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1. 发明申请

WO2014011215A1 METHODS FOR PASSIVATING METALLIC IMPLANTABLE MEDICAL DEVICES INCLUDING RADIOPAQUE MARKERS 审中-公开
标题翻译：用于吞入金属可植入医疗器械的方法，包括无线电标记
公开(公告)号：WO2014011215A1
公开(公告)日：2014-01-16
申请号：PCT/US2013/027501
申请日：2013-02-22
申请人： ABBOTT CARDIOVASCULAR SYSTEMS, INC. , LIN, Zhicheng
发明人： LIN, Zhicheng
IPC分类号： C25F3/18 , C25F3/16 , A61F2/91
CPC分类号： A61L31/18 , A61F2/86 , A61F2210/0076 , A61F2240/001 , A61F2250/0054 , A61F2250/0098 , A61L31/022 , C25F3/16 , F04C2270/041
摘要： The present disclosure is directed to methods of manufacturing and passivating stents and other implantable medical devices including one or more attached radiopaque markers. In one embodiment, the method includes providing a metallic implantable medical device body without any radiopaque marker(s) attached thereto, primary electropolishing the device body without any markers attached thereto, attaching one or more radiopaque markers to the device body, and lightly electropolishing the device including device body and attached radiopaque markers. Light electropolishing removes no more than about 5 percent by weight of the device (i.e., the device body and attached marker(s)). Light electropolishing passivates the exposed surfaces of the device body and markers, while also providing electropolishing to the region of any welds where the radiopaque marker(s) attach to the device body.
摘要翻译：本公开涉及制造和钝化支架和其它可植入医疗装置的方法，包括一个或多个附接的不透射线标记物。在一个实施例中，该方法包括提供金属可植入医疗装置主体，而没有附接到其上的任何不透射线的标记，初次电抛光装置主体而没有附接到其上的任何标记，将一个或多个不透射线的标记附接到装置主体，以及轻轻电解抛光装置包括装置主体和附接的不透射线标记。轻质电解抛光消除不超过装置重量的约5％（即，装置主体和附着的标记）。光电抛光钝化了器件主体和标记的暴露表面，同时还向不透射线标记附着到器件主体的任何焊缝的区域提供电抛光。

2. 发明申请

WO2009070784A1 FATIGUE-RESISTANT NICKEL-TITANIUM ALLOYS AND MEDICAL DEVICES USING SAME 审中-公开
标题翻译：耐疲劳镍 - 钛合金和使用相同的医疗器械
公开(公告)号：WO2009070784A1
公开(公告)日：2009-06-04
申请号：PCT/US2008/085074
申请日：2008-11-28
申请人： ABBOTT LABORATORIES , WONG, Sophia, L. , LIN, Zhicheng , TAHRAN, Alan, G., Jr.
发明人： WONG, Sophia, L. , LIN, Zhicheng , TAHRAN, Alan, G., Jr.
IPC分类号： C22C19/03 , C22F1/10 , C22C1/02 , C22C14/00
CPC分类号： B23P17/00 , A61L31/022 , A61L31/14 , A61L2400/16 , C08L2201/12 , C22C14/00 , C22C19/007 , C22C19/03 , C22F1/10 , Y10T29/49863
摘要： Superelastic and/or shape memory nickel-titanium alloys having an increased fatigue life that is superior to known nickel-titanium alloys are disclosed. The nickel- titanium alloys have a minimum fatigue life that may be at least about 10 million strain cycles at a strain greater than about 0.75%. The minimum fatigue life may be due, at least in part, to the nickel-titanium alloy having at least one of an oxygen concentration of less than about 200 ppm, a carbon concentration of less than about 200 ppm, the absence of oxide-based and/or carbide-based inclusions having a size greater than about 5 microns (μm), the presence of an R-phase, or combinations of the foregoing. Articles manufactured from such fatigue-resistant nickel-titanium alloys can be more durable because they are more resistant to repetitive strain and crack propagation.
摘要翻译：公开了具有优于已知镍 - 钛合金的疲劳寿命增加的超弹性和/或形状记忆镍钛合金。镍钛合金具有最小的疲劳寿命，在应变大于约0.75％时可能为至少约1000万个应变循环。最小的疲劳寿命可能至少部分地归因于具有小于约200ppm的氧浓度，小于约200ppm的碳浓度，低于约200ppm的氧浓度的氧 - 和/或具有大于约5微米（μm）的尺寸的碳化物基夹杂物，R相的存在或前述的组合。由这种耐疲劳镍钛合金制成的制品可以更耐用，因为它们更能抵抗重复的应变和裂纹扩展。

3. 发明申请

WO2006081011A2 NITINOL ALLOY DESIGN FOR IMPROVED MECHANICAL STABILITY AND BROADER SUPERELASTIC OPERATING WINDOW 审中-公开
标题翻译： NITINOL合金设计改进机械稳定性和广泛超级操作窗口
公开(公告)号：WO2006081011A2
公开(公告)日：2006-08-03
申请号：PCT/US2005/046022
申请日：2005-12-20
申请人： ADVANCED CARDIOVASCULAR SYSTEMS, INC. , BOYLAN, John, F. , LIN, Zhicheng , STALKER, Kent, C., B.
发明人： BOYLAN, John, F. , LIN, Zhicheng , STALKER, Kent, C., B.
IPC分类号： C22C14/00 , C22F1/00 , A61L31/02
CPC分类号： C22C30/00 , A61F2/915 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0098 , A61L31/022 , A61L31/18 , A61L2400/16 , C22C14/00 , C22C19/00 , C22F1/006
摘要： A nickel-titanium alloy having a large, superelastic operating temperature window or range. The nickel-titanium alloy includes at least an additional element such as platinum, palladium, manganese, boron aluminum, tungsten, and/or zirconium. When processed through heat treat and area reduction steps, the resultant alloy exhibits a wide superelastic temperature operating window if the characteristics of the alloy when plotted on a temperature versus stress curve can be expresses as UP=(0.66ksi/°C)(T)+σ 0 , with R 2 ≥0.98, wherein σ 0 is the upper plateau stress of the alloy at about 0°C, R 2 is the coefficient of determination, and UP is the upper plateau stress of the alloy.
摘要翻译：具有大的，超弹性的工作温度窗口或范围的镍钛合金。镍 - 钛合金至少包括另外的元素，如铂，钯，锰，硼铝，钨和/或锆。当通过热处理和面积缩小步骤加工时，如果在温度对应力曲线上绘制时合金的特性可表示为UP =（0.66ksi /℃）（T），则所得合金表现出宽的超弹性温度操作窗口 + 0 其中R 2 = 0.98，其中s 0 0是合金在约0℃的上平台应力， SUP> 2 是确定系数，UP是合金的上平台应力。

4. 发明申请

WO2006081011A3 NITINOL ALLOY FOR WITH GOOD MECHANICAL STABILITY AND A GOOD SUPERELASTIC OPERATING WINDOW 审中-公开
标题翻译： NITINOL合金具有良好的机械稳定性和良好的超级操作窗口
公开(公告)号：WO2006081011A3
公开(公告)日：2006-08-31
申请号：PCT/US2005046022
申请日：2005-12-20
申请人： ADVANCED CARDIOVASCULAR SYSTEM , BOYLAN JOHN F , LIN ZHICHENG , STALKER KENT C B
发明人： BOYLAN JOHN F , LIN ZHICHENG , STALKER KENT C B
IPC分类号： A61L29/00 , C22C14/00 , A61F2/00 , A61F2/06 , A61F2/84 , A61F2/90 , A61L31/02 , C22F1/00
CPC分类号： C22C30/00 , A61F2/915 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0098 , A61L31/022 , A61L31/18 , A61L2400/16 , C22C14/00 , C22C19/00 , C22F1/006
摘要： A nickel-titanium alloy having a large, superelastic operating temperature window or range. The nickel-titanium alloy includes at least an additional element such as platinum, palladium, manganese, boron aluminum, tungsten, and/or zirconium. When processed through heat treat and area reduction steps, the resultant alloy exhibits a wide superelastic temperature operating window if the characteristics of the alloy when plotted on a temperature versus stress curve can be expresses as UP=(0.66ksi/°C)(T)+s 0 , with R 2 =0.98, wherein s 0 is the upper plateau stress of the alloy at about 0°C, R 2 is the coefficient of determination, and UP is the upper plateau stress of the alloy.
摘要翻译：具有大的，超弹性的工作温度窗口或范围的镍钛合金。镍 - 钛合金至少包括另外的元素，如铂，钯，锰，硼铝，钨和/或锆。当通过热处理和面积缩小步骤加工时，如果在温度对应力曲线上绘制时合金的特性可表示为UP =（0.66ksi /℃）（T），则所得合金表现出宽的超弹性温度操作窗口 + 0 其中R 2 = 0.98，其中s 0 0是合金在约0℃的上平台应力， SUP> 2 是确定系数，UP是合金的上平台应力。

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