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1. 发明授权

US08415332B2 Methods of hormonal treatment utilizing ascending-dose extended cycle regimens 有权
标题翻译：使用升剂量延长周期治疗的激素治疗方法
公开(公告)号：US08415332B2
公开(公告)日：2013-04-09
申请号：US11892026
申请日：2007-08-17
申请人： Charles E. Diliberti , Kathleen Z. Reape , Lance J. Bronnenkant
发明人： Charles E. Diliberti , Kathleen Z. Reape , Lance J. Bronnenkant
IPC分类号： A61K31/56
CPC分类号： A61K31/567 , A61K31/56 , A61K31/57 , A61K2300/00
摘要： The present invention provides ascending-dose extended cycle regimens in which a female is administered an estrogen and a progestin for a period of greater than 30 or 31 consecutive days, optionally followed by a hormone-free period or by a period of administration of estrogen. The disclosed regimens can be administered to a female to provide contraceptive and non-contraceptive benefits.
摘要翻译：本发明提供了上升剂量延长的周期方案，其中女性给予雌激素和孕激素连续大于30天或31天，任选地随后无激素期或雌激素施用期。所公开的方案可以给予女性以提供避孕和非避孕益处。

2. 发明授权

US5370129A IUD inserting apparatus 失效
标题翻译： IUD插入装置
公开(公告)号：US5370129A
公开(公告)日：1994-12-06
申请号：US938208
申请日：1992-08-28
申请人： Juan Diaz , Lance J. Bronnenkant
发明人： Juan Diaz , Lance J. Bronnenkant
IPC分类号： A61F6/18 , A61F6/14 , A61F6/06
CPC分类号： A61F6/18
摘要： Methods and apparatus are disclosed for permitting a user to load an IUD into an IUD inserter within the confines of a tray and thereafter to safely insert the IUD into a patient's uterus to the proper depth while minimizing the risk of causing trauma to the uterine wall. An IUD inserter comprises an elongate shaft adapted to retain the arms of an IUD adjacent the distal end of the shaft, a slidable arm retainer mounted on the shaft adaptable to abut the outer portion of a patient's cervix, and a stop member adjustably mounted on the shaft so that the arm retainer is forced by the outer portion of a patient's cervix to abut the stop member as the IUD is advanced through the cervical canal of a patient to a preselected depth at the uterine fundus. An associated package permits an IUD having expandable arms thereon to be loaded into an arm retainer within the confines of the package immediately prior to insertion of the IUD into a patient's uterus. When it is desirable to insert the IUD into a patient after loading same in the arm retainer of an inserter, the steps include placing the slidable arm retainer of an IUD inserter against the outer portion of a patient's cervix, aligning the inserter and the IUD device therein with the cervical opening.
摘要翻译：公开了允许用户将IUD加载到托盘限制内的IUD插入器中的方法和装置，然后将IUD安全地插入患者的子宫中至适当的深度，同时最小化对子宫壁造成创伤的风险。 IUD插入器包括细长轴，其适于将IUD的臂保持在轴的远端附近，可滑动的臂保持器，其安装在适于抵靠患者子宫颈的外部的轴上，以及可调节地安装在患者的子宫颈上的止动构件轴，使得当IUD通过患者的子宫颈管进入到子宫底部的预选深度时，臂保持器被患者子宫颈的外部部分强迫以抵靠止动构件。相关联的包装允许在将IUD插入患者的子宫之前，将包含其中的可扩张臂的IUD装载到包装的范围内的臂保持器中。当将IUD插入到插入器的臂保持器中时希望将IUD插入患者后，步骤包括将IUD插入器的可滑动臂保持器抵靠患者子宫颈的外部部分，使插入器和IUD装置对准其中颈部开口。

3. 发明授权

US07855190B2 Methods of hormonal treatment utilizing contraceptive regimens with continuous estrogen administration 有权
标题翻译：使用连续雌激素给药的避孕方案的激素治疗方法
公开(公告)号：US07855190B2
公开(公告)日：2010-12-21
申请号：US10892404
申请日：2004-07-16
申请人： Robert G. Bell , Carole S. Ben-Maimon , Beata Iskold , Lance J. Bronnenkant , Howard Hait , Kathleen Z. Reape
发明人： Robert G. Bell , Carole S. Ben-Maimon , Beata Iskold , Lance J. Bronnenkant , Howard Hait , Kathleen Z. Reape
IPC分类号： A01N45/00 , A61K31/56
CPC分类号： A61K31/56 , A61K31/567
摘要： The present invention provides contraceptive regimens in which a female is administered a combined dosage form of estrogen and progestin followed by a period of administration of estrogen. The disclosed contraceptive regimens can be administered to a female as a method of providing non-contraceptive benefits.
摘要翻译：本发明提供了一种避孕方案，其中给予雌性雌激素和孕激素的组合剂型，随后施用雌激素的时期。公开的避孕方案可以作为提供非避孕益处的方法给予女性。

4. 发明授权

US07772219B2 Methods of hormonal treatment utilizing extended cycle contraceptive regimens 有权
标题翻译：使用延长周期避孕方案的激素治疗方法
公开(公告)号：US07772219B2
公开(公告)日：2010-08-10
申请号：US10837268
申请日：2004-05-03
申请人： Carole S. Ben-Maimon , Howard Hait , Kathleen Z. Reape , Lance J. Bronnenkant
发明人： Carole S. Ben-Maimon , Howard Hait , Kathleen Z. Reape , Lance J. Bronnenkant
IPC分类号： A61K31/56 , A61K31/58
CPC分类号： A61K31/565 , A61K31/57 , Y10S514/841 , Y10S514/843 , Y10S514/874 , A61K2300/00
摘要： The present invention provides extended cycle contraceptive regimens in which a female is administered a combined dosage form of estrogen and progestin. The disclosed extended cycle contraceptive regimens can be administered to a female as a method of providing non-contraceptive benefits.
摘要翻译：本发明提供延长的周期避孕方案，其中给予雌性雌激素和孕激素的组合剂型。公开的延长周期避孕方案可以作为提供非避孕益处的方法给予女性。

5. 发明授权

US5842474A IUD loading device 失效
标题翻译： IUD装载装置
公开(公告)号：US5842474A
公开(公告)日：1998-12-01
申请号：US678831
申请日：1996-07-12
申请人： Philip J. Blyskal , Lance J. Bronnenkant , George A. Clark
发明人： Philip J. Blyskal , Lance J. Bronnenkant , George A. Clark
IPC分类号： A61F6/18 , A61F6/14
CPC分类号： A61F6/18
摘要： The present invention provides an IUD loading device which folds the extended portions of an IUD such that the IUD may be placed into an insertion tube.
摘要翻译：本发明提供了IUD加载装置，其将IUD的延伸部分折叠，使得IUD可以放置在插入管中。

6. 发明授权

US08450299B2 Methods of hormonal treatment utilizing ascending-dose extended cycle regimens 有权
公开(公告)号：US08450299B2
公开(公告)日：2013-05-28
申请号：US13492138
申请日：2012-06-08
申请人： Charles E. Diliberti , Kathleen Z. Reape , Lance J. Bronnenkant
发明人： Charles E. Diliberti , Kathleen Z. Reape , Lance J. Bronnenkant
IPC分类号： A61K31/56
CPC分类号： A61K31/567 , A61K31/56 , A61K31/57 , A61K2300/00
摘要： The present invention provides ascending-dose extended cycle regimens in which a female is administered an estrogen and a progestin for a period of greater than 30 or 31 consecutive days, optionally followed by a hormone-free period or by a period of administration of estrogen. The disclosed regimens can be administered to a female to provide contraceptive and non-contraceptive benefits.

7. 发明申请

US20120252767A1 Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens 有权
标题翻译：使用升序剂量延长循环方案的激素治疗方法
公开(公告)号：US20120252767A1
公开(公告)日：2012-10-04
申请号：US13492138
申请日：2012-06-08
申请人： Charles E. Diliberti , Kathleen Z. Reape , Lance J. Bronnenkant
发明人： Charles E. Diliberti , Kathleen Z. Reape , Lance J. Bronnenkant
IPC分类号： A61K31/56 , A61P15/18
CPC分类号： A61K31/567 , A61K31/56 , A61K31/57 , A61K2300/00
摘要： The present invention provides ascending-dose extended cycle regimens in which a female is administered an estrogen and a progestin for a period of greater than 30 or 31 consecutive days, optionally followed by a hormone-free period or by a period of administration of estrogen. The disclosed regimens can be administered to a female to provide contraceptive and non-contraceptive benefits.
摘要翻译：本发明提供了上升剂量延长的周期方案，其中女性给予雌激素和孕激素连续大于30天或31天，任选地随后无激素期或雌激素施用期。所公开的方案可以给予女性以提供避孕和非避孕益处。

8. 发明申请

US20080125402A1 Methods of hormonal treatment utilizing ascending-dose extended cycle regimens 有权
标题翻译：使用升剂量延长周期治疗的激素治疗方法
公开(公告)号：US20080125402A1
公开(公告)日：2008-05-29
申请号：US11892026
申请日：2007-08-17
申请人： Charles E. Diliberti , Kathleen Z. Reape , Lance J. Bronnenkant
发明人： Charles E. Diliberti , Kathleen Z. Reape , Lance J. Bronnenkant
IPC分类号： A61K31/57 , A61P15/18 , A61P17/10
CPC分类号： A61K31/567 , A61K31/56 , A61K31/57 , A61K2300/00
摘要： The present invention provides ascending-dose extended cycle regimens in which a female is administered an estrogen and a progestin for a period of greater than 30 or 31 consecutive days, optionally followed by a hormone-free period or by a period of administration of estrogen. The disclosed regimens can be administered to a female to provide contraceptive and non-contraceptive benefits.
摘要翻译：本发明提供了上升剂量延长的周期方案，其中女性给予雌激素和孕激素连续大于30天或31天，任选地随后无激素期或雌激素施用期。所公开的方案可以给予女性以提供避孕和非避孕益处。

9. 发明申请

US20110124611A1 METHODS OF HORMONAL TREATMENT UTILIZING CONTRACEPTIVE REGIMENS WITH CONTINUOUS ESTROGEN ADMINISTRATION 审中-公开
标题翻译：利用连续的雌激素管理使用合同方案进行人体治疗的方法
公开(公告)号：US20110124611A1
公开(公告)日：2011-05-26
申请号：US12912583
申请日：2010-10-26
申请人： ROBERT G. BELL , CAROLE S. BEN-MAIMON , BEATA ISKOLD , LANCE J. BRONNENKANT , HOWARD HAIT , KATHLEEN Z. REAPE
发明人： ROBERT G. BELL , CAROLE S. BEN-MAIMON , BEATA ISKOLD , LANCE J. BRONNENKANT , HOWARD HAIT , KATHLEEN Z. REAPE
IPC分类号： A61K31/56 , A61P5/00 , A61P19/02 , A61P3/10 , A61P25/08 , A61P25/06
CPC分类号： A61K31/56 , A61K31/567
摘要： The present invention provides contraceptive regimens in which a female is administered a combined dosage form of estrogen and progestin followed by a period of administration of estrogen. The disclosed contraceptive regimens can be administered to a female as a method of providing non-contraceptive benefits.
摘要翻译：本发明提供了一种避孕方案，其中给予雌性雌激素和孕激素的组合剂型，随后施用雌激素的时期。公开的避孕方案可以作为提供非避孕益处的方法给予女性。

10. 再颁专利

USRE35636E IUD inserting apparatus 失效
标题翻译： IUD插入装置
公开(公告)号：USRE35636E
公开(公告)日：1997-10-21
申请号：US547946
申请日：1995-10-24
申请人： Juan Diaz , Lance J. Bronnenkant
发明人： Juan Diaz , Lance J. Bronnenkant
IPC分类号： A61F6/18 , A61F6/14 , A61F6/06
CPC分类号： A61F6/18
摘要： Methods and apparatus are disclosed for permitting a user to load an IUD into an IUD inserter within the confines of a tray and thereafter to safely insert the IUD into a patient's uterus to the proper depth while minimizing the risk of causing trauma to the uterine wall. An IUD inserter comprises an elongated shaft adapted to retain the arms of an IUD adjacent the distal end of the shaft, a slidable arm retainer mounted on the shaft adaptable to abut the outer portion of the patient's cervix, and a stop member adjustably mounted on the shaft so that the arm retainer is forced by the outer portion of a patient's cervix to abut the stop member as the IUD is advanced through the cervical canal of a patient to a preselected depth at the uterine fundus. An associated package permits an IUD having expandable arms thereon to be loaded into an arm retainer within the confines of the package immediately prior to insertion of the IUD into a patient's uterus. When it is desirable to insert the IUS into a patient after loading same in the arm retainer of an inserter, the steps include placing the slidable retainer of an IUD inserter against the outer portion of a patient's cervix, aligning the inserter and the IUD device therein with the cervical opening, advancing the end of the inserter through the cervical canal and into the uterus to that the arm retainer abuts a stop member arranged on the elongate shaft of the inserter, and withdrawing the elongate shaft from the uterus while the IUS is left at the proper depth therein.
摘要翻译：公开了允许用户将IUD加载到托盘限制内的IUD插入器中的方法和装置，然后将IUD安全地插入患者的子宫中至适当的深度，同时最小化对子宫壁造成创伤的风险。 IUD插入器包括细长轴，其适于将IUD的臂保持在轴的远端附近，可滑动的臂保持器，其安装在适于抵靠患者子宫颈的外部的轴上，以及可调节地安装在患者的子宫颈上的止动构件轴，使得当IUD通过患者的子宫颈管进入到子宫底部的预选深度时，臂保持器被患者子宫颈的外部部分强迫以抵靠止动构件。相关联的包装允许在将IUD插入患者的子宫之前，将包含其中的可扩张臂的IUD装载到包装的范围内的臂保持器中。当在将其装载到插入器的臂保持器中之后将IUS插入患者时，步骤包括将IUD插入件的可滑动保持器抵靠患者子宫颈的外部部分，将插入器和IUD装置对准通过颈部开口，使插入器的端部通过子宫颈管进入子宫，使得臂保持器抵靠插入件的细长轴上的止动构件，并且在离开IUS的同时将细长轴从子宫抽出在其中适当的深度。

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