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1. 发明专利

IL261395D0 Combination therapy with anti-cd73 antibodies 未知
公开(公告)号：IL261395D0
公开(公告)日：2018-10-31
申请号：IL26139518
申请日：2018-08-27
申请人： SQUIBB BRISTOL MYERS CO , KORMAN ALAN J , JURE KUNKEL MARIA , LONBERG NILS , LEI MING , SCHWEIZER LIANG , BARNHART BRYAN C , YAMNIUK AARON P , HENNING KARLA A , CHEN GUODONG , HUANG HAICHUN , HATCHER SANDRA V , SRIVISAN MOHAN , SEGA EMANUELA , GOODENOUGH ANGELA , SACK JOHN S , HUANG RICHARD Y , CORBETT MARTIN J , MYERS JOSEPH E JR , ALTURA RACHEL , ZHANG PINGPING , HILT EDWARD J , HEDRICK MICHAEL NATHAN
发明人： KORMAN ALAN J , JURE-KUNKEL MARIA , LONBERG NILS , LEI MING , SCHWEIZER LIANG , BARNHART BRYAN C , YAMNIUK AARON P , HENNING KARLA A , CHEN GUODONG , HUANG HAICHUN , HATCHER SANDRA V , SRIVISAN MOHAN , SEGA EMANUELA , GOODENOUGH ANGELA , SACK JOHN S , HUANG RICHARD Y , CORBETT MARTIN J , MYERS JOSEPH E JR , ALTURA RACHEL , ZHANG PINGPING , HILT EDWARD J , HEDRICK MICHAEL NATHAN
IPC分类号： C07K20060101
摘要： Provided are methods for clinical treatment of tumors (e.g., advanced solid tumors) using an anti-CD73 antibody in combination with an immuno-oncology agent, such as an anti-PD-1 antibody.

2. 发明专利

IL259399D0 Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof 未知
公开(公告)号：IL259399D0
公开(公告)日：2018-07-31
申请号：IL25939918
申请日：2018-05-16
申请人： SQUIBB BRISTOL MYERS CO , CHAKRABORTY INDRANI , KORMAN ALAN J , SRINIVASAN MOHAN , WONG SUSAN CHIEN SZU , LONBERG NILS , LEI MING , SCHWEIZER LIANG , RAJPAL ARVIND , BARNHART BRYAN C , YAMNIUK AARON P , WANG CHANGYU , SELBY MARK J , HENNING KARLA A , HAN MICHELLE MINHUA , CHEN GUODONG , HUANG RICHARD , HUANG HAICHUN , LI HUIMING , HATCHER SANDRA V
发明人： CHAKRABORTY INDRANI , KORMAN ALAN J , SRINIVASAN MOHAN , WONG SUSAN CHIEN-SZU , LONBERG NILS , LEI MING , SCHWEIZER LIANG , RAJPAL ARVIND , BARNHART BRYAN C , YAMNIUK AARON P , WANG CHANGYU , SELBY MARK J , HENNING KARLA A , HAN MICHELLE MINHUA , CHEN GUODONG , HUANG RICHARD , HUANG HAICHUN , LI HUIMING , HATCHER SANDRA V
IPC分类号： C07K20060101
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

3. 发明专利

IL255949D0 Antibodies against ox40 and uses thereof 未知
公开(公告)号：IL255949D0
公开(公告)日：2018-01-31
申请号：IL25594917
申请日：2017-11-27
申请人： SQUIBB BRISTOL MYERS CO , CAI ZHEHONG , CHAKRABORTY INDRANI , GARCIA MARIE MICHELLE NAVARRO , KEMPE THOMAS D , KORMAN ALAN J , KOZHICH ALEXANDER T , LEMAR HADIA , MAURER MARK , MILBURN CHRISTINA MARIA , QUIGLEY MICHAEL , RODRIGUEZ MARIA , SHAO XIANG , SRINIVASAN MOHAN , STEVENS BRENDA L , THUDIUM KENT , WONG SUSAN CHIEN SZU , GOKEMEIJER JOCHEM , WANG XI TAO , CHANG HAN , HUANG CHRISTINE , JURE KUNKEL MARIA , YANG ZHENG , FENG YAN , GUIRNALDA PATRICK , LONBERG NILS , BARNHART BRYAN C , YAMNIUK AARON P , HENNING KARLA A , HAN MICHELLE MINHUA , LEI MING , SCHWEIZER LIANG , HATCHER SANDRA V , RAJPAL ARVIND , AANUR PRAVEEN , SELBY MARK J
发明人： CAI ZHEHONG , CHAKRABORTY INDRANI , GARCIA MARIE MICHELLE NAVARRO , KEMPE THOMAS D , KORMAN ALAN J , KOZHICH ALEXANDER T , LEMAR HADIA , MAURER MARK , MILBURN CHRISTINA MARIA , QUIGLEY MICHAEL , RODRIGUEZ MARIA , SHAO XIANG , SRINIVASAN MOHAN , STEVENS BRENDA L , THUDIUM KENT , WONG SUSAN CHIEN SZU , GOKEMEIJER JOCHEM , WANG XI TAO , CHANG HAN , HUANG CHRISTINE , JURE KUNKEL MARIA , YANG ZHENG , FENG YAN , GUIRNALDA PATRICK , LONBERG NILS , BARNHART BRYAN C , YAMNIUK AARON P , HENNING KARLA A , HAN MICHELLE MINHUA , LEI MING , SCHWEIZER LIANG , HATCHER SANDRA V , RAJPAL ARVIND , AANUR PRAVEEN , SELBY MARK J
IPC分类号： C07K20060101
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

4. 发明专利

IL295230A Combination therapy with anti-cd73 antibodies 未知
公开(公告)号：IL295230A
公开(公告)日：2022-10-01
申请号：IL29523022
申请日：2022-07-31
申请人： BRISTOL MYERS SQUIBB CO , BARNHART BRYAN C , KORMAN ALAN J , LONBERG NILS , YAMNIUK AARON P , SRINIVASAN MOHAN , HENNING KARLA A , LEI MING , SEGA EMANUELA , GOODENOUGH ANGELA , JURE KUNKEL MARIA , CHEN GUODONG , SACK JOHN S , HUANG RICHARD Y , CORBETT MARTIN J , MYERS JOSEPH E JR , SCHWEIZER LIANG , HATCHER SANDRA V , ALTURA RACHEL , HUANG HAICHUN , ZHANG PINGPING , HILT EDWARD J , HEDRICK MICHAEL NATHAN
发明人： BARNHART BRYAN C , KORMAN ALAN J , LONBERG NILS , YAMNIUK AARON P , SRINIVASAN MOHAN , HENNING KARLA A , LEI MING , SEGA EMANUELA , GOODENOUGH ANGELA , JURE-KUNKEL MARIA , CHEN GUODONG , SACK JOHN S , HUANG RICHARD Y , CORBETT MARTIN J , MYERS JOSEPH E JR , SCHWEIZER LIANG , HATCHER SANDRA V , ALTURA RACHEL , HUANG HAICHUN , ZHANG PINGPING , HILT EDWARD J , HEDRICK MICHAEL NATHAN
IPC分类号： A61K39/00 , A61P11/00 , A61P15/00 , A61P35/00 , A61P43/00 , C07K16/28
摘要： Provided are methods for clinical treatment of tumors (e.g., advanced solid tumors) using an anti-CD73 antibody in combination with an immuno-oncology agent, such as an anti-PD-1 antibody.

5. 发明专利

IL283965D0 Antibodies against cd73 and uses thereof 未知
公开(公告)号：IL283965D0
公开(公告)日：2021-07-29
申请号：IL28396521
申请日：2021-06-14
申请人： BRISTOL MYERS SQUIBB PHARMA COMPANY , LONBERG NILS , KORMAN ALAN J , BARNHART BRYAN C , YAMNIUK AARON P , SRINIVASAN MOHAN , HENNING KARLA A , LEI MING , SEGA EMANUELA , GOODENOUGH ANGELA , JURE KUNKEL MARIA N , CHEN GUODONG , SACK JOHN , HUANG RICHARD , CORBETT MARTIN J , MYERS JOSEPH E , SCHWEIZER LIANG , HATCHER SANDRA V , HUANG HAICHUN , ZHANG PINGPING
发明人： LONBERG NILS , KORMAN ALAN J , BARNHART BRYAN C , YAMNIUK AARON P , SRINIVASAN MOHAN , HENNING KARLA A , LEI MING , SEGA EMANUELA , GOODENOUGH ANGELA , JURE-KUNKEL MARIA N , CHEN GUODONG , SACK JOHN , HUANG RICHARD , CORBETT MARTIN J , MYERS JOSEPH E , SCHWEIZER LIANG , HATCHER SANDRA V , HUANG HAICHUN , ZHANG PINGPING
IPC分类号： A61K39/00 , A61K39/395 , A61K45/06 , A61K47/68 , A61P35/00 , A61P35/02 , A61P35/04 , C07K16/28 , C07K16/30 , C07K16/40 , G01N33/573 , G01N33/574
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.

6. 实用新型

TWM338194U 機車置物架結構改良失效
简体标题：電單車置物架结构改良
公开(公告)号：TWM338194U
公开(公告)日：2008-08-11
申请号：TW096208630
申请日：2007-05-25
申请人：蔡雷鳴 TSAI, LEI MING
发明人：蔡雷鳴 TSAI, LEI MING
IPC分类号： B62J
摘要：本創作包括一支架本體、一卡榫單元及一被承載裝置,其中該支架本體置於機車後座,包含一卡合架、一中通連結管及一向後傾斜之托架,該托架結合於該中空連接管之下端;該中通連結管位於該卡合架之後端,該卡合架位於支架本體前緣;該卡榫單元包含一榫頭;該被承載裝置兩端各具有一固定腳,該固定腳包含至少一穿孔,其中該被承載裝置底部進一步結合一支撐桿,該支撐桿一端與被承載裝置樞接,另一端抵頂該卡合架;上述之支架本體與該被承載裝置穿合連接,以達到被承載裝置可掀起的功能。利用上述之結構,使得該被承載裝置得以相對於該支架本體旋轉。
简体摘要：本创作包括一支架本体、一卡榫单元及一被承载设备,其中该支架本体置于電單車后座,包含一卡合架、一中通链接管及一向后倾斜之托架,该托架结合于该中空连接管之下端;该中通链接管位于该卡合架之后端,该卡合架位于支架本体前缘;该卡榫单元包含一榫头;该被承载设备两端各具有一固定脚,该固定脚包含至少一穿孔,其中该被承载设备底部进一步结合一支撑杆,该支撑杆一端与被承载设备枢接,另一端抵顶该卡合架;上述之支架本体与该被承载设备穿合连接,以达到被承载设备可掀起的功能。利用上述之结构,使得该被承载设备得以相对于该支架本体旋转。

7. 实用新型

TWM338858U 隱藏式小便器失效
简体标题：隐藏式小便器
公开(公告)号：TWM338858U
公开(公告)日：2008-08-21
申请号：TW097202949
申请日：2008-02-20
申请人：蔡雷鳴 TSAI, LEI-MING
发明人：蔡雷鳴 TSAI, LEI-MING
IPC分类号： E03D
摘要：本創作係一種隱藏式小便器,尤指一種可增進美觀之小
便器,特別係指一種運用於戶內外活動之隱藏式小便器,本
創作主要係由一箱體及一小便器組所組成,其中小便器組係
樞設於箱體前緣,並可相對收合隱藏於箱體內,且箱體上設
有一對應小便器組的噴水頭,用以清理該小便器組,以保持
衛生,透過上述的設計,讓小便器於平時可收合於箱體內,
待需使用時再行拉出,以增進廁所或浴室的美觀,並可增加
空間運的的靈活性,同時進一步可減少尿液外噴的現象,以
維週邊環境的整潔,更甚者可方便架設於戶外空間,充作臨
時小便器,克服傳統野外活動時給人任意小解的問題。
简体摘要：本创作系一种隐藏式小便器,尤指一种可增进美观之小便器,特别系指一种运用于户内外活动之隐藏式小便器,本创作主要系由一箱体及一小便器组所组成,其中小便器组系枢设于箱体前缘,并可相对收合隐藏于箱体内,且箱体上设有一对应小便器组的喷水头,用以清理该小便器组,以保持卫生,透过上述的设计,让小便器于平时可收合于箱体内, 待需使用时再行拉出,以增进厕所或浴室的美观,并可增加空间运的的灵活性,同时进一步可减少尿液外喷的现象,以维周边环境的整洁,更甚者可方便架设于户外空间,充作临时小便器,克服传统野外活动时给人任意小解的问题。

8. 发明申请

WO2016164731A2 CD20 THERAPIES, CD22 THERAPIES, AND COMBINATION THERAPIES WITH A CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) - EXPRESSING CELL 审中-公开
标题翻译： CD20治疗方案，CD22治疗方案和与CD19基因抗体受体（CAR） - 表达细胞的联合治疗
公开(公告)号：WO2016164731A2
公开(公告)日：2016-10-13
申请号：PCT/US2016/026655
申请日：2016-04-08
申请人： NOVARTIS AG , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , BITTER, Hans , BORDEAUX, Jennifer, Mary , BRANNETTI, Barbara , BROGDON, Jennifer , DAKAPPAGARI, Naveen, Kumar , GILL, Saar , HIGHFILL, Steven , HUANG, Lu , JUNE, Carl, H. , KIM, Ju, Young , LEI, Ming , LI, Na , LOWE, Andreas , ORLANDO, Elena , RUELLA, Marco , TRAN, Thai , ZHANG, Jimin , ZHOU, Li
发明人： BITTER, Hans , BORDEAUX, Jennifer, Mary , BRANNETTI, Barbara , BROGDON, Jennifer , DAKAPPAGARI, Naveen, Kumar , GILL, Saar , HIGHFILL, Steven , HUANG, Lu , JUNE, Carl, H. , KIM, Ju, Young , LEI, Ming , LI, Na , LOWE, Andreas , ORLANDO, Elena , RUELLA, Marco , TRAN, Thai , ZHANG, Jimin , ZHOU, Li
IPC分类号： C07K14/725 , C07K16/28 , C12N5/0783
CPC分类号： C07K14/70596 , A61K38/00 , A61K39/0011 , A61K45/06 , A61K2039/5156 , A61K2039/5158 , A61K2039/70 , C07K14/7051 , C07K16/2803 , C07K16/2866 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD1O, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.
摘要翻译：本发明提供了用于治疗与CD19表达相关的疾病的组合物和方法，例如通过与一种或多种B细胞抑制剂组合施用包含本文所述的CD19 CAR的重组T细胞，例如一种或多种 CD1O，CD20，CD22，CD34，CD123，FLT-3，ROR1，CD79b，CD179b或CD79a。本公开另外具有指向CD20和CD22的新型抗原结合结构域和CAR分子，并且例如用作单一疗法或联合治疗。本发明还提供了本文所述的试剂盒和组合物。

9. 发明申请

WO2013181823A1 METHOD AND APPARATUS FOR INTERFERENCE CONTROL 审中-公开
标题翻译：干扰控制的方法和装置
公开(公告)号：WO2013181823A1
公开(公告)日：2013-12-12
申请号：PCT/CN2012/076585
申请日：2012-06-07
申请人： NEC(CHINA) CO., LTD. , LI, Chaofeng , LEI, Ming , XU, Wei , LIANG, Le , ZHANG, Hua , JIN, Shi
发明人： LI, Chaofeng , LEI, Ming , XU, Wei , LIANG, Le , ZHANG, Hua , JIN, Shi
IPC分类号： H04B7/06
CPC分类号： H04L5/0053 , H04B7/0617 , H04B7/0619 , H04B7/0626 , H04B15/00 , H04W76/14
摘要： Methods and apparatuses for interference control have been disclosed. A method for a base station in a wireless communication system, comprising: obtaining a system setting of the wireless communication system; selecting a transmission mode based at least in part on the system setting, wherein the transmission mode is one of an Interference Cancellation IC transmission mode and a Beamforming BF transmission mode; and configuring the selected transmission mode. The total system throughput may be maximized by dynamically switching the transmission mode between IC and BF at the base station. Further, the proposed switching mechanism may be applied to various communication networks where downlink interference may occur.
摘要翻译：已经公开了用于干扰控制的方法和装置。一种用于无线通信系统中的基站的方法，包括：获得所述无线通信系统的系统设置; 至少部分地基于系统设置选择传输模式，其中传输模式是干扰消除IC传输模式和波束形成BF传输模式之一; 以及配置所选择的传输模式。通过在基站上动态切换IC和BF之间的传输模式，可以使总系统吞吐量最大化。此外，所提出的切换机制可以应用于可能发生下行链路干扰的各种通信网络。

10. 发明申请

WO2013181818A1 METHOD AND APPARATUS FOR INTERFERENCE CONTROL IN A WIRELESS COMMUNICATION SYSTEM 审中-公开
标题翻译：无线通信系统干扰控制的方法与装置
公开(公告)号：WO2013181818A1
公开(公告)日：2013-12-12
申请号：PCT/CN2012/076567
申请日：2012-06-07
申请人： NEC(CHINA) CO., LTD. , JIANG, Lei , LEI, Ming , JIN, Shi , DAI, Yongyu
发明人： JIANG, Lei , LEI, Ming , JIN, Shi , DAI, Yongyu
IPC分类号： H04W72/12
CPC分类号： H04B7/024 , H04B7/0452 , H04B7/0456 , H04B7/0619 , H04W72/121 , H04W92/20
摘要： The present invention relates to method and apparatus for interference control in a wireless communication system. According to an embodiment of the present invention, a method for operating a base station is provided. The method comprises receiving, from each of a first group of user equipments served by a first base station, first feedback information, the first feedback information including at least information indicative of a first precoding matrix included in a first cluster and information indicative of a second cluster that includes a second precoding matrix different from the first precoding matrix; exchanging feedback information with a second base station, wherein the second base station receives from each of a second group of user equipments served by the second base station second feedback information, the second feedback information including at least information indicative of a first precoding matrix and information indicative of a cluster that includes a second precoding matrix different from the first precoding matrix; coordinately scheduling, at least based on the first feedback information and the second feedback information, the first group of user equipments and the second group of user equipments.
摘要翻译：本发明涉及无线通信系统中的干扰控制方法和装置。根据本发明的实施例，提供了一种用于操作基站的方法。该方法包括：从由第一基站服务的第一组用户设备中的每一个接收第一反馈信息，所述第一反馈信息至少包括指示包括在第一集群中的第一预编码矩阵的信息和指示第二反馈信息的信息簇，其包括不同于第一预编码矩阵的第二预编码矩阵; 与第二基站交换反馈信息，其中第二基站从由第二基站服务的第二组用户设备中的每一个接收第二反馈信息，第二反馈信息至少包括指示第一预编码矩阵和信息的信息指示包括不同于所述第一预编码矩阵的第二预编码矩阵的集群; 至少基于第一反馈信息和第二反馈信息协调调度第一组用户设备和第二组用户设备。

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