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1. 发明申请

WO2012093770A1 DIFFRACTION GRATING SPECTROMETER 审中-公开
标题翻译：衍射光谱仪
公开(公告)号：WO2012093770A1
公开(公告)日：2012-07-12
申请号：PCT/KR2011/008111
申请日：2011-10-28
申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE , LEE, Eun Seong , LEE, Jae Yong
发明人： LEE, Eun Seong , LEE, Jae Yong
IPC分类号： G01J3/18 , G01J3/02
CPC分类号： G01J3/1804 , G01J3/021 , G01J3/0256
摘要： Disclosed is a diffraction grating spectrometer. The diffraction grating spectrometer obtains the high spectral resolution by using diffraction gratings having a smaller number of grating lines and low grid density. In the diffraction grating spectrometer, a beam diffracted from a small-size diffraction grating is expanded through the intensity division and wave front reconstruction by using an intensity division/wave front reconstruction unit to obtain the spectral resolution realized by a large-size diffraction grating, so that the size of the diffraction grating spectrometer is reduced.
摘要翻译：公开了一种衍射光栅光谱仪。衍射光栅光谱仪通过使用具有较小数量的光栅线和低栅格密度的衍射光栅获得高光谱分辨率。在衍射光栅光谱仪中，通过使用强度分割/波前重构单元，通过强度分割和波前重构来扩大从小尺寸衍射光栅衍射的光束，以获得由大尺寸衍射光栅实现的光谱分辨率，使得衍射光栅光谱仪的尺寸减小。

2. 发明申请

WO2007058462A1 METHOD FOR PREPARING SUSTAINED-RELEASE MICROPARTICLES COMPRISING SUCROSE ACETATE ISOBUTYRATE 审中-公开
标题翻译：制备含有蔗糖乙酸异丁酯的持续释放微生物的方法
公开(公告)号：WO2007058462A1
公开(公告)日：2007-05-24
申请号：PCT/KR2006/004799
申请日：2006-11-15
申请人： AMOREPACIFIC CORPORATION , LEE, Eun Seong , LEE, Hyeok , KIM, Jung Ju
发明人： LEE, Eun Seong , LEE, Hyeok , KIM, Jung Ju
IPC分类号： A61K9/16
CPC分类号： A61K9/1647 , A61K9/19 , A61K47/14
摘要： A sustained release microparticles which is capable of releasing a protein drug continuously over a long period of time without initial burst release of the drug can be simply prepared by a method comprising the steps of a) dissolving a protein drug in an aqueous solution to obtain a water phase; b) dissolving sucrose acetate isobutyrate(SAIB) and a biodegradable polymer in an organic solvent to obtain an oil phase; c) adding the water phase obtained in step a) to the oil phase obtained in step b) to form a primary emulsion; and d) adding the primary emulsion to an external aqueous continuous phase to form a secondary emulsion and recovering the solid product formed in the secondary emulsion.
摘要翻译：能够长时间连续释放蛋白质药物而不会初次爆发药物的缓释微粒可以通过包括以下步骤的方法简单地制备：a）将蛋白质药物溶解在水溶液中以获得水相; b）将蔗糖乙酸异丁酸酯（SAIB）和可生物降解的聚合物溶于有机溶剂中以获得油相; c）将步骤a）中获得的水相加入到步骤b）中获得的油相中以形成初级乳液; 和d）将初级乳液加入到外部水性连续相中以形成二次乳液并回收在二次乳液中形成的固体产物。

3. 发明申请

WO2010027125A1 SPECTRALLY ENCODED CARS ENDOSCOPE 审中-公开
标题翻译：光谱编码车内镜
公开(公告)号：WO2010027125A1
公开(公告)日：2010-03-11
申请号：PCT/KR2008/006995
申请日：2008-11-27
申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE , LEE, Eun Seong , LEE, Jae Yong , MOON, Dae Won
发明人： LEE, Eun Seong , LEE, Jae Yong , MOON, Dae Won
IPC分类号： A61B1/00
CPC分类号： A61B5/6852 , A61B5/0066 , G01N21/65 , G01N2021/653
摘要： Disclosed is a spectrally encoded coherent anti-Stokes Raman scattering (CARS) endoscope that is capable of spatially encoding spectral dispersions of two light sources having frequency difference as much as a Raman shift and overlapping two laser beams on a position where a sample to be measured is placed, thereby acquiring a spatial distribution of CARS signals. The endoscope includes a cylindrical main body, a Stokes beam optical fiber and a pump beam optical fiber disposed above and below for transmitting a Stokes beam and a pump beam, respectively, a collimator lens for collimating the Stokes beam and the pump beam transmitted from the respective optical fibers, a diffraction grating for diffracting the collimated Stokes beam and the collimated pump beam such that the Stokes beam and the pump beam have the same spectral dispersion, a reflection mirror including a dichroic reflection part for reflecting the Stokes beam and re-reflecting CARS beams generated from a sample to the diffraction grating and a full reflection part for fully reflecting the pump beam, an object lens for condensing the reflected pump beam and the reflected Stokes beam to the sample, and a CARS beam transmission part for transmitting the CARS beams to a spectroscope.
摘要翻译：公开了一种频谱编码的相干反斯托克斯拉曼散射（CARS）内窥镜，其能够空间编码具有与拉曼位移一样多的频率差异的两个光源的光谱色散，并且在待测样品的位置上重叠两个激光束被放置，从而获得CARS信号的空间分布。内窥镜包括圆柱形主体，斯托克斯光束光纤和泵浦光束光纤，其分别设置用于透射斯托克斯光束和泵浦光束的用于准直斯托克斯光束的准直透镜和从其发射的泵浦光束相应的光纤，用于衍射准直的斯托克斯光束和准直的泵浦光束的衍射光栅，使得斯托克斯光束和泵浦光束具有相同的光谱色散;反射镜，包括用于反射斯托克斯光束的二向色反射部分和反射从样品到衍射光栅产生的CARS光束和用于完全反射泵浦光束的全反射部分，用于将反射的泵浦光束和反射的斯托克斯光束聚焦到样品的物镜，以及用于传送CARS的CARS光束传输部分光束到分光镜。

4. 发明申请

WO2009029935A1 DRUG DELIVERY VEHICLE THAT MIMICS VIRAL PROPERTIES 审中-公开
标题翻译：药物交付车辆，即MIMICS VIRAL PROPERTIES
公开(公告)号：WO2009029935A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/075029
申请日：2008-09-02
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , BAE, You, Han , LEE, Eun, Seong , KIM, Dongin , YOUN, Yu, Seok , OH, Kyung, Taek
发明人： BAE, You, Han , LEE, Eun, Seong , KIM, Dongin , YOUN, Yu, Seok , OH, Kyung, Taek
IPC分类号： A61K47/32 , A61K9/16
CPC分类号： A61K9/1658 , A61K9/1641 , A61K9/167
摘要： A drug delivery vehicle for targeted delivery of a drug mimics viral properties of size, capsid-like protein capsule, cell-specific entry, toxin release, destruction of infected cells, and migration to neighboring cells. This vehicle, termed a virogel, contains a hydrophobic polymeric core, a hydrophilic inner shell, a hydrophilic outer shell, and a ligand. An illustrative drug-loaded virogel includes poly(L-histidine-co-phenylalanine) as the core, doxorubicin loaded in the core, polyethylene glycol as the inner shell, bovine serum albumin as the outer shell, and folic acid as the ligand.
摘要翻译：用于靶向递送药物的药物递送载体模拟大小的病毒性质，衣壳样蛋白质胶囊，细胞特异性进入，毒素释放，感染细胞的破坏以及迁移至相邻细胞。这种载体，称为virogel，含有疏水聚合物芯，亲水内壳，亲水外壳和配体。一种说明性的药物载体的virogel包括聚（L-组氨酸 - 共 - 苯基丙氨酸）为核心，负责核心的多柔比星，作为内壳的聚乙二醇，作为外壳的牛血清白蛋白和叶酸作为配体。

5. 发明申请

WO2007058462A9 METHOD FOR PREPARING SUSTAINED-RELEASE MICROPARTICLES COMPRISING SUCROSE ACETATE ISOBUTYRATE 审中-公开
标题翻译：制备包含蔗糖乙酸异丁酯的持续释放微粒的方法
公开(公告)号：WO2007058462A9
公开(公告)日：2007-10-04
申请号：PCT/KR2006004799
申请日：2006-11-15
申请人： AMOREPACIFIC CORP , LEE EUN SEONG , LEE HYEOK , KIM JUNG JU
发明人： LEE EUN SEONG , LEE HYEOK , KIM JUNG JU
IPC分类号： A61K9/16
CPC分类号： A61K9/1647 , A61K9/19 , A61K47/14
摘要： A sustained release microparticles which is capable of releasing a protein drug continuously over a long period of time without initial burst release of the drug can be simply prepared by a method comprising the steps of a) dissolving a protein drug in an aqueous solution to obtain a water phase; b) dissolving sucrose acetate isobutyrate(SAIB) and a biodegradable polymer in an organic solvent to obtain an oil phase; c) adding the water phase obtained in step a) to the oil phase obtained in step b) to form a primary emulsion; and d) adding the primary emulsion to an external aqueous continuous phase to form a secondary emulsion and recovering the solid product formed in the secondary emulsion.
摘要翻译：能够长时间连续释放蛋白质药物而不释放药物的持续释放微粒可以通过包括以下步骤的方法简单地制备：a）将蛋白质药物溶解在水溶液中以获得水相; b）将乙酸异丁酸蔗糖酯（SAIB）和生物可降解聚合物溶解在有机溶剂中以获得油相; c）将步骤a）中获得的水相加入到步骤b）中获得的油相中以形成初级乳液; 和d）将初级乳液加入到外部连续水相中以形成第二乳液并回收在第二乳液中形成的固体产物。

6. 发明申请

WO2010071294A1 PHOTONIC BANDGAP FIBERS FOR HIGH EFFICIENCY COHERENT ANTI-STOKES RAMAN SCATTERING ENDOSCOPE 审中-公开
标题翻译：用于高效联锁防盗的光电带式光纤拉曼散射内窥镜
公开(公告)号：WO2010071294A1
公开(公告)日：2010-06-24
申请号：PCT/KR2009/005464
申请日：2009-09-24
申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE , AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , LEE, Jee Yong , LEE, Eun Seong , MOON, Dae Won , YEOM, Dong Il
发明人： LEE, Jee Yong , LEE, Eun Seong , MOON, Dae Won , YEOM, Dong Il
IPC分类号： G02B6/032
CPC分类号： G02B6/02347 , G02B6/02366 , G02B6/0238 , G02B6/032
摘要： Provided isa design of a novel photonic bandgap fiber structure for Coherent Anti-Stokes Raman Scattering (CARS) endoscope system. The fiber proposed herein is a solid-core dual- cladding photonic bandgap fiber, which guides a beam only in a specific wavelength (the wave length of pump and Stokes beams) by a photonic bandgap effect. Also, the fiber has a wide core area capable of inhibiting a non-linearity of the guided pump and Stokes beams and shows, at the same time, a low dispersion property in an operation region by the bandgap waveguide effect. Furthermore, the proposed fiber includes a dual cladding fiber structure with a high numerical aperture (> 0.5).
摘要翻译：提供了一种用于相干反斯托克斯拉曼散射（CARS）内窥镜系统的新型光子带隙光纤结构的设计。本文提出的光纤是固体双重包层光子带隙光纤，其通过光子带隙效应仅在特定波长（泵和斯托克斯波束的波长）中引导光束。此外，光纤具有能够抑制引导泵和斯托克斯光束的非线性的宽的核心区域，同时通过带隙波导效应在操作区域中显示出低的色散特性。此外，所提出的光纤包括具有高数值孔径（> 0.5）的双包层光纤结构。

7. 发明申请

WO2010044510A1 POLARIZATION MAINTAINING PHOTONIC CRYSTAL FIBER WITH LARGE SCALE FOR HIGH EFFICIENTY COHERENT ANTI-STOKES RAMAN SCATTERING ENDOSCOPE 审中-公开
标题翻译：偏振维护光电晶体光纤，具有大规模高效联锁防盗拉曼散射内窥镜
公开(公告)号：WO2010044510A1
公开(公告)日：2010-04-22
申请号：PCT/KR2008/006988
申请日：2008-11-27
申请人： KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE , AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , LEE, Jae Yong , LEE, Eun Seong , MOON, Dae Won , YEOM, Dong Il
发明人： LEE, Jae Yong , LEE, Eun Seong , MOON, Dae Won , YEOM, Dong Il
IPC分类号： G02B6/032
CPC分类号： G02B6/02347 , G02B6/02009 , G02B6/02361 , G02B6/02366
摘要： There is provided a design for the structure of a novel photonic crystal fiber for implementing a coherent anti- Stokes Raman scattering (CARS) endoscope system. The photonic crystal fiber is a double -cladding polarization maintaining photonic crystal fiber with large mode area. The proposed photonic crystal fiber has a highly birefringent core mode whose effective area is a few to a few tens times larger than that of a normal single mode fiber while maintaining a spatially single mode in the operational region. Such characteristics maximally reduce nonlinear distortion of high-power pump and Stokes laser pulses used in CARS imaging, thereby preventing generation efficiency of CARS signals passing through the waveguide from being lowered. Simultaneously, a double cladding structure having a high numerical aperture is introduced, thereby collecting weak CARS signals at high efficiency. When comparing the proposed photonic crystal fiber with the normal single mode fiber, a high-performance CARS endoscope system with more enhanced sensitivity can be implemented.
摘要翻译：提供了一种用于实现相干反斯托克斯拉曼散射（CARS）内窥镜系统的新型光子晶体光纤的结构设计。光子晶体光纤是具有大模式面积的双包层极化保持光子晶体光纤。所提出的光子晶体光纤具有高双折射核心模式，其有效面积比正常单模光纤的几十倍大，同时在操作区域中保持空间单一模式。这种特性最大限度地减少CARS成像中使用的大功率泵和斯托克斯激光脉冲的非线性失真，从而防止通过波导的CARS信号的发生效率降低。同时，引入具有高数值孔径的双包层结构，从而以高效率收集弱CARS信号。当将所提出的光子晶体光纤与普通单模光纤进行比较时，可以实现具有更高灵敏度的高性能CARS内窥镜系统。

8. 发明申请

US20080192260A1 Cascade type interferometric nonlinear optical imaging apparatus 审中-公开
标题翻译：级联型干涉式非线性光学成像装置
公开(公告)号：US20080192260A1
公开(公告)日：2008-08-14
申请号：US11821913
申请日：2007-06-26
申请人： Lee Eun Seong , Lee Jae Yong
发明人： Lee Eun Seong , Lee Jae Yong
IPC分类号： G01B9/02
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01N21/65 , G01N2021/653
摘要： The present invention relates to a cascade type interferometric nonlinear optical imaging apparatus, and the imaging apparatus comprises a light source for generating Stokes beam having a desired frequency band and a pump beam for exciting medium molecules in a sample with the Stokes beam; a phase shifting unit for shifting a phase of the beams passing through a standard sample and a phase of an anti-Stokes beam generated from the standard sample on the same path, wherein the Stokes beam and the pump beam generated from the light source pass through the standard sample at the same time to generate the anti-Stokes beam; a scanning unit for scanning the beam phase-shifted by the phase shifting unit onto a space of a test sample; and a detecting unit for detecting optical interference due to a phase difference between a light signal generated by passing the test sample and a light signal generated by passing the standard sample.
摘要翻译：本发明涉及级联型干涉式非线性光学成像装置，该成像装置包括用于产生具有期望频带的斯托克斯光束的光源和用于利用斯托克斯光束在样品中激发介质分子的泵浦光束; 移相单元，用于移动通过标准样品的光束的相位和在同一路径上从标准样品产生的反斯托克斯光束的相位，其中斯托克斯光束和从光源产生的泵浦光束通过标准样品同时产生反斯托克斯波束; 扫描单元，用于将由相移单元相移的光束扫描到测试样本的空间上; 以及检测单元，用于检测由于通过测试样本产生的光信号与通过标准样本产生的光信号之间的相位差的光学干涉。

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