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1. 发明申请

WO2011028195A3 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的使用
公开(公告)号：WO2011028195A3
公开(公告)日：2011-06-16
申请号：PCT/US2007088009
申请日：2007-12-18
申请人： AMBRX INC , MIAO ZHENWEI , LIU JUNJIE
发明人： MIAO ZHENWEI , LIU JUNJIE
IPC分类号： C07D209/20 , A61K38/02 , C07D209/08 , C07D209/56 , C07K1/107 , C07K2/00 , G01N33/68
CPC分类号： C07D209/10 , C07D209/20 , C07D209/94
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of functionalities, but typically have at least one indole, carbonyl, and/or hydrazine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one indole, carbonyl, and/or hydrazine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括宽范围的官能团，但通常具有至少一个吲哚，羰基和/或肼基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，经修饰的非天然氨基酸多肽包括至少一个吲哚，羰基和/或肼基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

2. 发明申请

WO2007079130A2 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的使用
公开(公告)号：WO2007079130A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/049397
申请日：2006-12-27
申请人： AMBRX, INC. , MIAO, Zhenwei , LIU, Junjie
发明人： MIAO, Zhenwei , LIU, Junjie
IPC分类号： A61K38/16
CPC分类号： C07K1/1072 , C07D231/12 , C07K14/61 , C12N9/93
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括多种可能的功能，但典型的具有至少一个杂环，醛醇基，二羰基和/或二胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个杂环，醛醇基，二羰基和/或二胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

3. 发明申请

WO03077868A3 SYNTHESIS OF SYNTHONS FOR THE MANUFACTURE OF BIOACTIVE COMPOUNDS 审中-公开
标题翻译：合成生物活性化合物的合成
公开(公告)号：WO03077868A3
公开(公告)日：2004-04-01
申请号：PCT/US0307982
申请日：2003-03-14
申请人： SCRIPPS RESEARCH INST , DIVERSA CORP , WONG CHI-HUEY , LIU JUNJIE , DE SANTIS GRACE , BURK MARK
发明人： WONG CHI-HUEY , LIU JUNJIE , DE SANTIS GRACE , BURK MARK
IPC分类号： C12N15/09 , C12N1/21 , C12N9/88 , C12P17/02 , C12P17/06 , C12P19/02 , C12Q1/02 , C12R1/19 , C12Q1/00 , C12N9/00 , C12P1/00 , C12P33/00
CPC分类号： C12P19/02 , C12N9/88 , C12P17/06 , C12R1/19
摘要： The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4) and variants thereof can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor aldehydes. The reaction products typically contain at least two new stereogenic centers and can be produced in enantiomerically pure form. As such, DERA catalyzed asymmetric aldol chemistry can be exploited to produce synthons for the synthesis of a variety of bioactive molecules.
摘要翻译：本发明基于以下发现：2-脱氧核糖-5-磷酸醛缩酶（DERA，EC 4.1.2.4）及其变体可用于催化多种供体和受体醛之间的顺序不对称醛醇反应。反应产物通常含有至少两个新的立体中心并且可以以对映体纯的形式制备。因此，DERA催化的不对称醛醇化学可以被利用来产生用于合成各种生物活性分子的合成物。

4. 发明申请

WO2013019681A2 SELECTIVE DELIVERY MOLECULES AND METHODS OF USE 审中-公开
标题翻译：选择性递送分子和使用方法
公开(公告)号：WO2013019681A2
公开(公告)日：2013-02-07
申请号：PCT/US2012/048732
申请日：2012-07-27
申请人： AVELAS BIOSCIENCES, INC. , LIU, Junjie , GONZALEZ, Jesus
发明人： LIU, Junjie , GONZALEZ, Jesus
IPC分类号： A61K47/42 , A61K47/48 , A61K49/14 , C07K14/00 , C12N5/09
CPC分类号： C07K7/08 , A61K38/00 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0054 , A61K49/0056 , C07K14/435 , G01N21/6428 , G01N33/574 , G01N33/582 , G01N2021/6432 , G01N2021/6439
摘要： Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
摘要翻译：本文公开了一种选择性递送分子，其包含：（a）有效抑制或阻止摄入细胞或组织滞留的酸性序列（部分A），（b）分子转运或保留序列（部分B）和（ c）部分A和部分B之间的接头，和（d）至少一个货物部分。

5. 发明申请

WO2012031250A8 COMPOSITIONS FOR LABELING NERVES AND METHODS OF USE 审中-公开
标题翻译：用于标记神经的组合物和使用方法
公开(公告)号：WO2012031250A8
公开(公告)日：2012-10-26
申请号：PCT/US2011050411
申请日：2011-09-02
申请人： AVELAS BIOSCIENCES INC , GONZALEZ JESUS , LIU JUNJIE
发明人： GONZALEZ JESUS , LIU JUNJIE
IPC分类号： C07K7/08 , A61K38/08 , A61K38/10 , A61K47/48 , A61K49/14 , C07K5/00 , C07K7/06
CPC分类号： C07K7/06 , A61K49/0056 , G09F13/04 , G09F13/18 , G09F13/22 , G09F13/44 , G09F2013/1863
摘要： The present invention provides methods for guiding preservation of neurons or nerves during surgery by administering a fluorescently-labeled peptide that associates with (e.g., specifically binds to) the neurons or nerves. The invention further provides targeting molecules of fluorescently-labeled peptides or aptamers that associate with (e.g., specifically bind to) neurons or nerves and for compositions thereof.
摘要翻译：本发明提供了通过施用与神经元或神经相关联（例如，特异性结合）的荧光标记肽来指导手术期间神经元或神经保存的方法。本发明还提供与（例如，特异性结合）神经元或神经及其组合物结合的荧光标记肽或适体的靶向分子。

6. 发明申请

WO2007079130A3 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的使用
公开(公告)号：WO2007079130A3
公开(公告)日：2008-09-25
申请号：PCT/US2006049397
申请日：2006-12-27
申请人： AMBRX INC , MIAO ZHENWEI , LIU JUNJIE
发明人： MIAO ZHENWEI , LIU JUNJIE
IPC分类号： A01N37/18 , A61K38/00
CPC分类号： C07K1/1072 , C07D231/12 , C07K14/61 , C12N9/93
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one heterocycle, aldol-based, dicarbonyl, and/or diamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括多种可能的功能，但典型的具有至少一个杂环，醛醇基，二羰基和/或二胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个杂环，醛醇基，二羰基和/或二胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

7. 发明申请

WO2007070659A2 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的使用
公开(公告)号：WO2007070659A2
公开(公告)日：2007-06-21
申请号：PCT/US2006047822
申请日：2006-12-13
申请人： AMBRX INC , MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA
发明人： MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA
IPC分类号： A61K39/395 , C12P21/06
CPC分类号： C07K2/00 , C07C229/42 , C07K1/006
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛范围的可能的官能团，但典型地具有至少一个芳族胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个烷基化胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

8. 发明申请

WO2003077868A2 SYNTHESIS OF SYNTHONS FOR THE MANUFACTURE OF BIOACTIVE COMPOUNDS 审中-公开
标题翻译：合成生物活性化合物的合成
公开(公告)号：WO2003077868A2
公开(公告)日：2003-09-25
申请号：PCT/US2003/007982
申请日：2003-03-14
申请人： THE SCRIPPS RESEARCH INSTITUTE , DIVERSA CORPORATION , WONG, Chi-Huey , LIU, Junjie , DE SANTIS, Grace , BURK, Mark
发明人： WONG, Chi-Huey , LIU, Junjie , DE SANTIS, Grace , BURK, Mark
IPC分类号： A61K
CPC分类号： C12P19/02 , C12N9/88 , C12P17/06 , C12R1/19
摘要： The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4) and variants thereof can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor aldehydes. The reaction products typically contain at least two new stereogenic centers and can be produced in enantiomerically pure form. As such, DERA catalyzed asymmetric aldol chemistry can be exploited to produce synthons for the synthesis of a variety of bioactive molecules.
摘要翻译：本发明基于以下发现：2-脱氧核糖-5-磷酸醛缩酶（DERA，EC 4.1.2.4）及其变体可用于催化多种供体和受体醛之间的顺序不对称醛醇反应。反应产物通常含有至少两个新的立体中心并且可以以对映体纯的形式制备。因此，DERA催化的不对称醛醇化学可以被利用来产生用于合成各种生物活性分子的合成物。

9. 发明申请

WO2012031250A2 COMPOSITIONS FOR LABELING NERVES AND METHODS OF USE 审中-公开
标题翻译：标记神经的组合物及使用方法
公开(公告)号：WO2012031250A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/050411
申请日：2011-09-02
申请人： AVELAS BIOSCIENCES, NC. , GONZALEZ, Jesus , LIU, Junjie
发明人： GONZALEZ, Jesus , LIU, Junjie
IPC分类号： C07K7/08 , C07K7/06 , C07K5/00 , A61K38/10 , A61K38/08 , A61K47/48 , A61K49/14
CPC分类号： C07K7/06 , A61K49/0056 , G09F13/04 , G09F13/18 , G09F13/22 , G09F13/44 , G09F2013/1863
摘要： The present invention provides methods for guiding preservation of neurons or nerves during surgery by administering a fluorescently-labeled peptide that associates with (e.g., specifically binds to) the neurons or nerves. The invention further provides targeting molecules of fluorescently-labeled peptides or aptamers that associate with (e.g., specifically bind to) neurons or nerves and for compositions thereof.
摘要翻译：本发明提供了在手术期间通过施用与神经元或神经结合（例如，特异性结合）的荧光标记的肽来指导神经元或神经保存的方法。本发明进一步提供了与神经元或神经结合（例如，特异性结合）神经元或神经的荧光标记肽或适体的靶向分子及其组合物。

10. 发明申请

WO2006069246A3 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的使用
公开(公告)号：WO2006069246A3
公开(公告)日：2008-09-25
申请号：PCT/US2005046618
申请日：2005-12-21
申请人： AMBRX INC , MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA , DRIVER RUSSELL
发明人： MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA , DRIVER RUSSELL
IPC分类号： C07C22/00 , A61K38/00 , C07C227/00 , C07K2/00
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛范围的可能的官能团，但是通常具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

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