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1. 发明申请

WO2007005940A3 COMBINATIONS OF ESZOPICLONE AND DIDESMETHYLSIBUTRAMINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS 审中-公开
公开(公告)号：WO2007005940A3
公开(公告)日：2007-01-11
申请号：PCT/US2006/026146
申请日：2006-07-05
申请人： SEPRACOR INC. , CARON, Judy , WESSEL, Thomas , LALJI, Karim , VARNEY, Mark A.
发明人： CARON, Judy , WESSEL, Thomas , LALJI, Karim , VARNEY, Mark A.
IPC分类号： A01N43/58 , A01N43/60 , A61K31/495 , A61K31/50
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is didesmethylsibutramine or (S)-didesmethylsibutramine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.

2. 发明申请

WO2007005962A3 COMBINATIONS OF ESZOPICLONE AND AN ANTIDEPRESSANT 审中-公开
标题翻译：精神分裂症和抗抑郁药的组合
公开(公告)号：WO2007005962A3
公开(公告)日：2007-09-27
申请号：PCT/US2006026186
申请日：2006-07-05
申请人： SEPRACOR INC , CARON JUDY , WESSEL THOMAS , LALJI KARIM , VARNEY MARK A
发明人： CARON JUDY , WESSEL THOMAS , LALJI KARIM , VARNEY MARK A
IPC分类号： A61K31/495
CPC分类号： A61K31/4985 , A61K31/343 , A61K31/381 , A61K31/4745 , A61K45/06 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is an antidepressant. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是抗抑郁药。本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。

3. 发明申请

WO2007006003A2 COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS 审中-公开
标题翻译：异佛尔酮和4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-氮杂吗啉或4-（3,4-二氯苯基）-1,2,3， 4-四氢-1-萘甲酰胺，以及治疗男性和儿童，男性和老年人的方法
公开(公告)号：WO2007006003A2
公开(公告)日：2007-01-11
申请号：PCT/US2006/026361
申请日：2006-07-06
申请人： SEPRACOR INC. , CARON, Judy , WESSEL, Thomas , LALJI, Karim , VARNEY, Mark , BAKALE, Roger, P. , SINGH, Surendra, P. , WILKINSON, H., Scott , SU, Xiping , HAN, Zhengxu , KOENIG, Stephan, G.
发明人： CARON, Judy , WESSEL, Thomas , LALJI, Karim , VARNEY, Mark , BAKALE, Roger, P. , SINGH, Surendra, P. , WILKINSON, H., Scott , SU, Xiping , HAN, Zhengxu , KOENIG, Stephan, G.
IPC分类号： A61K31/498
CPC分类号： A61K31/4985 , A61K31/135 , C07C211/42 , C07C2602/10 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或多种活性剂的药物组合物，当它们一起被用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基） -1,2,3,4-四氢-1-萘胺。本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑症和认知障碍的方法。

4. 发明申请

WO2007006003A3 COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISO 审中-公开
标题翻译：异佛尔酮与4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘甲酸或4-（3,4-二氯苯基）-1,2,3， 4-四氢-1-萘甲酰胺，以及治疗男性和儿童，男性和爱滋病的方法
公开(公告)号：WO2007006003A3
公开(公告)日：2009-04-30
申请号：PCT/US2006026361
申请日：2006-07-06
申请人： SEPRACOR INC , CARON JUDY , WESSEL THOMAS , LALJI KARIM , VARNEY MARK , BAKALE ROGER P , SINGH SURENDRA P , WILKINSON H SCOTT , SU XIPING , HAN ZHENGXU , KOENIG STEFAN G
发明人： CARON JUDY , WESSEL THOMAS , LALJI KARIM , VARNEY MARK , BAKALE ROGER P , SINGH SURENDRA P , WILKINSON H SCOTT , SU XIPING , HAN ZHENGXU , KOENIG STEFAN G
IPC分类号： A61K31/135
CPC分类号： A61K31/4985 , A61K31/135 , C07C211/42 , C07C2602/10 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基） -1,2,3,4-四氢-1-萘胺。本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。

5. 发明申请

WO2007005961A3 COMBINATIONS OF ESZOPICLONE AND O-DESMETHYLVENLAFAXINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS 审中-公开
标题翻译： ESZOPICLONE和O-DESMETHYLVENLAFAXINE的联合治疗及治疗偏头痛，情绪低落，焦虑和认知障碍的方法
公开(公告)号：WO2007005961A3
公开(公告)日：2007-02-22
申请号：PCT/US2006026185
申请日：2006-07-05
申请人： SEPRACOR INC , CARON JUDY , WESSEL THOMAS , LALJI KARIM , VARNEY MARK A
发明人： CARON JUDY , WESSEL THOMAS , LALJI KARIM , VARNEY MARK A
IPC分类号： A61K31/135 , A61K31/495
CPC分类号： A61K31/4985 , A61K31/137 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is O-desmethylvenlafaxine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂在一起时可用于治疗例如绝经，心境障碍，焦虑症或认知障碍。药物组合物的第一组分是镇静性右佐匹克隆。药物组合物的第二组分是O-去甲基文拉法辛。本发明还涉及治疗更年期，围绝经期，情绪障碍，焦虑症和认知障碍的方法。

6. 发明申请

WO2007005962A2 COMBINATIONS OF ESZOPICLONE AND AN ANTIDEPRESSANT, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS 审中-公开
标题翻译：精神分裂症和抗抑郁药的联合治疗，以及治疗男性和儿童，老年人和认知障碍的方法
公开(公告)号：WO2007005962A2
公开(公告)日：2007-01-11
申请号：PCT/US2006/026186
申请日：2006-07-05
申请人： SEPRACOR INC. , CARON, Judy , WESSEL, Thomas , LALJI, Karim , VARNEY, Mark, A.
发明人： CARON, Judy , WESSEL, Thomas , LALJI, Karim , VARNEY, Mark, A.
IPC分类号： A61K31/4745
CPC分类号： A61K31/4985 , A61K31/343 , A61K31/381 , A61K31/4745 , A61K45/06 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is an antidepressant. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是抗抑郁药。本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。

7. 发明申请

WO2007005961A2 COMBINATIONS OF ESZOPICLONE AND O-DESMETHYLVENLAFAXINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS 审中-公开
标题翻译：异氟烷酮和邻苯二酚的组合以及治疗男性和儿童，阴性和认知障碍的方法
公开(公告)号：WO2007005961A2
公开(公告)日：2007-01-11
申请号：PCT/US2006/026185
申请日：2006-07-05
申请人： SEPRACOR INC. , CARON, Judy , WESSEL, Thomas , LALJI, Karim , VARNEY, Mark, A.
发明人： CARON, Judy , WESSEL, Thomas , LALJI, Karim , VARNEY, Mark, A.
IPC分类号： A61K31/137
CPC分类号： A61K31/4985 , A61K31/137 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is O-desmethylvenlafaxine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是O-去甲基文拉法辛。本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。

8. 发明申请

WO2007005940A2 COMBINATIONS OF ESZOPICLONE AND DIDESMETHYLSIBUTRAMINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS 审中-公开
标题翻译：咪唑啉酮和二甲基嘧啶胺的组合，以及治疗男性和儿童，老年性和认知障碍的方法
公开(公告)号：WO2007005940A2
公开(公告)日：2007-01-11
申请号：PCT/US2006026146
申请日：2006-07-05
申请人： SEPRACOR INC , CARON JUDY , WESSEL THOMAS , LALJI KARIM , VARNEY MARK A
发明人： CARON JUDY , WESSEL THOMAS , LALJI KARIM , VARNEY MARK A
IPC分类号： A61K31/498
CPC分类号： A61K31/498 , A61K31/135 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is didesmethylsibutramine or (S)-didesmethylsibutramine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是二甲基西布曲明或（S） - 二甲基甲基西布曲明。本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。

9. 发明申请

WO2005063248A1 MODAFINIL COMBINATION THERAPY FOR IMPROVING SLEEP QUALITY 审中-公开
标题翻译： MODAFINIL组合治疗提高睡眠质量
公开(公告)号：WO2005063248A1
公开(公告)日：2005-07-14
申请号：PCT/US2004/042938
申请日：2004-12-21
申请人： SEPRACOR INC. , LALJI, Karim , BARBERICH, Timothy, J.
发明人： LALJI, Karim , BARBERICH, Timothy, J.
IPC分类号： A61K31/495
CPC分类号： A61K45/06 , A61K31/165 , A61K31/195 , A61K31/4164 , A61K31/495 , A61K31/7008 , A61K31/724 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions comprising a compound that modulates the orexin system and a sedative agent. In a preferred embodiment, the compound that modulates the orexin system is modafinil and the sedative agent is ( S )-zopiclone. The pharmaceutical compositions of the invention are useful in the treatment of various sleep disorders. In addition, the present invention relates to a method of treating a patient suffering from a sleep abnormality or insomnia comprising administering a therapeutically effective amount of a pharmaceutical composition of the invention.
摘要翻译：本发明的一个方面涉及包含调节食欲素系统的化合物和镇静剂的药物组合物。在优选的实施方案中，调节食欲素系统的化合物是莫达非尼，镇静剂是（S） - 佐匹克隆。本发明的药物组合物可用于治疗各种睡眠障碍。此外，本发明涉及治疗患有睡眠异常或失眠的患者的方法，包括给予治疗有效量的本发明的药物组合物。

10. 发明申请

WO2005060968A1 COMBINATION OF A SEDATIVE AND A NEUROTRANSMITTER MODULATOR, AND METHODS FOR IMPROVING SLEEP QUALITY AND TREATING DEPRESSION 审中-公开
标题翻译：消融和神经递质调节剂的组合以及改善睡眠质量和治疗抑郁症的方法
公开(公告)号：WO2005060968A1
公开(公告)日：2005-07-07
申请号：PCT/US2004/040962
申请日：2004-12-08
申请人： SEPRACOR INC. , LALJI, Karim , BARBERICH, Timothy, J. , CARON, Judy , WESSEL, Thomas
发明人： LALJI, Karim , BARBERICH, Timothy, J. , CARON, Judy , WESSEL, Thomas
IPC分类号： A61K31/4985
CPC分类号： A61K31/4985 , A61K31/137 , A61K31/138 , A61K31/495 , A61K31/724 , A61K45/06 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., insomnia and/or depression. The first component of the pharmaceutical composition is a GABA receptor modulating compound. The second component of the pharmaceutical composition is a serotonin reuptake inhibitor, a norepinephrine reuptake inhibitor, a 5-HT 2A modulator, or dopamine reuptake inhibitor. In certain embodiments, the pharmaceutical composition comprises eszopiclone. In a preferred embodiment, the pharmaceutical composition comprises eszopiclone and fluoxetine. The present invention also relates to a method of treating a sleep abnormality, treating insomnia, treating depression, augmenting antidepressant therapy, eliciting a dose-sparing effect, reducing depression relapse, improving the efficacy of antidepressant therapy or improving the tolerability of antidepressant therapy, comprising co-administering to a patient in need thereof a GABA-receptor-modulating compound; and a SRI, NRI, 5-HT 2A modulator or DRI.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，当它们一起被用于治疗，例如失眠和/或抑郁症时。药物组合物的第一组分是调节GABA受体的化合物。药物组合物的第二组分是5-羟色胺再摄取抑制剂，去甲肾上腺素再摄取抑制剂，5-HT2A调节剂或多巴胺再摄取抑制剂。在某些实施方案中，药物组合物包含依佐匹克。在优选的实施方案中，药物组合物包含依佐匹克和氟西汀。本发明还涉及一种治疗睡眠异常，治疗失眠，治疗抑郁症，增强抗抑郁药治疗，引发剂量保留作用，减少抑郁症复发，改善抗抑郁治疗疗效或提高抗抑郁治疗耐受性的方法，包括向有需要的患者共同施用GABA受体调节化合物; 和SRI，NRI，5-HT2A调节剂或DRI。

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