专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08367060B2 Pharmaceutical composition containing arazyme for the prevention of liver dysfunction 有权
标题翻译：含有arazyme用于预防肝功能障碍的药物组合物
公开(公告)号：US08367060B2
公开(公告)日：2013-02-05
申请号：US13234847
申请日：2011-09-16
申请人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
发明人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
IPC分类号： A61K38/48
CPC分类号： A61K38/4886 , A23L33/10 , A23L33/135
摘要： The present invention relates to a composition and a method for the treatment of liver dysfunction which contains administration of a composition containing arazyme as an active ingredient, more precisely arazyme produced by Aranicola proteolyticus. The arazyme of the present invention inhibits apoptosis in injured liver cells, increases SMP30 expression, inhibits P-smad3 expression and protects the liver by inhibiting liver injury around the central vein region. Therefore, the arazyme of the invention can be effectively used as a composition for the treatment of liver dysfunction.
摘要翻译：本发明涉及一种治疗肝功能障碍的组合物和方法，其包含施用含有阿拉木霉作为活性成分的组合物，更准确地说是由Aranicola proteolyticus产生的arazyme。本发明的arazyme抑制受损肝细胞凋亡，增加SMP30表达，抑制P-smad3表达，并通过抑制中心静脉区周围的肝损伤来保护肝脏。因此，本发明的胂酸盐可以有效地用作治疗肝功能障碍的组合物。

2. 发明申请

US20120003205A1 PHARMACEUTICAL COMPOSITION CONTAINING ARAZYME FOR THE PREVENTION OF LIVER DYSFUNCTION 有权
标题翻译：含有ARAZYME用于预防肝功能障碍的药物组合物
公开(公告)号：US20120003205A1
公开(公告)日：2012-01-05
申请号：US13234847
申请日：2011-09-16
申请人： Ho-Yong PARK , Kwang-Hee SON , Dong-Ha SHIN , Kyu-Shik JEONG
发明人： Ho-Yong PARK , Kwang-Hee SON , Dong-Ha SHIN , Kyu-Shik JEONG
IPC分类号： A61K38/48 , A61P31/14 , A61P1/16
CPC分类号： A61K38/4886 , A23L33/10 , A23L33/135
摘要： The present invention relates to a pharmaceutical composition for the prevention of liver dysfunction which contains arazyme as an active ingredient, more precisely a pharmaceutical composition for treating liver dysfunction which contains arazyme produced by Aranicola proteolyticus. The arazyme of the present invention inhibits apoptosis in injured liver cells, increases SMP30 expression, inhibits P-smad3 expression and protects liver by inhibiting liver injury around central vein region. Therefore, the arazyme of the invention can be effectively used as a pharmaceutical composition for the prevention of liver dysfunction.
摘要翻译：本发明涉及一种用于预防肝功能障碍的药物组合物，其包含作为活性成分的阿拉木霉，更准确地说，涉及一种用于治疗肝功能障碍的药物组合物，其含有由Aranicola proteolyticus产生的arazyme。本发明的arazyme抑制受损肝细胞凋亡，增加SMP30表达，抑制P-smad3表达，通过抑制中心静脉区域周围的肝损伤来保护肝脏。因此，本发明的芳脒可以有效地用作预防肝功能障碍的药物组合物。

3. 发明申请

US20100278806A1 Composition Containing Arazyme for the Prevention and Treatment of Arthritis 审中-公开
标题翻译：包含关于预防和治疗关节炎的疯狂的组合
公开(公告)号：US20100278806A1
公开(公告)日：2010-11-04
申请号：US12812388
申请日：2009-01-09
申请人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
发明人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
IPC分类号： A61K38/48 , A61P19/02
CPC分类号： A61K38/4886
摘要： Disclosed herein is a composition containing arazyme as an active ingredient for prevention and treatment of arthritis. More specifically, arazyme produced from Aranicola proteolyticus of the present invention may be useful as a composition for prevention and treatment of arthritis by inhibiting the expression of TNF-α which is an inflammation-inducing factor and preventing the loss of proteoglycan and collagen from joint cartilage to inhibit the progression of arthritis and protect joints.
摘要翻译：本文公开了含有作为预防和治疗关节炎的活性成分的阿拉木霉的组合物。更具体地说，本发明的由Aranicola proteolyticus产生的arazyme可用作通过抑制作为炎性诱导因子的TNF-α的表达来预防和治疗关节炎的组合物，并防止蛋白聚糖和胶原从关节软骨中的损失抑制关节炎的进展并保护关节。

4. 发明授权

US08399223B2 Composition containing arazyme for the prevention and treatment of cancer 有权
标题翻译：含有arazyme用于预防和治疗癌症的组合物
公开(公告)号：US08399223B2
公开(公告)日：2013-03-19
申请号：US13225317
申请日：2011-09-02
申请人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
发明人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
IPC分类号： A61K38/48
CPC分类号： A61K38/4886 , A23C15/065 , A23G1/423 , A23G3/366 , A23G4/123 , A23G9/363 , A23L2/02 , A23L2/66 , A23L13/424 , A23L13/48 , A23L23/00 , A23L33/19
摘要： The invention provides a method for treating lung cancer or breast cancer wherein the method comprises administering a pharmaceutically effective dose of arazyme enzyme to a subject with lung cancer or breast cancer. The arazyme enzyme is either a protein comprising the amino acid sequence of SEQ ID NO: 1; and/or a protein encoded by DNA comprising the coding region of the nucleotide sequence of SEQ ID NO: 2.
摘要翻译：本发明提供了一种治疗肺癌或乳腺癌的方法，其中所述方法包括向患有肺癌或乳腺癌的受试者施用药学有效剂量的阿拉酵酶。所述arazyme酶是包含SEQ ID NO：1的氨基酸序列的蛋白质; 和/或由包含SEQ ID NO：2的核苷酸序列的编码区的DNA编码的蛋白质。

5. 发明授权

US07527799B2 ENA mineral bioactive solution, manufacturing method thereof and its application for the osteoporosis prevention 有权
标题翻译： ENA矿物生物活性溶液及其制备方法及其在预防骨质疏松症中的应用
公开(公告)号：US07527799B2
公开(公告)日：2009-05-05
申请号：US11570962
申请日：2005-04-15
申请人： Sung-Yong Hwa , Kyu-Shik Jeong , Sun-Hee Do , Won-Il Jeong , Da-Hee Jeong , Gi-Ppeum Lee , Eun-Mi Cho , Hoon Ji
发明人： Sung-Yong Hwa , Kyu-Shik Jeong , Sun-Hee Do , Won-Il Jeong , Da-Hee Jeong , Gi-Ppeum Lee , Eun-Mi Cho , Hoon Ji
IPC分类号： A61K36/56 , A61K36/04
CPC分类号： A61K33/18 , A23L17/60 , A23L33/16 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/42 , A61K2300/00
摘要： The present invention is related to a method of manufacture of an alkaline mineral bioactive solution of which raw materials are squid bones burnt at a high temperature and crushed powder of red seaweeds and to compositions and health foods having the efficacy for the prevention of osteoporosis. The alkaline aqueous solutions having abundant minerals of the present invention may be used for bioactive solutions having the efficacy for the prevention and improvement of osseous diseases such as osteolysis and osteoporosis in mammals including human beings.
摘要翻译：本发明涉及一种生产碱性矿物质生物活性溶液的方法，其中原料是高温烧鱿鱼骨和红海藻的粉碎粉末，以及具有预防骨质疏松症功效的组合物和保健食品。本发明的具有丰富矿物质的碱性水溶液可用于具有预防和改善诸如包括人在内的哺乳动物的骨质疏松和骨质疏松症等骨质疾病的功效的生物活性溶液。

6. 发明申请

US20090104340A1 NATURAL BEAN-CURD AND ITS PREPARATION METHOD 审中-公开
标题翻译：自然波纹及其制备方法
公开(公告)号：US20090104340A1
公开(公告)日：2009-04-23
申请号：US11573532
申请日：2005-08-05
申请人： Sung-Yong Hwa , Kyu-Shik Jeong , Sun-Hee Do , Won-Il Jeong , Da-Hee Jeong , Gi-Ppeum Lee , Eun-Mi Cho
发明人： Sung-Yong Hwa , Kyu-Shik Jeong , Sun-Hee Do , Won-Il Jeong , Da-Hee Jeong , Gi-Ppeum Lee , Eun-Mi Cho
IPC分类号： A23L1/20
CPC分类号： A23L11/07
摘要： The present invention relates to natural and functional bean-curd having good storage stability and comprising various nutrients contained in Japanese apricots and red algae as well as those of soybean, which is—prepared by using fruit vinegar and red algae as natural coagulant. In the present invention, red algae and fruit vinegar employed as coagulant serves day as inorganic salts and as organic acid, respectively, to coagulate bean-curd, so that two coagulation principles work together, and thus it is distinguishable from conventional process for preparing bean-curd. The process according to the present invention comprises the steps of 1) washing and immersing soybean with water; 2) adding water and finely pulverizing the mixture by the use of a mixer to prepare bean paste! 3) heating the bean paste and removing bean-curd dregs to provide soybean milk; 4) introducing natural coagulant thereto and coagulating the soybean milk with stirring to provide uncurdled bean-curd; and 5) pouring the uncurdled bean-curd on a mold on which a hemp cloth is laid and compressing it to provide bean curd.
摘要翻译：本发明涉及具有良好储存稳定性的天然和功能性豆腐，其包含日本杏和红藻中的各种营养素以及通过使用水果醋和红藻作为天然凝结剂制备的大豆。在本发明中，作为絮凝剂使用的红藻和果醋分别作为无机盐和有机酸分别用于凝结豆腐，使得两种凝结原理一起工作，因此与常规的制备豆的方法是不同的 -凝乳。根据本发明的方法包括以下步骤：1）用水洗涤和浸渍大豆; 2）加水并用混合机细粉碎混合物，制成豆浆！ 3）加热豆浆并去除豆腐渣提供豆浆; 4）向其中引入天然凝结剂并搅拌使豆浆凝结，从而提供不变的豆腐; 和5）将未煮过的豆腐倒入放置大麻布的模具上并压缩以提供豆腐。

7. 发明申请

US20080274205A1 Ena Mineral Bioactive Solution, Manufacturing Method Thereof and Its Application for the Osteoporosis Prevention 有权
标题翻译： Ena矿物生物活性溶液及其制备方法及其在骨质疏松预防中的应用
公开(公告)号：US20080274205A1
公开(公告)日：2008-11-06
申请号：US11570962
申请日：2005-04-15
申请人： Sung-Yong Hwa , Kyu-Shik Jeong , Sun-Hee Do , Won-Il Jeong , Da-Hee Jeong , Gi-Ppeum Lee , Eun-Mi Cho , Hoon Ji
发明人： Sung-Yong Hwa , Kyu-Shik Jeong , Sun-Hee Do , Won-Il Jeong , Da-Hee Jeong , Gi-Ppeum Lee , Eun-Mi Cho , Hoon Ji
IPC分类号： A61K35/56 , A61P19/10
CPC分类号： A61K33/18 , A23L17/60 , A23L33/16 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/42 , A61K2300/00
摘要： The present invention is related to a method of manufacture of an alkaline mineral bioactive solution of which raw materials are squid bones burnt at a high temperature and crushed powder of red seaweeds and to compositions and health foods having the efficacy for the prevention of osteoporosis. The alkaline aqueous solutions having abundant minerals of the present invention may be used for bioactive solutions having the efficacy for the prevention and improvement of osseous diseases such as osteolysis and osteoporosis in mammals including human beings.
摘要翻译：本发明涉及一种生产碱性矿物质生物活性溶液的方法，其中原料是高温烧鱿鱼骨和红海藻的粉碎粉末，以及具有预防骨质疏松症功效的组合物和保健食品。本发明的具有丰富矿物质的碱性水溶液可用于具有预防和改善诸如包括人在内的哺乳动物的骨质疏松和骨质疏松症等骨质疾病的功效的生物活性溶液。

8. 发明申请

US20120003204A1 COMPOSITION CONTAINING ARAZYME FOR THE PREVENTION AND TREATMENT OF CANDER 有权
标题翻译：含有ARAZYME的组合物用于预防和治疗CANDER
公开(公告)号：US20120003204A1
公开(公告)日：2012-01-05
申请号：US13225317
申请日：2011-09-02
申请人： Ho-Yong PARK , Kwang-Hee SON , Dong-Ha SHIN , Kyu-Shik JEONG
发明人： Ho-Yong PARK , Kwang-Hee SON , Dong-Ha SHIN , Kyu-Shik JEONG
IPC分类号： A61K38/48 , A61P35/00
CPC分类号： A61K38/4886 , A23C15/065 , A23G1/423 , A23G3/366 , A23G4/123 , A23G9/363 , A23L2/02 , A23L2/66 , A23L13/424 , A23L13/48 , A23L23/00 , A23L33/19
摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of cancer comprising arazyme as an active ingredient. More precisely, when arazyme produced by Aranicola proteolycius was administered to the nude mice transplanted with human lung carcinoma cell line, weight gaining, inhibition of tumor cell growth and infiltration, and down-regulations of MMP-9, NF-κB and PCNA, were observed. In addition, when arazyme was treated to human breast cancer cells (MDA-MB-231), down regulations of p21, PCNA (Proliferating Cell Nuclear Antigen), VEGF (Vascular Endothelial Growth Factor), BCl2 (B-cell CLL/lymphoma 2), p-p38, PKC (Protein Kinase C) and MMP-1 (Matrix MetalloProteinase-1) which are involved in tumor cell growth, differentiation, proliferation and metastasis, were observed along with the up-regulation of catalase which inhibits tumor development. Therefore, the arazyme can be effectively used as a pharmaceutical composition for the prevention and treatment of cancer.
摘要翻译：本发明涉及一种用于预防和治疗癌症的药物组合物，其包含作为活性成分的阿拉木霉。更准确地说，当将Aranicola proteolycius产生的arazyme给予移植有人肺癌细胞系的裸鼠，体重增加，抑制肿瘤细胞生长和浸润，以及MMP-9，NF-和Kgr B和PCNA的下调，观察。另外，当将arazyme处理到人乳腺癌细胞（MDA-MB-231）时，下调p21，PCNA（增殖细胞核抗原），VEGF（血管内皮生长因子），BCl2（B细胞CLL /淋巴瘤2 ），参与肿瘤细胞生长，分化，增殖和转移的p-p38，PKC（蛋白激酶C）和MMP-1（基质金属蛋白酶-1）以及抑制肿瘤发生的过氧化氢酶的上调。因此，可以有效地使用胂酸盐作为预防和治疗癌症的药物组合物。

9. 发明申请

US20110268813A1 PREVENTING LIVER INJURY AND IMPROVING LIVER FUNCTION EFFECTS OF ENA-ACTIMINERAL RESOURCES 审中-公开
标题翻译：预防肝损伤和改善肝功能影响的肝功能影响
公开(公告)号：US20110268813A1
公开(公告)日：2011-11-03
申请号：US12680741
申请日：2009-09-17
申请人： Sung Yong Hwa , Kyu Shik Jeong , Jin Kyu Park , Jung Youn Han
发明人： Sung Yong Hwa , Kyu Shik Jeong , Jin Kyu Park , Jung Youn Han
IPC分类号： A61K35/64 , A61P1/16
CPC分类号： A61K36/04 , A23L17/60 , A23L33/105 , A23V2002/00 , A61K35/618 , A23V2200/302 , A23V2200/32 , A23V2250/202
摘要： Disclosed is a composition with anti-oxidative, anti-aging and liver-function improvement activities containing ENA actimineral resource A activated water. More specifically, disclosed are a pharmaceutical composition and a health food or health supplement containing, as an active ingredient, an alkaline ENA actimineral resource A activated water prepared from Sepia bone and red algae powders, for preventing aging due to inhibitory activity on decrease in serum vitamin C, or preventing liver damage or improving liver functions due to inhibitory activity on damage, apotosis or necrosis of hepatic cells. The composition inhibits a decrease in in vivo serum vitamin C, to inhibit aging and prevents damage, apotosis or necrosis of hepatic cells, and fundamentally protects liver cells to inhibit damage, apotosis or necrosis of hepatic cells by aging in the liver and improve liver function.
摘要翻译：公开了一种具有抗氧化，抗衰老和肝功能改善活性的组合物，其含有ENA活性物质A活化水。更具体地说，公开了一种药物组合物和保健食品或保健品，其中含有作为活性成分的碱性ENA活性物质资源A由Sepia骨和红藻粉制备的活化水，用于防止由于血清降低引起的抑制活性而老化维生素C，或由于对肝细胞的损伤，凋亡或坏死的抑制活性而预防肝损伤或改善肝功能。该组合物抑制体内血清维生素C的降低，抑制老化，防止肝细胞的损伤，凋亡或坏死，从根本上保护肝细胞，通过肝脏衰老来改善肝细胞的损伤，凋亡或坏死，改善肝功能。

10. 发明申请

US20100322917A1 PHARMACEUTICAL COMPOSITION CONTAINING ARAZYME FOR THE PREVENTION OF LIVER DYSFUNCTION 审中-公开
标题翻译：含有ARAZYME用于预防肝功能障碍的药物组合物
公开(公告)号：US20100322917A1
公开(公告)日：2010-12-23
申请号：US12521618
申请日：2006-12-28
申请人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
发明人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
IPC分类号： A61K38/48 , A61P1/16 , A61P35/00 , C12N9/52
CPC分类号： A61K38/4886 , A23L33/10 , A23L33/135
摘要： The present invention relates to a pharmaceutical composition for the prevention of liver dysfunction which contains arazyme as an active ingredient, more precisely a pharmaceutical composition for the prevention of liver dysfunction which contains arazyme produced by Aranicola proteolyticus. The arazyme of the present invention inhibits apoptosis in injured liver cells, increases SMP30 expression, inhibits P-smad3 expression and protects liver by inhibiting liver injury around central vein region. Therefore, the arazyme of the invention can be effectively used as a pharmaceutical composition for the prevention of liver dysfunction.
摘要翻译：本发明涉及一种用于预防肝功能障碍的药物组合物，其含有作为活性成分的阿拉木霉，更准确地说，涉及含有由Aranicola proteolyticus产生的arazyme的用于预防肝功能障碍的药物组合物。本发明的arazyme抑制受损肝细胞凋亡，增加SMP30表达，抑制P-smad3表达，通过抑制中心静脉区域周围的肝损伤来保护肝脏。因此，本发明的芳脒可以有效地用作预防肝功能障碍的药物组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式