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1. 发明申请

WO2012154483A1 DRY POWDER FOSFOMYCIN/TOBRAMYCIN FORMULATION FOR INHALATION 审中-公开
标题翻译：干粉FOSFOMYCIN / TOBRAMYCIN制剂用于吸入
公开(公告)号：WO2012154483A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/036260
申请日：2012-05-03
申请人： GILEAD SCIENCES, INC. , LAI, Johnny , BROWN, Josiah , STAPLETON, Kevin, Walter
发明人： LAI, Johnny , BROWN, Josiah , STAPLETON, Kevin, Walter
IPC分类号： A61K31/198 , A61K31/665 , A61K31/7036 , A61P11/00 , A61K9/00
CPC分类号： A61K9/0073 , A61K9/0075 , A61K31/198 , A61K31/665 , A61K31/7036 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： The present invention provides an inhaled dry powder formulation containing a combination of fosfomycin salt and tobramycin-leucine compound particles. The use of such formulation for the treatment of patients who have Chronic Obstructive Pulmonary Disease (COPD) and who are experiencing or at risk of experiencing acute exacerbation, as well as patients who have other bacterial infections of the respiratory tract, particularly the lower respiratory tract, and methods for treating the same are also provided.
摘要翻译：本发明提供含有磷霉素盐和妥布霉素 - 亮氨酸复合物颗粒的组合的吸入干粉制剂。使用这种制剂治疗患有慢性阻塞性肺疾病（COPD）并且正在经历或正在经历急性加重的患者的患者，以及患有其它呼吸道细菌感染的患者，特别是下呼吸道，还提供了其处理方法。

2. 发明申请

WO2007100741A3 SYSTEM FOR DELIVERING NEBULIZED CYCLOSPORINE AND METHODS OF TREATMENT 审中-公开
标题翻译：输送神经性环磷酰胺的系统和治疗方法
公开(公告)号：WO2007100741A3
公开(公告)日：2007-12-27
申请号：PCT/US2007004861
申请日：2007-02-22
申请人： NOVARTIS PHARMA AG , LAI JOHNNY
发明人： LAI JOHNNY
IPC分类号： A61M16/10
CPC分类号： A61M16/105 , A61M16/0093 , A61M16/1065
摘要： Systems comprising a pressurized delivery device and a formulation of cyclosporine coupled to an exhalation filter or trap that is capable of preventing cyclosporine from escaping into the local environment are provided. An apparatus for use in the system comprises either an exhalation filter and a pressurized delivery device, wherein the exhalation filter is capable of providing high filter efficiency and maintaining low filter resistance after usage with the formulation, or a trap which provides a means for expired gas to be released into a solvent chamber containing a solvent with a high affinity for cyclosporine. These systems may be used to treat patients with pulmonary disorders, organ transplant patients such as lung transplant patients, and other immune-related disorders.
摘要翻译：提供了包括加压输送装置和联接到呼气过滤器或捕集器的环孢菌素制剂的系统，其能够防止环孢菌素逃逸到局部环境中。用于该系统的装置包括呼气过滤器和加压输送装置，其中呼气过滤器能够在与配方一起使用之后提供高过滤效率并保持低过滤器阻力，或者提供用于呼出气体的装置的捕集器被释放到含有对环孢菌素具有高亲和力的溶剂的溶剂室中。这些系统可用于治疗肺部疾病患者，器官移植患者如肺移植患者，以及其他免疫相关疾病。

3. 发明申请

WO2007124382A2 INHALED IMIPENEM 审中-公开
标题翻译：吸入的IMIPENEM
公开(公告)号：WO2007124382A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/067002
申请日：2007-04-19
申请人： NOVARTIS VACCINES AND DIAGNOSTICS, INC. , LAI, Johnny , SHAWAR, Ribhi
发明人： LAI, Johnny , SHAWAR, Ribhi
CPC分类号： A61K9/0075 , A61K9/0078 , A61K9/008 , C07D477/20
摘要： The present invention relates to inhaled formulations containing imipenem for increased efficacy and decreased toxicity in treating microbial infections.
摘要翻译：本发明涉及含有亚胺培南的吸入制剂，其用于增加治疗微生物感染的功效和降低的毒性。

4. 发明申请

WO2007100741A2 SYSTEM FOR DELIVERING NEBULIZED CYCLOSPORINE AND METHODS OF TREATMENT 审中-公开
标题翻译：递送环磷酰胺系统和治疗方法
公开(公告)号：WO2007100741A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/004861
申请日：2007-02-22
申请人： NOVARTIS PHARMA AG , LAI, Johnny
发明人： LAI, Johnny
IPC分类号： A61M16/10
CPC分类号： A61M16/105 , A61M16/0093 , A61M16/1065
摘要： Systems comprising a pressurized delivery device and a formulation of cyclosporine coupled to an exhalation filter or trap that is capable of preventing cyclosporine from escaping into the local environment are provided. An apparatus for use in the system comprises either an exhalation filter and a pressurized delivery device, wherein the exhalation filter is capable of providing high filter efficiency and maintaining low filter resistance after usage with the formulation, or a trap which provides a means for expired gas to be released into a solvent chamber containing a solvent with a high affinity for cyclosporine. These systems may be used to treat patients with pulmonary disorders, organ transplant patients such as lung transplant patients, and other immune-related disorders.
摘要翻译：提供了包括加压输送装置和联合到呼出过滤器或捕集器的环孢菌素制剂的系统，其能够防止环孢菌素逃逸到局部环境中。用于该系统的装置包括呼气过滤器和加压输送装置，其中呼气过滤器能够在配制剂使用后提供高过滤效率和维持低过滤阻力，或提供呼出气体的装置被释放到含有对环孢菌素具有高亲和力的溶剂的溶剂室中。这些系统可用于治疗肺部疾病患者，器官移植患者如肺移植患者和其他免疫相关疾病。

5. 发明申请

WO9924016A8 EMULSIONS FOR AEROSOLIZATION AND DRUG DELIVERY 审中-公开
标题翻译：用于气雾剂和药物递送的乳剂
公开(公告)号：WO9924016A8
公开(公告)日：1999-07-29
申请号：PCT/US9823900
申请日：1998-11-09
申请人： SONUS PHARMA INC , LAI JOHNNY , KESSLER DEAN R , QUAY STEVEN C
发明人： LAI JOHNNY , KESSLER DEAN R , QUAY STEVEN C
IPC分类号： A61K9/00 , A61K9/107 , A61K9/12
CPC分类号： A61K9/0026 , A61K9/0078
摘要： Compositions containing drug- or therapeutic agent-containing solutions and fluorocarbons are disclosed for pulmonary delivery of the drug or therapeutic agent. Suitable fluorocarbons have relatively high vapor pressures or corresponding low boiling points, preferably between about -30 DEG to about 150 DEG C, and include dodecafluoropentane, dodecafluoroneopentane, perfluorocyclopentane, perfluoro-2-methyl pentane, perfluorohexane, perfluoroheptane, perfluorooctane, perfluorodecalin and isomers and mixtures thereof. Aerosolized emulsions of these fluorocarbons produce fine aerosol particles of
摘要翻译：含有含药物或治疗剂的溶液和碳氟化合物的组合物被公开用于药物或治疗剂的肺部递送。合适的碳氟化合物具有较高的蒸气压或相应的低沸点，优选约-30至约150℃，包括十二氟戊烷，十二氟戊酮戊烷，全氟环戊烷，全氟-2-甲基戊烷，全氟己烷，全氟庚烷，全氟辛烷，全氟萘烷和异构体和其混合物。这些碳氟化合物的雾化乳剂产生≤5微米的精细气溶胶颗粒，并且还可以提供药物或治疗剂的改善的溶解度。碳氟化合物也具有足够高的蒸气压，并且以足够小的量使用，以有效地将药物或治疗剂递送至肺，然后通过蒸发离开肺的空气空间。

6. 发明申请

WO2007124382A3 INHALED IMIPENEM 审中-公开
标题翻译：吸入的IMIPENEM
公开(公告)号：WO2007124382A3
公开(公告)日：2008-05-29
申请号：PCT/US2007067002
申请日：2007-04-19
申请人： NOVARTIS VACCINES & DIAGNOSTIC , LAI JOHNNY , SHAWAR RIBHI
发明人： LAI JOHNNY , SHAWAR RIBHI
IPC分类号： A61K9/00 , A61K9/20 , C07D477/20
CPC分类号： A61K9/0075 , A61K9/0078 , A61K9/008 , C07D477/20
摘要： The present invention relates to inhaled formulations containing imipenem for increased efficacy and decreased toxicity in treating microbial infections.
摘要翻译：本发明涉及含有亚胺培南的吸入制剂，其用于增加治疗微生物感染的功效和降低的毒性。

7. 发明申请

WO2006033713A3 METHODS FOR CIPROFLOXACIN INHALATION 审中-公开
标题翻译： CIPROFLOXACIN吸入的方法
公开(公告)号：WO2006033713A3
公开(公告)日：2006-08-24
申请号：PCT/US2005028102
申请日：2005-08-09
申请人： CHIRON CORP , LAI JOHNNY , WAGMAN ALLAN , CHALLONER PETE , SHAWAR RIBHI , TOWELL ANDY , TAK RAHUL , HUH KAY
发明人： LAI JOHNNY , WAGMAN ALLAN , CHALLONER PETE , SHAWAR RIBHI , TOWELL ANDY , TAK RAHUL , HUH KAY
IPC分类号： A61K9/00 , A61K9/14 , A61K38/05
CPC分类号： A61K9/0075 , A61K47/183 , A61K47/24 , A61K47/42
摘要： The present invention relates to dry power inhaled formulations containing ciprofloxacin for increased efficacy and decreased toxicity in treating microbial infections.
摘要翻译：本发明涉及含有环丙沙星的干力吸入制剂，其用于增加治疗微生物感染的功效和降低的毒性。

8. 发明申请

WO2006033713A2 METHODS FOR CIPROFLOXACIN INHALATION 审中-公开
标题翻译： CIPROFLOXACIN吸入方法
公开(公告)号：WO2006033713A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/028102
申请日：2005-08-09
申请人： CHIRON CORPORATION , LAI, Johnny , WAGMAN, Allan , CHALLONER, Pete , SHAWAR, Ribhi , TOWELL, Andy , TAK, Rahul , HUH, Kay
发明人： LAI, Johnny , WAGMAN, Allan , CHALLONER, Pete , SHAWAR, Ribhi , TOWELL, Andy , TAK, Rahul , HUH, Kay
IPC分类号： A61K9/72
CPC分类号： A61K9/0075 , A61K47/183 , A61K47/24 , A61K47/42 , Y02A50/473
摘要： The present invention relates to dry power inhaled formulations containing ciprofloxacin for increased efficacy and decreased toxicity in treating microbial infections.
摘要翻译：本发明涉及含有环丙沙星的干粉吸入制剂，用于提高疗效并降低治疗微生物感染的毒性。

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