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1. 发明申请

WO9726853A3 DNA ENCODING GALANIN GALR2 RECEPTORS AND USES THEREOF 审中-公开
标题翻译： DNA编码GALANIN GALR2受体及其用途
公开(公告)号：WO9726853A3
公开(公告)日：1997-10-23
申请号：PCT/US9701301
申请日：1997-01-24
申请人： SYNAPTIC PHARMA CORP , SMITH KELLI E , GERALD CHRISTOPHE P G , WEINSHANK RICHARD L , LINEMEYER DAVID , BRANCHEK THERESA , FORRAY CARLOS
发明人： SMITH KELLI E , GERALD CHRISTOPHE P G , WEINSHANK RICHARD L , LINEMEYER DAVID , BRANCHEK THERESA , FORRAY CARLOS
IPC分类号： A01K67/027 , A61K31/00 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/00 , A61P3/04 , A61P25/28 , A61P29/00 , C07K14/705 , C07K14/72 , C07K16/28 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/566 , A61K
CPC分类号： C12P21/02 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/72
摘要： This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

2. 发明申请

WO1997026853A2 DNA ENCODING GALANIN GALR2 RECEPTORS AND USES THEREOF 审中-公开
标题翻译： DNA编码GALANIN GALR2受体及其用途
公开(公告)号：WO1997026853A2
公开(公告)日：1997-07-31
申请号：PCT/US1997001301
申请日：1997-01-24
申请人： SYNAPTIC PHARMACEUTICAL CORPORATION , SMITH, Kelli, E. , GERALD, Christophe, P., G. , WEINSHANK, Richard, L. , LINEMEYER, David , BRANCHEK, Theresa , FORRAY, Carlos
发明人： SYNAPTIC PHARMACEUTICAL CORPORATION
IPC分类号： A61K00/00
CPC分类号： C12P21/02 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/72
摘要： This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
摘要翻译：本发明提供了编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含这种载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测编码哺乳动物甘丙肽受体，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽受体结合的方法。

3. 发明申请

WO1996023809A1 NEUROPEPTIDE Y RECEPTOR 审中-公开
标题翻译：神经元Y受体
公开(公告)号：WO1996023809A1
公开(公告)日：1996-08-08
申请号：PCT/US1996001444
申请日：1996-01-30
申请人： MERCK & CO., INC. , CASCIERI, Margaret, A. , LINEMEYER, David, L. , MacNEIL, Douglas, J. , SHIAO, Lin-Lin , STRADER, Catherine, , WEINBERG, David, H. , TAN, Carina, P.
发明人： MERCK & CO., INC.
IPC分类号： C07H21/02
CPC分类号： C07K14/70571 , A61K38/00 , C12N2799/026 , G01N33/74
摘要： A novel mammalian neuropeptide Y receptor and method of making the receptor are provided. The invention includes DNA encoding the receptor, assays employing the receptor, cells expressing the receptor, antibodies which bind specifically to the receptor, RNA encoded by the DNA sequence or its complementary sequence, and single-stranded DNA with a sequence complementary to the RNA which encodes the receptor. The receptor and assays employing the receptor are useful for identifying compounds which bind to the receptor, including specific modulators of the receptor. Such compounds are useful for treating a variety of disease conditions, including obesity, diabetes, anxiety, hypertension, cocaine withdrawal, congestive heart failure, memory enhancement, cardiac and cerebral vasospasm, pheochromocytoma and ganglioneuroblastoma, and Huntington's, Alzheimer's and Parkinson's diseases.
摘要翻译：提供了一种新型哺乳动物神经肽Y受体和制备受体的方法。本发明包括编码受体的DNA，使用受体的测定，表达受体的细胞，与受体特异性结合的抗体，由DNA序列或其互补序列编码的RNA，以及与RNA互补的序列的单链DNA 编码受体。使用受体的受体和测定可用于鉴定结合受体的化合物，包括受体的特异性调节剂。这些化合物可用于治疗各种疾病状况，包括肥胖症，糖尿病，焦虑症，高血压，可卡因戒断，充血性心力衰竭，记忆增强，心脏和脑血管痉挛，嗜铬细胞瘤和神经节细胞瘤，以及亨廷顿舞蹈症，阿尔茨海默病和帕金森病。

4. 发明申请

WO1995028474A1 DNA ENCODING BRADYKININ B1 RECEPTOR 审中-公开
标题翻译： DNA编码BRADYKININ B1受体
公开(公告)号：WO1995028474A1
公开(公告)日：1995-10-26
申请号：PCT/US1995004464
申请日：1995-04-10
申请人： MERCK & CO., INC. , LINEMEYER, David, L. , HESS, John, W. , BORKOWSKI, Joseph, A. , BIERILO, Kathleen, K. , MENKE, John, G.
发明人： MERCK & CO., INC.
IPC分类号： C12N01/20
CPC分类号： C07K14/72 , A61K38/00 , A61K48/00
摘要： DNAs encoding bradykinin B1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind des-Arg kallidin and other B1-specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译：从哺乳动物细胞编码缓激肽B1受体的DNA被克隆和表征。重组受体能够形成结合des-Arg10突触蛋白和其他B1特异性配体的受体。 DNA已经在产生活性重组蛋白的重组宿主细胞中表达。此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。

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