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1. 发明专利

CA213742A DIPPER ATTACHMENT FOR STEAM SHOVELS 未知
公开(公告)号：CA213742A
公开(公告)日：1921-10-11
申请号：CA213742D
申请人： LUTZ ROBERT HAMILTON
发明人： LUTZ ROBERT HAMILTON

2. 发明专利

CA140784A SNOW PLOUGH 未知
公开(公告)号：CA140784A
公开(公告)日：1912-05-28
申请号：CA140784D
申请日：1912-01-24
申请人： LUTZ ROBERT HAMILTON
发明人： LUTZ ROBERT HAMILTON

3. 发明专利

CA1322798C IMPACT RESISTANT BLENDS OF THERMOPLASTIC POLYAMIDES, POLYOLEFINS AND ELASTOMERS AND PROCESS FOR THE PREPARATION THEREOF 未知
公开(公告)号：CA1322798C
公开(公告)日：1993-10-05
申请号：CA545952
申请日：1987-09-02
申请人： LUTZ ROBERT G
发明人： LUTZ ROBERT G , GELLES RICHARD , GERGEN WILLIAM P
IPC分类号： C08L51/06 , C08L53/02 , C08L77/00
摘要： T 4076 IMPACT RESISTANT BLENDS OF THERMOPLASTIC POLYAMIDES, POLYOLEFINS AND ELASTOMERS AND PROCESS FOR THE PREPARATION THEREOF An impact resistant polymeric composition comprising 1-95 %wt of a polyamide, 1-95 %wt of a polyolefin to which an acid compound may have been grafted, and 1-50 %wt of an elastomer to which an acid compound has been grafted and a process for the preparation thereof by melt-blending. T4076.TXT

4. 发明专利

CA1322797C IMPACT RESISTANT BLENDS OF THERMOPLASTIC POLYAMIDES, POLYOLEFINS AND ELASTOMERS AND PROCESS FOR THE PREPARATION THEREOF 未知
公开(公告)号：CA1322797C
公开(公告)日：1993-10-05
申请号：CA545946
申请日：1987-09-02
申请人： LUTZ ROBERT G
发明人： LUTZ ROBERT G , GERGEN WILLIAM P
IPC分类号： C08L51/06 , C08L53/02 , C08L77/00
摘要： K 4840 CAN IMPACT RESISTANT BLENDS OF THERMOPLASTIC POLYAMIDES, POLYOLEFINS AND ELASTOMERS AND PROCESS FOR THE PREPARATION THEREOF Impact resistant polymeric composition comprising 1-95 %wt of a polyamide, 1-95 %wt of a functionalized polyolefin and 1-50 %wt of an elastomer and process for the preparation thereof by melt-blending. K4840.TXT

5. 发明专利

CA1340630C THERMAL STABILIZATION OF CARBON MONOXIDE COPOLYMERS 未知
公开(公告)号：CA1340630C
公开(公告)日：1999-07-06
申请号：CA587868
申请日：1989-01-10
申请人： LUTZ ROBERT GARDINER , SYRIER JOHANNES LEOPOLD MARIE , VAN DE WEG HENDRIK
发明人： LUTZ ROBERT GARDINER , SYRIER JOHANNES LEOPOLD MARIE , VAN DE WEG HENDRIK
IPC分类号： C08L73/00 , C08K5/13 , C08K5/18 , C08K5/20 , C08K5/25 , C08K5/3477 , C08K5/372 , C08L23/08 , C08L23/14
摘要： Stabilized copolymer compositions comprising an alternating copolymer of carbon monoxide and an olefinically unsaturated compound and from 0.03 to 3.0 %w of a sterically hindered phenolic (blend) compound selected from: 1) bis- and tris-phenolic alkanes, 2) tris-phenolic (alkyl)benzenes, 3 tris-phenolic cyanurates, 4) symmectrical diesters of hydroxyphenyl substituted aliphatic monocarboxylic acids and N,N'-bis(hydroxy-alkyl)oxalamide, 5) blends comprising on the one hand specific defined phenolic compounds, and on the other hand aromatic amines and/or compounds of general formula R100C-(CH2)p-S-(CH2)q-COOR2 in which p, q, R1 and R2 have defined meanings.

6. 发明专利

AT18841B 未知
公开(公告)号：AT18841B
公开(公告)日：1905-01-10
申请号：AT18841D
申请日：1903-04-21
申请人： LUTZ ROBERT , HINTERBERGER HEINRICH , HINTERBERGER MARIE
发明人： LUTZ ROBERT , HINTERBERGER HEINRICH , HINTERBERGER MARIE

7. 发明申请

WO2010008726A1 NOVEL SYNERGISTIC EFFECTS 审中-公开
标题翻译：新的协同效应
公开(公告)号：WO2010008726A1
公开(公告)日：2010-01-21
申请号：PCT/US2009/047449
申请日：2009-06-16
申请人： IMMUNOGEN INC. , LUTZ, Robert J. , WHITEMAN, Kathleen R.
发明人： LUTZ, Robert J. , WHITEMAN, Kathleen R.
IPC分类号： A61K39/38
CPC分类号： C07K16/2803 , A61K31/198 , A61K31/436 , A61K31/454 , A61K31/57 , A61K31/675 , A61K31/69 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/24 , A61K2300/00
摘要： The present invention encompasses a combination of at least one conjugate and one or more chemotherapeutic agent(s) which when administered exerts an unexpectedly enhanced therapeutic effect. The therapeutic effectiveness of the combination is greater than that of the conjugate alone or the administration of one or more of the drug(s) without the conjugate. The present invention is also directed to compositions comprising at least one conjugate and at one or more of chemotherapeutic agent and to methods of treating cancer using at least one conjugate and at least one or more of chemotherapeutic agent (s). The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of one or more chemotherapeutic agent(s) and at least one conjugate. In each case, such combination has therapeutic synergy or improves the therapeutic index in the treatment of cancer over the anticancer agent(s) alone.
摘要翻译：本发明包括至少一种缀合物和一种或多种化学治疗剂的组合，其当施用时施加意想不到的增强的治疗效果。组合的治疗效果大于单独的缀合物或施用一种或多种没有缀合物的药物。本发明还涉及包含至少一种缀合物和一种或多种化学治疗剂的组合物和使用至少一种缀合物和至少一种或多种化学治疗剂治疗癌症的方法。本发明还提供了通过施用治疗有效量的一种或多种化学治疗剂和至少一种缀合物来调节所选细胞群体例如癌细胞的生长的方法。在每种情况下，这种组合具有治疗性协同作用或改善治疗癌症的治疗指数超过单独的抗癌剂。

8. 发明申请

WO2015126911A1 SPORTS SLED 审中-公开
标题翻译：运动鞋
公开(公告)号：WO2015126911A1
公开(公告)日：2015-08-27
申请号：PCT/US2015/016332
申请日：2015-02-18
申请人： HERITAGE INDUSTRIES , TOMPKINS, Rodney, R. , SYNNOT, David, Edward , POEHLMAN, Richard, Todd , SCHULTZE, Timothy, Elmer , SPANN, Sean, Stacy , WALDO, Robert, Lee , LUTZ, Robert, James
发明人： TOMPKINS, Rodney, R. , SYNNOT, David, Edward , POEHLMAN, Richard, Todd , SCHULTZE, Timothy, Elmer , SPANN, Sean, Stacy , WALDO, Robert, Lee , LUTZ, Robert, James
IPC分类号： A63B69/00 , A63B69/34
CPC分类号： A63B69/345 , A63B71/0054 , A63B2071/0063 , A63B2071/025 , A63B2071/026 , A63B2210/50 , A63B2225/09
摘要： Aspects of the disclosure relate to a sports sled configured to be used individually or in connection with one or more additional sports sleds. The sports sled includes a support base and a support frame fixedly attached to the support base. The support frame can be configured to support an attachable pad that absorbs impacts thereupon such that the support base can slide on a support surface, such as the ground. The sports sled can also include connection plates and connectors configured to couple the sports sled to another sports sled positioned adjacent to the sports sled. In some embodiments, a first connection plate and its associated connectors can extend parallel to the ground, and a second connection plate and its associated connectors can extend perpendicular to the ground. The connection plates can be removably connected to the sports sled using, for example, connectors configured as pegs.
摘要翻译：本公开的方面涉及被配置为单独使用或与一个或多个附加运动滑车相关联的运动滑雪板。运动滑板包括支撑基座和固定地附接到支撑基座的支撑框架。支撑框架可以被配置为支撑吸收其上的冲击的可附接垫，使得支撑基座可以在诸如地面的支撑表面上滑动。运动雪橇还可以包括连接板和连接器，其被配置为将运动滑雪板耦合到位于运动滑雪板附近的另一运动滑雪板。在一些实施例中，第一连接板及其相关联的连接器可以平行于地面延伸，并且第二连接板及其相关联的连接器可以垂直于地面延伸。连接板可以使用例如被配置为钉的连接件可拆卸地连接到运动滑板。

9. 发明申请

WO2012138749A1 METHODS FOR DECREASING OCULAR TOXICITY OF ANTIBODY DRUG CONJUGATES 审中-公开
标题翻译：降低抗体药物偶联毒性的方法
公开(公告)号：WO2012138749A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/032155
申请日：2012-04-04
申请人： IMMUNOGEN, INC. , LUTZ, Robert, J. , CHARI, Ravi, V. J.
发明人： LUTZ, Robert, J. , CHARI, Ravi, V. J.
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K47/6851 , A61K47/6803 , A61K47/6809
摘要： The invention relates to charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of using the same to reduce ocular toxicity associated with administration of antibody drug conjugates.
摘要翻译：本发明涉及带电或带电荷的交联部分和细胞结合剂的缀合物和包含带电荷或带正电荷的交联部分的药物及其使用方法，以减少与施用抗体药物偶联物相关的眼部毒性。

10. 发明申请

WO2012138537A1 COMPOSITIONS AND METHODS FOR TREATMENT OF OVARIAN, PERITONEAL, AND FALLOPIAN TUBE CANCER 审中-公开
标题翻译： OVARIAN，PERITONEAL和FALLOPIAN TUBE CANCER的组合物和方法
公开(公告)号：WO2012138537A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/031181
申请日：2012-03-29
申请人： IMMUNOGEN, INC. , WHITEMAN, Kathleen R. , O'LEARY, James J. , LUTZ, Robert John
发明人： WHITEMAN, Kathleen R. , O'LEARY, James J. , LUTZ, Robert John
IPC分类号： A61K39/00 , C12P21/08
CPC分类号： C07K16/2803 , A61K39/39558 , C07K2317/24 , A61K2300/00
摘要： The disclosure relates to anti-cancer drug combinations, pharmaceutical compositions for treating ovarian, peritoneal, or fallopian tube cancer. Specifically, the disclosure is based on the discovery that the administration of a CD56 antibody linked to a cytotoxic compound (e.g." an immunoconjugate) in combination with a chemotherapeutic agent (in particular a gemcitabine compound, a topotecan compound, and a doxorubicin compound), improves the therapeutic index in the treatment of ovarian, peritoneal, or fallopian tube cancer over and above the additive effects of the anticancer agents used alone. Combinations of the CD56 antibody, or fragment thereof, linked to a cytotoxic compound plus an additional chemotherapeutic agent have a synergistic effect in the ovarian cancer therapeutic index. Further disclosed are methods of modulating the growth of selected cell populations, such as ovarian, peritoneal, or fallopian tube cancer cells, by administering a therapeutically effective amount of such combinations.
摘要翻译：本公开涉及抗癌药物组合，用于治疗卵巢，腹膜或输卵管癌的药物组合物。具体地，本公开是基于以下发现：与化学治疗剂（特别是吉西他滨化合物，拓扑替康化合物和多柔比星化合物）联合的细胞毒性化合物（例如“免疫偶联物”）的CD56抗体的施用，改善治疗卵巢，腹膜或输卵管癌的治疗指标，超过单独使用的抗癌剂的加和效应。与细胞毒性化合物加上另外的化学治疗剂连接的CD56抗体或其片段的组合具有进一步公开了通过施用治疗有效量的这种组合来调节所选细胞群体如卵巢，腹膜或输卵管癌细胞的生长的方法。

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