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1. 发明申请

WO2011100114A1 STERILE HYALURONIC ACID SOLUTIONS 审中-公开
标题翻译：纯化的羟丙酸溶液
公开(公告)号：WO2011100114A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/022656
申请日：2011-01-27
申请人： BAUSCH & LOMB INCORPORATED , LIU, Xiaojun, Michael , HEILER, David, Joseph , MENZEL, Thomas , BRONGO, Abbie , BURKE, Susan, E. , CUMMINS, Karl
发明人： LIU, Xiaojun, Michael , HEILER, David, Joseph , MENZEL, Thomas , BRONGO, Abbie , BURKE, Susan, E. , CUMMINS, Karl
IPC分类号： A61L2/02
CPC分类号： A61K31/728 , A61L2/022 , C08B37/0072
摘要： A process for sterilizing a solution comprising hyaluronic acid. The process comprises providing an aqueous solution of hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04 % to 0.8 % by weight. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3 % to 30 % by weight. Once the aqueous, high salt, hyaluronic acid solution is prepared the solution is maintained at a temperature from 40 0C to 80 0C for at least 1 hour and not longer than six days. Following the heat treatment step, the aqueous solution is filtered through a sterilization filter medium to provide a sterilized high salt, hyaluronic acid solution.
摘要翻译：一种对包含透明质酸的溶液进行灭菌的方法。该方法包括提供重均分子量为0.6MDa至3.6MDa的透明质酸水溶液，透明质酸的浓度为0.04％至0.8％重量。水溶液的离子强度相当于氯化钠水溶液的重量的3〜30重量％。一旦制备了水性高盐透明质酸溶液，将溶液保持在40℃至80℃的温度下至少1小时并且不超过6天。在热处理步骤之后，通过灭菌过滤介质过滤水溶液，得到无菌高盐透明质酸溶液。

2. 发明申请

WO2009143694A1 HYBRID POWER DRIVING SYSTEM 审中-公开
标题翻译：混合动力驱动系统
公开(公告)号：WO2009143694A1
公开(公告)日：2009-12-03
申请号：PCT/CN2009/000560
申请日：2009-05-21
申请人： BYD COMPANY LIMITED , REN, Yi , NIU, Ruru , LIU, Xiaojun
发明人： REN, Yi , NIU, Ruru , LIU, Xiaojun
IPC分类号： B60K6/48
CPC分类号： B60K6/365 , B60K6/48 , F16H3/54 , Y02T10/6221
摘要： A hybrid power driving system includes a planetary gear mechanism having a first rotating component, a second rotating component, and a third rotating component. The system also includes an electric motor (1) operatively coupled to the first rotating component, a clutch (9), an internal-combustion engine (2) operatively coupled to the first rotating component by the clutch (9), and a brake (8) operatively coupled to the second rotating component and configured to control the second rotating component in a locked position or in an unlocked position. The third rotating component is operatively coupled to an output end (10) to provide driving power.
摘要翻译：混合动力驱动系统包括具有第一旋转部件，第二旋转部件和第三旋转部件的行星齿轮机构。该系统还包括可操作地联接到第一旋转部件的电动机（1），离合器（9），通过离合器（9）可操作地联接到第一旋转部件的内燃机（2）和制动器 8），其可操作地联接到第二旋转部件并且被配置为在锁定位置或解锁位置中控制第二旋转部件。第三旋转部件可操作地联接到输出端（10）以提供驱动力。

3. 发明申请

WO2006127121A3 POLYSACCHARIDE AND POLYOL COMPOSITION FOR TREATING DRY EYE AND RELATED METHODS OF MANUFACTURE AND METHODS OF USE 审中-公开
标题翻译：用于治疗干眼症的多糖和多元醇组合物及其制备方法和使用方法
公开(公告)号：WO2006127121A3
公开(公告)日：2007-01-18
申请号：PCT/US2006011703
申请日：2006-03-30
申请人： BAUSCH & LOMB , SALAMONE JOSEPH C , XIA ERNING , LIU XIAOJUN MICHAEL
发明人： SALAMONE JOSEPH C , XIA ERNING , LIU XIAOJUN MICHAEL
IPC分类号： A61K9/00 , A61K47/10 , A61K47/38 , A61P27/02 , A61P27/04
CPC分类号： A61K47/10 , A61K9/0048 , A61K47/38
摘要： The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
摘要翻译：本发明涉及用于治疗干眼症的组合物，在一个实施方案中包括羧甲基纤维素和多元醇。已经发现这样的组合物可以缓解干眼症状并长期保留在眼睛中。

4. 发明申请

WO2015112626A9 ENHANCED ANTIGEN PRESENTING ABILITY OF CAR T CELLS BY CO-INTRODUCTION OF COSTIMULATORY MOLECULES 审中-公开
标题翻译：通过引入成本分子的增强抗体呈递能力
公开(公告)号：WO2015112626A9
公开(公告)日：2016-10-13
申请号：PCT/US2015012284
申请日：2015-01-21
申请人： JUNE CARL H , LIU XIAOJUN , SHEDLOCK DEVON J , ZHAO YANGBING , NOVARTIS AG , UNIV PENNSYLVANIA
发明人： JUNE CARL H , LIU XIAOJUN , SHEDLOCK DEVON J , ZHAO YANGBING
IPC分类号： C07K14/725 , C07K14/705 , C12N5/0783
CPC分类号： C07K14/70517 , A61K38/00 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K39/39 , A61K39/3955 , A61K2039/5158 , C07K14/54 , C07K14/5418 , C07K14/5443 , C07K14/55 , C07K14/7051 , C07K14/70521 , C07K14/70532 , C07K14/70575 , C07K14/70596 , C07K16/28 , C07K2317/53 , C07K2317/622 , C07K2319/30 , C12N5/0638 , C12N7/00 , C12N15/86 , C12N2501/51 , C12N2501/515 , C12N2510/00 , C12N2760/16034 , G01N33/505
摘要： The invention provides T cells comprising nucleic acid sequence encoding a chimeric antigen receptor and a nucleic acid sequence encoding an enhancer of T cell priming, compositions including the T cells, and methods of using the T cells to treat diseases associated with the expression of disease-associated antigens.
摘要翻译：本发明提供了包含编码嵌合抗原受体的核酸序列和编码T细胞引发增强子的核酸序列的T细胞，以及使用该T细胞治疗与疾病相关的疾病相关疾病的方法，相关抗原。

5. 发明申请

WO2015112626A8 ENHANCED ANTIGEN PRESENTING ABILITY OF CAR T CELLS BY CO-INTRODUCTION OF COSTIMULATORY MOLECULES 审中-公开
标题翻译：通过引入成本分子的增强抗体呈递能力
公开(公告)号：WO2015112626A8
公开(公告)日：2015-10-01
申请号：PCT/US2015012284
申请日：2015-01-21
申请人： JUNE CARL H , LIU XIAOJUN , SHEDLOCK DEVON J , ZHAO YANGBING
发明人： JUNE CARL H , LIU XIAOJUN , SHEDLOCK DEVON J , ZHAO YANGBING
IPC分类号： C07K14/725 , C07K14/705 , C12N5/0783
CPC分类号： C07K14/70517 , A61K38/00 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K39/39 , A61K39/3955 , A61K2039/5158 , C07K14/54 , C07K14/5418 , C07K14/5443 , C07K14/55 , C07K14/7051 , C07K14/70521 , C07K14/70532 , C07K14/70575 , C07K14/70596 , C07K16/28 , C07K2317/53 , C07K2317/622 , C07K2319/30 , C12N5/0638 , C12N7/00 , C12N15/86 , C12N2501/51 , C12N2501/515 , C12N2510/00 , C12N2760/16034 , G01N33/505
摘要： The invention provides T cells comprising nucleic acid sequence encoding a chimeric antigen receptor and a nucleic acid sequence encoding an enhancer of T cell priming, compositions including the T cells, and methods of using the T cells to treat diseases associated with the expression of disease-associated antigens.
摘要翻译：本发明提供了包含编码嵌合抗原受体的核酸序列和编码T细胞引发增强子的核酸序列的T细胞，以及使用该T细胞治疗与疾病相关的疾病相关疾病的方法，相关抗原。

6. 发明申请

WO2008043201A8 PHOTO-IONIZATION SENSOR FOR DETECTING THE CONCENTRATION OF GAS AND METHOD THEREOF 审中-公开
标题翻译：用于检测气体浓度的光电传感器及其方法
公开(公告)号：WO2008043201A8
公开(公告)日：2009-06-04
申请号：PCT/CN2006002609
申请日：2006-10-08
申请人： RAE SYSTEMS SHANGHAI INC , QIAN YONGBIAO , SU AIMIN , LIU XIAOJUN , HSI PETER C
发明人： QIAN YONGBIAO , SU AIMIN , LIU XIAOJUN , HSI PETER C
IPC分类号： G01N27/66
CPC分类号： G01N27/66 , H01J41/02
摘要： A photo-ionization detector for detecting gas concentration and method thereof. Said detector includes a first bias electrode and a first measurement electrode. The first bias electrode is connected with a first bias circuit for absorbing one type of charge ion. The first measurement electrode is connected with a measurement circuit for absorbing one type of reverse charge ion. The constituent of inert gases in said ultraviolet lamp, the material of optical window and the material of low potential electrode, which is the material of said first measurement electrode or said first bias electrode, are selected that the ultraviolet light createdby the ultraviolet lamp and transmitted through said optical window incident upon the surface of said low potential electrode can create the photoelectric effect and that said driver electrodes can apply an high voltage AC signal on said ultraviolet lamp, which is high enough so that the number of discharged electrons overflow from the surface of said low potential electrode are enough to neutralize the positive ions, which are deposited near the three-dimensional space range of said low potential electrode, so that the saturated phenomenon of concentration measurement caused by the deposition of positive ions can be eliminated.
摘要翻译：一种用于检测气体浓度的光电离检测器及其方法。所述检测器包括第一偏置电极和第一测量电极。第一偏置电极与用于吸收一种类型的电荷离子的第一偏置电路连接。第一测量电极与用于吸收一种反向电荷离子的测量电路连接。选择所述紫外灯中的惰性气体的组分，光学窗口的材料和作为所述第一测量电极或所述第一偏置电极的材料的低电位电极的材料，使得由紫外线灯产生的紫外线和透射通过入射在所述低电位电极的表面上的所述光学窗口可以产生光电效应，并且所述驱动电极可以对所述紫外线灯施加高电压AC信号，所述高电压AC信号足够高，使得放电的电子数量从表面溢出所述低电位电极足以中和沉积在所述低电位电极的三维空间范围附近的正离子，从而可以消除由正离子的沉积引起的饱和浓度测量现象。

7. 发明申请

WO2006127121A2 POLYSACCHARIDE AND POLYOL COMPOSITION FOR TREATING DRY EYE AND RELATED METHODS OF MANUFACTURE AND METHODS OF USE 审中-公开
标题翻译：用于治疗干眼症的多糖和多元醇组合物及其制备方法和使用方法
公开(公告)号：WO2006127121A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/011703
申请日：2006-03-30
申请人： BAUSCH & LOMB INCORPORATED , SALAMONE, Joseph, C. , XIA, Erning , LIU, Xiaojun, Michael
发明人： SALAMONE, Joseph, C. , XIA, Erning , LIU, Xiaojun, Michael
IPC分类号： A61K9/00 , A61K47/10 , A61K47/38 , A61P27/02 , A61P27/04
CPC分类号： A61K47/10 , A61K9/0048 , A61K47/38
摘要： The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
摘要翻译：本发明涉及一种用于治疗干眼症的组合物，在一个实施方案中包括羧甲基纤维素和多元醇。已经发现这样的组合物可以缓解干眼症状并长期保留在眼睛中。

8. 发明申请

WO0212442A3 HETEROCYCLIC COMPOUNDS AS LIGANDS OF THE GABAA RECEPTOR 审中-公开
标题翻译：杂环化合物作为GABAA受体的配体
公开(公告)号：WO0212442A3
公开(公告)日：2003-05-01
申请号：PCT/US0141572
申请日：2001-08-06
申请人： NEUROGEN CORP , PFIZER , MAYNARD GEORGE , YOHANNES DANIEL , YUAN JUN , XIE LINGHONG , GHOSH MANUKA , LUKE GEORGE P , LIU XIAOJUN , NAGEL ARTHUR ADAM , VINCENT LAWRENCE ALBERT , CURRIE KEVIN S , WANG ZHE-QING , LEE KYUNGAE
发明人： MAYNARD GEORGE , YOHANNES DANIEL , YUAN JUN , XIE LINGHONG , GHOSH MANUKA , LUKE GEORGE P , LIU XIAOJUN , NAGEL ARTHUR ADAM , VINCENT LAWRENCE ALBERT , CURRIE KEVIN S , WANG ZHE-QING , LEE KYUNGAE
IPC分类号： A61K31/4162 , A61K31/4178 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4709 , A61K31/4745 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61P25/00 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D403/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D498/04 , C07D513/04 , A61K31/407
CPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D513/04
摘要： Disclosed are heterocyclic compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables A, V, Y, J, E, X, G, Q, W, Z, b, n and m are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptor.
摘要翻译：公开了下式的杂环化合物及其药学上可接受的盐，其中变量A，V，Y，J，E，X，G，Q，W，Z，b，n和m在本文中定义。这些化合物是GABAA脑受体的高度选择性激动剂，拮抗剂或反向激动剂或GABA A受体的激动剂，拮抗剂或反向激动剂的前药。

9. 发明申请

WO2003004018A1 CYCLOALKYLPYRROLE-3-CARBOXYLIC ACID DERIVATIVES AND HETEROCYCLOALKYLPYRROLE-3-CARBOXYLIC ACID DERIVATIVES AS GABA-A RECEPTOR LIGANDS 审中-公开
标题翻译：作为GABA-A受体配体的环丙基-3-羧酸衍生物和杂环基二甲基-3-羧酸衍生物
公开(公告)号：WO2003004018A1
公开(公告)日：2003-01-16
申请号：PCT/IB2002/002499
申请日：2002-06-27
申请人： PFIZER PRODUCTS INC. , NEUROGEN CORPORATION , YOHANNES, Daniel , LIU, Xiaojun , MAYNARD, George, Daniel
发明人： YOHANNES, Daniel , LIU, Xiaojun , MAYNARD, George, Daniel
IPC分类号： A61K31/40
CPC分类号： C07D401/12 , C07D209/42 , C07D209/52
摘要： This invention relates to cycloalkylpyrolle-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives that bind with high selectively and/or high affinity to the benzodiazepine site of GABA A receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in the treatment of central nervous system (CNS) diseases. This invention also relates to the use of these cycloalkylpyrolle-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the detection of GABA A receptors in tissue samples.
摘要翻译：本发明涉及以高选择性和/或高亲和力结合GABA A受体的苯并二氮杂位点的环烷基吡咯-3-羧酸衍生物和杂环烷基吡咯-3-羧酸衍生物。本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗中枢神经系统（CNS）疾病中的用途。本发明还涉及这些环烷基吡咯-3-羧酸衍生物和杂环烷基吡咯-3-羧酸衍生物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。此外，本发明涉及使用这些化合物作为检测组织样品中GABA A受体的探针。

10. 发明申请

WO2015112626A1 ENHANCED ANTIGEN PRESENTING ABILITY OF CAR T CELLS BY CO-INTRODUCTION OF COSTIMULATORY MOLECULES 审中-公开
标题翻译：通过引入成本分子的增强抗体呈递能力
公开(公告)号：WO2015112626A1
公开(公告)日：2015-07-30
申请号：PCT/US2015/012284
申请日：2015-01-21
申请人： JUNE, Carl, H. , LIU, Xiaojun , SHEDLOCK, Devon, J. , ZHAO, Yangbing
发明人： JUNE, Carl, H. , LIU, Xiaojun , SHEDLOCK, Devon, J. , ZHAO, Yangbing
IPC分类号： C07K14/725 , C12N5/0783 , C07K14/705
CPC分类号： C07K14/70517 , A61K38/00 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K39/39 , A61K39/3955 , A61K2039/5158 , C07K14/54 , C07K14/5418 , C07K14/5443 , C07K14/55 , C07K14/7051 , C07K14/70521 , C07K14/70532 , C07K14/70575 , C07K14/70596 , C07K16/28 , C07K2317/53 , C07K2317/622 , C07K2319/30 , C12N5/0638 , C12N7/00 , C12N15/86 , C12N2501/51 , C12N2501/515 , C12N2510/00 , C12N2760/16034 , G01N33/505 , Y02A50/465
摘要： The invention provides T cells comprising nucleic caid sequence encoding a chimeric antigen receptor and a nucleic acid sequence encoding an enhancer of T cell priming, compositions including the T cells, and methods of using the T cells to treat diseases associated with the expression of disease-associated antigens.
摘要翻译：本发明提供了包含编码嵌合抗原受体的核酸序列和编码T细胞引发增强子的核酸序列的T细胞，以及使用该T细胞治疗与疾病相关的疾病相关疾病的方法，相关抗原。

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