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1. 发明申请

WO2002081730A2 TRAC1: MODULATORS OF LYMPHOCYTE ACTIVATION 审中-公开
标题翻译： TRAC1：淋巴细胞激活的调节剂
公开(公告)号：WO2002081730A2
公开(公告)日：2002-10-17
申请号：PCT/US2002/011205
申请日：2002-04-08
申请人： RIGEL PHARMACEUTICALS, INC. , CHU, Peter , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , PARDO, Jorge , ZHAO, Haoran
发明人： CHU, Peter , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , PARDO, Jorge , ZHAO, Haoran
IPC分类号： C12Q
CPC分类号： G01N33/573 , C07K14/4702 , G01N33/505 , G01N2333/9015 , G01N2500/04
摘要： The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding TRAC1, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, RNAi, and ribozymes, that modulate lymphocyte activation via modulation of TRAC1; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.
摘要翻译：本发明涉及淋巴细胞活化的调节。更具体地，本发明涉及编码TRAC1的核酸，其涉及淋巴细胞活化的调节。本发明还涉及用于鉴定和使用通过调节TRAC1来调节淋巴细胞活化的试剂，包括小有机分子，肽，环状肽，抗体，脂质，反义核酸，RNAi和核酶的试剂; 以及在与淋巴细胞活化和抑制相关的诊断和治疗中使用表达谱和组合物。

2. 发明申请

WO02081730A3 TRAC1: MODULATORS OF LYMPHOCYTE ACTIVATION 审中-公开
标题翻译： TRAC1：淋巴细胞激活的调节剂
公开(公告)号：WO02081730A3
公开(公告)日：2003-02-06
申请号：PCT/US0211205
申请日：2002-04-08
申请人： RIGEL PHARMACEUTICALS INC , CHU PETER , LI CONGFEN , LIAO X CHARLENE , MASUDA ESTEBAN , PARDO JORGE , ZHAO HAORAN
发明人： CHU PETER , LI CONGFEN , LIAO X CHARLENE , MASUDA ESTEBAN , PARDO JORGE , ZHAO HAORAN
IPC分类号： C07K14/47 , C12Q1/68 , G01N33/50 , G01N33/573 , C07K1/00 , G01N33/53
CPC分类号： G01N33/573 , C07K14/4702 , G01N33/505 , G01N2333/9015 , G01N2500/04
摘要： The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding TRAC1, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, RNAi, and ribozymes, that modulate lymphocyte activation via modulation of TRAC1; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.
摘要翻译：本发明涉及淋巴细胞活化的调节。更具体地，本发明涉及编码TRAC1的核酸，其涉及淋巴细胞活化的调节。本发明还涉及用于鉴定和使用通过调节TRAC1来调节淋巴细胞活化的试剂，包括小有机分子，肽，环状肽，抗体，脂质，反义核酸，RNAi和核酶的试剂; 以及在与淋巴细胞活化和抑制相关的诊断和治疗中使用表达谱和组合物。

3. 发明申请

WO2002085290A2 EDG : MODULATORS OF LYMPHOCYTE ACTIVATION AND MIGRATION 审中-公开
标题翻译： EDG：淋巴细胞活化和迁移的调节剂
公开(公告)号：WO2002085290A2
公开(公告)日：2002-10-31
申请号：PCT/US2002/012342
申请日：2002-04-18
申请人： RIGEL PHARMACEUTICALS, INC. , CHU, Peter , JIANG, Yingping , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , PARDO, Jorge , SPENCER, Colin , ZHAO, Haoran
发明人： CHU, Peter , JIANG, Yingping , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , PARDO, Jorge , SPENCER, Colin , ZHAO, Haoran
IPC分类号： A61K
CPC分类号： C07K14/705 , G01N33/56972 , G01N2333/4703 , G01N2500/10
摘要： The present invention relates to regulation of lymphocyte activa tion and migration. More particularly, the present invention is directed to nucleic acids encoding EDG family GPCR proteins, e.g., EDG-1, 2, 3, 4, 5, 6, 7, or 8, which are involved in modulation of lymphocyte activation and migration. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate lymphocyte activation or migration via modulation of EDG GPCRs and EDG related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.
摘要翻译：本发明涉及淋巴细胞活化和迁移的调节。更具体地，本发明涉及编码EDG家族GPCR蛋白质的核酸，例如涉及淋巴细胞活化和迁移调节的EDG-1,2,3,4,5,6,7或8。本发明还涉及用于鉴定和使用通过调节EDG GPCR和EDG来调节淋巴细胞活化或迁移的包括小有机分子，抗体，肽，环肽，核酸，反义核酸，鞘脂类似物和核酶的试剂的方法相关信号转导; 以及在与淋巴细胞活化和抑制以及淋巴细胞迁移相关的诊断和治疗中使用表达谱和组合物。

4. 发明申请

WO2003029280A3 GRB7: NOVEL REGULATOR OF LYMPHOCYTE SIGNALING 审中-公开
公开(公告)号：WO2003029280A3
公开(公告)日：2003-04-10
申请号：PCT/US2002/031622
申请日：2002-10-02
申请人： RIGEL PHARMACEUTICALS, INC. , PARDO, Jorge , CHU, Peter , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , ZHAO, Haoran
发明人： PARDO, Jorge , CHU, Peter , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , ZHAO, Haoran
IPC分类号： C12Q1/68
摘要： The present invention relates to regulation of T lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding GRB7, which is involved in modulation of T lymphocyte activation and TCR signaling. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, RNAi, and ribozymes, that modulate lymphocyte activation and TCR signaling via modulation of GRB7; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.

5. 发明申请

WO2003029277A2 MODULATORS OF LYMPHOCYTE ACTIVATION AND MIGRATION 审中-公开
标题翻译：淋巴细胞活化和迁移的调节剂
公开(公告)号：WO2003029277A2
公开(公告)日：2003-04-10
申请号：PCT/US2002/031618
申请日：2002-10-02
申请人： RIGEL PHARMACEUTICALS, INC. , CHU, Peter , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , PARDO, Jorge , ZHAO, Haoran
发明人： CHU, Peter , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , PARDO, Jorge , ZHAO, Haoran
IPC分类号： C07K
CPC分类号： G01N33/505 , G01N2500/00
摘要： The present invention relates to regulation of lymphocyte activation and migration. More particularly, the present invention is directed to nucleic acids encoding the nucleic acids and proteins listed in Figure 7, which are involved in modulation of lymphocyte activation and migration, e.g., A-raf-1, Lck, Zap70, Syk, PLCγ1, PAG, SHP/PTP1C, CSK, nucleolin, SLAP, PAK2, TRAC1, TCPTP/PTPN2, EDG1, IL10-Rα, integrinα2, Enolase 1a, PRSM1, CLN2, P2X5b, 6PFKL, DUSP1, KIAA0251, GG2-1, GRB7, SH2-B, STAT1, TCF19, HFP101S, RERE, SudD, Ku70, SCAMP2, Fibulin-5, KIAA1228, Est from clone 2108068, vimentin, filamin A α, centractin α, moesin, TIMP3, and RNH. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, siRNA, and ribozymes, that modulate lymphocyte activation or migration; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.
摘要翻译：本发明涉及淋巴细胞活化和迁移的调控。更具体地，本发明涉及编码图7所列核酸和蛋白质的核酸，其涉及淋巴细胞活化和迁移的调节，例如A-raf-1，Lck，Zap70，Syk，PLCγ1 ，PAG，SHP / PTP1C，CSK，核仁素，SLAP，PAK2，TRAC1，TCPTP / PTPN2，EDG1，IL10-Rα，整合素α2，烯醇化酶1a，PRSM1，CLN2，P2X5b，6PFKL，DUSP1，KIAA0251，GG2-1 ，GRB7，SH2-B，STAT1，TCF19，HFP101S，RERE，SudD，Ku70，SCAMP2，Fibulin-5，KIAA1228，来自克隆2108068的Est，波形蛋白，丝氨酸Aα，中心素α，moesin，TIMP3和RNH。本发明还涉及用于鉴定和使用调节淋巴细胞活化或迁移的试剂（包括小有机分子，抗体，肽，环肽，核酸，反义核酸，siRNA和核酶）的方法; 以及在与淋巴细胞活化和抑制以及淋巴细胞迁移相关的诊断和治疗中使用表达谱和组合物。

6. 发明申请

WO02078610A3 PAK2: MODULATORS OF LYMPHOCYTE ACTIVATION 审中-公开
标题翻译： PAK2：淋巴细胞激活的调节剂
公开(公告)号：WO02078610A3
公开(公告)日：2003-06-26
申请号：PCT/US0210257
申请日：2002-04-01
申请人： RIGEL PHARMACEUTICALS INC , LIAO X CHARLENE , CHU PETER , PARDO JORGE , LI CONGFEN , ZHAO HAORAN , WU JUN
发明人： LIAO X CHARLENE , CHU PETER , PARDO JORGE , LI CONGFEN , ZHAO HAORAN , WU JUN
IPC分类号： C12N9/12 , C12Q1/68 , G01N33/569 , C12N9/00 , C07H21/04 , C12N5/00
CPC分类号： C12N9/1205 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/56972
摘要： The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding PAK2, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, RNAi, and ribozymes, that modulate lymphocyte activation via modulation of PAK2; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.
摘要翻译：本发明涉及淋巴细胞活化的调节。更具体地，本发明涉及编码PAK2的核酸，其涉及淋巴细胞活化的调节。本发明还涉及用于鉴定和使用通过调节PAK2调节淋巴细胞活化的试剂，包括小有机分子，肽，环肽，抗体，脂质，反义核酸，RNAi和核酶的试剂; 以及在与淋巴细胞活化和抑制相关的诊断和治疗中使用表达谱和组合物。

7. 发明申请

WO2003029278A3 IL10-R: MODULATORS OF LYMPHOCYTE ACTIVATION 审中-公开
公开(公告)号：WO2003029278A3
公开(公告)日：2003-04-10
申请号：PCT/US2002/031619
申请日：2002-10-02
申请人： RIGEL PHARMACEUTICALS, INC. , PARDO, Jorge , CHU, Peter , LI, Congfen , LIAO, Charlene, x.
发明人： PARDO, Jorge , CHU, Peter , LI, Congfen , LIAO, Charlene, x.
IPC分类号： C12N15/12
摘要： The present invention relates to regulation of T cell activation. More particularly, the present invention is directed to nucleic acids encoding IL10-R, e.g., IL10-Rα. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, antisense nucleic acids, RNAi and ribozymes, that modulate T cell activation via modulation of IL10-R and IL10-R -related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to autoimmune disease and tissue and organ transplant.

8. 发明申请

WO2003029278A2 IL10-R: MODULATORS OF LYMPHOCYTE ACTIVATION 审中-公开
标题翻译： IL10-R：淋巴细胞激活的调节剂
公开(公告)号：WO2003029278A2
公开(公告)日：2003-04-10
申请号：PCT/US2002/031619
申请日：2002-10-02
申请人： RIGEL PHARMACEUTICALS, INC. , PARDO, Jorge , CHU, Peter , LI, Congfen , LIAO, Charlene, x.
发明人： PARDO, Jorge , CHU, Peter , LI, Congfen , LIAO, Charlene, x.
IPC分类号： C07K
CPC分类号： G01N33/564 , G01N33/505 , G01N2333/715 , G01N2500/10
摘要： The present invention relates to regulation of T cell activation. More particularly, the present invention is directed to nucleic acids encoding IL10-R, e.g., IL10-Rα. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, antisense nucleic acids, RNAi and ribozymes, that modulate T cell activation via modulation of IL10-R and IL10-R -related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to autoimmune disease and tissue and organ transplant.
摘要翻译：本发明涉及T细胞活化的调控。更具体地，本发明涉及编码IL10-R的核酸，例如IL10-Rα。本发明还涉及用于鉴定和使用包括小有机分子，抗体，肽，环肽，反义核酸，RNAi和核酶的试剂的方法，其通过调节IL10-R和IL10-R相关信号调节T细胞活化转; 以及在与自身免疫疾病和组织和器官移植相关的诊断和治疗中使用表达谱和组合物。

9. 发明申请

WO2002101070A3 ALPHA 2 INTEGRIN: MODULATORS OF LYMPHOCYTE ACTIVATION 审中-公开
公开(公告)号：WO2002101070A3
公开(公告)日：2002-12-19
申请号：PCT/US2002/017417
申请日：2002-05-31
申请人： RIGEL PHARMACEUTICALS, INC. , CHU, Peter , LI, Congfen , LIAO, X., Charlene , PARDO, Jorge
发明人： CHU, Peter , LI, Congfen , LIAO, X., Charlene , PARDO, Jorge
IPC分类号： G01N33/53
摘要： The present invention relates to regulation of T cell activation. More particularly, the present invention is directed to nucleic acids encoding alpha 2 integrin. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, siRNA, antisense nucleic acids, and ribozymes, that modulate T cell activation via modulation of alpha 2 integrin and alpha 2 integrin -related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to autoimmune disease and tissue and organ transplant.

10. 发明申请

WO2003029280A2 GRB7: NOVEL REGULATOR OF LYMPHOCYTE SIGNALING 审中-公开
标题翻译： GRB7：LYMPHOCYTE信号的新型调节剂
公开(公告)号：WO2003029280A2
公开(公告)日：2003-04-10
申请号：PCT/US2002/031622
申请日：2002-10-02
申请人： RIGEL PHARMACEUTICALS, INC. , PARDO, Jorge , CHU, Peter , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , ZHAO, Haoran
发明人： PARDO, Jorge , CHU, Peter , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , ZHAO, Haoran
IPC分类号： C07K
CPC分类号： C07K14/4713 , G01N33/505 , G01N2333/4706 , G01N2500/10
摘要： The present invention relates to regulation of T lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding GRB7, which is involved in modulation of T lymphocyte activation and TCR signaling. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, RNAi, and ribozymes, that modulate lymphocyte activation and TCR signaling via modulation of GRB7; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.
摘要翻译：本发明涉及T淋巴细胞活化的调控。更具体地，本发明涉及编码GRB7的核酸，其涉及T淋巴细胞活化和TCR信号传导的调节。本发明还涉及用于鉴定和使用通过调节GRB7来调节淋巴细胞活化和TCR信号的试剂，包括小有机分子，肽，环状肽，抗体，脂质，反义核酸，RNAi和核酶的方法; 以及在与淋巴细胞活化和抑制相关的诊断和治疗中使用表达谱和组合物。

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