专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009152805A1 VERFAHREN ZUR BESTIMMUNG VON LIPOPROTEINKOMPONENTEN IN EINEM ZU ANALYSIERENDEN LIPOPROTEINGEMISCH UND DATENVERARBEITUNGSANLAGE 审中-公开
标题翻译：用于确定脂蛋白组分在被分析LIPOPROTEINGEMISCH系统和数据处理
公开(公告)号：WO2009152805A1
公开(公告)日：2009-12-23
申请号：PCT/DE2009/000821
申请日：2009-06-10
申请人： LIPOFIT ANALYTIC GMBH , KALBITZER, Hans, Robert , LANG, Elmar , HUBER, Fritz , KREMER, Werner , THEIS, Fabian
发明人： KALBITZER, Hans, Robert , LANG, Elmar , HUBER, Fritz , KREMER, Werner , THEIS, Fabian
IPC分类号： G01R33/46
CPC分类号： G01R33/4625
摘要： Ein Verfahren zur Bestimmung von Lipoproteinkomponenten in einem zu analysierenden Lipoproteingemisch umfasst die Schritte: A) Aufnahme von N>1 Messspektren des zu analysierenden Lipoproteingemischs bei N verschiedenen Messbedingungen, wobei jedes der N Messspektren jeweils M Messpunkte aufweist, B) Bereitstellen einer Mischmatrix W mit N mal L zufällig gewählten, nicht-negativen Mischparametern, einer Quellspektrenmatrix H mit L Quellspektren mit jeweils M zufällig gewählten, nicht-negativen Quellspektrumspunkten und einer Messspektrenmatrix X, die gebildet wird durch die N Messspektren, C) Modifizieren der jeweils M Quellspektrumspunkte der L Quellspektren durch Annäherung des Matrixprodukts der Mischmatrix W und der Quellspektrenmatrix H an die Messspektrenmatrix X mittels einer nicht-negativen Matrixfaktorisierung unter der Randbedingung, dass die L Quellspektren sparsam kodiert sind, D) Zuordnen der aus dem Schritt C durch die Modifizierung erhaltenen L Quellspektren zu bekannten Spektren von Lipoproteinkomponenten.
摘要翻译：脂蛋白成分的测定中的分析物Lipoproteingemisch包括以下步骤的方法：在N个不同的测量条件N> 1点的测量光谱Lipoproteingemischs的A）接收的分析物，每个所述N个测量光谱的每一个都具有m个数据点，B）提供一个混合矩阵W与N- 时间内为随机选择的非负混音参数，其中L源光谱的源光谱矩阵H中，每个具有M随机选择的非负源光谱点和测量的光谱矩阵X，它是由N测定光谱，C）通过修改将L源谱的各自的M个源光谱点形成的混合矩阵W和源光谱矩阵bekan H至所述测量光谱矩阵X由边界条件下的非负矩阵分解的装置，其将L源光谱编码微D的矩阵积的近似值）相关联，所述用L源光谱的修改从步骤C中得到脂蛋白成分的第n个光谱。

2. 发明申请

WO2012045773A9 METHOD FOR CHARACTERIZING A SAMPLE BY DATA ANALYSIS 审中-公开
标题翻译：通过数据分析来表征样本的方法
公开(公告)号：WO2012045773A9
公开(公告)日：2012-10-18
申请号：PCT/EP2011067383
申请日：2011-10-05
申请人： LIPOFIT ANALYTIC GMBH , HUBER FRITZ , KIRCHHOEFER RENATE , PFAHLERT VOLKER
发明人： HUBER FRITZ , KIRCHHOEFER RENATE , PFAHLERT VOLKER
IPC分类号： G01N24/08 , A61B5/055 , G01R33/46 , G06F19/24
CPC分类号： G06F19/10 , G01N24/08 , G01R33/4625 , G06F19/24
摘要： The invention relates to a method for characterizing a sample, having the following steps: providing at least one analysis result having a plurality of values, wherein the analysis result was generated by the analysis of a sample by at least one analysis method; determining the value of at least one mathematic relation between at least two values of the plurality of values; generating a characterizing signature of the sample on the basis of the value of the at least one mathematic relation. The invention further relates to a method for characterizing a system in which method the preceding method is used.
摘要翻译：具有以下步骤：提供具有多个值的至少一个分析结果，其中所述分析结果是通过至少一种分析方法分析样品而生成的; 确定所述多个值中的至少两个值之间的至少一个数学关系的值; 基于至少一个数学关系的值生成样本的表征签名。本发明还涉及一种用于表征使用前述方法的系统的方法。

3. 发明申请

WO2012045773A1 METHOD FOR CHARACTERIZING A SAMPLE BY DATA ANALYSIS 审中-公开
标题翻译：通过数据分析表征样品的方法
公开(公告)号：WO2012045773A1
公开(公告)日：2012-04-12
申请号：PCT/EP2011/067383
申请日：2011-10-05
申请人： LIPOFIT ANALYTIC GMBH , HUBER, Fritz , KIRCHHÖFER, Renate , PFAHLERT, Volker
发明人： HUBER, Fritz , KIRCHHÖFER, Renate , PFAHLERT, Volker
IPC分类号： G01N24/08 , G01R33/46 , G06F19/24 , A61B5/055
CPC分类号： G06F19/10 , G01N24/08 , G01R33/4625 , G06F19/24
摘要： The invention relates to a method for characterizing a sample, having the following steps: providing at least one analysis result having a plurality of values, wherein the analysis result was generated by the analysis of a sample by at least one analysis method; determining the value of at least one mathematic relation between at least two values of the plurality of values; generating a characterizing signature of the sample on the basis of the value of the at least one mathematic relation. The invention further relates to a method for characterizing a system in which method the preceding method is used.
摘要翻译：本发明涉及一种用于表征样品的方法，具有以下步骤：提供具有多个值的至少一个分析结果，其中通过至少一种分析方法对样品进行分析而产生分析结果; 确定所述多个值中的至少两个值之间的至少一个数学关系的值; 基于所述至少一个数学关系的值生成所述样本的表征特征。本发明还涉及一种用于表征其中使用前述方法的方法的系统的方法。

4. 发明专利

CA2568705A1 PROCESS FOR THE DETERMINATION OF LIPOPROTEINS IN BODY FLUIDS 未知
公开(公告)号：CA2568705A1
公开(公告)日：2005-12-15
申请号：CA2568705
申请日：2005-06-01
申请人： LIPOFIT ANALYTIC GMBH
发明人： KALBITZER HANS ROBERT , KREMER WERNER , HUBER FRITZ
IPC分类号： G01R33/465 , G01N24/08 , G01N33/483 , G01N33/68 , G01N33/92 , G01R33/46
摘要： Determination of lipoprotein classes (I) in body fluids comprises: (a) analyzing NMR spectra of a plasma or serum sample and measuring under different measuring conditions; and (b) determining the different effects of these measuring conditions on the intensity and line forms of the NMR signals (A) of the individual (I); where a density and/or size distribution is assigned to the individual (I) on the basis of the different effects on (A). Process for the determination of lipoprotein classes (I) in body fluids comprises; (a) analyzing NMR spectra of a plasma or serum sample and measuring under different measuring conditions (different magnetic field gradients and varying temperatures); and (b) determining the different effects of these measuring conditions on the intensity and line forms of the NMR signals (A) of the individual (I); where a density and/or size distribution is assigned to the individual (I) on the basis of the different effects on (A). Independent claims are also included for: (1) an apparatus for the analysis of (I) in body fluids comprising a first device for detecting NMR reference data sets for each lipoprotein class with the corresponding reference parameters as a function of different measuring conditions (different magnetic field gradients or varying temperatures), a second device for detecting the NMR spectra of a plasma or serum sample to be analyzed under different measuring conditions as in the first device, a third device for determining the concentrations and the density and/or size distributions for each lipoprotein class on the basis of an approximation of calculated NMR spectra to the NMR spectra to be analyzed and detected in the second device by weighting with the reference parameters determined with the first device; and (2) a process for the determination of the concentrations of (I) and subclasses in a body fluid to be analyzed, where characteristic reference parameters of an NMR spectrum for each lipoprotein class and subclass to be analyzed are determined and calculated NMR spectra are fitted to the measured NMR spectra of the plasma or serum sample to be analyzed by means of a weighting of these reference parameters using weighting factors, the concentrations of (I) and lipoprotein subclasses are determined using the weighting factors.

5. 发明专利

CA2568705C PROCESS FOR THE DETERMINATION OF LIPOPROTEINS IN BODY FLUIDS 未知
公开(公告)号：CA2568705C
公开(公告)日：2015-08-04
申请号：CA2568705
申请日：2005-06-01
申请人： LIPOFIT ANALYTIC GMBH
发明人： HUBER FRITZ , KREMER WERNER , KALBITZER HANS ROBERT
IPC分类号： G01R33/465 , G01N24/08 , G01N33/483 , G01N33/68 , G01N33/92 , G01R33/46
摘要： The invention describes a process for the determination of the concentration distribution and size distribution of lipoprotein classes in body fluids, e.g. blood. For this purpose, NMR spectra of a sample to be analysed are measured by magnetic field gradient intensities and temperatures under different diffusion-weighted measuring conditions selected according to different pulse programs (e.g. PFG-STE, PFG-LED etc) and consequently in a differentiated manner according to the relaxation times. The different effects of these measuring conditions on the intensity/line form of the NMR signals of the individual lipoprotein classes are determined and permit the determination of a concentration distribution/size distribution of the individual lipoprotein classes.

6. 发明专利

DE102010038014A1 Verfahren zur Charakterisierung einer Probe und eines Systems 未知
公开(公告)号：DE102010038014A1
公开(公告)日：2012-04-12
申请号：DE102010038014
申请日：2010-10-06
申请人： LIPOFIT ANALYTIC GMBH
发明人： HUBER FRITZ DR , KIRCHHOEFER RENATE DR , PFAHLERT VOLKER DR
IPC分类号： G01N33/50
摘要： Die Erfindung betrifft ein Verfahren zur Charakterisierung einer Probe mit den folgenden Schritten: Bereitstellung mindestens eines Analyseergebnisses mit einer Vielzahl von Werten, wobei das Analyseergebnis durch die Analyse einer Probe mittels mindestens eines Analyseverfahrens erstellt wurde; Bestimmung des Werts mindestens einer mathematischen Beziehung zwischen mindestens zwei Werten der Vielzahl von Werten; Erstellung einer charakterisierenden Signatur der Probe auf der Grundlage des Werts der mindestens einen mathematischen Beziehung. Die Erfindung betrifft ferner ein Verfahren zur Charakterisierung eines Systems, bei dem das vorstehende Verfahren angewandt wird.

7. 发明专利

CA2813863A1 METHOD FOR CHARACTERIZING A SAMPLE BY DATA ANALYSIS 未知
公开(公告)号：CA2813863A1
公开(公告)日：2012-04-12
申请号：CA2813863
申请日：2011-10-05
申请人： LIPOFIT ANALYTIC GMBH
发明人： HUBER FRITZ , KIRCHHOEFER RENATE , PFAHLERT VOLKER
IPC分类号： G01N24/08 , A61B5/055 , G01R33/46 , G06F19/24
摘要： The invention relates to a method for characterizing a sample, having the following steps: providing at least one analysis result having a plurality of values, wherein the analysis result was generated by the analysis of a sample by at least one analysis method; determining the value of at least one mathematic relation between at least two values of the plurality of values; generating a characterizing signature of the sample on the basis of the value of the at least one mathematic relation. The invention further relates to a method for characterizing a system in which method the preceding method is used.

8. 发明公开

EP1774356A1 PROCESS FOR THE DETERMINATION OF LIPOPROTEINS IN BODY FLUIDS 有权转让
标题翻译：方法确定体液中的脂蛋白
公开(公告)号：EP1774356A1
公开(公告)日：2007-04-18
申请号：EP05753614.6
申请日：2005-06-01
申请人： LipoFit Analytic GmbH
发明人： HUBER, Fritz , KREMER, Werner , KALBITZER, Hans Robert
IPC分类号： G01R33/465 , G01N24/08 , G01N33/92
CPC分类号： G01N24/08 , G01R33/4625 , G01R33/465 , Y10T436/24
摘要： The invention describes a process for the determination of the concentration distribution and size distribution of lipoprotein classes in body fluids, e.g. blood. For this purpose, NMR spectra of a sample to be analysed are measured by magnetic field gradient intensities and temperatures under different diffusion-weighted measuring conditions selected according to different pulse programs (e.g. PFG-STE, PFG-LED etc) and consequently in a differentiated manner according to the relaxation times. The different effects of these measuring conditions on the intensity/line form of the NMR signals of the individual lipoprotein classes are determined and permit the determination of a concentration distribution/size distribution of the individual lipoprotein classes.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式