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1. 发明申请

US20180311199A1 COMBINATION TREATMENT FOR INFLAMMATORY DISEASES 审中-公开
公开(公告)号：US20180311199A1
公开(公告)日：2018-11-01
申请号：US15502318
申请日：2017-01-11
申请人： Lawrence CHAN
发明人： Lawrence CHAN
IPC分类号： A61K31/222 , A61P17/06 , A61P19/02 , A61P29/00 , C07K16/24
CPC分类号： A61K31/222 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to a combination treatment for inflammatory diseases. Specifically, the treatment described herein involves administering to a subject suffering from an inflammatory disease a combination of an anti-TNF-alpha inhibitor and at least one small molecule anti-inflammatory agent, to treat the inflammatory disease.

2. 发明申请

US20140227348A1 PEPTIDES THAT TARGET DORSAL ROOT GANGLION NEURONS 有权
标题翻译：目标是目标背根神经元神经元
公开(公告)号：US20140227348A1
公开(公告)日：2014-08-14
申请号：US14175387
申请日：2014-02-07
申请人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
发明人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
IPC分类号： A61K9/127 , A61K38/08 , A61K45/06 , C07K7/06
CPC分类号： C07K7/06 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K9/127 , A61K35/761 , A61K38/00 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/185 , A61K38/1883 , A61K38/2066 , A61K45/06 , A61K47/64 , A61K48/00 , C07K2319/33 , C12N7/00 , C12N9/2462 , C12N15/8509 , C12N15/86 , C12N15/88 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.
摘要翻译：本发明涉及使用靶向背根神经节（DRG）神经元的肽的方法和组合物。特别地，肽例如用于将治疗剂，例如蛋白质，脂质体或包含治疗性多核苷酸的病毒颗粒靶向一种或多种外周神经病或神经性疼痛。在特殊情况下，周围神经病变或神经性疼痛直接或间接地由DRG神经元病变引起。

3. 发明授权

US08907057B2 Peptides that target dorsal root ganglion neurons 有权
公开(公告)号：US08907057B2
公开(公告)日：2014-12-09
申请号：US14175387
申请日：2014-02-07
申请人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
发明人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
IPC分类号： A61K31/00 , C07K4/00 , C12N15/62 , A61K45/06 , A61K9/127 , A61K38/08 , C07K7/06
CPC分类号： C07K7/06 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K9/127 , A61K35/761 , A61K38/00 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/185 , A61K38/1883 , A61K38/2066 , A61K45/06 , A61K47/64 , A61K48/00 , C07K2319/33 , C12N7/00 , C12N9/2462 , C12N15/8509 , C12N15/86 , C12N15/88 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.

4. 发明申请

US20140248334A1 PEPTIDES THAT TARGET DORSAL ROOT GANGLION NEURONS 有权
公开(公告)号：US20140248334A1
公开(公告)日：2014-09-04
申请号：US14175471
申请日：2014-02-07
申请人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
发明人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
IPC分类号： A61K47/48 , A61K38/18 , A61K38/20 , A61K35/76
CPC分类号： C07K7/06 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K9/127 , A61K35/761 , A61K38/00 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/185 , A61K38/1883 , A61K38/2066 , A61K45/06 , A61K47/64 , A61K48/00 , C07K2319/33 , C12N7/00 , C12N9/2462 , C12N15/8509 , C12N15/86 , C12N15/88 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.

5. 发明授权

US08674071B2 Peptides that target dorsal root ganglion neurons 失效
标题翻译：靶向背根神经节神经元的肽
公开(公告)号：US08674071B2
公开(公告)日：2014-03-18
申请号：US12864895
申请日：2009-01-30
申请人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
发明人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
IPC分类号： A61K31/00 , C07K4/00
CPC分类号： C07K7/06 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K9/127 , A61K35/761 , A61K38/00 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/185 , A61K38/1883 , A61K38/2066 , A61K45/06 , A61K47/64 , A61K48/00 , C07K2319/33 , C12N7/00 , C12N9/2462 , C12N15/8509 , C12N15/86 , C12N15/88 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.
摘要翻译：本发明涉及使用靶向背根神经节（DRG）神经元的肽的方法和组合物。特别地，肽例如用于将治疗剂，例如蛋白质，脂质体或包含治疗性多核苷酸的病毒颗粒靶向一种或多种外周神经病或神经性疼痛。在特殊情况下，周围神经病变或神经性疼痛直接或间接地由DRG神经元病变引起。

6. 发明申请

US20110189263A1 PEPTIDES THAT TARGET DORSAL ROOT GANGLION NEURONS 失效
标题翻译：目标是目标背根神经元神经元
公开(公告)号：US20110189263A1
公开(公告)日：2011-08-04
申请号：US12864895
申请日：2009-01-30
申请人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
发明人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
IPC分类号： A61K9/127 , C07K7/06 , A61K38/08 , C07K19/00 , A61K35/76 , A61K38/20 , C07H21/00 , A61P25/00 , A61P35/00 , A61P31/00 , A61P3/00
CPC分类号： C07K7/06 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K9/127 , A61K35/761 , A61K38/00 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/185 , A61K38/1883 , A61K38/2066 , A61K45/06 , A61K47/64 , A61K48/00 , C07K2319/33 , C12N7/00 , C12N9/2462 , C12N15/8509 , C12N15/86 , C12N15/88 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.
摘要翻译：本发明涉及使用靶向背根神经节（DRG）神经元的肽的方法和组合物。特别地，肽例如用于将治疗剂，例如蛋白质，脂质体或包含治疗性多核苷酸的病毒颗粒靶向一种或多种外周神经病或神经性疼痛。在特殊情况下，周围神经病变或神经性疼痛直接或间接地由DRG神经元病变引起。

7. 发明申请

US20070210785A1 STUD SENSING DEVICE 有权
标题翻译： STUD感应装置
公开(公告)号：US20070210785A1
公开(公告)日：2007-09-13
申请号：US11692391
申请日：2007-03-28
申请人： Hughes SANONER , Desmond TSE , Lawrence CHAN
发明人： Hughes SANONER , Desmond TSE , Lawrence CHAN
IPC分类号： G01R19/00
CPC分类号： G01R29/085 , G01V3/088
摘要： A multiple sensitivity stud sensing device for determining a location of objects behind a wall lining has a housing with a surface for moving over the wall lining. Within the housing are a capacitive sensor with first and second capacitances provided adjacent the surface and control circuitry. The control circuitry includes a detecting circuit connected to the sensor for providing a detection signal related to an imbalance between the first and second capacitances, a processor for receiving the detection signals signal and providing a display signal. A display is provided on the housing for indicating a location of an object behind the wall lining. The processor compares the detection signal to stored predetermined threshold values of detection signals associated with different wall lining thickness and displays a thickness value to the user.
摘要翻译：用于确定墙壁衬里后面的物体的位置的多灵敏度螺柱感测装置具有壳体，其具有用于在壁衬里移动的表面。在壳体内是电容式传感器，其中第一和第二电容靠近表面和控制电路设置。所述控制电路包括连接到所述传感器的检测电路，用于提供与所述第一和第二电容之间的不平衡相关的检测信号;处理器，用于接收所述检测信号信号并提供显示信号。在外壳上提供显示器，用于指示墙壁后面的物体的位置。处理器将检测信号与存储的与不同壁衬厚度相关联的检测信号的预定阈值进行比较，并向用户显示厚度值。

8. 发明授权

US5683623A Dioxane derivatives 失效
标题翻译：二恶烷衍生物
公开(公告)号：US5683623A
公开(公告)日：1997-11-04
申请号：US392903
申请日：1995-03-01
申请人： Lawrence Chan , John William Goodby , Peter Styring , Chuan Chu Dong
发明人： Lawrence Chan , John William Goodby , Peter Styring , Chuan Chu Dong
IPC分类号： G02F1/13 , C07D319/06 , C07F5/02 , C09K19/34 , C09K19/40 , C07D407/00
CPC分类号： C09K19/404 , C07D319/06 , C07F5/025 , C09K19/3402 , C09K2019/3422
摘要： Dioxane derivatives for use as components in liquid crystal devices (LCDs) of general formula (A), wherein X is CH or B; R.sup.1, R.sup.2 are each A.sup.1, OA.sup.1, OCOA.sup.2, or COOA.sup.2 ; A.sup.1 is a straight or branched chain alkyl group containing from 1 to 20 carbon atoms and may be substituted with one or more F or CN. A.sup.2 is a straight or branched chain alkyl group containing from 1 to 20 carbon atoms and may be substituted with one or more F or CN and if straight may be unsubstituted. Y.sup.1, Y.sup.2, Y.sup.3 may each be (CH.sub.2).sub.p, (CH.sub.2).sub.p COO or OCO(CH.sub.2).sub.p ; p is from 0 to 10, n is 0 or 1, m is 0 or 1, either or both of Z.sub.1 and Z.sub.2 are F and, when not F, are H; Y.sup.4 is a covalent bond or, when n is 0, may be (a) LCDs, containing the devices exhibit very fast switching speed, bi-stable characteristics, enhanced greyscale and storage capabilities and a wide viewing angle.
摘要翻译： PCT No.PCT / GB93 / 01929 Sec。 371 1995年3月1日 102（e）1995年3月1日PCT PCT 1993年9月13日PCT公布。公开号WO94 / 06885 （a）用作通式（A）的液晶装置（LCD）中的组分的二恶烷衍生物，其中X是CH或B;（A） R1，R2分别为A1，OA1，OCOA2或COOA2; A1是含有1至20个碳原子的直链或支链烷基，并且可被一个或多个F或CN取代。 A2是含有1至20个碳原子的直链或支链烷基，并且可以被一个或多个F或CN取代，如果直链可以是未取代的。 Y1，Y2，Y3各自为（CH 2）p，（CH 2）p COO或OCO（CH 2）p; p为0至10，n为0或1，m为0或1，Z1和Z2中的任一个或两个为F，当不为F时，为H; Y4是共价键，或者当n为0时，可以是（a）含有这些器件的LCD显示出非常快的开关速度，双稳态特性，增强的灰度和存储能力以及广视角。

9. 发明授权

US08859728B2 Peptides that target dorsal root ganglion neurons 有权
公开(公告)号：US08859728B2
公开(公告)日：2014-10-14
申请号：US14175471
申请日：2014-02-07
申请人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
发明人： Lawrence Chan , Hideto Kojima , Tomoya Terashima
IPC分类号： A61K31/00 , C07K4/00 , C12N15/62 , A61K38/18 , A61K35/76 , A61K47/48 , A61K38/20
CPC分类号： C07K7/06 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A01K2267/0362 , A61K9/127 , A61K35/761 , A61K38/00 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/185 , A61K38/1883 , A61K38/2066 , A61K45/06 , A61K47/64 , A61K48/00 , C07K2319/33 , C12N7/00 , C12N9/2462 , C12N15/8509 , C12N15/86 , C12N15/88 , C12N2710/10343 , C12N2710/10345 , C12N2810/40
摘要： The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such as proteins, liposomes, or viral particles comprising therapeutic polynucleotides, to one or more peripheral neuropathies or neuropathic pain, for example. In particular cases, the peripheral neuropathies or neuropathic pain is caused directly or indirectly by DRG neuronopathy.

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