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1. 发明申请

WO2012044655A3 COLOR-CHANGING EMULSIONS FOR FREEZE INDICATORS 审中-公开
标题翻译：变色乳剂冻结指标
公开(公告)号：WO2012044655A3
公开(公告)日：2012-05-18
申请号：PCT/US2011053607
申请日：2011-09-28
申请人： TEMPTIME CORP , TAYLOR DENE H , LENTZ CARL M , SMITH DAWN E
发明人： TAYLOR DENE H , LENTZ CARL M , SMITH DAWN E
IPC分类号： G01K11/06
CPC分类号： G01K11/12 , G01K3/04 , G01K11/06
摘要： A color-changing emulsion for use in a freeze indicator can employ a dispersion medium, for example, an aqueous liquid, a first reactant phase and a second reactant phase, which two reactant phases can both be dispersed in the dispersion medium. The first reactant phase includes a hydrophobic liquid and a first reactant, for example, a color precursor such as a leuco dye. The second reactant phase can include a hydrophobic liquid, and includes, or can be, a second reactant, for example, a color developer such as a leuco dye developer. The first and second reactant phases can be essentially unmixed, and can be co-reactable to provide a color change. In response to a freezing temperature, the color-changing emulsion can coagulate and change color irreversibly. An intense color change can be obtained by using, for example, a suitable leuco dye precursor and developer.
摘要翻译：用于冷冻指示器的变色乳剂可以使用分散介质，例如水性液体，第一反应物相和第二反应物相，其中两种反应物相都可以分散在分散介质中。第一反应物相包括疏水性液体和第一反应物，例如颜色前体，例如无色染料。第二反应物相可以包括疏水液体，并且包括或可以是第二反应物，例如，诸如无色染料显影剂的彩色显影剂。第一和第二反应物相可以基本上不混合，并且可以共反应以提供颜色变化。响应于冷冻温度，变色乳剂可以凝结并不可逆地改变颜色。通过使用例如合适的无色染料前体和显影剂可以获得强烈的颜色变化。

2. 发明申请

WO2011026020A2 FREEZE INDICATORS WITH A CONTROLLED TEMPERATURE RESPONSE 审中-公开
标题翻译：具有受控温度响应的冷冻指示器
公开(公告)号：WO2011026020A2
公开(公告)日：2011-03-03
申请号：PCT/US2010/047121
申请日：2010-08-30
申请人： TEMPTIME CORPORATION , SMITH, Dawn, E. , LENTZ, Carl, M. , TAYLOR, Dene, H. , OSUNGA, Yvonne , HUFFMAN, Brian
发明人： SMITH, Dawn, E. , LENTZ, Carl, M. , TAYLOR, Dene, H. , OSUNGA, Yvonne , HUFFMAN, Brian
IPC分类号： G01K11/12 , G01K11/16 , G01K11/18 , G01K11/08
CPC分类号： G01K11/12 , G01K11/08 , G01K11/16 , G01K11/18
摘要： A freeze indicator can include an indicator dispersion having an aqueous liquid medium and organic material indicator particles dispersed in the aqueous liquid medium. The indicator dispersion can have an initial appearance before freezing and an irreversibly different appearance after freezing and can exhibit a freeze-onset temperature of about -1.9°C or higher. Some factors helpful to providing a relatively high freeze onset temperature are employment of a proteinaceous ice-nucleating agent, control of pH, use of a protein stabilizer and control of the ratio of protein stabilizer to ice-nucleating agent.
摘要翻译：冻结指示剂可以包括具有含水液体介质和分散在含水液体介质中的有机材料指示剂颗粒的指示剂分散体。指示剂分散体在冷冻之前可以具有初始外观并且在冷冻后具有不可逆的不同外观并且可以表现出约-1.9℃或更高的冷冻起始温度。一些有助于提供相对高的冷冻起始温度的因素是蛋白质冰成核剂的使用，pH的控制，蛋白质稳定剂的使用以及蛋白质稳定剂与冰成核剂的比例的控制。

3. 发明申请

WO2010014730A1 FREEZE INDICATORS, COMPONENTS THEREFOR AND PREPARATIVE PROCESSES 审中-公开
标题翻译：冷冻指示剂，组分及其制备方法
公开(公告)号：WO2010014730A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/052130
申请日：2009-07-29
申请人： TEMPTIME CORPORATION , LENTZ, Carl , SMITH, Dawn, E. , TAYLOR, Dene, H.
发明人： LENTZ, Carl , SMITH, Dawn, E. , TAYLOR, Dene, H.
IPC分类号： G01K1/02
CPC分类号： G01K11/06 , G01K3/04 , Y10S252/962
摘要： Freeze indicators can include an indicator dispersion, a liquid medium, indicator particles dispersed in the liquid medium and a particulate inorganic nucleating agent to inhibit supercooling of the liquid medium. The inorganic nucleating agent can have an ionic surface coating which can help provide a sharp end point. Optionally, freeze indicators can include indicator particles comprising an organic material and a softener to soften the indicator particles and provide the freeze indication with an enhanced visual appearance. Another option is to provide a temperature-sensitive stabilizer to inhibit coagulation of the indicator dispersion at temperatures above the liquid medium frozen state melting point while permitting coagulation of the indicator dispersion at the liquid medium frozen state melting point.
摘要翻译：冷冻指示剂可以包括指示剂分散体，液体介质，分散在液体介质中的指示剂颗粒和颗粒状无机成核剂以抑制液体介质的过冷。无机成核剂可以具有可以帮助提供尖锐终点的离子表面涂层。任选地，冷冻指示器可以包括包含有机材料和柔软剂的指示剂颗粒，以软化指示剂颗粒并提供具有增强的视觉外观的冷冻指示。另一个选择是提供温度敏感的稳定剂，以在高于液体介质冷冻状态熔点的温度下抑制指示剂分散体的凝结，同时允许指示剂分散体在液体介质冷冻状态熔点下凝结。

4. 发明申请

WO2013058991A1 COMPUTING SYSTEMS AND METHODS FOR ELECTRONICALLY INDICATING THE ACCEPTABILITY OF A PRODUCT 审中-公开
标题翻译：电子系统和电子显示产品可接受性的方法
公开(公告)号：WO2013058991A1
公开(公告)日：2013-04-25
申请号：PCT/US2012/058699
申请日：2012-10-04
申请人： TEMPTIME CORPORATION , GRABINER, Frederick, Robert , LENTZ, Carl, Michael , MOORE, Emily , PRUSIK, Thaddeus , PURO, Nicholas , OSBORN, Bruce-erik
发明人： GRABINER, Frederick, Robert , LENTZ, Carl, Michael , MOORE, Emily , PRUSIK, Thaddeus , PURO, Nicholas , OSBORN, Bruce-erik
IPC分类号： G06Q99/00
CPC分类号： G16H20/00 , G06F19/00 , G06F19/321 , G06F19/3462 , G06F19/3475 , G06K9/4652 , G06K9/6215 , G06K2009/4666 , G06Q10/0833 , G06Q10/087 , G06Q30/0623 , G06T7/73 , G06T7/90 , G07G1/0054 , G07G1/0081 , G16H10/00 , G16H15/00 , G16H40/20 , G16H40/67
摘要： Computing systems and methods for electronically indicate the acceptability of a product. An image capture and communication device may analyze a product label that includes one or more monitors, authentication elements, and identification elements. The image capture and communication device may determine the type and features of the monitors, authentication elements, and identification elements. The image capture and communication device may transmit data based on the type and features to a host server, which may transmit data associated with the host product to the image capture and communication device in, inter alia, the form of an acceptability report.
摘要翻译：用于电子地指示产品的可接受性的计算系统和方法。图像捕获和通信设备可以分析包括一个或多个监视器，认证元件和识别元件的产品标签。图像捕获和通信设备可以确定监视器，认证元件和识别元件的类型和特征。图像捕获和通信设备可以基于类型和特征将数据发送到主机服务器，主机服务器可以特别地以可接受性报告的形式将与主机产品相关联的数据传送到图像捕获和通信设备。

5. 发明申请

WO2011026020A4 FREEZE INDICATORS WITH A CONTROLLED TEMPERATURE RESPONSE 审中-公开
标题翻译：具有控制温度响应的冻结指示器
公开(公告)号：WO2011026020A4
公开(公告)日：2011-06-16
申请号：PCT/US2010047121
申请日：2010-08-30
申请人： TEMPTIME CORP , SMITH DAWN E , LENTZ CARL M , TAYLOR DENE H , OSUNGA YVONNE , HUFFMAN BRIAN
发明人： SMITH DAWN E , LENTZ CARL M , TAYLOR DENE H , OSUNGA YVONNE , HUFFMAN BRIAN
IPC分类号： G01K11/12 , G01K11/08 , G01K11/16 , G01K11/18
CPC分类号： G01K11/12 , G01K11/08 , G01K11/16 , G01K11/18
摘要： A freeze indicator can include an indicator dispersion having an aqueous liquid medium and organic material indicator particles dispersed in the aqueous liquid medium. The indicator dispersion can have an initial appearance before freezing and an irreversibly different appearance after freezing and can exhibit a freeze-onset temperature of about -1.9°C or higher. Some factors helpful to providing a relatively high freeze onset temperature are employment of a proteinaceous ice-nucleating agent, control of pH, use of a protein stabilizer and control of the ratio of protein stabilizer to ice-nucleating agent.
摘要翻译：冷冻指示剂可以包括具有水性液体介质的指示剂分散体和分散在水性液体介质中的有机材料指示剂颗粒。指示剂分散体在冷冻之前可以具有初始外观，并且在冷冻后具有不可逆的外观，并且可以显示约-1.9℃或更高的冷冻起始温度。有助于提供相对高的冷冻起始温度的一些因素是使用蛋白质冰成核剂，控制pH，使用蛋白质稳定剂和控制蛋白质稳定剂与冰核成核剂的比例。

6. 发明申请

WO2012044655A4 COLOR-CHANGING EMULSIONS FOR FREEZE INDICATORS 审中-公开
公开(公告)号：WO2012044655A4
公开(公告)日：2012-07-05
申请号：PCT/US2011053607
申请日：2011-09-28
申请人： TEMPTIME CORP , TAYLOR DENE H , LENTZ CARL M , SMITH DAWN E
发明人： TAYLOR DENE H , LENTZ CARL M , SMITH DAWN E
IPC分类号： G01K11/06
CPC分类号： G01K11/12 , G01K3/04 , G01K11/06
摘要： A color-changing emulsion for use in a freeze indicator can employ a dispersion medium, for example, an aqueous liquid, a first reactant phase and a second reactant phase, which two reactant phases can both be dispersed in the dispersion medium. The first reactant phase includes a hydrophobic liquid and a first reactant, for example, a color precursor such as a leuco dye. The second reactant phase can include a hydrophobic liquid, and includes, or can be, a second reactant, for example, a color developer such as a leuco dye developer. The first and second reactant phases can be essentially unmixed, and can be co-reactable to provide a color change. In response to a freezing temperature, the color-changing emulsion can coagulate and change color irreversibly. An intense color change can be obtained by using, for example, a suitable leuco dye precursor and developer.

7. 发明申请

WO2012050824A1 TEMPERATURE-ACTIVATABLE TIME-TEMPERATURE INDICATOR 审中-公开
标题翻译：温度可激活时间温度指示器
公开(公告)号：WO2012050824A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/053416
申请日：2011-09-27
申请人： TEMPTIME CORPORATION , HUFFMAN, Brian, S. , SMITH, Dawn, E. , LENTZ, Carl, M.
发明人： HUFFMAN, Brian, S. , SMITH, Dawn, E. , LENTZ, Carl, M.
IPC分类号： G01K1/00
CPC分类号： G01K1/02 , G01K3/04 , G01K11/06
摘要： A temperature-activatable time-temperature indicator that can be used to monitor the historical exposure of a host product to ambient temperatures includes an optically readable, thermally sensitive indicator element. The indicator element can be inactive below a base temperature and is intrinsically thermally responsive at or above an activation temperature which is equal to or greater than the base temperature. The indicator can record cumulative ambient temperature exposure above the activation temperature irreversibly with respect to time. The indicator element can include a synthetic polymeric material, and optionally, a dye. A side-chain crystallizable polymer such as poly(hexadecylmethacrylate), that is solid below the base temperature and is a viscous liquid above the activation temperature can be employed. Intense indicator element colors can be obtained using an appropriate dye or dyes. Various structural configurations of indicator are described and illustrated.
摘要翻译：可用于监测主体产品对环境温度的历史曝光的温度可激活的时间温度指示器包括光学可读的热敏指示元件。指示元件可以在基础温度以下是无效的，并且在等于或大于基础温度的活化温度或更高的本征热响应。该指示器可以相对于时间不可逆地记录高于激活温度的累积环境温度暴露。指示剂元件可以包括合成聚合物材料和任选的染料。可以使用侧链可结晶聚合物如聚（十六烷基甲基丙烯酸酯），其低于基础温度下的固体，并且是高于活化温度的粘性液体。可以使用适当的染料或染料获得强烈的指示剂元素颜色。指示器的各种结构构造被描述和示出。

8. 发明申请

WO2012044655A2 COLOR-CHANGING EMULSIONS FOR FREEZE INDICATORS 审中-公开
标题翻译：冷冻指示剂的颜色变化乳液
公开(公告)号：WO2012044655A2
公开(公告)日：2012-04-05
申请号：PCT/US2011/053607
申请日：2011-09-28
申请人： TEMPTIME CORPORATION , TAYLOR, Dene, H. , LENTZ, Carl, M. , SMITH, Dawn, E.
发明人： TAYLOR, Dene, H. , LENTZ, Carl, M. , SMITH, Dawn, E.
IPC分类号： G01D21/00 , G01N21/75
CPC分类号： G01K11/12 , G01K3/04 , G01K11/06
摘要： A color-changing emulsion for use in a freeze indicator can employ a dispersion medium, for example, an aqueous liquid, a first reactant phase and a second reactant phase, which two reactant phases can both be dispersed in the dispersion medium. The first reactant phase includes a hydrophobic liquid and a first reactant, for example, a color precursor such as a leuco dye. The second reactant phase can include a hydrophobic liquid, and includes, or can be, a second reactant, for example, a color developer such as a leuco dye developer. The first and second reactant phases can be essentially unmixed, and can be co-reactable to provide a color change. In response to a freezing temperature, the color-changing emulsion can coagulate and change color irreversibly. An intense color change can be obtained by using, for example, a suitable leuco dye precursor and developer.
摘要翻译：用于冷冻指示剂的变色乳液可以使用分散介质，例如水性液体，第一反应物相和第二反应物相，其中两个反应物相都可以分散在分散介质中。第一反应物相包括疏水性液体和第一反应物，例如着色前体如无色染料。第二反应物相可以包括疏水性液体，并且包括或可以是第二反应物，例如彩色显影剂，例如无色染料显影剂。第一和第二反应物相可以基本上不混合，并且可以共同反应以提供颜色变化。响应于冷冻温度，变色乳液可以凝固并且不可逆地改变颜色。通过使用例如合适的无色染料前体和显影剂可以获得强烈的颜色变化。

9. 发明申请

WO2011026020A3 FREEZE INDICATORS WITH A CONTROLLED TEMPERATURE RESPONSE 审中-公开
标题翻译：具有受控温度响应的冷冻指示器
公开(公告)号：WO2011026020A3
公开(公告)日：2011-04-21
申请号：PCT/US2010047121
申请日：2010-08-30
申请人： TEMPTIME CORP , SMITH DAWN E , LENTZ CARL M , TAYLOR DENE H , OSUNGA YVONNE , HUFFMAN BRIAN
发明人： SMITH DAWN E , LENTZ CARL M , TAYLOR DENE H , OSUNGA YVONNE , HUFFMAN BRIAN
IPC分类号： G01K11/12 , G01K11/08 , G01K11/16 , G01K11/18
CPC分类号： G01K11/12 , G01K11/08 , G01K11/16 , G01K11/18
摘要： A freeze indicator can include an indicator dispersion having an aqueous liquid medium and organic material indicator particles dispersed in the aqueous liquid medium. The indicator dispersion can have an initial appearance before freezing and an irreversibly different appearance after freezing and can exhibit a freeze-onset temperature of about -1.9°C or higher. Some factors helpful to providing a relatively high freeze onset temperature are employment of a proteinaceous ice-nucleating agent, control of pH, use of a protein stabilizer and control of the ratio of protein stabilizer to ice-nucleating agent.
摘要翻译：冷冻指示器可以包括具有水性液体介质和分散在水性液体介质中的有机材料指示剂颗粒的指示剂分散体。指示剂分散体在冷冻之前可以具有初始外观并且在冷冻后具有不可逆的不同外观，并且可以表现出约-1.9℃或更高的冷冻起始温度。一些有助于提供相对高的冷冻起始温度的因素是使用蛋白质冰成核剂，控制pH值，使用蛋白质稳定剂和控制蛋白质稳定剂与冰成核剂的比例。

10. 发明申请

WO2013002748A1 COMPUTING SYSTEMS AND METHODS FOR ELECTRONICALLY INDICATING THE ACCEPTABILITY OF A PRODUCT 审中-公开
标题翻译：电子系统和电子显示产品可接受性的方法
公开(公告)号：WO2013002748A1
公开(公告)日：2013-01-03
申请号：PCT/US2011/001158
申请日：2011-06-28
申请人： TEMPTIME CORPORATION , GRABINER, Fred , LENTZ, Carl M. , MOORE, Emily , PRUSIK, Thaddeus , PURO, Nicholas
发明人： GRABINER, Fred , LENTZ, Carl M. , MOORE, Emily , PRUSIK, Thaddeus , PURO, Nicholas
IPC分类号： G08B1/00
CPC分类号： G06Q10/0838 , G06Q10/0833 , G06Q50/28
摘要： Computing systems and methods for electronically indicating the acceptability of a product. An image capture and communication device may analyze a product label that includes one or more monitors, authentication elements, and identification elements. The image capture and communication device may determine the type and features of the monitors, authentication elements, and identification elements and, based on the type of the monitors, authentication elements, and identification elements. The image capture and communication device may transmit data based on the type and features to a host server, which may transmit data associated with the host product to the image capture and communication device in, inter alia , the form of an acceptability report.
摘要翻译：用于电子指示产品可接受性的计算系统和方法。图像捕获和通信设备可以分析包括一个或多个监视器，认证元件和识别元件的产品标签。图像捕获和通信设备可以基于监视器的类型，认证元件和识别元件来确定监视器，认证元件和识别元件的类型和特征。图像捕获和通信设备可以基于类型和特征将数据发送到主机服务器，主机服务器可以特别地以可接受性报告的形式将与主机产品相关联的数据传送到图像捕获和通信设备。

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