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1. 发明申请

WO2008077555A3 SUBSTITUTED ISOQUINOLINES AND THEIR USE AS RHO-KINASE INHIBITORS 审中-公开
标题翻译：取代的异喹啉及其作为RHO-激酶抑制剂的用途
公开(公告)号：WO2008077555A3
公开(公告)日：2009-05-07
申请号：PCT/EP2007011168
申请日：2007-12-19
申请人： SANOFI AVENTIS , PLETTENBURG OLIVER , LORENZ KATRIN , GOERLITZER JOCHEN , LOEHN MATTHIAS
发明人： PLETTENBURG OLIVER , LORENZ KATRIN , GOERLITZER JOCHEN , LOEHN MATTHIAS
IPC分类号： C07D401/12 , A61K31/4725 , A61P3/00 , A61P7/00 , A61P9/00 , A61P25/00 , C07D401/14 , C07D405/14 , C07D451/06
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D451/06
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译：本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物，化合物。

2. 发明申请

WO2008077556A1 CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES 审中-公开
标题翻译：环丙基胺取代的异喹啉和异喹啉衍生物
公开(公告)号：WO2008077556A1
公开(公告)日：2008-07-03
申请号：PCT/EP2007/011169
申请日：2007-12-19
申请人： SANOFI-AVENTIS , PLETTENBURG, Oliver , LORENZ, Katrin , GOERLITZER, Jochen , LÖHN, Matthias , BISCARRAT, Sandrine , JEANNOT, Frédéric , DUCLOT, Olivier
发明人： PLETTENBURG, Oliver , LORENZ, Katrin , GOERLITZER, Jochen , LÖHN, Matthias , BISCARRAT, Sandrine , JEANNOT, Frédéric , DUCLOT, Olivier
IPC分类号： C07D217/24 , A61K31/472 , A61P9/12
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译：本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物，化合物。

3. 发明申请

WO2013037914A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDINES, THEIR USE AS MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM 审中-公开
标题翻译：取代4,5,6,7-四氢-1H-吡唑并[4,3-C]吡啶，它们作为药物使用，以及包含它们的药物制剂
公开(公告)号：WO2013037914A1
公开(公告)日：2013-03-21
申请号：PCT/EP2012/067995
申请日：2012-09-13
申请人： SANOFI , BIALY, Laurent , LORENZ, Katrin , WIRTH, Klaus , STEINMEYER, Klaus , HESSLER, Gerhard , PERNERSTORFER, Josef , BRENDEL, Joachim
发明人： BIALY, Laurent , LORENZ, Katrin , WIRTH, Klaus , STEINMEYER, Klaus , HESSLER, Gerhard , PERNERSTORFER, Josef , BRENDEL, Joachim
IPC分类号： C07D471/04 , A61K31/437 , A61P9/06
CPC分类号： C07D471/04
摘要： The invention relates to substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines of formula (I), their use as medicament, and pharmaceutical preparations comprising them. The compounds of formula (I) act on the TASK-1 potassium channel. The compounds are suitable for the treatment or prevention of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.
摘要翻译：本发明涉及式（I）的取代的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶，它们作为药物的用途，以及包含它们的药物制剂。式（I）化合物作用于TASK-1钾通道。该化合物适用于治疗或预防心律失常，例如心房颤动（AF）或心房颤动。

4. 发明申请

WO2013037415A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDINES, THEIR USE AS MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM 审中-公开
标题翻译：取代4,5,6,7-四氢-1H-吡唑并[4,3-C]吡啶，它们作为药物使用，以及包含它们的药物制剂
公开(公告)号：WO2013037415A1
公开(公告)日：2013-03-21
申请号：PCT/EP2011/066061
申请日：2011-09-16
申请人： SANOFI , BIALY, Laurent , LORENZ, Katrin , WIRTH, Klaus , STEINMEYER, Klaus , HESSLER, Gerhard , PERNERSTORFER, Josef , BRENDEL, Joachim
发明人： BIALY, Laurent , LORENZ, Katrin , WIRTH, Klaus , STEINMEYER, Klaus , HESSLER, Gerhard , PERNERSTORFER, Josef , BRENDEL, Joachim
IPC分类号： C07D471/04 , C07D471/18 , A61K31/437 , A61K31/439 , A61P9/06
CPC分类号： C07D471/04 , C07D471/18
摘要： The invention relates to substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines of formula (I), their use as medicament, and pharmaceutical preparations comprising them. The compounds of formula (I) act on the TASK-1 potassium channel. The compounds are particularly suitable for the treatment or prevention of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.
摘要翻译：本发明涉及式（I）的取代的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶，它们作为药物的用途，以及包含它们的药物制剂。式（I）化合物作用于TASK-1钾通道。该化合物特别适用于治疗或预防房性心律失常，例如房颤（AF）或心房扑动。

5. 发明申请

WO2011045382A1 METHOD AND DEVICE FOR MAINTAINING A CONCENTRATION OF A TREATMENT BATH 审中-公开
标题翻译：用于维持治疗浴浓度的方法和装置
公开(公告)号：WO2011045382A1
公开(公告)日：2011-04-21
申请号：PCT/EP2010/065438
申请日：2010-10-14
申请人： NOVARTIS AG , BIEL, Roger , LORENZ, Katrin, Sylke
发明人： BIEL, Roger , LORENZ, Katrin, Sylke
IPC分类号： B29D11/00 , G02B1/04 , G02C7/04
CPC分类号： B29D11/00125
摘要： There is described a method for maintaining the concentration of a treatment liquid bath in the production process for contact lenses which comprises the process steps of rinsing each lens in a water bath immediately prior to immersing the lens in a liquid bath for extraction and/or rinsing and/or coating thereof. Immediately following the rinsing in the water bath each contact lens is immersed in an arrangement of two or more successive treatment liquid baths of the same kind. The treatment liquids in the successive baths are continuously renewed and are transported from one bath to the preceding bath in a direction opposite to a transport direction of the contact lenses from bath to bath. A metered volume of treatment liquid is continuously introduced into the last bath of the arrangement of treatment liquid baths in dependency of a measured concentration, and a specified volume of treatment liquid is continuously removed from the first bath.
摘要翻译：描述了一种用于在隐形眼镜制造过程中维持治疗液浴浓度的方法，该方法包括以下步骤：在将晶状体浸入用于萃取和/或漂洗的液浴之前立即在水浴中冲洗每个晶状体和/或其涂层。在水浴中冲洗后，将每个隐形眼镜立即浸入相同种类的两个或多个连续处理液浴的排列中。连续浴中的处理液体被连续地更新，并且从一个浴槽到与之前的浴槽相反的方向从隐形眼镜的运输方向从浴槽转移到浴液。根据测量浓度，将计量体积的处理液体连续地引入处理液槽布置的最后一个浴中，并且从第一个浴中连续地移除指定体积的处理液体。

6. 发明申请

WO2009156092A3 BI-AND POLYCYCLIC SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINE DERIVATIVES AS RHO KINASE INHIBITORS 审中-公开
标题翻译：作为RHO激酶抑制剂的BI-和多环取代的异喹啉和异喹啉衍生物
公开(公告)号：WO2009156092A3
公开(公告)日：2010-04-08
申请号：PCT/EP2009004393
申请日：2009-06-18
申请人： SANOFI AVENTIS , PLETTENBURG OLIVER , LORENZ KATRIN , LOEHN MATTHIAS , DUCLOS OLIVIER , BISCARRAT SANDRINE
发明人： PLETTENBURG OLIVER , LORENZ KATRIN , LOEHN MATTHIAS , DUCLOS OLIVIER , BISCARRAT SANDRINE
IPC分类号： C07D217/24 , A61K31/472 , A61P9/00 , A61P25/00 , A61P27/00 , A61P37/00 , C07D493/08 , C07D495/08
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译：本发明涉及式（I）的双和多环取代的异喹啉和异喹啉酮，其中R 1至R 12如本申请中所定义，可用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的相关疾病肌球蛋白轻链磷酸酶的磷酸化，以及含有这些化合物的组合物。

7. 发明申请

WO2009156092A2 BI- AND POLYCYCLIC SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES 审中-公开
标题翻译：双取代和多环取代的异喹啉和异喹啉衍生物
公开(公告)号：WO2009156092A2
公开(公告)日：2009-12-30
申请号：PCT/EP2009/004393
申请日：2009-06-18
申请人： SANOFI-AVENTIS , PLETTENBURG, Oliver , LORENZ, Katrin , LOEHN, Matthias , DUCLOS, Olivier , BISCARRAT, Sandrine
发明人： PLETTENBURG, Oliver , LORENZ, Katrin , LOEHN, Matthias , DUCLOS, Olivier , BISCARRAT, Sandrine
IPC分类号： C07D217/24 , C07D493/08 , C07D495/08 , A61K31/472 , A61P27/00 , A61P9/00 , A61P25/00 , A61P37/00
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R 1 to R 12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译：本发明涉及式（I）的双和多环取代的异喹啉和异喹啉酮，其中R 1至R 12如本申请中所定义，可用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的相关疾病肌球蛋白轻链磷酸酶的磷酸化，以及含有这些化合物的组合物。

8. 发明申请

WO2008077555A2 NEW SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES 审中-公开
标题翻译：新替代的异喹啉和异喹啉衍生物
公开(公告)号：WO2008077555A2
公开(公告)日：2008-07-03
申请号：PCT/EP2007/011168
申请日：2007-12-19
申请人： SANOFI-AVENTIS , PLETTENBURG, Oliver , LORENZ, Katrin , GOERLITZER, Jochen , LÖHN, Matthias
发明人： PLETTENBURG, Oliver , LORENZ, Katrin , GOERLITZER, Jochen , LÖHN, Matthias
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D451/06
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译：本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物，化合物。

9. 发明申请

WO2008077551A1 CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLONE DERIVATIVES 审中-公开
标题翻译：环丙基胺取代的异喹啉衍生物
公开(公告)号：WO2008077551A1
公开(公告)日：2008-07-03
申请号：PCT/EP2007/011164
申请日：2007-12-19
申请人： SANOFI-AVENTIS , PLETTENBURG, Oliver , HOFMEISTER, Armin , LORENZ, Katrin , BRENDEL, Joachim , LÖHN, Matthias , WESTON, John
发明人： PLETTENBURG, Oliver , HOFMEISTER, Armin , LORENZ, Katrin , BRENDEL, Joachim , LÖHN, Matthias , WESTON, John
IPC分类号： C07D217/24 , C07D401/12 , A61K31/472 , A61K31/4725 , A61K31/5377
CPC分类号： C07D217/24 , C07D401/12
摘要： The invention relates to 6-substituted isoquinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译：本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代的异喹诺酮衍生物和含有这些化合物的组合物。

10. 发明申请

WO2011045384A1 CONTAINER FOR THE ACCOMMODATION OF A CONTACT LENS 审中-公开
标题翻译：用于接触镜片的容器
公开(公告)号：WO2011045384A1
公开(公告)日：2011-04-21
申请号：PCT/EP2010/065440
申请日：2010-10-14
申请人： NOVARTIS AG , BIEL, Roger , LORENZ, Katrin Sylke , WOODWARD, Adrian Michael , HOWARTH, James Robert Stirling
发明人： BIEL, Roger , LORENZ, Katrin Sylke , WOODWARD, Adrian Michael , HOWARTH, James Robert Stirling
IPC分类号： B29C71/00 , B29D11/00 , C08J7/02
CPC分类号： B29D11/0023
摘要： There is described a container (1) for the accommodation of a contact lens during treatment process such as extraction and/or rinsing and/or coating processes, which comprises an elongated tubular body (2) having a sidewall (3) and at one longitudinal end thereof a bottom (4) which protrudes convexly towards the outside of the tubular body (2). At the opposite longitudinal end the tubular body (2) has an access opening (5). The bottom (4) is provided with a number of apertures (41, 42) which enable a free flow of a liquid into and out of the tubular body (2). A retaining element (6) is located inside the tubular body (2), which allows access of a transfer means into the tubular body (2) towards the bottom (4) thereof for insertion and removal of a contact lens, and enables a free rising of the liquid inside the tubular body (2), but prohibits the contact lens from being washed out of the tubular body (2).
摘要翻译：描述了用于在诸如提取和/或漂洗和/或涂覆过程的处理过程期间容纳隐形眼镜的容器（1），其包括具有侧壁（3）并且在一个纵向上的细长管状体（2）端部具有朝向管状体（2）的外侧凸出的底部（4）。在相对的纵向端，管状体（2）具有进入开口（5）。底部（4）设置有多个孔（41,42），其能够使液体自由流入和流出管状体（2）。保持元件（6）位于管状体（2）的内部，其允许转移装置朝向其底部（4）进入管状体（2），用于插入和移除隐形眼镜，并且使自由管状体（2）内的液体升高，但是禁止隐形眼镜从管状体（2）中洗出。

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