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1. 发明申请

WO2007117221A1 CATALYSTS FOR RING CLOSING METATHESIS 审中-公开
标题翻译：催化剂用于闭合元件
公开(公告)号：WO2007117221A1
公开(公告)日：2007-10-18
申请号：PCT/SG2007/000096
申请日：2007-04-11
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , LEE, SU SEONG , YING, JACKIE Y. , LIM, JAEHONG
发明人： LEE, SU SEONG , YING, JACKIE Y. , LIM, JAEHONG
IPC分类号： B01J31/16 , B01J32/00 , B01J35/10 , B01J31/28 , B01J35/00
CPC分类号： B01J31/1625 , B01J21/08 , B01J31/2273 , B01J31/2278 , B01J35/04 , B01J2231/54 , B01J2531/821
摘要： A catalyst composition is provided, which may be used for ring closing metathesis. In the composition, a catalyst is immobilized on a siliceous mesocellular foam support. A suitable catalyst for use in the composition is a Grubbs- type catalyst or a Hoveyda-Grubbs-type catalyst.
摘要翻译：提供了可用于闭环复分解的催化剂组合物。在组合物中，将催化剂固定在硅质中孔泡沫支持体上。用于组合物中的合适的催化剂是Grubbs型催化剂或Hoveyda-Grubbs型催化剂。

2. 发明申请

WO2011008173A1 IMPROVED SCREENING OF BIOPOLYMERS 审中-公开
标题翻译：改善生物玻璃的筛选
公开(公告)号：WO2011008173A1
公开(公告)日：2011-01-20
申请号：PCT/SG2010/000266
申请日：2010-07-15
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , HEATH, James R. , LEE, Su Seong , LIM, Jaehong , CHA, Junhoe , TAN, Sylvia , YEO, Shi Yun , ANG, Yi Li , ZHANG, Yiran
发明人： HEATH, James R. , LEE, Su Seong , LIM, Jaehong , CHA, Junhoe , TAN, Sylvia , YEO, Shi Yun , ANG, Yi Li , ZHANG, Yiran
IPC分类号： C07H21/00 , C12Q1/68 , C08L89/00 , G01N33/50
CPC分类号： G01N33/6845 , C07K1/047 , C08L5/00 , C08L89/00 , C12N15/1034 , G01N33/54313
摘要： Described herein are inventive compositions and methods relating to sampling of biopolymers and, in particular, to fractional sampling of biopolymers. In one aspect, embodiments are generally related to unique biopolymer species where a fraction of each biopolymer species contains a cleavable linker. The biopolymer species may, in some embodiments, be attached to a surface. For example, the biopolymer species may be attached to beads. In some embodiments, a portion of a unique biopolymer species may be sampled by cleaving the cleavable linker. In some cases, the sample may be analyzed to determine the sequence of the biopolymer.
摘要翻译：本文描述了与生物聚合物的取样相关的本发明组合物和方法，特别是生物聚合物的分数取样。在一个方面，实施方案通常涉及独特的生物聚合物种类，其中每个生物聚合物种类的一部分含有可切割的连接体。在一些实施方案中，生物聚合物物质可附着于表面。例如，生物聚合物物质可以连接到珠粒上。在一些实施方案中，可以通过切割可切割接头来采样一部分独特的生物聚合物种类。在一些情况下，可以分析样品以确定生物聚合物的顺序。

3. 发明申请

WO2012026887A1 PEPTIDE LIBRARIES FOR SCREENING AND OTHER APPLICATIONS 审中-公开
标题翻译：用于筛选和其他应用的肽图书馆
公开(公告)号：WO2012026887A1
公开(公告)日：2012-03-01
申请号：PCT/SG2011/000298
申请日：2011-08-29
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , LEE, Su Seong , LIM, Jaehong , CHA, Junhoe , ANG, Yi Li , ZHENG, Yiran , TAN, Sylvia
发明人： LEE, Su Seong , LIM, Jaehong , CHA, Junhoe , ANG, Yi Li , ZHENG, Yiran , TAN, Sylvia
IPC分类号： C40B20/04 , C40B20/08 , C40B50/16 , C07K1/04 , C40B30/10 , C07K17/00 , C40B40/10
CPC分类号： G01N33/6818 , C07K1/047 , C07K1/13 , C07K7/06 , C40B20/08 , C40B40/04 , C40B50/18 , C40B70/00
摘要： The present invention generally relates to various peptides and particles, for example, for use in screening of particle- or bead-based peptide libraries. In one aspect, the present invention is generally directed to articles including peptides attached to one or more particles, which may have structures such as (particle)-M-Q-Z n -X-J, (particle)-M-Q-Z n -X 1 -X 2 -X 3 -X 4 -X 5 -J, (particle)-M-R-Z n -X 1 -X 2 -X 3 -X 4 -X 5 -J, (particle)-M-R- - X 1 -X 2 -X 3 -X 4 -X 5 -Z n -Q-J, (particle)-M-X 1 -X 2 -X- 3 X 4 -X 5 -Z n -R-J, etc., where M is a methionine residue, M1 is a cleavable linker residue, Q is a group able to enhance intensity and/or sensitivity of mass spectrometry, X comprises one or more amino acid residues, n is a positive integer, Z is a covalent bond or a spacer, and J is an endgroup. In some embodiments, the spacer may comprise a structure such as:(I). Other aspects of the present invention generally relate to methods of using such articles, e.g., by exposing the article to a target molecule such as a protein, for example, for use in screening of particle-based peptide libraries. Still other aspects of the present invention generally relate to methods of making such articles, methods of promoting such articles, kits involving such articles, or the like.
摘要翻译：本发明通常涉及各种肽和颗粒，例如用于筛选基于颗粒或珠的肽文库。一方面，本发明一般涉及包含连接到一个或多个颗粒上的肽的制品，其可以具有诸如（颗粒）-MQ-Zn-XJ，（颗粒）-MQ-Zn-X1-X2-X3 -X4-X5-J，（颗粒）-MR-Zn-X1-X2-X3-X4-X5-J，（颗粒）-MR-X1-X2-X3-X4-X5-Zn-QJ ）-M-X1-X2-X-3X4-X5-Zn-RJ等，其中M是甲硫氨酸残基，M1是可切割的接头残基，Q是能够增强质谱的强度和/或灵敏度的基团 X包含一个或多个氨基酸残基，n为正整数，Z为共价键或间隔基，J为端基。在一些实施方案中，间隔物可以包含如下结构：（I）。本发明的其它方面通常涉及使用这种制品的方法，例如通过将制品暴露于靶分子例如蛋白质，例如用于筛选基于颗粒的肽文库。本发明的其它方面通常涉及制造这种制品的方法，促进这种制品的方法，涉及这种制品的试剂盒等。

4. 发明申请

WO2011010964A1 DIFFERENTIATION OF ISOBARIC AMINO ACIDS AND OTHER SPECIES 审中-公开
标题翻译： ISOBARIC氨基酸和其他物种的差异
公开(公告)号：WO2011010964A1
公开(公告)日：2011-01-27
申请号：PCT/SG2009/000258
申请日：2009-07-22
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , HEATH, James R. , LEE, Su Seong , LIM, Jaehong , CHA, Junhoe , TAN, Sylvia , YEO, Shi Yun
发明人： HEATH, James R. , LEE, Su Seong , LIM, Jaehong , CHA, Junhoe , TAN, Sylvia , YEO, Shi Yun
IPC分类号： C40B50/16 , C40B20/04 , C40B20/08 , C07K1/04 , C07K17/00
CPC分类号： G01N33/6848 , C07B2200/11 , C07K1/047 , C07K1/13 , C07K7/06 , C40B50/16 , G01N33/6812 , G01N33/6818
摘要： Techniques for differentiating isobaric species are described. An isobaric species may be substituted with a tagging species identified using mass spectrometry. The isobaric species may be a subunit of a first polymer having a defined sequence, e.g., the isobaric species may be an amino acid in a protein or a peptide sequence. A tagging species may be substituted for the isobaric species in a second polymer having an otherwise identical sequence as the first polymer. The second polymer may have the same number of sequences as the first polymer, and substantially the same sequence of subunits, with a few exceptions such as the tagging species for the isobaric species. The first polymer and the second polymer may be prepared in the same reaction vessel. A polymer/protein of defined subunit sequence containing an isobaric species or a tagging species may be analyzed by mass spectrometry to determine the sequence.
摘要翻译：描述了用于区分等压物种的技术。同量异位物质可以用通过质谱鉴定的标记物种代替。等压物质可以是具有确定的序列的第一聚合物的亚基，例如同量异位物质可以是蛋白质或肽序列中的氨基酸。在具有与第一聚合物相同的顺序的第二聚合物中，标记物质可以代替同量异位物质。第二聚合物可以具有与第一聚合物相同数量的序列，以及基本上相同的亚基序列，只有少数例外，例如同量异序物种的标记物种。第一聚合物和第二聚合物可以在相同的反应容器中制备。可以通过质谱分析含有等压物种或标记物质的限定亚单位序列的聚合物/蛋白质以确定序列。

5. 发明申请

WO2008115154A1 CATALYST IMMOBILIZATION ON SILICEOUS MESOCELLULAR FOAM VIA CLICK CHEMISTRY 审中-公开
标题翻译：通过点击化学催化剂对硅酸盐泡沫进行催化
公开(公告)号：WO2008115154A1
公开(公告)日：2008-09-25
申请号：PCT/SG2008/000088
申请日：2008-03-20
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie, Y. , LIM, Jaehong , LEE, Su Seong , RIDUAN, Siti Nurhanna Binte
发明人： YING, Jackie, Y. , LIM, Jaehong , LEE, Su Seong , RIDUAN, Siti Nurhanna Binte
IPC分类号： C07D249/02 , B01J32/00 , B01J35/10 , B01J31/28 , B01J35/00 , C07B47/00
CPC分类号： B01J31/1633 , B01J21/08 , B01J31/0254 , B01J31/182 , B01J31/2265 , B01J35/04 , B01J2231/325 , B01J2231/326 , B01J2231/327 , B01J2231/54 , B01J2231/543 , B01J2531/16 , B01J2531/821 , C07D403/12 , Y02P20/588
摘要： The present invention relates to a method for preparing a heterogenised catalyst, comprising grafting a catalyst or catalyst precursor, via click chemistry, to a siliceous mesocellular foam (MCF). The invention also relates to a heterogenised catalyst comprising a catalyst species grafted onto a siliceous mesocellular foam (MCF) via a 1,2,3- triazole.
摘要翻译：本发明涉及一种制备异质化催化剂的方法，包括通过点击化学将催化剂或催化剂前体接枝到硅质中孔泡沫（MCF）上。本发明还涉及包含通过1,2,3-三唑接枝到硅质中孔泡沫（MCF）上的催化剂种类的异质化催化剂。

6. 发明申请

WO2008020811A1 RECIRCULATING REACTOR 审中-公开
标题翻译：再生反应器
公开(公告)号：WO2008020811A1
公开(公告)日：2008-02-21
申请号：PCT/SG2007/000245
申请日：2007-08-10
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YING, Jackie Y , LEE, Su Seong , LIM, Jaehong , SITI, Nurhanna Binte Riduan
发明人： YING, Jackie Y , LEE, Su Seong , LIM, Jaehong , SITI, Nurhanna Binte Riduan
IPC分类号： B01J19/00 , B01J19/20 , B01J19/32 , B01J19/26 , B01J19/18 , B01J19/30 , B01J19/14 , B01J19/28 , B01J19/06 , B01J19/24 , B01J19/02 , B01J19/22 , B01J19/16
CPC分类号： B01J8/025 , B01J8/0214 , B01J8/20 , B01J8/22 , B01J19/0093 , B01J2208/00867 , B01J2219/00788 , B01J2219/00835 , B01J2219/00873 , B01J2219/00905
摘要： The invention provides a recirculating reactor for converting a substrate to a product. The reactor comprises a reaction chamber and a recirculation system, said recirculation system comprising a separator. The reaction chamber contains a catalyst, and comprises a chamber body, a chamber inlet and a chamber outlet. The recirculation system is adapted for recirculating liquid from the chamber outlet to the chamber inlet, and the separator is used for separating a by-product from the liquid.
摘要翻译：本发明提供一种用于将基材转化成产品的再循环反应器。反应器包括反应室和再循环系统，所述再循环系统包括分离器。反应室包含催化剂，并且包括室主体，室入口和室出口。再循环系统适于将液体从室出口再循环到室入口，并且分离器用于从液体中分离副产物。

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