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1. 发明申请

WO2011085353A1 MANIFOLD FOR SOLVENT MIXING IN LIQUID CHROMATOGRAPHY SYSTEMS 审中-公开
标题翻译：用于液相色谱系统中溶剂混合的说明
公开(公告)号：WO2011085353A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020792
申请日：2011-01-11
申请人： WATERS TECHNOLOGIES CORPORATION , ANGELOSANTO, John , MURPHY, Charles, T. , JOUDREY, Kurt , O'DONNEL, Kara , LINDERSON, Paul, E. , LEBEAU, Michael , LEVEILLE, Wade, P. , JACKSON, Michael, R.
发明人： ANGELOSANTO, John , MURPHY, Charles, T. , JOUDREY, Kurt , O'DONNEL, Kara , LINDERSON, Paul, E. , LEBEAU, Michael , LEVEILLE, Wade, P. , JACKSON, Michael, R.
IPC分类号： B01F15/00
CPC分类号： G01N30/32 , B01D15/166 , B29B7/007 , B29B7/385 , G01N30/24 , G01N30/34 , G01N2030/201 , G01N2030/326 , G01N2030/347
摘要： Low-pressure mixing of fluids includes a pumping system having a pump and a fluidic inlet port through which fluid is introduced to the pump. A fluid proportioning system is in fluidic communication with the fluidic inlet port of the pumping system to deliver thereto a fluid stream comprised of multiple different fluids. The fluid proportioning system includes a manifold having a plurality of inlet ports, an outlet port connected by tubing to the fluidic inlet port of the pumping system, and an outlet conduit providing an internal fluidic passageway to the outlet port. Each inlet port is fluidically coupled to a fluid source to receive one of the different fluids and to the outlet conduit to deliver thereto the received fluid for delivery out of the manifold through the outlet port to the fluidic inlet port of the pumping system.
摘要翻译：液体的低压混合包括具有泵和流体入口的泵送系统，流体通过该入口进入泵。流体配比系统与泵送系统的流体入口端口流体连通，以向其输送由多种不同流体组成的流体流。流体分配系统包括具有多个入口端口的歧管，通过管道连接到泵送系统的流体入口端口的出口端口以及向出口端口提供内部流体通道的出口管道。每个入口端口流体耦合到流体源以接收不同流体中的一种和出口管道，以将其接收到的流体输送到歧管通过出口到达泵送系统的流体入口。

2. 发明申请

WO2010102199A1 ELECTROMECHANICAL AND FLUIDIC INTERFACE TO A MICROFLUIDIC SUBSTRATE 审中-公开
标题翻译：电化学和流体界面到微流化基底
公开(公告)号：WO2010102199A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/026352
申请日：2010-03-05
申请人： WATERS TECHNOLOGIES CORPORATION , PRENTICE, David, P. , KEENE, Russell, L. , KOZIOL, Stanislaw , MICHIENZI, Joseph, D. , LINDERSON, Paul, E. , BERTONE, Gary, W.
发明人： PRENTICE, David, P. , KEENE, Russell, L. , KOZIOL, Stanislaw , MICHIENZI, Joseph, D. , LINDERSON, Paul, E. , BERTONE, Gary, W.
IPC分类号： B01L3/02
CPC分类号： B01D15/10 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L3/563 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0883 , B05B1/00 , B05B1/02 , G01N27/44791 , G01N30/6095 , G01N30/72 , G01N30/7233 , G01N30/724 , G01N30/7266 , H01J49/167 , Y10T137/598 , Y10T436/24
摘要： A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.
摘要翻译：液相色谱模块包括容纳具有用于输送流体的通道的微流体基板的微流体盒。微流体衬底具有流体孔，通道将流体供应到通道。墨盒的一侧具有喷嘴开口，每个与微流体基板中的流体孔对准并且接收流体喷嘴。夹紧组件具有可移动到夹紧位置的柱塞和限定腔室的端部壳体。端部壳体的一个壁具有流体块，流体喷嘴延伸到腔室中。第二壁具有狭槽，盒通过该槽进入腔室。当墨盒在腔室中移动到夹紧位置时，柱塞将墨盒推向流体块，使得每个流体喷嘴进入一个喷嘴开口并且与微流体衬底中的一个流体孔隙建立流体连通。

3. 发明申请

WO2012122361A3 SYSTEM AND METHOD OF COOLING A PUMP HEAD USED IN CHROMATOGRAPHY 审中-公开
标题翻译：冷却在色谱中使用的泵头的系统和方法
公开(公告)号：WO2012122361A3
公开(公告)日：2014-04-17
申请号：PCT/US2012028246
申请日：2012-03-08
申请人： WATERS TECHNOLOGIES CORP , JOUDREY KURT D , LINDERSON PAUL E
发明人： JOUDREY KURT D , LINDERSON PAUL E
IPC分类号： F04B53/08
CPC分类号： B01D15/40 , F04B53/08 , F04B53/16 , F28D1/00 , G01N30/32 , G01N2030/326 , G01N30/30
摘要： Disclosed is a system and method of cooling a pump head by transferring heat to the actuator body, which is joined to the pump head via a support plate. In some embodiments the heat transfer is accomplished by means of two conductive plates, one placed on either side of the support plate between it and the pump head and actuator body. In some embodiments the heat transfer is controlled by a thermoelectric device. Also disclosed is a second system and method of cooling fluid to move through a pump head by pre-chilling it.
摘要翻译：公开了一种通过将热传递到致动器主体来冷却泵头的系统和方法，致动器主体经由支撑板连接到泵头。在一些实施例中，热传递通过两个导电板来实现，一个放置在支撑板的与泵头和致动器本体之间的任一侧上。在一些实施例中，热传导由热电装置控制。还公开了冷却流体以通过预冷而移动通过泵头的第二系统和方法。

4. 发明申请

WO2012122361A2 SYSTEM AND METHOD OF COOLING A PUMP HEAD USED IN CHROMATOGRAPHY 审中-公开
标题翻译：冷却在色谱中使用的泵头的系统和方法
公开(公告)号：WO2012122361A2
公开(公告)日：2012-09-13
申请号：PCT/US2012/028246
申请日：2012-03-08
申请人： WATERS TECHNOLOGIES CORPORATION , JOUDREY, Kurt, D. , LINDERSON, Paul, E.
发明人： JOUDREY, Kurt, D. , LINDERSON, Paul, E.
IPC分类号： A61K39/395
CPC分类号： B01D15/40 , F04B53/08 , F04B53/16 , F28D1/00 , G01N30/32 , G01N2030/326 , G01N30/30
摘要： An actuator has a support plate, a pump head in thermally conductive contact with the support plate, and an actuator body. Cooling means is disposed between the support plate and the actuator body. The cooling means is configured to remove and transfer heat from the pump head to the actuator body. In one embodiment, the cooling means includes two thermally conductive plates (called cold-side and hot-side plates) and a thermoelectric device disposed in thermally conductive contact between the cold-side and hot-side plates. The cold-side plate is in thermal communication with the pump head through the support plate. The hot-side plate is in thermal communication with the actuator body. The thermoelectric device is configured to transfer heat from the cold-side plate, which is in thermal communication with the pump head, to the hot-side plate, which is in thermal communication with the actuator body, thereby removing heat from the pump head.
摘要翻译：致动器具有支撑板，与支撑板导热接触的泵头和致动器主体。冷却装置设置在支撑板和致动器主体之间。冷却装置构造成将热泵从泵头移除并传递到致动器主体。在一个实施例中，冷却装置包括两个导热板（称为冷侧和热侧板）和设置在冷侧和热侧板之间的导热接触的热电装置。冷侧板通过支撑板与泵头热连通。热侧板与致动器主体热连通。热电装置被配置为将热量从与泵头热连通的冷侧板传递到与致动器主体热连通的热侧板，从而从泵头移除热量。

5. 发明申请

WO2010102194A1 ELECTROSPRAY INTERFACE TO A MICROFLUIDIC SUBSTRATE 审中-公开
标题翻译：与微流体基板的电绝缘接口
公开(公告)号：WO2010102194A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/026342
申请日：2010-03-05
申请人： WATERS TECHNOLOGIES CORPORATION , PRENTICE, David, P. , KEENE, Russell, L. , KOZIOL, Stanislaw , MICHIENZI, Joseph, D. , LINDERSON, Paul, E.
发明人： PRENTICE, David, P. , KEENE, Russell, L. , KOZIOL, Stanislaw , MICHIENZI, Joseph, D. , LINDERSON, Paul, E.
IPC分类号： B01D15/08
CPC分类号： B01D15/10 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L3/563 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0883 , B05B1/00 , B05B1/02 , G01N27/44791 , G01N30/6095 , G01N30/72 , G01N30/7233 , G01N30/724 , G01N30/7266 , H01J49/167 , Y10T137/598 , Y10T436/24
摘要： An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal.
摘要翻译：一种用于化学分离的装置包括具有用于输出样品洗脱液的出口孔的微流体衬底，具有用于接收洗脱液的入口的喷雾单元和用于喷射洗脱液的出口以及施力单元。喷射单元具有限定入口的可变形部分，并且具有低于微流体衬底的弹性模量的弹性模量。力施加单元（例如弹簧）被设置成推动与基底接触的可变形部分以形成基本上流体密封的密封。

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