12Q1/22 , C12Q1/25
CPC分类号： C12Q1/22
摘要： A rapid method of determining the efficacy of a sterilization cycle, and an indicator adapted to perform such method, comprising subjecting to the sterilization cycle a source of active enzyme having activity which correlates with the viability of a microorganism commonly used to monitor sterilization, and incubating the enzyme source, following the completion of the sterilization cycle, with an effective amount of a substrate system capable of reacting with any residual active enzyme to produce a detectable enzyme-modified product.

4. 发明授权

US6004438A Biofilm reduction sterilizer 失效
标题翻译：生物膜减压灭菌器
公开(公告)号：US6004438A
公开(公告)日：1999-12-21
申请号：US816157
申请日：1991-12-31
申请人： Lewis P. Woodson
发明人： Lewis P. Woodson
IPC分类号： A61L2/03 , A61L2/18 , A61L12/02 , C02F1/46 , C02F1/467 , C02F1/48 , C02F1/50 , C02F1/68 , C25B9/00
CPC分类号： C02F1/48 , A61L12/023 , A61L2/035 , A61L2/18 , C02F1/4606 , C02F1/467 , C02F1/50 , C02F1/682 , C02F2303/04 , C02F2303/22 , Y10S204/09
摘要： A method of killing microorganisms which form a biofilm on surfaces, including the surfaces of medical articles or on tissue or implant surfaces in a living subject. Killing of biofilm microorganisms is accomplished by applying an electric field to an electrically conductive medium in which the biofilm is contained. The electrically conductive medium either includes a biocide or is capable of generating a biocide in situ upon application of an electric field. A means of utilizing the method in vivo and a sterilizer are disclosed.
摘要翻译：杀死在表面上形成生物膜的微生物的方法，包括医疗制品的表面或生物体内的组织或植入物表面。通过将电场施加到其中包含生物膜的导电介质来实现生物膜微生物的杀伤。导电介质还包括杀生物剂，或者能够在施加电场时就地产生杀生物剂。公开了利用该方法的手段和灭菌器。

5. 发明授权

US5252484A Rapid read-out biological indicator 失效
标题翻译：快速读出生物指标
公开(公告)号：US5252484A
公开(公告)日：1993-10-12
申请号：US748327
申请日：1991-08-21
申请人： Richard R. Matner , William E. Foltz , Lewis P. Woodson
发明人： Richard R. Matner , William E. Foltz , Lewis P. Woodson
IPC分类号： C12Q1/22 , C12M1/00 , C12M1/34
CPC分类号： C12Q1/22 , Y10S435/81
摘要： A rapid method of determining the efficacy of a sterilization cycle, and an indicator adapted to perform such method, comprising subjecting to the sterilization cycle a source of active enzyme having activity which correlates with the viability of a microorganism commonly used to monitor sterilization, and incubating the enzyme source, following the completion of the sterilization cycle, with an effective amount of a substrate system capable of reacting with any residual active enzyme to produce a detectable enzyme-modified product.
摘要翻译：确定灭菌循环功效的快速方法，以及适于进行这种方法的指示剂，包括对灭菌周期进行活性酶源，该酶活性与通常用于监测灭菌的微生物的活力相关，并且孵育在灭菌周期完成之后，酶源与有效量的能够与任何残留活性酶反应以产生可检测酶修饰产物的底物系统。

6. 发明授权

US5223401A Rapid read-out sterility indicator 失效
标题翻译：快速读出不育指标
公开(公告)号：US5223401A
公开(公告)日：1993-06-29
申请号：US277570
申请日：1988-11-29
申请人： William E. Foltz , Richard R. Matner , Lewis P. Woodson
发明人： William E. Foltz , Richard R. Matner , Lewis P. Woodson
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22 , Y10S435/808 , Y10S435/81 , Y10S436/805
摘要： A unitary sterility indicator and a method for its use, the indicator comprising an outer container having liquid impermeable and gas non-absorptive walls, and having a gas-transmissive, bacteria impermeable opening therein; contained within the outer container, a detectable amount of a source of active enzyme and/or another microorganism commonly used to monitor sterilization; a sealed, openable gas and liquid impermeable inner container containing an aqueous medium and/or a nutrient growth medium, disposed in the outer container; an enzyme substrate system capable of reacting with active enzyme to produce a detectable enzyme-modified product and/or a detector material sensitive to microorganism growth, contained in one of the containers; and means contained within the outer container for restricting the area in which enzyme-modified product and/or growing microorganisms are contained, after the inner container is opened, to an area which is less than the volume of aqueous solution contained in the inner container.
摘要翻译：一种单一的无菌指示剂及其使用方法，该指示剂包括具有不透液体和气体不吸收壁的外部容器，并且其中具有气体透过的细菌不可渗透的开口; 包含在外容器内的可检测量的活性酶源和/或通常用于监测灭菌的另一种微生物来源; 包含设置在外部容器中的含有水性介质和/或营养生长介质的密封且可开启的气体和液体不可渗透的内部容器; 能够与活性酶反应以产生可检测的酶修饰产物和/或容纳在其中一个容器中的对微生物生长敏感的检测器材料的酶底物系统; 以及包含在外容器内的装置，用于将内容器打开之后将酶改性产物和/或生长微生物包含的区域限制在小于内容器中所含的水溶液体积的区域。

7. 发明授权

US5866356A Protective housing for biological indicator for testing the effectiveness of a sterilization procedure 失效
标题翻译：用于测试灭菌程序有效性的生物指示器的防护罩
公开(公告)号：US5866356A
公开(公告)日：1999-02-02
申请号：US954218
申请日：1997-10-20
申请人： Heidemarie Albert , William F. Foltz , Lewis P. Woodson
发明人： Heidemarie Albert , William F. Foltz , Lewis P. Woodson
IPC分类号： A61L2/28 , C12Q1/22 , C12Q1/00 , G01N21/00
CPC分类号： A61L2/28 , C12Q1/22
摘要： A protective housing for a biological indicator for testing the effectiveness of a sterilization procedure comprises a tube constructed of a liquid impermeable and gas-nonabsorptive polymer, a cap assembly having an aperture that allows sterilant to enter the housing during the sterilization procedure and contact the biological indicator, and an absorptive material in the cap assembly to prevent condensed sterilant from entering the housing and contacting the biological indicator. During a sterilization procedure the protective housing reduces premature inactivation of biological indicators, especially biological indicators that measure the effectiveness of a sterilization procedure by monitoring an enzyme whose activity can be correlated with the viability of at least one microorganism commonly used to monitor sterilization efficacy.
摘要翻译：用于测试灭菌程序有效性的生物学指示器的保护壳体包括由液体不可渗透和不吸气聚合物构成的管，帽组件，其具有允许灭菌剂在灭菌过程中进入壳体的孔，并与生物指示器和帽组件中的吸收材料，以防止冷凝的灭菌剂进入壳体并接触生物指示器。在灭菌过程中，保护性壳体减少生物指示器的过早失活，特别是通过监测其活性可与通常用于监测灭菌功效的至少一种微生物的活力相关的酶来测量灭菌程序的有效性的生物学指标。

8. 发明授权

US06566090B2 Rapid readout sterilization indicator for liquid peracetic acid sterilization procedures 失效
公开(公告)号：US06566090B2
公开(公告)日：2003-05-20
申请号：US10016007
申请日：2001-12-06
申请人： Kelvin J. Witcher , Lewis P. Woodson
发明人： Kelvin J. Witcher , Lewis P. Woodson
IPC分类号： C12Q122
CPC分类号： A61L2/28 , C12Q1/22 , C12Q2334/22 , Y10S435/81
摘要： A sterilization indicator is useful for testing the effectiveness of sterilization procedures that disinfect objects by contacting them with a liquid sterilization procedure. The indicator includes an outer container having an open end and a cover material associated with the open end that is impermeable to liquids and bacteria. An enzyme-gel matrix is coated on a surface within the outer container that comprises a biologically inert polymeric gel and a source of an active enzyme dispersed within the gel. The enzyme has an activity that is correlated with the survival of at least one test microorganism that is commonly used to monitor the effectiveness of a sterilization procedure. A breakable ampoule within the outer container contains a substrate that is capable of reacting with any active enzyme remaining after the indicator has been subjected to a sterilization procedure to provide a detectable indication that the sterilization procedure was ineffective.

9. 发明授权

US06352837B1 Rapid readout sterilization indicator for liquid peracetic acid sterilization procedures 有权
公开(公告)号：US06352837B1
公开(公告)日：2002-03-05
申请号：US09255240
申请日：1999-02-22
申请人： Kelvin J. Witcher , Lewis P. Woodson
发明人： Kelvin J. Witcher , Lewis P. Woodson
IPC分类号： C12Q122
CPC分类号： A61L2/28 , C12Q1/22 , C12Q2334/22 , Y10S435/81
摘要： A sterilization indicator is useful for testing the effectiveness of sterilization procedures that disinfect objects by contacting them with a liquid sterilization procedure. The indicator includes an outer container having an open end and a cover material associated with the open end that is impermeable to liquids and bacteria. An enzyme-gel matrix is coated on a surface within the outer container that comprises a biologically inert polymeric gel and a source of an active enzyme dispersed within the gel. The enzyme has an activity that is correlated with the survival of at least one test microorganism that is commonly used to monitor the effectiveness of a sterilization procedure. A breakable ampoule within the outer container contains a substrate that is capable of reacting with any active enzyme remaining after the indicator has been subjected to a sterilization procedure to provide a detectable indication that the sterilization procedure was ineffective.

10. 发明授权

US5462644A Biofilm reduction method 失效
标题翻译：生物膜还原法
公开(公告)号：US5462644A
公开(公告)日：1995-10-31
申请号：US257877
申请日：1994-06-10
申请人： Lewis P. Woodson
发明人： Lewis P. Woodson
IPC分类号： A61L2/03 , A61L2/18 , A61L12/02 , C02F1/46 , C02F1/467 , C02F1/48 , C02F1/50 , C02F1/68
CPC分类号： C02F1/48 , A61L12/023 , A61L2/035 , A61L2/18 , C02F1/4606 , C02F1/467 , C02F1/50 , C02F1/682 , C02F2303/04 , C02F2303/22 , Y10S204/09
摘要： A method of killing microorganisms which form a biofilm on surfaces, including the surfaces of medical articles or on tissue or implant surfaces in a living subject. Killing of biofilm microorganisms is accomplished by applying an electric field to an electrically conductive medium in which the biofilm is contained. The electrically conductive medium either includes a biocide or is capable of generating a biocide in situ upon application of an electric field. A means of utilizing the method in vivo and a sterilizer are disclosed.
摘要翻译：杀死在表面上形成生物膜的微生物的方法，包括医疗制品的表面或生物体内的组织或植入物表面。通过将电场施加到其中包含生物膜的导电介质来实现生物膜微生物的杀伤。导电介质还包括杀生物剂，或者能够在施加电场时就地产生杀生物剂。公开了利用该方法的手段和灭菌器。

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