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1. 发明专利

JP2021509413A カポックの木の花抽出物、及びそれを含有する美容、医薬又は皮膚科用組成物审中-公开
公开(公告)号：JP2021509413A
公开(公告)日：2021-03-25
申请号：JP2020554935
申请日：2018-12-21
申请人：ラボラトワールエクスパンサイエンス , LABORATOIRES EXPANSCIENCE
发明人：ルクレール−ビアンフェ, ソフィー , ブレディフ, ステファニー
IPC分类号： A61K8/9789 , A61Q19/00 , A61P43/00 , A61P39/06 , A61P29/00 , A61P17/00 , A61P9/00 , A61K31/353 , A61Q19/08 , A61K36/185
摘要：本発明は、カポックの木、特にボンバクス・コスタツムからの花、好ましくは萼の抽出物、それを調製するためのプロセス、及び前記プロセスによって得られる抽出物に関する。本発明は、こうした抽出物を含む組成物にも関し、組成物は有利には、美容、医薬又は皮膚科用組成物である。本発明は、こうした組成物、又は皮膚、粘膜若しくはケラチン付属器の障害若しくは疾患を防止又は治療することにおける使用のための及び血管障害を防止若しくは治療することにおける使用のためのこうした抽出物にも関する。本発明は、最終的に、状態又は外観を改善することを考慮した皮膚、ケラチン付属器又は粘膜のための美容ケアプロセスに関し、該プロセスは、こうした組成物又はこうした抽出物を投与することからなる。【選択図】なし

2. 发明授权

US12061189B2 Models of reconstructed sensitive skin 有权
公开(公告)号：US12061189B2
公开(公告)日：2024-08-13
申请号：US16624087
申请日：2018-06-21
申请人： Laboratoires Expanscience
发明人： Gaelle Bellemere , Stephanie Bredif , Gaetan Boyer , Caroline Baudouin
IPC分类号： G01N33/50 , C12N5/071
CPC分类号： G01N33/5088 , C12N5/0698 , C12N2503/06
摘要： The present invention relates to models of reconstructed sensitive skin reproducing the features of sensitive skin, as well as to processes for obtaining such models. The present invention further relates to in vitro processes for testing formulations or active ingredients for the prevention or treatment of sensitive skin.

3. 发明授权

US10444225B2 Surface isotropy as a marker for epidermal maturation 有权
公开(公告)号：US10444225B2
公开(公告)日：2019-10-15
申请号：US14418645
申请日：2013-08-02
申请人： LABORATOIRES EXPANSCIENCE
发明人： Philippe Msika , Nadège Lachmann , Joachim Fluhr
IPC分类号： G01N33/50
摘要： The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.

4. 发明申请

US20190000902A1 PASSION FLOWER SEED EXTRACT, AND COSMETIC, PHARMACEUTICAL OR DERMATOLOGICAL COMPOSITIONS CONTAINING SAME 审中-公开
公开(公告)号：US20190000902A1
公开(公告)日：2019-01-03
申请号：US16064312
申请日：2016-12-21
申请人： LABORATOIRES EXPANSCIENCE
发明人： Sophie LECLERE-BIENFAIT , Stéphanie BREDIF
IPC分类号： A61K36/185 , A61K8/9789 , A61K8/49 , A61K8/368 , A61Q19/08 , A61Q17/04 , A61P17/16 , A61P29/00 , A61K31/353 , A61K31/192
摘要： The invention relates to a polyphenolic extract of passion flower seeds, in particular Passiflora incarnata or Passiflora edulis seeds, comprising at least 30 percent by weight polyphenols, expressed as gallic acid equivalent, relative to the weight of the dry extract. The invention also relates to a method for preparing an extract of said type, a composition containing same, and the cosmetic, dermatological or therapeutic use thereof.

5. 发明申请

US20180369193A1 AVOCADO FLESH AND/OR SKIN EXTRACT RICH IN POLYPHENOLS AND COSMETIC, DERMATOLOGICAL AND NUTRACEUTICAL COMPOSITIONS COMPRISING SAME 审中-公开
公开(公告)号：US20180369193A1
公开(公告)日：2018-12-27
申请号：US16117511
申请日：2018-08-30
申请人： LABORATOIRES EXPANSCIENCE
发明人： Alex SAUNOIS , Caroline BAUDOUIN , Sophie LECLERE-BIENFAIT , Sebastien GARNIER , Philippe MSIKA
IPC分类号： A61K31/353 , A23L33/105 , A61Q19/00 , A23L19/00 , A61K9/00 , A61K8/49 , A61Q19/08 , A61Q19/02 , A61Q17/00 , A61K36/54 , A61K8/97 , A61Q17/04 , A61Q5/12 , A61K45/06
摘要： The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which consists in administering such a composition or such an extract.

6. 发明授权

US10143648B2 Peptide and oside extract of schisandra fruit and improvement in the response of the cutaneous neurosensory system 有权
公开(公告)号：US10143648B2
公开(公告)日：2018-12-04
申请号：US15529694
申请日：2015-11-26
申请人： LABORATOIRES EXPANSCIENCE
发明人： Philippe Msika , Caroline Baudouin , Stéphanie Bredif
IPC分类号： A61K36/79 , A61K8/97 , A61Q19/00 , A61Q7/00 , A61Q17/04 , A61Q19/08 , A61K36/00
摘要： The present invention relates to the use of a peptide and glycoside extract of Schizandra fruit as a cutaneous neurosensory agent, for improving the response of the cutaneous neurosensory system, in particular for: —improving cutaneous innervation in the basal state, —combatting age-related loss of cutaneous innervation in the basal state, advantageously for preventing loss of the cutaneous sensitivity and/or combatting thinning of the epidermis, and/or —improving cutaneous perception of the environment, more particularly for combatting burns, extreme cold and/or pain.

7. 发明申请

US20170241989A1 METHOD FOR EVALUATING THE HARMFUL EFFECTS OF URINE ON CHILDREN'S SKIN 审中-公开
公开(公告)号：US20170241989A1
公开(公告)日：2017-08-24
申请号：US15128717
申请日：2015-03-31
申请人： LABORATOIRES EXPANSCIENCE
发明人： Caroline Baudouin
IPC分类号： G01N33/50 , G01N33/68 , C12Q1/68
CPC分类号： G01N33/5088 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/6881 , G01N2500/04 , G01N2500/10
摘要： The invention relates to biomarkers of the skin of children and, in particular, that of infants, having altered expression in the presence of urine. Such markers are particularly advantageous as they allow the skin's response to urine to be monitored. The inventors have developed methods for evaluating the efficacy in vitro of formulations in preventing the harmful effects of urine on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

8. 发明授权

US09616009B2 Composition containing at least one C7 sugar for alopecia treatment, cosmetic treatment of hair and nails, and care of hair, eyelashes or nails 有权
公开(公告)号：US09616009B2
公开(公告)日：2017-04-11
申请号：US14514646
申请日：2014-10-15
申请人： LABORATOIRES EXPANSCIENCE
发明人： Caroline Baudouin , Philippe Msika
IPC分类号： A61K8/60 , A61K8/97 , A61K9/48 , A61K31/70 , A61K31/7004 , A61K36/54 , A61K45/06 , A61Q3/00 , A61Q7/00 , A23L2/52 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A23L7/126 , A61Q5/00
CPC分类号： A61K8/60 , A23L2/52 , A23L7/126 , A23V2002/00 , A61K8/97 , A61K9/4858 , A61K31/70 , A61K31/7004 , A61K36/54 , A61K45/06 , A61K2800/5922 , A61K2800/92 , A61Q3/00 , A61Q5/00 , A61Q5/006 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q7/00 , A61K2300/00
摘要： The present invention relates to a composition including at least one C7 sugar, or derivative from esterification of said sugar, and a pharmaceutically acceptable carrier for treating alopecia. The present invention also relates to a method for cosmetically treating hair and nails, said method being intended to stimulate the growth thereof and/or slow the loss thereof. According to said method, a cosmetic composition including at least one C7 sugar, or derivative from esterification of said sugar, is administered. The present invention finally relates to a method for cosmetic care of hair and/or eyelashes and/or nails.

9. 发明授权

US09422504B2 Use of whole soft avocados for preparing avocado oil rich in unsaponifiables 有权
标题翻译：使用全软牛油制备富含不皂化物的鳄梨油
公开(公告)号：US09422504B2
公开(公告)日：2016-08-23
申请号：US14368895
申请日：2012-12-26
申请人： LABORATOIRES EXPANSCIENCE
发明人： Philippe Msika , Jacques Legrand
IPC分类号： C11B1/00 , C11B1/06 , A23L1/30 , A61K36/54 , C11B1/04 , C11B1/10 , C11B1/08 , A23L1/212
CPC分类号： C11B1/06 , A23L19/00 , A23L33/105 , A23L33/115 , A61K36/54 , C11B1/04 , C11B1/08 , C11B1/10 , C11B1/102
摘要： The present invention relates to the use of whole soft avocados to obtain an avocado oil rich in unsaponifiable, said unsaponifiable containing aliphatic acetogenins and/or their derivatives. Advantageously, the oil has an acid value less than or equal to 3 mgKOH/g. The invention also relates to a process for obtaining an avocado oil rich in unsaponifiable from whole soft avocados. said unsaponifiable containing aliphatic acetogenins and/or their derivatives. The invention also relates to an avocado oil rich in unsaponifiable obtainable by this process. The invention also relates to the use of the avocado oil to prepare a concentrate of avocado oil enriched in unsaponifiable or an avocado unsaponifiable rich in aliphatic furans. Finally, the invention relates to an avocado unsaponifiable rich in aliphatic furans or a concentrate of avocado oil enriched in unsaponifiable, obtainable from said avocado oil, for its use as a drug, advantageously in the prevention and/or the treatment of connective tissue disorders such as arthrosis, articular pathologies such as rhumatisms, or parodontal disorders, such as gingivitis or parodontitis.
摘要翻译：本发明涉及使用整个软的鳄梨来获得富含不皂化的所述不皂化的含脂肪酸乙偶姻和/或其衍生物的鳄梨油。有利地，油的酸值小于或等于3mgKOH / g。本发明还涉及一种从整个软鳄梨中获得不可皂化的鳄梨油的方法。所述不可皂化的含脂肪族乙酰胆酸和/或其衍生物。本发明还涉及一种富含不可皂化的鳄梨油，可通过该方法获得。本发明还涉及鳄梨油用于制备富含不可皂化的鳄梨油的浓缩物或不可皂化的富含脂肪族呋喃的鳄梨油。最后，本发明涉及不可皂化的富含脂肪呋喃的鳄梨或富含不皂化油的鳄梨油浓缩物，可从所述鳄梨油获得，用于药物，有利地用于预防和/或治疗结缔组织疾病，例如作为关节病，关节病变如眩晕症或传染疾病，例如牙龈炎或牙菌斑。

10. 发明专利

TW201332562A 使用酪梨皮以獲得增富有飽和脂族碳氫化合物及固醇之酪梨不可皂化物的用途审中-公开
简体标题：使用酪梨皮以获得增富有饱和脂族碳氢化合物及固醇之酪梨不可皂化物的用途
公开(公告)号：TW201332562A
公开(公告)日：2013-08-16
申请号：TW102101123
申请日：2013-01-11
申请人：擴展科學實驗室 , LABORATOIRES EXPANSCIENCE
发明人：米斯卡飛利浦 , MSIKA, PHILIPPE , 黎葛蘭特加奎斯 , LEGRAND, JACQUES , 嘉尼爾賽伯斯汀 , GARNIER, SEBASTIEN
IPC分类号： A61K36/54 , A61K31/01 , C11B1/04 , C11B3/14 , A61P1/02 , A61P19/02 , A61K131/00
CPC分类号： A61K36/54 , A23D9/00 , A23D9/02 , A23L33/105 , A23L33/11 , A23L33/115 , A61K31/01 , A61K31/575 , C11B1/08
摘要：本發明關於一種使用酪梨皮以獲得增富有飽和脂族碳氫化合物及固醇之酪梨不可皂化物的用途。相對於所用酪梨之總重，該酪梨皮以重量計占5至50%。本發明也關於一種用以至少從酪梨皮中獲得增富有飽和脂族碳氫化合物及固醇之酪梨不可皂化物的方法，相對於所用酪梨之總重，該酪梨皮以重量計占5至50%。本發明也關於一種可藉由此種方法獲得之增富有飽和脂族碳氫化合物及固醇的酪梨不可皂化物。最後，本發明關於此種增富有飽和脂族碳氫化合物及固醇之酪梨不可皂化物，其用作藥物之用途，有利地，在於預防及/或治療結締組織病症(諸如，關節炎)、關節病理(諸如，風濕病)或齒槽病(諸如，牙齦炎或牙周病)。
简体摘要：本发明关于一种使用酪梨皮以获得增富有饱和脂族碳氢化合物及固醇之酪梨不可皂化物的用途。相对于所用酪梨之总重，该酪梨皮以重量计占5至50%。本发明也关于一种用以至少从酪梨皮中获得增富有饱和脂族碳氢化合物及固醇之酪梨不可皂化物的方法，相对于所用酪梨之总重，该酪梨皮以重量计占5至50%。本发明也关于一种可借由此种方法获得之增富有饱和脂族碳氢化合物及固醇的酪梨不可皂化物。最后，本发明关于此种增富有饱和脂族碳氢化合物及固醇之酪梨不可皂化物，其用作药物之用途，有利地，在于预防及/或治疗结缔组织病症(诸如，关节炎)、关节病理(诸如，风湿病)或齿槽病(诸如，牙龈炎或牙周病)。

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