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1. 发明申请

WO2011032181A2 LIBRARIES OF GENETIC PACKAGES COMPRISING NOVEL HC CDR3 DESIGNS 审中-公开
标题翻译：包含新HC HC CDR3设计的遗传包的图书馆
公开(公告)号：WO2011032181A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/048830
申请日：2010-09-14
申请人： DYAX CORP. , LADNER, Robert, C.
发明人： LADNER, Robert, C.
IPC分类号： C40B40/08 , C40B40/10
CPC分类号： C07K16/005 , C07K2317/21 , C07K2317/565
摘要： Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long. Libraries encoding antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.
摘要翻译：提供了用于制备和鉴定具有从很短到很长的序列和长度变化的CDR3的抗体的组合物和方法。还提供了编码具有CDR3的抗体的文库。可以通过修改预先存在的核酸文库来提供文库。

2. 发明申请

WO2007079218A2 METALLOPROTEINASE BINDING PROTEINS 审中-公开
标题翻译：金属蛋白酶结合蛋白
公开(公告)号：WO2007079218A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/049566
申请日：2006-12-29
申请人： DYAX CORP. , DEVY, Laetitia , PIETERS, Henk , FRANS, Nicolas , NAA, Laurent , KUANG, Guannan , VAN GOOL, Reinoud , LADNER, Robert C. , BREPOELS, Eddy , NIXON, Andrew , HOET, Rene , HENDERIKX, Paula
发明人： DEVY, Laetitia , PIETERS, Henk , FRANS, Nicolas , NAA, Laurent , KUANG, Guannan , VAN GOOL, Reinoud , LADNER, Robert C. , BREPOELS, Eddy , NIXON, Andrew , HOET, Rene , HENDERIKX, Paula
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96486
摘要： Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
摘要翻译：描述了结合基质金属蛋白酶14的蛋白质和使用这些蛋白质的方法。

3. 发明申请

WO2006017538A9 HK1-BINDING PROTEINS 审中-公开
标题翻译： HK1结合蛋白
公开(公告)号：WO2006017538A9
公开(公告)日：2006-03-30
申请号：PCT/US2005027493
申请日：2005-08-03
申请人： DYAX CORP , SEXTON DANIEL J , NIXON ANDREW , WILLIAMS ANTHONY , LADNER ROBERT C , WU QI-LONG
发明人： SEXTON DANIEL J , NIXON ANDREW , WILLIAMS ANTHONY , LADNER ROBERT C , WU QI-LONG
IPC分类号： C07K16/00
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/564 , G01N2800/122
摘要： The invention features hKl binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides.
摘要翻译：本发明的特征在于hK1结合多肽以及包含这些多肽的组合物以及制备和使用这些多肽的方法。

4. 发明申请

WO2005021556A2 MODIFIED PROTEASE INHIBITORS 审中-公开
标题翻译：修饰的蛋白酶抑制剂
公开(公告)号：WO2005021556A2
公开(公告)日：2005-03-10
申请号：PCT/US2004028256
申请日：2004-08-30
申请人： DYAX CORP , LADNER ROBERT C , SATO AARON K , AMARAL MICHELLE , BOSSARD MARY J , ROBERTS MICHAEL J , ZHANG YAN , LEY ARTHUR C
发明人： LADNER ROBERT C , SATO AARON K , AMARAL MICHELLE , BOSSARD MARY J , ROBERTS MICHAEL J , ZHANG YAN , LEY ARTHUR C
IPC分类号： A61K38/00 , A61K47/48 , A61K49/00 , C07F20060101 , C07K14/00 , C07K14/81 , C12N9/00 , C12N9/66 , C07F
CPC分类号： C07K14/8114 , A61K38/00 , A61K47/60 , A61K49/0002
摘要： DX-890 inhibits elastase. DX-890 can be attached a single polyethylene glycol moiety. The polyethylene glycol is at least 18 kDa in molecular weight and is attached to the polypeptide by a single covalent bond to the N-terminus of the polypeptide.
摘要翻译： DX-890抑制弹性蛋白酶。 DX-890可以连接一个单一的聚乙二醇部分。聚乙二醇的分子量至少为18kDa，并且通过与多肽的N末端单一共价键与多肽连接。

5. 发明申请

WO2003103475A3 PREVENTION AND REDUCTION OF BLOOD LOSS 审中-公开
公开(公告)号：WO2003103475A3
公开(公告)日：2003-12-18
申请号：PCT/US2003/017665
申请日：2003-06-06
申请人： DYAX CORP. , LADNER, Robert, C. , LEY, Arthur, C. , HIRANI, Shirish , WILLIAMS, Anthony
发明人： LADNER, Robert, C. , LEY, Arthur, C. , HIRANI, Shirish , WILLIAMS, Anthony
IPC分类号： A61K9/00
摘要： Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g ., coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.

6. 发明申请

WO2009132287A3 LIBRARIES OF GENETIC PACKAGES COMPRISING NOVEL HC CDR1, CDR2, AND CDR3 AND NOVEL LC CDR1, CDR2, AND CDR3 DESIGNS 审中-公开
公开(公告)号：WO2009132287A3
公开(公告)日：2009-10-29
申请号：PCT/US2009/041688
申请日：2009-04-24
申请人： DYAX CORP. , LADNER, Robert, C.
发明人： LADNER, Robert, C.
IPC分类号： C40B40/10
摘要： Provided are compositions and methods for preparing and identifying antibodies having CDR3s that vary in sequence and in length from very short to very long which in certain embodiments may bind to a carbohydrate moiety or the active site of an enzyme. Libraries coding for antibodies with the CDR3s are also provided. The libraries can be provided by modifying a pre-existing nucleic acid library.

7. 发明申请

WO2006084050A3 LIBRARIES AND METHODS FOR ISOLATING ANTIBODIES 审中-公开
标题翻译：用于分离抗体的图书馆和方法
公开(公告)号：WO2006084050A3
公开(公告)日：2007-02-22
申请号：PCT/US2006003705
申请日：2006-02-01
申请人： DYAX CORP , HOET RENE , SCHOONBROODT SONIA , LADNER ROBERT C
发明人： HOET RENE , SCHOONBROODT SONIA , LADNER ROBERT C
IPC分类号： C07H21/04 , C07K16/00 , C12P21/06 , G01N33/53 , G01N33/557
CPC分类号： C07K16/005 , C07K16/00 , C07K16/18 , C07K16/2896 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C40B30/04
摘要： The disclosure features methods for identifying antibodies that bind to a carbohydrate moiety. Libraries coding for antibodies that bind to a carbohydrate moiety are provided. The libraries can be provided by modifying a pre-existing nucleic acid library. Antibodies that bind to a carbohydrate moiety are described.
摘要翻译：本公开的特征在于鉴定结合于碳水化合物部分的抗体的方法。提供编码结合于碳水化合物部分的抗体的文库。可以通过修饰预先存在的核酸文库来提供文库。描述了与碳水化合物部分结合的抗体。

8. 发明申请

WO2004078778A2 PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (cMet) AND USES THEREOF 审中-公开
标题翻译：肽特异性结合HGF受体（cMet）及其用途
公开(公告)号：WO2004078778A2
公开(公告)日：2004-09-16
申请号：PCT/US2004/006473
申请日：2004-03-03
申请人： DYAX CORP. , BRACCO INTERNATIONAL B.V. , SATO, Aaron, K. , DRANSFIELD, Daniel, T. , LADNER, Robert, C. , SHRIVASTAVA, Ajay , NANJAPPAN, Palaniappa
发明人： SATO, Aaron, K. , DRANSFIELD, Daniel, T. , LADNER, Robert, C. , SHRIVASTAVA, Ajay , NANJAPPAN, Palaniappa
IPC分类号： C07K
CPC分类号： C07K7/08 , A61K47/543 , A61K47/60 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K51/08 , B82Y5/00 , C07K14/00 , C07K14/4753
摘要： A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
摘要翻译：公开了具有结合cMet的能力的多肽或多聚体多肽构建体或包含cMet和HGF的复合物，以及使用方法。

9. 发明申请

WO2003074005A2 KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 审中-公开
标题翻译： KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用
公开(公告)号：WO2003074005A2
公开(公告)日：2003-09-12
申请号：PCT/US2003/006731
申请日：2003-03-03
申请人： DYAX CORP. , BRACCO INTERNATIONAL B.V. , SATO, Aaron, K. , SEXTON, Daniel, J. , LADNER, Robert, C. , DRANSFIELD, Daniel, T. , SWENSON, Rolf, E. , MARINELLI, Edmund, R. , RAMALINGAM, Kondareddiar , NUNN, Adrian, D. , VON WRONSKI, Mathew, A. , SHRIVASTAVA, Ajay , POCHON, Sibylle , BUSSAT, Philippe , ARBOGAST, Christophe , PILLAI, Radhakrishna , FAN, Hong , LINDER, Karen, E. , SONG, Bo , NANJAPPAN, Palaniappa
发明人： SATO, Aaron, K. , SEXTON, Daniel, J. , LADNER, Robert, C. , DRANSFIELD, Daniel, T. , SWENSON, Rolf, E. , MARINELLI, Edmund, R. , RAMALINGAM, Kondareddiar , NUNN, Adrian, D. , VON WRONSKI, Mathew, A. , SHRIVASTAVA, Ajay , POCHON, Sibylle , BUSSAT, Philippe , ARBOGAST, Christophe , PILLAI, Radhakrishna , FAN, Hong , LINDER, Karen, E. , SONG, Bo , NANJAPPAN, Palaniappa
IPC分类号： A61K
CPC分类号： C07K7/08 , A61K38/00 , A61K49/223 , A61K51/088 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要： The present invention provides binding polypetides for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, Detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K D
摘要翻译：本发明提供了用于KDR或VEGF / KDR复合物的结合多肽，其在治疗，检测，分离或定位血管发生的任何地方具有多种用途是有利的。特别公开的是能够以高亲和力结合KDR或VEGF / KDR复合物的合成的，分离的多肽（例如具有KD <1微摩尔）。

10. 发明申请

WO2003048902A2 LIBRARY SCREENING 审中-公开
标题翻译：图书馆筛选
公开(公告)号：WO2003048902A2
公开(公告)日：2003-06-12
申请号：PCT/US2002/038539
申请日：2002-12-03
申请人： DYAX CORPORATION , WHELIHAN, Fayelle, E. , LADNER, Robert, C.
发明人： WHELIHAN, Fayelle, E. , LADNER, Robert, C.
IPC分类号： G06F
CPC分类号： G06Q50/22 , G06F19/28 , Y02A90/22
摘要： Systems, methods, and apparati for screening libraries, particularly display libraries are disclosed. Methods can be automated or at least partially machine-based. Also disclosed are software and databases that interface with a library screening process such as a display library screening process. A computer system can be used to store, manage, and generate information that includes assay results and sample tracking from various automation stations. The system can include interfaces for project management, data analysis, and sample tacking and auditing. A database can manage hits identified during screening of a library. The database can be a relational database that includes tables for projects, libraries, screens, and hits.
摘要翻译：披露了筛选库，特别是显示库的系统，方法和装置。方法可以自动化或至少部分基于机器。还公开了与图书馆筛选过程（例如显示库筛选过程）相连接的软件和数据库。计算机系统可用于存储，管理和生成包括来自各种自动化站的测定结果和样品追踪的信息。该系统可以包括用于项目管理，数据分析和样本处理和审计的接口。数据库可以管理在筛选图书馆期间识别的命中。该数据库可以是关系数据库，其中包括项目，库，屏幕和命中的表。

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