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1. 发明申请

WO2008013416A1 PROCESS FOR PREPARING POWDER COMPRISING NANOPARTICLES OF SPARINGLY SOLUBLE DRUG 审中-公开
标题翻译：制备包含可溶性药物纳米颗粒的粉末的方法
公开(公告)号：WO2008013416A1
公开(公告)日：2008-01-31
申请号：PCT/KR2007/003599
申请日：2007-07-26
申请人： AMOREPACIFIC CORPORATION , BAE, Joon Ho , LEE, Jong Hwi , LEE, Hyeok , KIM, Jung Ju
发明人： BAE, Joon Ho , LEE, Jong Hwi , LEE, Hyeok , KIM, Jung Ju
IPC分类号： A61K9/14
CPC分类号： A61K9/5123 , A61K9/0019 , A61K9/0095 , A61K9/145 , A61K9/146 , A61K9/5161 , A61K9/5192
摘要： A powder comprising nanoparticles of a sparingly water-soluble drug prepared in accordance with the present invention exhibits enhanced bioavailability without generating adverse side effects caused by impurities, while the nano-particle size of the drug remains unchanged when administered. Accordingly, the powder can be useful for the development of a formulation of a sparingly water-soluble drug for oral and parenteral administration.
摘要翻译：包含根据本发明制备的微水溶性药物的纳米颗粒的粉末表现出增强的生物利用度，而不产生由杂质引起的不良副作用，而药物的纳米粒度在施用时保持不变。因此，粉末可用于开发用于口服和肠胃外给药的微水溶性药物的制剂。

2. 发明申请

WO2010053335A3 METHOD FOR PRODUCING POWDER CONTAINING NANOPARTICLES OF INSOLUBLE DRUG, POWDER PRODUCED THEREBY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME 审中-公开
标题翻译：生产含有不溶性药物的纳米颗粒的粉末的方法，生产的粉末和含有它们的药物组合物
公开(公告)号：WO2010053335A3
公开(公告)日：2010-09-10
申请号：PCT/KR2009006585
申请日：2009-11-10
申请人： AMOREPACIFIC CORP , BAE JOON-HO , LEE HYEOK , HONG DEOK-KI , LEE JONG-HWI
发明人： BAE JOON-HO , LEE HYEOK , HONG DEOK-KI , LEE JONG-HWI
IPC分类号： A61K9/16 , A61K47/48
CPC分类号： A61K9/146 , A61K9/1694 , A61K9/19
摘要： The present invention relates to a production method for a powder containing nanoparticles of an insoluble drug, a powder produced thereby, and a pharmaceutical composition containing the same. The method comprises the steps of: providing a uniformly dispersed solution of an insoluble drug which has been formed into nanoparticles in the presence of a surface stabilizer; mixing the uniformly dispersed solution with a water-soluble dispersant solution; and drying the resulting mixed solution and thereby recovering a powder. When the powder containing the nanoparticles of the insoluble drug obtained by the method of the present invention is again dispersed in an aqueous solution, the insoluble drug retains a particle size in the nano scale while the solubility and the dissolution rate of the drug are increased, thereby providing enhanced bioavailability. Consequently, the present invention can be used effectively in the development of otherwise insoluble drug preparations for oral or parenteral administration.
摘要翻译：本发明涉及一种含有不溶性药物的纳米颗粒的粉末的生产方法，由此制备的粉末和含有它的药物组合物。该方法包括以下步骤：提供在表面稳定剂存在下已形成纳米颗粒的不溶性药物的均匀分散溶液; 将均匀分散的溶液与水溶性分散剂溶液混合; 并干燥得到的混合溶液，从而回收粉末。当通过本发明方法获得的含有不溶性药物的纳米颗粒的粉末再次分散在水溶液中时，不溶性药物保持纳米级的粒径，同时药物的溶解度和溶解速率增加，从而提供增强的生物利用度。因此，本发明可以有效地用于开发用于口服或肠胃外给药的其它不溶性药物制剂。

3. 发明申请

WO2009142340A1 DENTAL COMPOSITION CONTAINING ORGANIC NANOTUBE 审中-公开
标题翻译：含有机碳纳米管的牙齿组合物
公开(公告)号：WO2009142340A1
公开(公告)日：2009-11-26
申请号：PCT/KR2008/002788
申请日：2008-05-19
申请人： VERICOM CO., LTD. , OH, Myung-Hwan , KIM, Won-Ho , HAM, Mi Hyoun , LEE, Jong-Hwi , KIM, Yun-Ki
发明人： OH, Myung-Hwan , KIM, Won-Ho , HAM, Mi Hyoun , LEE, Jong-Hwi , KIM, Yun-Ki
IPC分类号： A61K6/08 , A61K6/00
CPC分类号： A61K6/083 , A61K6/0067 , A61K6/09 , Y10S977/919 , C08L33/04 , C08L25/04 , C08L63/00 , C08L75/16
摘要： Disclosed is a dental composition, comprising unsaturated double bond-containing monomers and/or oligomers, a catalytic amount of polymerization initiator to initiate polymerization, and a filler, wherein the dental composition comprises an organic nanotube containing an antibacterial or anticariogenic material to inhibit or prevent tooth decay. The dental composition comprises an organic nanotube containing an antibacterial or anticariogenic material, thus uniformly and continuously exhibiting anticariogenic and antibacterial activities, while avoiding deterioration in physical properties required for the dental material.
摘要翻译：公开了一种牙科用组合物，其包含不饱和双键的单体和/或低聚物，催化量的引发聚合的聚合引发剂和填料，其中所述牙科组合物包含含有抗细菌剂或抗龋齿材料的有机纳米管，以抑制或预防蛀牙牙科用组合物包含含有抗菌或抗焦虑物质的有机纳米管，从而均匀且连续地显示抗焦虑和抗菌活性，同时避免牙科材料所需的物理性质的恶化。

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