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1. 发明申请

WO2006136391A2 METHOD OF TREATING A SOLID TUMOR DISEASE COMPRISING ADMINISTERING A COMBINATION COMPRISING IMATINIB AND AN INHIBITOR OF AN EFFLUX PUMP ACTIVE AT THE BLOOD BRAIN BARRIER OR DEMETHYL IMATINIB 审中-公开
标题翻译：治疗包括包含IMATINIB的组合和在血脑屏障或DEMETHYL IMATINIB上活化的血液泵的抑制剂的固体肿瘤疾病的方法
公开(公告)号：WO2006136391A2
公开(公告)日：2006-12-28
申请号：PCT/EP2006005960
申请日：2006-06-21
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , BIHOREL SEBASTIEN , GROSS GERHARD , LEMAIRE MICHEL , CAMENISCH GIAN P
发明人： BIHOREL SEBASTIEN , GROSS GERHARD , LEMAIRE MICHEL , CAMENISCH GIAN P
IPC分类号： F16H7/20 , F16C1/00
CPC分类号： A61K45/06 , A61K31/506 , A61K2300/00
摘要： The invention relates to a method of treating a warm-blooded animal having a solid tumor disease comprising administering a combination which comprises: a) a N-phenyl-2- pyrimidine-amine derivative, especially N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]- 2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine, b) at least one compound inhibiting the efflux pump active at the blood brain barrier selected from MDR1 and MRP2, c) optionally an antineoplastic agent, especially as defined herein, d) optionally an alkylating agent and e) optionally, hydroxyurea; to the use of such a combination for the preparation of a medicament for the treatment of a solid tumor disease; and to a commercial package or product comprising such a combination together with instructions for the treatment of a solid tumor disease. In a further aspect, the present invention pertains to a combination which comprises: a) optionally a N-phenyl-2-pyrimidine-amine derivative, especially N-{5-[4-(4- methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine (STI571 ), b) N-{5-[4-(piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2- pyrimidine-amine (CGP74588), c) optionally an antineoplastic agent, d) optionally an alkylating agent and e) optionally, hydroxyurea; to the use of such a combination for the preparation of a medicament for the treatment of a solid tumor disease; and to a commercial package or product comprising such a combination together with instructions for the treatment of a solid tumor disease.
摘要翻译：本发明涉及一种治疗具有实体肿瘤疾病的温血动物的方法，包括施用组合，其包含：a）N-苯基-2-嘧啶胺衍生物，特别是N- {5- [4-（4 - 甲基 - 哌嗪子基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺，b）至少一种抑制血液屏障的外排泵活性的化合物，其选自MDR1和 MRP2，c）任选的抗肿瘤剂，特别是如本文定义的d）任选的烷化剂和e）任选的羟基脲; 涉及使用这种组合来制备用于治疗实体瘤疾病的药物; 以及包含这种组合的商业包装或产品以及治疗实体瘤疾病的说明书。在另一方面，本发明涉及一种组合，其包括：a）任选地N-苯基-2-嘧啶胺衍生物，特别是N- {5- [4-（4-甲基 - 哌嗪子基 - 甲基） - 苯甲酰氨基 ] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺（STI571），b）N- {5- [4-（哌嗪基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4- （3-吡啶基）-2-嘧啶胺（CGP74588），c）任选的抗肿瘤剂，d）任选的烷化剂和e）任选的羟基脲; 涉及使用这种组合来制备用于治疗实体瘤疾病的药物; 以及包含这种组合的商业包装或产品以及治疗实体瘤疾病的说明书。

2. 发明申请

WO2006136391A3 TREATMENT OF SOLID TUMOR DISEASE WITH COMBINATIONS COMPRISING IMATINIB AND AN EFFLUX PUMP INHIBITOR 审中-公开
公开(公告)号：WO2006136391A3
公开(公告)日：2006-12-28
申请号：PCT/EP2006/005960
申请日：2006-06-21
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , BIHOREL, Sebastien , GROSS, Gerhard , LEMAIRE, Michel , CAMENISCH, Gian, P.
发明人： BIHOREL, Sebastien , GROSS, Gerhard , LEMAIRE, Michel , CAMENISCH, Gian, P.
IPC分类号： A61K31/506 , A61K45/06 , A61P35/00
摘要： The invention relates to a method of treating a warm-blooded animal having a solid tumor disease comprising administering a combination which comprises: a) a N-phenyl-2- pyrimidine-amine derivative, especially N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]- 2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine, b) at least one compound inhibiting the efflux pump active at the blood brain barrier selected from MDR1 and MRP2, c) optionally an antineoplastic agent, especially as defined herein, d) optionally an alkylating agent and e) optionally, hydroxyurea; to the use of such a combination for the preparation of a medicament for the treatment of a solid tumor disease; and to a commercial package or product comprising such a combination together with instructions for the treatment of a solid tumor disease. In a further aspect, the present invention pertains to a combination which comprises: a) optionally a N-phenyl-2-pyrimidine-amine derivative, especially N-{5-[4-(4- methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine (STI571 ), b) N-{5-[4-(piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2- pyrimidine-amine (CGP74588), c) optionally an antineoplastic agent, d) optionally an alkylating agent and e) optionally, hydroxyurea; to the use of such a combination for the preparation of a medicament for the treatment of a solid tumor disease; and to a commercial package or product comprising such a combination together with instructions for the treatment of a solid tumor disease.

3. 发明专利

FR2671466A1 Combined unattended deposit unit 未知
公开(公告)号：FR2671466A1
公开(公告)日：1992-07-17
申请号：FR9100642
申请日：1991-01-15
申请人： LEMAIRE MICHEL
发明人： ALAIN LEMAIRE MICHEL
IPC分类号： A47B81/00 , D06F95/00
摘要： The present invention relates to a combined unattended deposit unit. The device relates to an ecological receptacle (Figure 1), none of the articles deposited being treated on site. It is characterised by a representative design specifically adapted to the kind of work proposed according to its purpose and use. Nevertheless, it is adapted to the depositing of articles required to be treated externally by service providers who first collect the deposited articles from the receptacle (Figure 1). It consists of a receptacle (Figure 1) in the middle of which is a round door (Figure 2) which opens externally and closes automatically (Figures 3 and 5) on a hatch (Figure 4). A device (Figure 6) located between the door (Figure 2) and the hatch (Figure 4) allows articles to be deposited in the receptacle (Figure 1) but not withdrawn therefrom once deposited. An outer door (Figure 7) adjoining the receptacle (Figure 1) allows a worker to remove the articles. A shelf (Figure 9) mounted horizontally on the receptacle (Figure 1) is movable and can be pivoted upwards (Figure 11), to protect the deposit means after use. The receptacle (Figure 13) is mounted on wheels (Figure 12) to allow it to be moved as required. The complete receptacle (Figure 13) is made up of eight separate parts. Kit assembly is therefore possible and it can be industrialised. According to the device, the complete receptacle (Figure 13) is intended to take deposits of articles having to undergo garment degreasing operations (dyeing, pressing), or repairs (shoe-mending, etc.) or articles requiring chemical processing such as photographic or film development (not restricted).

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