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1. 发明授权

US08499966B2 Method of moving a delivery member of a dispensing device for administration of oral transmucosal dosage forms 有权
标题翻译：移动用于口服经粘膜剂型的给药的分配装置的递送部件的方法
公开(公告)号：US08499966B2
公开(公告)日：2013-08-06
申请号：US12521983
申请日：2007-12-28
申请人： Pamela Palmer , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards , Edmond Chiu , Thomas Schreck , Stelios Tzannis , Larry Hamel
发明人： Pamela Palmer , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards , Edmond Chiu , Thomas Schreck , Stelios Tzannis , Larry Hamel
IPC分类号： A61M31/00 , B65H5/00
CPC分类号： A61K9/006 , A61J7/0038 , A61J7/0053 , A61J7/0418 , A61J7/0445 , A61J7/0481 , A61J2200/30 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2072 , A61K31/4535 , A61M15/00 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M2205/276 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/583 , A61M2205/6054 , A61M2205/609 , A61M2209/086 , G07C9/00031 , G07F17/0092 , H01Q1/2208
摘要： A method of administering small, bioadhesive drug tablets includes moving an end portion of a delivery member. A surface of the delivery member can be positioned to prevent movement of the drug tablet from a tablet cartridge channel to a delivery passage of a delivery device when the end portion of the delivery member is in a first stopped position. The end portion of the delivery member can be moved to a second position within the delivery passage such that the tablet cartridge channel is in communication with the delivery passage. The drug tablet can be conveyed into the delivery passage via the tablet cartridge channel. The end portion of the delivery member can be moved to a third position within the delivery passage to convey the drug tablet through an exit opening of the delivery device.
摘要翻译：施用小的生物粘附药物片剂的方法包括移动递送构件的端部。当输送构件的端部处于第一停止位置时，输送构件的表面可以被定位成防止药片从药片通道移动到输送装置的输送通道。输送构件的端部可以移动到输送通道内的第二位置，使得药片通道与输送通道连通。药片可经由药片通道输送到输送通道中。输送构件的端部可以移动到输送通道内的第三位置，以将药片输送通过输送装置的出口。

2. 发明申请

US20130165481A1 SMALL-VOLUME ORAL TRANSMUCOSAL DOSAGE FORMS 有权
标题翻译：小容量口服转移剂量形式
公开(公告)号：US20130165481A1
公开(公告)日：2013-06-27
申请号：US13561543
申请日：2012-07-30
申请人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine
发明人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine
IPC分类号： A61K9/20 , A61K31/4535
CPC分类号： A61K9/006 , A61J7/0038 , A61J7/0053 , A61J7/0418 , A61J7/0445 , A61J7/0481 , A61J2200/30 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2072 , A61K31/4535 , A61M15/00 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M2205/276 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/583 , A61M2205/6054 , A61M2205/609 , A61M2209/086 , G07C9/00031 , G07F17/0092 , H01Q1/2208
摘要： Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.
摘要翻译：提供了包含预定量的药物活性药物的小体积口腔粘膜剂型或NanoTabs。示例性应用包括使用NanoTabs®来施用用于治疗急性，术后或突破性疼痛的药物。

3. 发明申请

US20110288128A1 Oral Transmucosal Administration of Sufentanil 审中-公开
标题翻译：舒芬太尼口服粘膜下管理
公开(公告)号：US20110288128A1
公开(公告)日：2011-11-24
申请号：US12784653
申请日：2010-05-21
申请人： Pamela Palmer , Shamim Pushpala , Evangeline Cruz , Larry Hamel , Linda Judge
发明人： Pamela Palmer , Shamim Pushpala , Evangeline Cruz , Larry Hamel , Linda Judge
IPC分类号： A61K31/4535 , A61P25/04 , C07D409/06
CPC分类号： A61K31/4468 , A61K9/0056 , A61K9/006 , A61K9/2018
摘要： Compositions and methods for administration of sufentanil-containing drug formulations to the oral mucosa of a subject are disclosed.
摘要翻译：公开了将含有舒芬太尼的药物制剂施用于受试者的口腔粘膜的组合物和方法。

4. 发明授权

US08945592B2 Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same 有权
标题翻译：包含除氧剂的舒芬太尼固体剂型及其使用方法
公开(公告)号：US08945592B2
公开(公告)日：2015-02-03
申请号：US12275485
申请日：2008-11-21
申请人： Shamim Pushpala , Larry Hamel , Stelios Tzannis , Evangeline Cruz
发明人： Shamim Pushpala , Larry Hamel , Stelios Tzannis , Evangeline Cruz
IPC分类号： A61K9/00 , A61K31/445 , A61K31/4535 , A61K9/20
CPC分类号： A61K31/4535 , A61K9/2054
摘要： Compositions and methods effective to minimize or eliminate the presence of oxidative degradation products in solid dosage forms comprising sufentanil are provided.
摘要翻译：提供了有效地最小化或消除包含舒芬太尼的固体剂型中氧化降解产物的存在的组合物和方法。

5. 发明授权

US08865743B2 Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain 有权
标题翻译：含有舒芬太尼治疗疼痛的小体积口腔粘膜剂型
公开(公告)号：US08865743B2
公开(公告)日：2014-10-21
申请号：US11985162
申请日：2007-11-14
申请人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
发明人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
IPC分类号： A01N43/40 , A61K31/445 , A61K31/4535 , A61K9/70 , A61K9/20 , G06F19/00 , A61K9/00
CPC分类号： A61K9/006 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/7007 , A61K31/4535 , G06F19/00 , G06F19/3456 , G16H20/10
摘要： Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.
摘要翻译：公开了用于使用装置治疗疼痛的受试者的舌下粘膜给予小体积舒芬太尼药物剂型的组合物，系统和方法。

6. 发明授权

US08865211B2 Bioadhesive drug formulations for oral transmucosal delivery 有权
标题翻译：用于口腔粘膜递送的生物粘附药物制剂
公开(公告)号：US08865211B2
公开(公告)日：2014-10-21
申请号：US13595879
申请日：2012-08-27
申请人： Stelios Tzannis , Larry Hamel , Pamela Palmer , Thomas Schreck , Andrew I. Poutiatine
发明人： Stelios Tzannis , Larry Hamel , Pamela Palmer , Thomas Schreck , Andrew I. Poutiatine
IPC分类号： A61K9/20 , A61K9/00 , A61K31/4468
CPC分类号： A61K9/2072 , A61J3/005 , A61J7/00 , A61J7/0023 , A61J7/0046 , A61J7/0053 , A61K9/006 , A61K31/4468 , A61K31/4535
摘要： Bioadhesive drug formulations that adhere to an oral mucosal membrane of a subject are provided together with single dose applicators and devices for delivering the drug formulations to the oral mucosa, and methods for using the same.
摘要翻译：与用于将药物制剂递送到口腔粘膜的单剂量施用器和装置一起提供粘附于受试者的口腔粘膜的生物粘附药物制剂及其使用方法。

7. 发明授权

US08778393B2 Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain 有权
标题翻译：含有舒芬太尼治疗疼痛的小体积口腔粘膜剂型
公开(公告)号：US08778393B2
公开(公告)日：2014-07-15
申请号：US13555948
申请日：2012-07-23
申请人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
发明人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
IPC分类号： A61K9/20 , A61K9/00 , A61K31/4535
CPC分类号： A61K9/006 , A61J7/0038 , A61J7/0053 , A61J7/0418 , A61J7/0445 , A61J7/0481 , A61J2200/30 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2072 , A61K31/4535 , A61M15/00 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M2205/276 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/583 , A61M2205/6054 , A61M2205/609 , A61M2209/086 , G07C9/00031 , G07F17/0092 , H01Q1/2208
摘要： Compositions, methods and systems for administration of small volume sufentanil-containing drug dosage forms to the oral mucosa of a subject are disclosed.
摘要翻译：公开了用于向受试者的口腔粘膜施用小体积舒芬太尼的药物剂型的组合物，方法和系统。

8. 发明授权

US07475404B2 System and method for implementing click-through for browser executed software including ad proxy and proxy cookie caching 有权
公开(公告)号：US07475404B2
公开(公告)日：2009-01-06
申请号：US09860379
申请日：2001-05-18
申请人： Larry Hamel
发明人： Larry Hamel
IPC分类号： G06F13/00
CPC分类号： G06Q30/02 , G06F17/30902 , G06Q30/0247 , G06Q30/0255 , G06Q30/0261 , G06Q30/0273 , G06Q30/0277
摘要： An improved proxy is disclosed for allowing click-through on an ad URL delivered on a web page within a Java® applet executing on a client machine. The proxy caches cookie information for the browser, to support java applications that do not allow for planting of cookies directly. When the user clicks on the ad URL, the proxy retrieves the relevant cookie and link information from a host side database, and uses the same to help the browser open the correct URL associated with the ad. Additional controls are provided for the proxy including the ability to filter ads in an appropriate fashion for the applet, to cache ads from third party servers, to monitor applet behavior, to cache/pass on client IP address information, and to perform administrative tasks for the applet within the browser to enhance and facilitate ad delivery between advertisers and their intended audiences. The proxy thus acts to extend the reach and access of a conventional applet beyond the resources of a download host associated with such applet. In another embodiment, the applet controls a hidden frame within the browser, which hidden frame, unlike the applet frame, is able to download and plant a cookie from an ad server within the browser. When the user clicks on the ad URL, the browser uses the cooked from the hidden frame and passes it on to the Ad Server along with the URL, so that the user experiences a seamless and smooth transfer as would occur from a conventional HTML tag within the page.

9. 发明申请

US20100105735A1 Small Volume Oral Transmucosal Dosage Forms Containing Sufentanil for Treatment of Pain 有权
标题翻译：含有舒芬太尼治疗疼痛的小体积口腔粘膜粘膜剂量形式
公开(公告)号：US20100105735A1
公开(公告)日：2010-04-29
申请号：US12521949
申请日：2007-12-28
申请人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
发明人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
IPC分类号： A61K31/4535 , A61P25/00
CPC分类号： A61K9/006 , A61J7/0038 , A61J7/0053 , A61J7/0418 , A61J7/0445 , A61J7/0481 , A61J2200/30 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2072 , A61K31/4535 , A61M15/00 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M2205/276 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/583 , A61M2205/6054 , A61M2205/609 , A61M2209/086 , G07C9/00031 , G07F17/0092 , H01Q1/2208
摘要： Compositions, methods and systems for administration of small volume sufentanil-containing drug dosage forms to the oral mucosa of a subject are disclosed.
摘要翻译：公开了用于向受试者的口腔粘膜施用小体积舒芬太尼的药物剂型的组合物，方法和系统。

10. 发明申请

US20070207207A1 Bioadhesive drug formulations for oral transmucosal delivery 有权
标题翻译：用于口腔粘膜递送的生物粘附药物制剂
公开(公告)号：US20070207207A1
公开(公告)日：2007-09-06
申请号：US11650227
申请日：2007-01-05
申请人： Stelios Tzannis , Pamela Palmer , Thomas Schreck , Larry Hamel , Andrew Poutiatine
发明人： Stelios Tzannis , Pamela Palmer , Thomas Schreck , Larry Hamel , Andrew Poutiatine
IPC分类号： A61K31/485 , A61K31/445 , A61K9/20
CPC分类号： A61K9/006 , A61J3/005 , A61K9/2072
摘要： Formulations for controlled delivery of oral transmucosal medications are provided. The formulations are characterized as hydrogel-forming or eroding-types which are bioadhesive and provide for controlled and sustained release of the medication such that enhanced bioavailability and efficacy is provided.
摘要翻译：提供了用于口服经粘膜药物的控制递送的制剂。制剂的特征在于水凝胶形成或侵蚀型，其是生物粘附性的并且提供药物的受控和持续释放，从而提供增强的生物利用度和功效。

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