专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007133749A3 METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING PERIPHERAL NERVE DAMAGE 审中-公开
标题翻译：用于治疗和预防外周神经损伤的方法和组合物
公开(公告)号：WO2007133749A3
公开(公告)日：2008-04-17
申请号：PCT/US2007011576
申请日：2007-05-14
申请人： CHILDRENS MEDICAL CENTER , LARRY BENOWITZ I , YIN YUQIN
发明人： LARRY BENOWITZ I , YIN YUQIN
IPC分类号： A61K38/17 , A61K31/352 , A61K31/7004 , A61K31/7076 , A61P25/02
CPC分类号： A61K38/1738 , A61K31/352 , A61K31/7004 , A61K31/7076 , A61K2300/00
摘要： Disclosed herein is a method for treating and/or preventing peripheral nerve damage in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.
摘要翻译：本文公开了一种用于治疗和/或预防受试者的周围神经损伤的方法，包括向受试者施用治疗有效量的调霉素。优选地，受试者是哺乳动物，最优选人。在优选的实施方案中，调节蛋白可以与甘露糖，甘露糖衍生物和/或肌苷组合使用。

2. 发明申请

WO2007133749A2 METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING PERIPHERAL NERVE DAMAGE 审中-公开
标题翻译：用于治疗和预防外周神经损伤的方法和组合物
公开(公告)号：WO2007133749A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011576
申请日：2007-05-14
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , LARRY, Benowitz, I. , YIN, Yuqin
发明人： LARRY, Benowitz, I. , YIN, Yuqin
IPC分类号： A61K38/17 , A61K31/352 , A61K31/7004 , A61K31/7076 , A61P25/02
CPC分类号： A61K38/1738 , A61K31/352 , A61K31/7004 , A61K31/7076 , Y02A50/401 , Y02A50/469 , A61K2300/00
摘要： Disclosed herein is a method for treating and/or preventing peripheral nerve damage in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.
摘要翻译：本文公开了用于治疗和/或预防受试者的周围神经损伤的方法，其包括向受试者施用治疗有效量的调霉素。优选地，受试者是哺乳动物，最优选人。在优选的实施方案中，调节蛋白可以与甘露糖，甘露糖衍生物和/或肌苷组合使用。

3. 发明申请

US20070232523A1 Methods and compositions for treating ocular disorders 有权
标题翻译：治疗眼部疾病的方法和组合物
公开(公告)号：US20070232523A1
公开(公告)日：2007-10-04
申请号：US11804295
申请日：2007-05-17
申请人： Larry Benowitz , Yuqin Yin
发明人： Larry Benowitz , Yuqin Yin
IPC分类号： A61K38/00
CPC分类号： A61K38/1841 , A61K9/0048 , A61K9/2009 , A61K9/2059 , A61K31/352 , A61K38/1738 , A61K38/2278 , A61K45/06 , A61K47/44 , Y10S435/975 , Y10S514/912 , Y10S514/913 , A61K2300/00
摘要： The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.
摘要翻译：本发明提供了治疗和/或预防受试者对视网膜或视神经损伤的方法，其包括向受试者施用治疗有效量的调霉素。优选地，受试者是哺乳动物，最优选人。在优选的实施方案中，调节蛋白可以与甘露糖，甘露糖衍生物和/或肌苷组合使用。

4. 发明申请

US20050277614A1 Methods for modulating the axonal outgrowth of central nervous system neurons 有权
标题翻译：调节中枢神经系统轴突生长的方法
公开(公告)号：US20050277614A1
公开(公告)日：2005-12-15
申请号：US11132701
申请日：2005-05-19
申请人： Larry Benowitz
发明人： Larry Benowitz
IPC分类号： C07H19/167 , A61K31/52 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61K31/708 , A61P25/00 , A61P25/08 , A61P43/00
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/70 , A61K31/708
摘要： Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons are also provided. Finally, a packed formulation comprising a pharmaceutical composition comprising an inosine nucleoside and a pharmaceutically acceptable carrier packed with instructions for use of the pharmaceutical composition for treatment of a central nervous system disorder is provided.
摘要翻译：提供了调节中枢神经系统轴突产生的方法。还提供了用于刺激损伤后中枢神经系统神经元（例如中风，创伤性脑损伤，脑动脉瘤，脊髓损伤等）的轴突生长的方法以及用于抑制中枢神经系统神经元的轴突向外生长的方法。最后，提供一种包含含有肌苷核苷的药物组合物和填充有用于治疗中枢神经系统疾病的药物组合物的说明书的药学上可接受的载体的包装制剂。

5. 发明申请

US20070213294A1 Methods for modulating the axonal growth of central nervous system neurons 有权
标题翻译：调节中枢神经系统神经元轴突生长的方法
公开(公告)号：US20070213294A1
公开(公告)日：2007-09-13
申请号：US11708098
申请日：2007-02-16
申请人： Larry Benowitz
发明人： Larry Benowitz
IPC分类号： A61K31/70
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/70 , A61K31/708
摘要： Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons are also provided. Finally, a packed formulation comprising a pharmaceutical composition comprising an inosine nucleoside and a pharmaceutically acceptable carrier packed with instructions for use of the pharmaceutical composition for treatment of a central nervous system disorder is provided.
摘要翻译：提供了调节中枢神经系统轴突产生的方法。还提供了用于刺激损伤后中枢神经系统神经元（例如中风，创伤性脑损伤，脑动脉瘤，脊髓损伤等）的轴突生长的方法以及用于抑制中枢神经系统神经元的轴突向外生长的方法。最后，提供一种包含含有肌苷核苷的药物组合物和填充有用于治疗中枢神经系统疾病的药物组合物的说明书的药学上可接受的载体的包装制剂。

6. 发明授权

US07935680B2 Methods for modulating the axonal growth of central nervous system neurons 有权
标题翻译：调节中枢神经系统神经元轴突生长的方法
公开(公告)号：US07935680B2
公开(公告)日：2011-05-03
申请号：US11708098
申请日：2007-02-16
申请人： Larry Benowitz
发明人： Larry Benowitz
IPC分类号： A61K9/16 , A61K31/52 , A61K9/127
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/70 , A61K31/708
摘要： Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons are also provided. Finally, a packed formulation comprising a pharmaceutical composition comprising an inosine nucleoside and a pharmaceutically acceptable carrier packed with instructions for use of the pharmaceutical composition for treatment of a central nervous system disorder is provided.
摘要翻译：提供了调节中枢神经系统轴突产生的方法。还提供了用于刺激损伤后中枢神经系统神经元（例如中风，创伤性脑损伤，脑动脉瘤，脊髓损伤等）的轴突生长的方法以及用于抑制中枢神经系统神经元的轴突向外生长的方法。最后，提供一种包含含有肌苷核苷的药物组合物和填充有用于治疗中枢神经系统病症的药物组合物的说明书的药学上可接受的载体的包装制剂。

7. 发明申请

US20050054558A1 Methods and compositions for treating ocular disorders 有权
公开(公告)号：US20050054558A1
公开(公告)日：2005-03-10
申请号：US10933684
申请日：2004-09-03
申请人： Larry Benowitz
发明人： Larry Benowitz
IPC分类号： A61K38/18 , A61K38/17 , A61K31/675 , A61K31/7076
CPC分类号： A61K38/1841 , A61K9/0048 , A61K9/2009 , A61K9/2059 , A61K31/352 , A61K38/1738 , A61K38/2278 , A61K45/06 , A61K47/44 , Y10S435/975 , Y10S514/912 , Y10S514/913 , A61K2300/00
摘要： The present invention provides a method for treating and/or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and/or inosine.

8. 发明申请

US20070231376A1 Methods and compositions for modulating axonal outgrowth of central nervous system neurons 审中-公开
标题翻译：调节中枢神经系统轴突生长的方法和组成
公开(公告)号：US20070231376A1
公开(公告)日：2007-10-04
申请号：US11640811
申请日：2006-12-18
申请人： Larry Benowitz
发明人： Larry Benowitz
IPC分类号： A61K9/127 , A61K31/00 , C07K14/00 , C07K16/00 , C07K7/00 , C12N5/00 , C12Q1/48
CPC分类号： C12N9/1205 , G01N33/6896 , G01N2500/00
摘要： Methods and compositions for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injury and the like) and methods for inhibiting the axonal outgrowth of central nervous system neurons in conditions such as epilepsy, e.g., posttraumatic epilepsy, and neuropathic pain syndrome, are also provided. These methods generally involve contacting the central nervous system neurons with a compound that modulates the activity of N-kinase, or analog thereof. The methods and compositions are particularly useful for modulating the axonal outgrowth of mammalian central nervous system neurons, such as mammalian cortical neurons or retinal ganglion cells. Pharmaceutical and packaged formulations that include the compounds of the invention that modulate the activity of N-kinase are also provided.
摘要翻译：提供了调节中枢神经系统轴突产生的方法和组合物。刺激中枢神经系统神经元（例如中风，创伤性脑损伤，脑动脉瘤，脊髓损伤等）的轴突向外生长的方法以及抑制中枢神经系统神经元在诸如癫痫等症状的轴突生长的方法，例如创伤后癫痫和神经性疼痛综合征。这些方法通常涉及使中枢神经系统神经元与调节N-激酶或其类似物的活性的化合物接触。所述方法和组合物特别可用于调节哺乳动物中枢神经系统神经元（例如哺乳动物皮质神经元或视网膜神经节细胞）的轴突向外生长。还提供了包括调节N-激酶活性的本发明化合物的药物和包装制剂。

9. 发明申请

US20050256059A1 Methods and compositions for treatment of neurological disorder 有权
标题翻译：用于治疗神经障碍的方法和组合物
公开(公告)号：US20050256059A1
公开(公告)日：2005-11-17
申请号：US10528685
申请日：2003-09-25
申请人： Larry Benowitz
发明人： Larry Benowitz
IPC分类号： A61K31/70 , A61K31/7024 , A61K38/18 , A61K45/06
CPC分类号： A61K45/06 , A61K31/70 , A61K31/7024 , A61K38/1709 , A61K38/191 , A61K2300/00
摘要： The present invention provides methods and compositions for producing a neurosalutary effect in a subject useful in treatment of neurological disorders, including retinal and optic nerve damage, in a subject in need thereof. The method includes administering to a subject a therapeutically effective amount of a hexose, such as mannose.
摘要翻译：本发明提供用于在有需要的受试者中治疗神经系统疾病（包括视网膜和视神经损伤）的受试者中产生神经营养作用的方法和组合物。该方法包括向受试者施用治疗有效量的己糖，例如甘露糖。

10. 发明申请

US20050059594A1 Methods and compositions for producing a neurosalutary effect in a subject 审中-公开
标题翻译：用于在受试者中产生神经营养作用的方法和组合物
公开(公告)号：US20050059594A1
公开(公告)日：2005-03-17
申请号：US10894351
申请日：2004-07-19
申请人： Larry Benowitz
发明人： Larry Benowitz
IPC分类号： A61K9/10 , A61K9/12 , A61K9/127 , A61K31/7076 , A61K35/26 , A61K38/18 , A61K38/22 , A61K45/00 , A61P25/00 , A61P25/08 , A61P25/28 , A61P43/00
CPC分类号： A61K38/1738 , A61K9/127 , A61K31/7076 , A61K38/18 , A61K38/1841 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for producing a neurosalutary effect in a subject, such as modulating neuronal survival and/or regeneration in a subject, are provided. Pharmaceutical and packaged formulations are also provided.
摘要翻译：提供了用于在受试者中产生神经元效应的方法和组合物，例如调节受试者的神经元存活和/或再生。还提供药物和包装制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式