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1. 发明申请

WO2012158798A3 HOT BEVERAGE MAKER 审中-公开
标题翻译：热饮料制造商
公开(公告)号：WO2012158798A3
公开(公告)日：2013-03-21
申请号：PCT/US2012038138
申请日：2012-05-16
申请人： SUNBEAM PRODUCTS INC , HO WILLIAM , LEUNG DENNIS
发明人： HO WILLIAM , LEUNG DENNIS
IPC分类号： A47J31/40 , A47J31/44 , A47J31/54
CPC分类号： A47J31/4496 , A47J31/0605 , A47J31/4403
摘要： A hot beverage maker is provided for making latte by frothing milk in a carafe before and/or while brewing coffee and directing the brewed coffee into the carafe for mixing with the frothed milk. An agitating element, extends downwardly from a frothing motor attached to the cover of a carafe into the carafe for frothing milk while coffee is being brewed in a brew head of the beverage maker. Brewed coffee is directed into the milk as it is being frothed and is mixed with the milk by the frothing elements to make latte. A lever assembly is selectively movable between an "On" and "Off" position. In the "On" position, terminal pins are moved into contact with terminal plates on the carafe cover to provide electricity to the frothing motor. In the 'Off position, the terminal pins are moved away from contact with the terminal plates.
摘要翻译：提供一种热饮料制造商，用于通过在咖啡中发泡牛奶和/或在冲煮咖啡并将煮制的咖啡引入到玻璃瓶中以与发泡的牛奶混合时制成拿铁咖啡。一个搅拌元件，从附着在玻璃瓶盖上的发泡马达向下延伸到咖啡壶中，以便在饮料制造商的酿造头中冲泡咖啡。煮沸的咖啡被引导到牛奶中，因为它被发泡，并且通过起泡元件与牛奶混合以制作拿铁咖啡。杠杆组件可选择性地在“开”和“关”位置之间移动。在“开”位置，端子销移动与盖玻璃盖上的端子板接触，为发泡马达提供电力。在“关闭”位置，端子针脚与端子板接触。

2. 发明申请

WO2012158798A2 HOT BEVERAGE MAKER 审中-公开
标题翻译：热饮料制造商
公开(公告)号：WO2012158798A2
公开(公告)日：2012-11-22
申请号：PCT/US2012/038138
申请日：2012-05-16
申请人： SUNBEAM PRODUCTS, INC. , HO, William , LEUNG, Dennis
发明人： HO, William , LEUNG, Dennis
CPC分类号： A47J31/4496 , A47J31/0605 , A47J31/4403
摘要： A hot beverage maker is provided for making latte by frothing milk in a carafe before and/or while brewing coffee and directing the brewed coffee into the carafe for mixing with the frothed milk. An agitating element, extends downwardly from a frothing motor attached to the cover of a carafe into the carafe for frothing milk while coffee is being brewed in a brew head of the beverage maker. Brewed coffee is directed into the milk as it is being frothed and is mixed with the milk by the frothing elements to make latte. A lever assembly is selectively movable between an "On" and "Off" position. In the "On" position, terminal pins are moved into contact with terminal plates on the carafe cover to provide electricity to the frothing motor. In the 'Off position, the terminal pins are moved away from contact with the terminal plates.
摘要翻译：提供一种热饮料制造商，用于通过在咖啡中发泡牛奶和/或在冲煮咖啡并将煮制的咖啡引入到玻璃瓶中以与发泡的牛奶混合时制成拿铁咖啡。一个搅拌元件，从附着在玻璃瓶盖上的发泡马达向下延伸到咖啡壶中，以便在饮料制造商的酿造头中冲泡咖啡。煮沸的咖啡被引导到牛奶中，因为它被发泡，并且通过起泡元件与牛奶混合以制作拿铁咖啡。杠杆组件可选择性地在“开”和“关”位置之间移动。在“开”位置，端子销移动与盖玻璃盖上的端子板接触，为发泡马达提供电力。在“关闭”位置，端子针脚与端子板接触。

3. 发明申请

WO2013066735A1 NANO-SUSPENSION PROCESS 审中-公开
标题翻译：纳米悬浮过程
公开(公告)号：WO2013066735A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/062026
申请日：2012-10-26
申请人： MERCK SHARP & DOHME CORP. , LEUNG, Dennis , NELSON, Todd, D. , RHODES, Timothy, A. , KWONG, Elizabeth
发明人： LEUNG, Dennis , NELSON, Todd, D. , RHODES, Timothy, A. , KWONG, Elizabeth
IPC分类号： A61K9/00
CPC分类号： B02C19/18 , A61K9/10 , A61K9/145 , A61K9/1688 , A61K31/192 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/38
摘要： Described herein is a process for preparing nano-suspensions, wherein the process comprises: providing an admixture of at least one active pharmaceutical compound, an aqueous dispersion medium, and milling media and applying thereto acoustic energy having a frequency of from about 10 hertz to 1000 hertz and which supplies a linear acceleration of from about 10 G's to about 100 G's (where "G" is the force of gravity) for a period sufficient to supply a nano-suspension having a D 50 of less than about 1 micron, preferably less than about 500 nm. Described also are nano-suspensions having novel properties prepared via the inventive process.
摘要翻译：本文描述的是制备纳米悬浮液的方法，其中所述方法包括：提供至少一种活性药物化合物，水性分散介质和研磨介质的混合物，并向其施加具有约10赫兹至1000的频率的声能并且其提供从约10G至约100G的线性加速度（其中“G”是重力））足以提供具有小于约1微米，优选小于约1微米的D50的纳米悬浮液约500nm。还描述了通过本发明方法制备的具有新特性的纳米悬浮液。

4. 发明申请

WO2019040346A1 METHODS FOR PREPARING STABILIZED AMORPHOUS DRUG FORMULATIONS USING ACOUSTIC FUSION 审中-公开
公开(公告)号：WO2019040346A1
公开(公告)日：2019-02-28
申请号：PCT/US2018/047015
申请日：2018-08-20
申请人： MERCK SHARP & DOHME CORP. , LEUNG, Dennis, H. , GUO, Zhiqiang , BOYCE, Christopher, W.
发明人： LEUNG, Dennis, H. , GUO, Zhiqiang , BOYCE, Christopher, W.
IPC分类号： A61K9/14 , A61K9/16
CPC分类号： A61K9/146 , A61K9/0095 , A61K9/10 , A61K9/145 , A61K9/2004 , A61K9/48 , A61K47/10 , A61K47/38
摘要： The present invention relates to methods for producing a stable amorphous dispersion of a pharmaceutically active substance having poor water solubility by applying low frequency acoustic energy to a mixture comprising the active substance and at least one polymer and heating the mixture until a stable amorphous dispersion is formed. The methods of the invention are an effective means of converting a crystalline API to a substantially amorphous and stable form, i.e., wherein the crystallinity is less than about 5%. The methods of the invention result in more complete amorphization, increased solubility, drug loading and stability as compared to typical amorphization or literature methods.

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