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1. 发明公开

EP2206556A1 Emptying panel of a bin for shredders of sheet like material 审中-公开
标题翻译： Entleerungsklappe desBehälterseines Aktenvernichters
公开(公告)号：EP2206556A1
公开(公告)日：2010-07-14
申请号：EP10000173.4
申请日：2010-01-11
申请人： Davis, Josh , Jensen, Jeffrey , Renji, Zhang , Xin, Xiang , Zhi Guo, Li Henry
发明人： Davis, Josh , Jensen, Jeffrey , Renji, Zhang , Xin, Xiang , Zhi Guo, Li Henry
IPC分类号： B02C18/00 , B65F1/12
CPC分类号： B02C18/0007 , B02C2018/0046
摘要： A chad containment bin includes a chad containment space formed by a pair of opposing longitudinally extending sidewalls connected by a pair of opposing, laterally extending sidewalls. A shredder head assembly is situated above the chad containment bin. A cabinet body supports the shredder head assembly while removeably housing the chad containment bin. A generally vertically oriented support member extends upwardly from a first of the longitudinally extending sidewalls. The support member includes a handle on an outer face for carrying the chad containment bin. A panel is pivotally connected to the chad containment bin for providing access to the chad containment space when the chad containment bin is suspended by the handle over a waste receptacle.
摘要翻译：笛子收容箱包括由一对相对的纵向延伸的侧壁形成的ch壳容纳空间，该侧壁通过一对相对的横向延伸的侧壁连接。切碎机头组件位于ad壳收容箱的上方。橱柜主体支撑粉碎机头组件，同时可拆卸地容纳ch壳容纳箱。大致垂直取向的支撑构件从纵向延伸的第一侧壁向上延伸。支撑构件包括在外表面上用于承载ch壳容纳箱的把手。当ch子收容箱被手柄悬挂在废物容器上时，面板枢转地连接到ch ad容纳箱，用于提供对ch壳容纳空间的通路。

2. 发明申请

WO2006002022A3 COMPOSITIONS AND METHODS USEFUL FOR THE TREATMENT OF HYPERGLYCEMIA 审中-公开
标题翻译：用于治疗高血压的组合物和方法
公开(公告)号：WO2006002022A3
公开(公告)日：2009-04-09
申请号：PCT/US2005020724
申请日：2005-06-10
申请人： IMMUSOL INC , GRIFMAN MIRTA , LI HENRY , MACDONALD JAMES E , WONG-STAAL FLOSSIE
发明人： GRIFMAN MIRTA , LI HENRY , MACDONALD JAMES E , WONG-STAAL FLOSSIE
IPC分类号： A61K31/56
CPC分类号： A61K31/58
摘要： The present invention provides compositions and methods for the treatment of disorders characterized by hyperglycemia, in particular, Type II diabetes. The invention also provides a method for identifying novel compositions useful for the treatment of such disorders.
摘要翻译：本发明提供用于治疗以高血糖症为特征的疾病，特别是II型糖尿病的组合物和方法。本发明还提供了用于鉴定可用于治疗这种疾病的新组合物的方法。

3. 发明申请

WO2006020557A3 METHODS OF USING OR IDENTIFYING AGENTS THAT INHIBIT CANCER GROWTH 审中-公开
标题翻译：使用或识别抑制癌症生长的药物的方法
公开(公告)号：WO2006020557A3
公开(公告)日：2007-08-16
申请号：PCT/US2005028100
申请日：2005-08-09
申请人： IMMUSOL INC , QI-XIAN LI HENRY , KE NING , GRIFMAN MIRTA , FAN WUFANG , DEHUA YU , WONG-STAAL FLOSSIE
发明人： QI-XIAN LI HENRY , KE NING , GRIFMAN MIRTA , FAN WUFANG , DEHUA YU , WONG-STAAL FLOSSIE
IPC分类号： A61K31/70
CPC分类号： C07K16/2863 , C07K14/705 , C07K2317/34 , C07K2317/73 , C12N15/1138 , C12N2310/111 , C12N2310/14
摘要： The present invention is directed in general to methods of inhibiting the growth of cancer cells or tumors. The present invention is also directed to identifying agents useful for the treatment of cancer. These methods generally involve targeting two genes or their encoded proteins, GPR56 or DNER.
摘要翻译：本发明总体上涉及抑制癌细胞或肿瘤生长的方法。本发明还涉及鉴定可用于治疗癌症的药剂。这些方法通常涉及靶向两种基因或其编码的蛋白质GPR56或DNER。

4. 发明申请

WO2004009794A2 NOVEL SIRNA GENE LIBRARIES AND METHODS FOR THEIR PRODUCTION AND USE 审中-公开
标题翻译：新的SIRNA基因库及其生产和使用方法
公开(公告)号：WO2004009794A2
公开(公告)日：2004-01-29
申请号：PCT/US0323157
申请日：2003-07-23
申请人： IMMUSOL INC , LI HENRY , CHATTERTON JON E , KE NING , WONG-STAAL FLOSSIE
发明人： LI HENRY , CHATTERTON JON E , KE NING , WONG-STAAL FLOSSIE
IPC分类号： C12N15/09 , C12N15/10 , C12N15/11 , C12N
CPC分类号： C12N15/111 , C12N15/1075 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/31
摘要： The present invention relates to methods and compositions for the elucidation of gene function and the identification of novel genes. Specifically, the present invention relates to methods and compositions for improved functional genomic screening, functional inactivation of specific essential or non-essential genes, and identification of genes that are modulated in response to specific stimuli or encode recognizable phenotypic traits. In particular, the compositions of the present invention include, but are not limited to, expression cassettes comprising a novel dual promoter transcription system, that utilizes modified promoters, preferably containing complementary termination sequences, positioned across a coding sequence and in opposite orientation to each other. In addition, the present invention includes libraries comprising the expression cassettes of the invention, including vectors for transforming cells, such as replication-deficient retroviral vectors. The invention also includes methods for the production and screening of dsRNA/siRNA libraries, as well as therapeutic uses for the siRNAs expressed in accordance with the invention.
摘要翻译：本发明涉及阐明基因功能和鉴定新基因的方法和组合物。具体而言，本发明涉及用于改进功能基因组筛选，特异性必需或非必需基因的功能失活以及根据特定刺激或编码可识别的表型性状调节的基因的鉴定的方法和组合物。特别地，本发明的组合物包括但不限于包含新颖的双重启动子转录系统的表达盒，其利用修饰的启动子，优选含有互补终止序列，跨越编码序列并且彼此相反取向。此外，本发明包括包含本发明的表达盒的文库，包括用于转化细胞的载体，例如复制缺陷型逆转录病毒载体。本发明还包括用于生产和筛选dsRNA / siRNA文库的方法以及根据本发明表达的siRNA的治疗用途。

5. 发明申请

WO2008067451A1 NOVEL 3-BENZYLIDINE AND 3-BENZYL SUBSTITUTED CHROMANONES 审中-公开
标题翻译：新型3-苄氧基和3-苄基取代的CHROMANONES
公开(公告)号：WO2008067451A1
公开(公告)日：2008-06-05
申请号：PCT/US2007/085914
申请日：2007-11-29
申请人： ITHERX PHARMACEUTICALS, INC. , MACDONALD, James E. , HYSELL, Michelle K. , LIU, Qi , YU, Dehua , KE, Ning , LIU, Guohong , LI, Henry, Q., X. , WONG-STAAL, Flossie
发明人： MACDONALD, James E. , HYSELL, Michelle K. , LIU, Qi , YU, Dehua , KE, Ning , LIU, Guohong , LI, Henry, Q., X. , WONG-STAAL, Flossie
IPC分类号： A01N43/16 , A61K31/35
CPC分类号： C07D311/22
摘要： The present invention provides novel chromanone derivatives that are useful for the treatment of inflammatory diseases, cancer and age-related macular degeneration
摘要翻译：本发明提供了可用于治疗炎性疾病，癌症和年龄相关性黄斑变性的新型色酮衍生物

6. 发明申请

WO2006002022A2 COMPOSITIONS AND METHODS USEFUL FOR THE TREATMENT OF HYPERGLYCEMIA 审中-公开
标题翻译：用于治疗高血压的组合物和方法
公开(公告)号：WO2006002022A2
公开(公告)日：2006-01-05
申请号：PCT/US2005/020724
申请日：2005-06-10
申请人： IMMUSOL INCORPORATED , GRIFMAN, Mirta , LI, Henry , MACDONALD, James E. , WONG-STAAL, Flossie
发明人： GRIFMAN, Mirta , LI, Henry , MACDONALD, James E. , WONG-STAAL, Flossie
IPC分类号： A61K31/58
CPC分类号： A61K31/58
摘要： The present invention provides compositions and methods for the treatment of disorders characterized by hyperglycemia, in particular, Type II diabetes. The invention also provides a method for identifying novel compositions useful for the treatment of such disorders.
摘要翻译：本发明提供用于治疗特征在于高血糖症，特别是II型糖尿病的疾病的组合物和方法。本发明还提供了用于鉴定可用于治疗这种疾病的新组合物的方法。

7. 发明申请

WO2004072261A3 SIRNA LIBRARIES OPTIMIZED FOR PREDETERMINED PROTEIN FAMILIES 审中-公开
标题翻译：针对预测蛋白家族优化的SIRNA图书馆
公开(公告)号：WO2004072261A3
公开(公告)日：2005-06-09
申请号：PCT/US2004003949
申请日：2004-02-10
申请人： IMMUSOL INC , LI HENRY , CHATTERTON JON E , FAN WUFANG , KE NING , WONG-STAAL FLOSSIE
发明人： LI HENRY , CHATTERTON JON E , FAN WUFANG , KE NING , WONG-STAAL FLOSSIE
IPC分类号： C12N15/11 , C12N15/113 , C07H21/00
CPC分类号： C12N15/111 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/31 , C12Y207/10001 , C12Y207/10002
摘要： siRNA Libraries Optimized for Predetermined Protein Families ABSTRACT Libraries for generating small inhibitory RNA (siRNA) are provided where the members of the library are optimized to inhibit the expression of genes that encode a predetermined family of proteins. The members of the library target at least mRNA encoding all members of the family of proteins. Methods for generating siRNA libraries of the present invention are also provided.
摘要翻译：针对预定蛋白家族优化的siRNA文库摘要提供用于产生小抑制性RNA（siRNA）的文库，其中文库成员被优化以抑制编码预定蛋白质家族的基因的表达。图书馆的成员至少靶向编码蛋白质家族成员的mRNA。还提供了用于产生本发明的siRNA文库的方法。

8. 发明申请

WO2006078880A2 INDUCIBLE SIRNA EXPRESSION CASSETTE AND METHOD OF USE 审中-公开
标题翻译：可诱导的SIRNA表达盒及其使用方法
公开(公告)号：WO2006078880A2
公开(公告)日：2006-07-27
申请号：PCT/US2006/001997
申请日：2006-01-18
申请人： IMMUSOL INCORPORATED , ZHOU, Demin , CHATTERTON, Jon E. , KE, Ning , ZHANG, Jing , BLIESATH, Joshua , LI, Henry , WONG-STAAL, Flossie
发明人： ZHOU, Demin , CHATTERTON, Jon E. , KE, Ning , ZHANG, Jing , BLIESATH, Joshua , LI, Henry , WONG-STAAL, Flossie
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A01K2267/0331 , C12N15/111 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2320/10 , C12N2320/30 , C12N2320/50 , C12N2330/31 , C12N2740/15043 , C12N2830/006 , C12N2840/203
摘要： An inducible siRNA expression polynucleotide and methods for its use are provided. The expression polynucleotide comprises a bicistronic expression cassette that encodes a repressor and a detectable marker, wherein the repressor controls expression of siRNA expression in the absence of an inducer.
摘要翻译：提供了诱导型siRNA表达多核苷酸及其使用方法。表达多核苷酸包含编码阻遏物和可检测标记的双顺反子表达盒，其中阻遏物在不存在诱导物的情况下控制siRNA表达的表达。

9. 发明申请

WO2006078754A1 NOVEL QUINOLINIUM SALTS AND DERIVATIVES 审中-公开
标题翻译：新贵金属盐和衍生物
公开(公告)号：WO2006078754A1
公开(公告)日：2006-07-27
申请号：PCT/US2006/001793
申请日：2006-01-18
申请人： IMMUSOL INCORPORATED , MACDONALD, James, E. , HYSELL, Michelle, K. , YU, Dehua , LI, Henry , WONG-STAAL, Flossie
发明人： MACDONALD, James, E. , HYSELL, Michelle, K. , YU, Dehua , LI, Henry , WONG-STAAL, Flossie
IPC分类号： A61K31/45 , C07D271/02
CPC分类号： C07D215/02 , C07D215/38 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D413/06
摘要： The present invention relates generally to the synthesis of novel quinolinium salts and derivative compounds. Such salts and compounds are useful for inhibiting the growth of cancer cells.
摘要翻译：本发明一般涉及新型喹啉盐及其衍生物的合成。这些盐和化合物可用于抑制癌细胞的生长。

10. 发明申请

WO2005017112A2 METHODS OF INHIBITING CANCER GROWTH BY BINDING TO NUCLEAR RECEPTORS 审中-公开
标题翻译：通过与核受体结合抑制癌症生长的方法
公开(公告)号：WO2005017112A2
公开(公告)日：2005-02-24
申请号：PCT/US2004023821
申请日：2004-07-23
申请人： IMMUSOL INC , LI HENRY , KE NING , GRIFMAN MIRTA , CLAASSEN GISELA , HU XIUYUAN , DEFIFE KRISTIN , HABITA CELLIA , FAN WUFANG , RHOADES KRISTINA , TAN PHILIP , WONG-STAAL FLOSSIE
发明人： LI HENRY , KE NING , GRIFMAN MIRTA , CLAASSEN GISELA , HU XIUYUAN , DEFIFE KRISTIN , HABITA CELLIA , FAN WUFANG , RHOADES KRISTINA , TAN PHILIP , WONG-STAAL FLOSSIE
IPC分类号： C12N20060101 , C12N15/113 , G01N33/50 , C12N
CPC分类号： G01N33/5011 , C12N15/1138 , C12N2310/121 , C12N2310/14 , G01N2510/00
摘要： The present invention provides methods for identifying agents useful for inhibiting cancer cells by binding to various nuclear receptor proteins, or to the genes or RNA encoding such proteins.
摘要翻译：本发明提供了通过结合各种核受体蛋白质或编码这些蛋白质的基因或RNA鉴定可用于抑制癌细胞的药剂的方法。

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