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1. 发明专利

IL286665D0 Apparatus and method of estimating values from images 未知
公开(公告)号：IL286665D0
公开(公告)日：2021-10-31
申请号：IL28666521
申请日：2021-09-24
申请人： ILLUMINA INC , LANGLOIS ROBERT , LU BO , REN HONGJI , PINTO JOSEPH FRANCIS , PRINCE SIMON , CORBETT AUSTIN
发明人： LANGLOIS ROBERT , LU BO , REN HONGJI , PINTO JOSEPH FRANCIS , PRINCE SIMON , CORBETT AUSTIN
IPC分类号： G01N21/64 , G02B21/06 , G02B21/14 , G02B21/36 , G06T7/00
摘要： A method is used to generate a distortion model for a structured illumination microscopy (SIM) optical system. A sliding window is moved in relation to a plurality of images to define a plurality of sub-tiles. Each sub-tile represents a portion of the corresponding image. Parameters are estimated for each sub-tiles. The parameters include two or more parameters selected from the group consisting of modulation, angle, spacing, phase offset, and phase deviation. A full width at half maximum (FWHM) value associated with each sub-tile is estimated. A distortion model is estimated, based at least in part on a combination of the estimated parameters and FWHM values stored in the predetermined format and an estimated center window parameter. A two-dimensional image may be generated, based at least in part on the estimated distortion model. The two-dimensional image may include representations indicating where distortions occur in the optical system.

2. 发明专利

IL286661D0 Apparatus and method of providing parameter estimation 未知
公开(公告)号：IL286661D0
公开(公告)日：2021-10-31
申请号：IL28666121
申请日：2021-09-24
申请人： ILLUMINA INC , CORBETT AUSTIN , LU BO , LANGLOIS ROBERT , PINTO JOSEPH FRANCIS , CHEN YU , NEWMAN PETER CLARKE , REN HONGJI
发明人： CORBETT AUSTIN , LU BO , LANGLOIS ROBERT , PINTO JOSEPH FRANCIS , CHEN YU , NEWMAN PETER CLARKE , REN HONGJI
IPC分类号： G02B21/00 , G02B21/08 , G02B21/36 , G02B26/06 , G06T7/00 , G06T7/80 , H04N5/225
摘要： A method is used to generate a report presenting parameter values corresponding to a structured illumination microscopy (SIM) optical system. The parameter values are based at least in part on the performed modulation calculation corresponding to an image set captured with the SIM optical system. A minimum FWHM slice is identified, based at least in part on an average FWHM value across the images in the first image set. Parameter estimation is performed on the identified minimum FWHM slice. Best in-focus parameters are identified based at least in part on the performed estimation. A phase estimate is performed for each image in the set. A modulation calculation is performed based at least in part on the identified best in-focus parameters. The report is based at least in part on the performed modulation calculation.

3. 发明专利

AU2003289628A1 DEVICE FOR PREVENTING SNORING 未知
公开(公告)号：AU2003289628A1
公开(公告)日：2005-06-17
申请号：AU2003289628
申请日：2003-11-27
申请人： WEN YUN , LU BO
发明人： WEN YUN , LU BO
IPC分类号： A61F5/56

4. 发明申请

WO2011150357A3 METHODS AND DESIGN OF MEMBRANE FILTERS 审中-公开
标题翻译：膜过滤器的方法与设计
公开(公告)号：WO2011150357A3
公开(公告)日：2012-04-26
申请号：PCT/US2011038390
申请日：2011-05-27
申请人： CALIFORNIA INST OF TECHN , TAI YU-CHONG , LU BO
发明人： TAI YU-CHONG , LU BO
IPC分类号： G01N33/48 , C12M1/12 , C40B30/04 , G01N33/15 , G01N33/574
CPC分类号： G01N33/5011 , B01D65/10
摘要： The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of "key engineering design parameters" that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, transfilter pressure and total filtration time.
摘要翻译：本发明提供了用于设计用于捕获活肿瘤细胞的过滤系统的方法，例如高效率和高活力的循环肿瘤细胞。这些方法涉及开发一组对于实现高肿瘤细胞活力至关重要的“关键工程设计参数”。这些重要的设计参数包括过滤器几何设计，流体输送方法，输送机压力和总过滤时间。

5. 发明申请

WO2010135603A2 METHOD FOR CANCER DETECTION, DIAGNOSIS AND PROGNOSIS 审中-公开
标题翻译：癌症检测，诊断和预防方法
公开(公告)号：WO2010135603A2
公开(公告)日：2010-11-25
申请号：PCT/US2010035684
申请日：2010-05-20
申请人： CALIFORNIA INST OF TECHN , UNIV SOUTHERN CALIFORNIA , GOLDKORN AMIR , TAI YU-CHONG , XU TONG , LU BO
发明人： GOLDKORN AMIR , TAI YU-CHONG , XU TONG , LU BO
IPC分类号： C12Q1/25 , C12N5/09 , C12Q1/68 , G01N33/50
CPC分类号： G01N33/57496 , C12N5/0693 , C12N2503/00 , C12Q1/6806 , C12Q1/6886 , C12Q2600/118 , C12Y207/07049 , G01N1/30 , G01N1/4077 , G01N33/5094 , G01N2001/4088 , G01N2333/9128 , Y10T436/25375
摘要： The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting of a parylene substrate, which has an array of holes with a predetermined shape and size; and detecting and quantifying telomerase activity in blood circulating tumor cells. The invention further provides methods of using cells live-captured in various applications.
摘要翻译：本发明提供一种用于诊断癌症的方法，预测患者样品中的疾病结果或对治疗的反应。该方法包括使用聚对二甲苯微型过滤器装置从样品中分离循环肿瘤细胞（CTC），例如可行的CTC，所述聚对二甲苯微型过滤器包括具有具有预定形状的孔阵列的具有聚对二甲苯衬底或由聚对二甲苯衬底组成的膜过滤器，尺寸; 并检测和定量血液循环肿瘤细胞中的端粒酶活性。本发明还提供了使用在各种应用中实时捕获的细胞的方法。

6. 发明申请

WO2017143192A3 EXTRANEURAL CUFF WITH SPIKE-SHAPED ELECTRODES FOR STIMULATION AND RECORDING 审中-公开
公开(公告)号：WO2017143192A3
公开(公告)日：2017-08-24
申请号：PCT/US2017/018372
申请日：2017-02-17
申请人： VERILY LIFE SCIENCES LLC , LU, Bo
发明人： LU, Bo , PEPIN, Brian, Marc
IPC分类号： A61N1/05 , A61N1/375 , A61N1/36 , A61N1/372
摘要： An electrode system for neuromodulation and for recording of nerve activity is provided. The system can include a plurality of raised, spike-shaped electrodes provided on a flexible, non-conductive substrate. The substrate can be rolled into a cuff for encircling a nerve bundle of a patient. The plurality of electrodes on the cuff can be connected to a controller provided either on the cuff or in the patient's body in close proximity to the cuff. The controller can instruct the electrodes to deliver electrical pulses to the nerve fiber to stimulate it and/or to sense nerve activity from the nerve fiber. The spike shape of the electrodes can allow them to penetrate the myelin sheet of a nerve bundle and come in closer contact with the nerve fiber, which in turn can increase specificity, improve the signal-to-noise ratio of acquired neuro signals, and allow lower currents to be used for neuromodulation.

7. 发明申请

WO2017143192A2 EXTRANEURAL CUFF WITH SPIKE-SHAPED ELECTRODES FOR STIMULATION AND RECORDING 审中-公开
标题翻译：具有用于刺激和记录的尖状电极的外部封套
公开(公告)号：WO2017143192A2
公开(公告)日：2017-08-24
申请号：PCT/US2017/018372
申请日：2017-02-17
申请人： VERILY LIFE SCIENCES LLC , LU, Bo
发明人： LU, Bo , PEPIN, Brian, Marc
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/3605 , A61N1/37211 , A61N1/375
摘要： An electrode system for neuromodulation and for recording of nerve activity is provided. The system can include a plurality of raised, spike-shaped electrodes provided on a flexible, non-conductive substrate. The substrate can be rolled into a cuff for encircling a nerve bundle of a patient. The plurality of electrodes on the cuff can be connected to a controller provided either on the cuff or in the patient's body in close proximity to the cuff. The controller can instruct the electrodes to deliver electrical pulses to the nerve fiber to stimulate it and/or to sense nerve activity from the nerve fiber. The spike shape of the electrodes can allow them to penetrate the myelin sheet of a nerve bundle and come in closer contact with the nerve fiber, which in turn can increase specificity, improve the signal-to-noise ratio of acquired neuro signals, and allow lower currents to be used for neuromodulation.
摘要翻译：提供用于神经调节和记录神经活动的电极系统。该系统可以包括设置在柔性非导电衬底上的多个凸起的钉状电极。衬底可卷成袖口以环绕患者的神经束。袖带上的多个电极可以连接到设置在袖带上或靠近袖口的患者体内的控制器。控制器可以指示电极向神经纤维递送电脉冲以刺激它和/或感测来自神经纤维的神经活动。电极的尖峰形状可以允许它们穿透神经束的髓鞘层并且与神经纤维更紧密接触，这反过来可以增加特异性，改善获得的神经信号的信噪比并且允许较低的电流用于神经调节。

8. 发明申请

WO2009097247A1 METHOD AND APPARATUS FOR MICROFILTRATION TO PERFORM CELL SEPARATION 审中-公开
标题翻译：用于微细分离以进行细胞分离的方法和装置
公开(公告)号：WO2009097247A1
公开(公告)日：2009-08-06
申请号：PCT/US2009/032054
申请日：2009-01-26
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTHERN CALIFORNIA , ZHENG, Siyang , COTE, Richard , LIN, Henry , LU, Bo , TAI, Yu-Chong
发明人： ZHENG, Siyang , COTE, Richard , LIN, Henry , LU, Bo , TAI, Yu-Chong
IPC分类号： C12M1/12 , C12M3/06 , G01N33/48
CPC分类号： B01D69/12 , B01D61/18 , B01D63/082 , B01D67/0034 , B01D71/28 , B01D2325/021
摘要： A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using microfabrication techniques. The porous membranes are arranged so that the pores in the top membrane are offset from the pores in the bottom membrane.
摘要翻译：一种使用具有顶部多孔膜和底部多孔膜的微量过滤装置从样品中分离诸如循环肿瘤细胞的细胞的微滤装置和方法。多孔膜由聚对二甲苯形成并使用微细加工技术组装。多孔膜被布置成使得顶部膜中的孔与底部膜中的孔偏离。

9. 发明申请

WO2017143189A1 EXTRANEURAL CUFF WITH FLEXIBLE INTERCONNECTS FOR STIMULATON AND RECORDING 审中-公开
标题翻译：用于刺激和记录的具有柔性互连的外部封套
公开(公告)号：WO2017143189A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/018368
申请日：2017-02-17
申请人： VERILY LIFE SCIENCES LLC , LU, Bo
发明人： LU, Bo , PEPIN, Brian, Marc
IPC分类号： A61B5/04 , A61B5/00 , A61N1/05
CPC分类号： A61N1/0556 , A61B5/04001 , A61B5/4041 , A61B5/686 , A61B5/6877 , A61B2562/166 , A61N1/36057 , A61N1/36125
摘要： An electrode system for neuromodulation and for recording of signals indicative of nerve activity is provided. The system can include a plurality of electrodes provided on a flexible, non-conductive substrate. The substrate can be rolled into a cuff for encircling a nerve bundle of a patient. The plurality of electrodes on the cuff can be interconnected using flexible conductors provided on the substrate. In one implementation, the electrodes can be interconnected using conductors that have spring-like configuration. Flexibility of the conductors allows the cuff to expand and contract with the nerve without causing excessive stress/strain at the nerve-cuff interface.
摘要翻译：提供了用于神经调节和记录指示神经活动的信号的电极系统。该系统可以包括设置在柔性非导电衬底上的多个电极。衬底可卷成袖口以环绕患者的神经束。套囊上的多个电极可以使用设置在衬底上的柔性导体互连。在一个实施方式中，电极可以使用具有弹簧状配置的导体互连。导线的灵活性使得袖带能够与神经扩张和收缩，而不会在神经 - 袖带界面处造成过度的压力/应变。

10. 发明申请

WO2011150357A2 METHODS AND DESIGN OF MEMBRANE FILTERS 审中-公开
标题翻译：膜过滤器的方法与设计
公开(公告)号：WO2011150357A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/038390
申请日：2011-05-27
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , TAI, Yu-Chong , LU, Bo
发明人： TAI, Yu-Chong , LU, Bo
IPC分类号： G01N33/48 , C12M1/12 , G01N33/15 , G01N33/574 , C40B30/04
CPC分类号： G01N33/5011 , B01D65/10
摘要： The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of "key engineering design parameters" that are crucial to achieve high tumor cell viability. These important design parameters include the filter geometry design, fluid delivery method, transfilter pressure and total filtration time.
摘要翻译：本发明提供了用于设计用于捕获活肿瘤细胞的过滤系统的方法，例如高效率和高活力的循环肿瘤细胞。这些方法涉及开发一组对于实现高肿瘤细胞活力至关重要的“关键工程设计参数”。这些重要的设计参数包括过滤器几何设计，流体输送方法，输送机压力和总过滤时间。

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