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1. 发明申请

WO2009138714A1 PURIFICATION PROCESS FOR ANTIBODY FRAGMENTS USING DERIVATIZED TRIAZINES AS AFFINITY LIGANDS 审中-公开
标题翻译：使用衍生化的TRIAZINES作为AFFINITY LIGANDS的抗体片段的纯化过程
公开(公告)号：WO2009138714A1
公开(公告)日：2009-11-19
申请号：PCT/GB2009/001126
申请日：2009-05-07
申请人： AVECIA BIOLOGICS LIMITED , LIDDELL, John, Macdonald
发明人： LIDDELL, John, Macdonald
IPC分类号： C07K16/00 , C07K1/22 , C07D251/12
CPC分类号： C07D251/48 , A61K39/39591 , B01D15/3804 , B01J20/3246 , C07K1/22
摘要： A process for the separation of a fragment antibody from a medium is provided. The process comprises contacting the medium comprising the fragment antibody with a synthetic affinity ligand attached to a support matrix under conditions whereby the fragment antibody binds to the synthetic affinity ligand. The synthetic affinity ligand has the formula (I): wherein Q represents an attachment to a solid support matrix, optionally via a spacer group; A and B are each independently -Y-phenyl or -Y-naphthyl groups substituted with one or more substituents capable of hydrogen bonding, preferably one or more of -OH, -SH or - CO 2 H groups; each Y independently represents -NR-, -O- or -S-; and each R independently represents H or a C 1-4 alkyl group.
摘要翻译：提供了从介质中分离片段抗体的方法。该方法包括在包含片段抗体结合于合成亲和配体的条件下使包含片段抗体的培养基与连接于载体基质的合成亲和配体接触。合成亲和配体具有式（I）：其中Q表示与固体支持基质的连接，任选经由间隔基团; A和B各自独立地是被一个或多个能够键合氢取代基，优选一个或多个-OH，-SH或-CO 2 H基取代的-Y-苯基或-Y-萘基; 每个Y独立地表示-NR-，-O-或-S-; 并且每个R独立地表示H或C 1-4烷基。

2. 发明申请

WO1997023549A1 HOT SHAPING POLYHYDROXYALKANOATE POLYMERS 审中-公开
标题翻译：热成型聚羟基烷基酯聚合物
公开(公告)号：WO1997023549A1
公开(公告)日：1997-07-03
申请号：PCT/US1996020545
申请日：1996-12-18
申请人： MONSANTO COMPANY , MONTADOR, James, Henry , GEORGE, Neil , LIDDELL, John, MacDonald
发明人： MONSANTO COMPANY
IPC分类号： C08J03/12
CPC分类号： C08J3/12 , C08J5/00 , C08J2367/04
摘要： This invention relates to processes for producing a shaped object of polyhydroxyalkanoate (PHA) that makes it possible to omit the preliminary extrusion-compounding step, thus saving expense and limiting loss of molecular weight. The process comprises producing a biomass containing particles of PHA and non-PHA cell material (NPCM), separating the NPCM, suspending the PHA particles in water, agglomerating the suspended PHA particles to a suitable weight average particle diameter, separating the agglomerated PHA particles from the suspension, drying the agglomerated PHA particles, and hot shaping the dry, agglomerated PHA particles. In one embodiment, the weight average particle diameter is 50 mu m to 5000 mu m. In another embodiment, a plasticiser is added to the agglomerated PHA particles.
摘要翻译：本发明涉及生产聚羟基链烷酸酯（PHA）的成型体的方法，其可以省略预挤出复合步骤，从而节省成本并限制分子量的损失。该方法包括生产含有PHA和非PHA细胞材料（NPCM）的颗粒的生物质，分离NPCM，将PHA颗粒悬浮在水中，将悬浮的PHA颗粒附聚到合适的重均粒径，将附聚的PHA颗粒从悬浮液，干燥附聚的PHA颗粒，并热干燥，附聚的PHA颗粒。在一个实施方式中，重均粒径为50μm〜5000μm。在另一个实施方案中，将增塑剂加入到附聚的PHA颗粒中。

3. 发明申请

WO1997022654A1 POLYESTER PARTICLES 审中-公开
标题翻译：聚酯颗粒
公开(公告)号：WO1997022654A1
公开(公告)日：1997-06-26
申请号：PCT/US1996020016
申请日：1996-12-13
申请人： MONSANTO COMPANY , GEORGE, Neil , LIDDELL, John, Macdonald
发明人： MONSANTO COMPANY
IPC分类号： C08J03/12
CPC分类号： C08J3/12 , C08J2367/04
摘要： This invention relates to a process for producing polyhydroxyalkanoate (PHA) that overcomes a problem encountered when seeking to separate PHA particles without centrifugation. The process comprises producing a biomass containing PHA particles and non-PHA cell material (NPCM), solubilising the NPCM, oxidizing the resulting product mixture to further solubilise NPCM, adding a water soluble surfactant to produce a suspension, and heating the suspension below the melting point of the PHA to agglomerate the PHA particles to a suitable weight average diameter. In one emdobiment, the surfactant is a monomeric water soluble surfactant. In another embodiment, the weight average particle diameter is 200 mu m to 500 mu m.
摘要翻译：本发明涉及一种生产聚羟基链烷酸酯（PHA）的方法，其克服了在不离心分离PHA颗粒时遇到的问题。该方法包括生产含有PHA颗粒和非PHA细胞材料（NPCM）的生物质，增溶NPCM，氧化所得产物混合物以进一步溶解NPCM，加入水溶性表面活性剂以产生悬浮液，并将该悬浮液加热至熔融以下 PHA颗粒聚集到合适的重均粒径。在一个实例中，表面活性剂是单体水溶性表面活性剂。在另一个实施方式中，重均粒径为200μm〜500μm。

4. 发明申请

WO1996006178A1 PRODUCTION OF POLYMERS OF HYDROXYALKANOIC ACIDS 审中-公开
标题翻译：羟基甘氨酸聚合物的生产
公开(公告)号：WO1996006178A1
公开(公告)日：1996-02-29
申请号：PCT/GB1995001925
申请日：1995-08-15
申请人： ZENECA LIMITED , LIDDELL, John, MacDonald , GEORGE, Neil , HALL, Alan
发明人： ZENECA LIMITED
IPC分类号： C12P07/62
CPC分类号： C12P7/625 , C08G63/89
摘要： A process of recovering PHA from a suspension which comprises particles of PHA in a liquid which comprises maintaining the suspension at a temperature at which the PHA melts and substantial coalescence of PHA particles occurs thereby at least partly forming a layer of molten PHA and separating the layer of PHA optionally after its cooling to form a solid.
摘要翻译：从悬浮液中回收PHA的方法，其包括在液体中的PHA颗粒，其包括将悬浮液保持在PHA熔化的温度和PHA颗粒的大量聚结的温度，从而至少部分地形成熔融PHA层并分离层的PHA，任选地在其冷却后形成固体。

5. 发明申请

WO1994002541A1 POLYMER COMPOSITIONS AND PROCESSES 审中-公开
标题翻译：聚合物组合物和方法
公开(公告)号：WO1994002541A1
公开(公告)日：1994-02-03
申请号：PCT/GB1993001492
申请日：1993-07-15
申请人： ZENECA LIMITED , LIDDELL, John, MacDonald , GREER, William
发明人： ZENECA LIMITED
IPC分类号： C08K03/30
CPC分类号： C08K3/30 , C08L67/04
摘要： Melt processed articles of improved colour and odour can be produced from hydroxyalkanoic acid polymers if they are melt processed in the presence of a temperature stable sulphite salt, and compositions for use in such processes are disclosed.
摘要翻译：如果在温度稳定的亚硫酸盐存在下熔融加工，则可以由羟基链烷酸聚合物制备具有改善的颜色和气味的熔融加工制品，并且公开了用于这些方法的组合物。

6. 发明申请

WO1996006179A1 PROCESS FOR THE RECOVERY OF POLYHYDROXYALKANOIC ACID 审中-公开
标题翻译：回收聚羟基烷酸的方法
公开(公告)号：WO1996006179A1
公开(公告)日：1996-02-29
申请号：PCT/GB1995001926
申请日：1995-08-15
申请人： ZENECA LIMITED , LIDDELL, John, Macdonald
发明人： ZENECA LIMITED
IPC分类号： C12P07/62
CPC分类号： C12P7/625 , C08G63/89 , Y10S435/829 , Y10S435/874
摘要： A hydroxyalkanoic acid (PHA) is recovered from matter derived from living organisms by dissolving the PHA in a solvent which is a lower ketone, dialkyl ether or a lower alcohol or a monocarboxylic acid ester thereof, separating the solution from such matter and recovering PHA from the solution.
摘要翻译：通过将PHA溶解在作为低级酮，二烷基醚或低级醇或其一元羧酸酯的溶剂中，从生物体的物质中回收羟基链烷酸（PHA），将溶液与该物质分离，并将PHA从解决方案。

7. 发明申请

WO2011012841A1 PLASMID DNA EXTRACTION PROCESS 审中-公开
标题翻译： PLASMID DNA提取过程
公开(公告)号：WO2011012841A1
公开(公告)日：2011-02-03
申请号：PCT/GB2010/001388
申请日：2010-07-22
申请人： MSD BIOLOGICS (UK) LIMITED , LIDDELL, John Macdonald
发明人： LIDDELL, John Macdonald
IPC分类号： C12N1/06 , C12N15/10
CPC分类号： C12N15/1003
摘要： A process for the extraction of pDNA from cells is provided. In one aspect, the process comprises heating a liquid comprising the cells to an average temperature of from 95°C to about 120°C for a time of less than 10 seconds. In certain preferred aspects, the pDNA is extracted by the use of flow-through apparatus.
摘要翻译：提供从细胞中提取pDNA的方法。在一个方面，该方法包括将包含细胞的液体加热至95℃至约120℃的平均温度少于10秒的时间。在某些优选方面，通过使用流通装置提取pDNA。

8. 发明申请

WO1997017459A1 PROCESS TO RECOVER POLYESTERS FROM TRANSGENIC PLANTS 审中-公开
标题翻译：从转基因植物回收聚酯的方法
公开(公告)号：WO1997017459A1
公开(公告)日：1997-05-15
申请号：PCT/US1996017757
申请日：1996-11-06
申请人： MONSANTO COMPANY , LIDDELL, John, Macdonald
发明人： MONSANTO COMPANY
IPC分类号： C12P07/62
CPC分类号： C08G63/89 , C12P7/625
摘要： Polyhydroxyalkanoate (PHA) polyester is recovered from vegetable matter associated with its production in transgenic plants. The process involves contacting the vegetable matter with one or more reagents inactive toward PHA but effective to solubilize at least part of the vegetable matter, taking off the resulting solution, and recovering PHA from the residue enriched therein. Effective solubilizing reagents that are preferred include enzyme formulations comprising carbohydrases, hydrolases or proteases.
摘要翻译：聚羟基链烷酸酯（PHA）聚酯是从与转基因植物生产相关的植物物质中回收的。该方法包括使植物物质与一种或多种对PHA无活性的试剂接触，但有效地溶解至少部分植物物质，脱除所得溶液，并从富含其中的残余物中回收PHA。优选的有效增溶试剂包括含有糖酶，水解酶或蛋白酶的酶制剂。

9. 发明申请

WO1997004121A1 EXTRACTION OF TRIGLYCERIDES FROM MICROORGANISMS 审中-公开
标题翻译：从微生物提取TRIGLYCERIDES
公开(公告)号：WO1997004121A1
公开(公告)日：1997-02-06
申请号：PCT/GB1996001703
申请日：1996-07-16
申请人： ZENECA LIMITED , LIDDELL, John, Macdonald
发明人： ZENECA LIMITED
IPC分类号： C12P07/64
CPC分类号： C12P7/6463 , C11B1/10 , C12N1/005 , C12N1/06 , Y10S435/911
摘要： Oil is extracted from oil containing microorganisms by disintegrating the microorganisms and contacting them in the presence of a water content of at least 70 % by weight of that originally present in the cellular material with a water immiscible solvent for the oil, separating the solvent from the microorganisms and recovering the oil from the solvent.
摘要翻译：通过分解微生物并在原料存在于细胞材料中的至少70重量％的水含量存在下用油与水不混溶的溶剂将油从含油微生物中提取出来，将溶剂与微生物并从溶剂中回收油。

10. 发明申请

WO2012114063A1 CELL LYSIS PROCESS 审中-公开
标题翻译：细胞分析过程
公开(公告)号：WO2012114063A1
公开(公告)日：2012-08-30
申请号：PCT/GB2012/000164
申请日：2012-02-17
申请人： FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED , LIDDELL John MacDonald , RAZZAQ Azam
发明人： LIDDELL John MacDonald , RAZZAQ Azam
IPC分类号： C12N1/06 , C12N1/00
CPC分类号： C12N1/06 , C12M47/06 , C12N1/066 , C12N13/00
摘要： A process for cell lysis is provided. The process comprises passing a mixture comprising a suspension of cells and a lysis reagent through a flow-through reactor, wherein the mixture passes through the reactor with pulsed or superimposed oscillating flow. The process is preferably employed for the preparation of biological products, such as pDNA or inclusion bodies.
摘要翻译：提供了细胞裂解的方法。该方法包括使包含细胞悬浮液和裂解剂的混合物通过流通反应器，其中混合物以脉冲或叠加的振荡流通过反应器。该方法优选用于制备生物制品，例如pDNA或包涵体。

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