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1. 发明申请

WO2006119115A3 ANTI-IL-6 ANTIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
公开(公告)号：WO2006119115A3
公开(公告)日：2006-11-09
申请号：PCT/US2006/016457
申请日：2006-04-28
申请人： CENTOCOR, INC. , APPLIED MOLECULAR EVOLUTION, INC. , CHEN, Yan , GARDNER, Debra , KNIGHT, David, M. , LARK, Michael, W. , LIANG, Bailin , SHEALY, David, J. , SONG, Xiao-Yu, R. , STOJANOVIC-SUSULIC, Vedrana , SWEET, Raymond, W. , TAM, Susan, H. , WU, Sheng-Jiun , YANG, Jing , MARQUIS, David, Matthew , SMITH, Eric, Michael , VASSEROT, Alain, Philippe
发明人： CHEN, Yan , GARDNER, Debra , KNIGHT, David, M. , LARK, Michael, W. , LIANG, Bailin , SHEALY, David, J. , SONG, Xiao-Yu, R. , STOJANOVIC-SUSULIC, Vedrana , SWEET, Raymond, W. , TAM, Susan, H. , WU, Sheng-Jiun , YANG, Jing , MARQUIS, David, Matthew , SMITH, Eric, Michael , VASSEROT, Alain, Philippe
IPC分类号： C12N5/10 , C12N15/12 , C12N15/13 , C12N15/63 , A61K39/395 , G01N33/53 , G01N33/567
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

2. 发明申请

WO2006119115A2 ANTI-IL-6 ANTIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译：抗IL-6抗体，组合物，方法和用途
公开(公告)号：WO2006119115A2
公开(公告)日：2006-11-09
申请号：PCT/US2006016457
申请日：2006-04-28
申请人： CENTOCOR INC , APPLIED MOLECULAR EVOLUTION , CHEN YAN , GARDNER DEBRA , KNIGHT DAVID M , LARK MICHAEL W , LIANG BAILIN , SHEALY DAVID J , SONG XIAO-YU R , STOJANOVIC-SUSULIC VEDRANA , SWEET RAYMOND W , TAM SUSAN H , WU SHENG-JIUN , YANG JING , MARQUIS DAVID MATTHEW , SMITH ERIC MICHAEL , VASSEROT ALAIN PHILIPPE
发明人： CHEN YAN , GARDNER DEBRA , KNIGHT DAVID M , LARK MICHAEL W , LIANG BAILIN , SHEALY DAVID J , SONG XIAO-YU R , STOJANOVIC-SUSULIC VEDRANA , SWEET RAYMOND W , TAM SUSAN H , WU SHENG-JIUN , YANG JING , MARQUIS DAVID MATTHEW , SMITH ERIC MICHAEL , VASSEROT ALAIN PHILIPPE
IPC分类号： A61K39/395 , C07H21/04 , C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用方法在诊断和/或治疗组合物中的应用，方法和设备。

3. 发明申请

WO1994007511A1 ANTIBODIES DETECTING STROMELYSIN CLEAVAGE PRODUCTS 审中-公开
标题翻译：检测结构产品的抗体
公开(公告)号：WO1994007511A1
公开(公告)日：1994-04-14
申请号：PCT/US1993008940
申请日：1993-09-21
申请人： MERCK & CO., INC. , MUMFORD, Richard, A. , LARK, Michael, W. , BAYNE, Ellen, B., K. , HOERRNER, Lori, A.
发明人： MERCK & CO., INC.
IPC分类号： A61K35/16
CPC分类号： C07K14/78 , C07K14/4713 , C07K16/18
摘要： Monospecific antibodies are produced which are specific for fragments of the connective tissue protein aggrecan, generated by specific stromelysin cleavage. These monospecific antibodies are used in an assay system to detect polypeptide fragments of aggrecan, produced by the specific cleavage of aggrecan by stromelysin. The presence of aggrecan polypeptide fragments demonstrates stromelysin activity. Elevations of stromelysin occur in osteoarthritis, rheumatoid arthritis, atherosclerotic lesions, gout, inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF), certain cancers, joint injuries, and numerous inflammatory diseases. The monospecific antibodies and the assay system are used to quantitate aggrecan polypeptide fragments as a readout of stromelysin activity and to evaluate potential stromelysin inhibitors.
摘要翻译：产生单特异性抗体，其特异性是通过特异性溶质酶切割产生的结缔组织蛋白聚集蛋白聚糖的片段。这些单特异性抗体用于测定系统中以检测通过溶基质解素特异性切割聚集蛋白聚糖的聚集蛋白聚糖蛋白聚糖的多肽片段。聚集蛋白聚糖多肽片段的存在显示了基质溶蛋白酶活性。基质溶素的升高发生在骨关节炎，类风湿性关节炎，动脉粥样硬化病变，痛风，炎性肠病（IBD），特发性肺纤维化（IPF），某些癌症，关节损伤和许多炎性疾病中。单特异性抗体和测定系统用于定量聚集蛋白聚糖多肽片段作为溶质蛋白酶活性的读数并评价潜在的溶基质蛋白酶抑制剂。

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