专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08614285B2 Photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy 有权
标题翻译：基于聚合物衍生物的光敏剂 - 用于光动力疗法的光敏剂共轭物
公开(公告)号：US08614285B2
公开(公告)日：2013-12-24
申请号：US12595103
申请日：2008-04-23
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Jong-Ho Kim , Kyeong-Soon Park
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Jong-Ho Kim , Kyeong-Soon Park
IPC分类号： C08F251/00 , A61K31/555
CPC分类号： A61K41/0071 , A61K47/61 , A61K47/6929
摘要： Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizes for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.
摘要翻译：公开了一种基于用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物的新型光敏剂，其能够选择性地积累在癌组织中并通过激光照射产生单线态氧或自由基。用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物制备为纳米尺寸颗粒，并且对于癌组织具有优异的选择和积累比。光敏剂共轭物可以通过特定的激光波长产生单线态氧或自由基。由于癌组织的优异的选择和积累比，共轭物使具有低分子量的常规光敏剂的光细胞毒性最小化。因此，缀合物对于具有降低的副作用和优异治疗有效性的光动力疗法的光敏剂是非常有用的。

2. 发明申请

US20120065242A1 POLYMERIC NANO-PARTICLES FOR siRNA DELIVERY USING CHARGE INTERACTION AND COVALENT BONDING 有权
标题翻译：使用电荷交互和共价键合的siRNA交付的聚合纳米颗粒
公开(公告)号：US20120065242A1
公开(公告)日：2012-03-15
申请号：US12905212
申请日：2010-10-15
申请人： Kwang Meyung KIM , Ick Chan KWON , Kuiwon CHOI , Myung Sook HUH , Seung Young LEE , So Jin LEE
发明人： Kwang Meyung KIM , Ick Chan KWON , Kuiwon CHOI , Myung Sook HUH , Seung Young LEE , So Jin LEE
IPC分类号： A61K31/713 , A61P35/00 , C07H21/04 , B82Y5/00
CPC分类号： A61K47/4823 , A61K47/61 , A61K47/6939 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/351 , C12N2320/32
摘要： Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof.The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.
摘要翻译：公开了将siRNA与聚合物组合的聚合物-siRNA递送载体及其用途。更具体地，公开了一种稳定的体内聚合物-siRNA递送载体，其中通过使用电荷相互作用和可生物降解的共价键在同一时间将聚合物和siRNA组合起来，以及其用途。通过使用电荷相互作用和可生物降解的共价键合将聚合物和siRNA组合的聚合物-siRNA递送载体在体内对目标部分具有高的siRNA递送效率。因此，根据聚合物-siRNA粘合剂，即使施用相对低的浓度，也可以将治疗用siRNA有效地输送到诸如体内癌组织等目标部位，广泛用于各种治疗各种疾病

3. 发明申请

US20110213121A1 NANOPARTICLE SENSOR FOR MEASURING PROTEASE ACTIVITY AND METHOD FOR MANUFACTURING THE SAME 有权
标题翻译：用于测量蛋白酶活性的纳米颗粒传感器及其制造方法
公开(公告)号：US20110213121A1
公开(公告)日：2011-09-01
申请号：US13060902
申请日：2009-08-27
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park , Dae-Hyuk Moon , Dae-Yoon Chi , Seung-Jin Lee , Seung-Jae Myung
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park , Dae-Hyuk Moon , Dae-Yoon Chi , Seung-Jin Lee , Seung-Jae Myung
IPC分类号： C07K9/00 , B82Y5/00
CPC分类号： C12Q1/37 , G01N33/54346 , Y10S977/773 , Y10S977/774 , Y10S977/807 , Y10S977/811 , Y10S977/953
摘要： Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and a quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis and dementia.
摘要翻译：公开了用于测定蛋白酶活性的蛋白酶成像用纳米粒子传感器及其制备方法。更具体地，本发明涉及用于测量蛋白酶活性的纳米颗粒传感器，其中荧光团和猝灭剂缀合的肽底物与生物相容性聚合物纳米颗粒缀合。肽底物被蛋白酶特异性裂解。根据本发明的传感器能够抑制荧光材料上猝灭剂具有高灭绝活性的荧光发射。但是如果肽底物被特异性蛋白酶裂解，则强荧光是特异性发射的。因此，该传感器作为筛选新型药物如蛋白酶过表达抑制剂的方法，以及早期诊断不治之症以及各种疾病，如自身免疫性疾病，包括癌症，骨关节炎，类风湿性关节炎和痴呆症，都是特别有用的。

4. 发明授权

US09061068B2 Polymeric nano-particles for siRNA delivery using charge interaction and covalent bonding 有权
标题翻译：用于使用电荷相互作用和共价键的siRNA递送的聚合物纳米颗粒
公开(公告)号：US09061068B2
公开(公告)日：2015-06-23
申请号：US12905212
申请日：2010-10-15
申请人： Kwang Meyung Kim , Ick Chan Kwon , Kuiwon Choi , Myung Sook Huh , Seung Young Lee , So Jin Lee
发明人： Kwang Meyung Kim , Ick Chan Kwon , Kuiwon Choi , Myung Sook Huh , Seung Young Lee , So Jin Lee
IPC分类号： C07H21/02 , A61K47/48 , C12N15/11 , C12N15/87
CPC分类号： A61K47/4823 , A61K47/61 , A61K47/6939 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/351 , C12N2320/32
摘要： Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof.The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.
摘要翻译：公开了将siRNA与聚合物组合的聚合物-siRNA递送载体及其用途。更具体地，公开了一种稳定的体内聚合物-siRNA递送载体，其中通过使用电荷相互作用和可生物降解的共价键在同一时间将聚合物和siRNA组合起来，以及其用途。通过使用电荷相互作用和可生物降解的共价键合将聚合物和siRNA组合的聚合物-siRNA递送载体在体内对目标部分具有高的siRNA递送效率。因此，根据聚合物-siRNA粘合剂，即使施用相对低的浓度，也可以将治疗用siRNA有效地输送到诸如体内癌组织等目标部位，广泛用于各种治疗各种疾病

5. 发明申请

US20130338422A1 ANTICANCER PRODRUG ACTIVATED BY RADIATION OR ULTRAVIOLET TREATMENT AND USE THEREOF 有权
标题翻译：通过辐射或超紫外线治疗及其使用活化的抗癌药物
公开(公告)号：US20130338422A1
公开(公告)日：2013-12-19
申请号：US14001745
申请日：2011-03-02
申请人： Ju-Hee Ryu , Kwang-Meyung Kim , Ick-Chan Kwon , Kui-Won Choi , Sang-Yoon Kim , Beom-Suk Lee , Dae-Yoon Chi , Hee-Seup Kil , Hyun-Ju Sung
发明人： Ju-Hee Ryu , Kwang-Meyung Kim , Ick-Chan Kwon , Kui-Won Choi , Sang-Yoon Kim , Beom-Suk Lee , Dae-Yoon Chi , Hee-Seup Kil , Hyun-Ju Sung
IPC分类号： A61K41/00 , A61N5/06 , A61N5/10
CPC分类号： A61K41/0042 , A61K31/704 , A61K38/00 , A61K47/64 , A61N5/062 , A61N5/1001
摘要： The present invention relates to an anticancer prodrug consisting of peptide of acetyl-SEQ ID NO: 1-linker-anticancer drug. The anticancer prodrug effectively provides an anticancer drug unstable in acid or base, such as doxorubicin, in a form of prodrug. Thus, the anticancer prodrug exists as a non-toxic inactive form when administered into the body, but effectively releases the anticancer drug as an active ingredient in the target area in the presence of caspase activated by radiation or UV treatment after administered into the body. Accordingly, the anticancer drug exhibits selective anticancer effects on cancer cells, thereby maximizing the therapeutic effect and minimizing the side-effects of chemotherapy.
摘要翻译：本发明涉及一种由乙酰基-SEQ ID NO.1-接头 - 抗癌药物的肽组成的抗癌药物。抗癌前药有效地提供了在酸或碱中不稳定的抗癌药物，例如以前药形式的多柔比星。因此，当施用于体内时，抗癌前药以无毒无活性形式存在，但在施用于体内后，通过辐射或UV治疗活化的半胱天冬酶存在下，有效地将抗癌药物作为活性成分释放到目标区域。因此，抗癌药物对癌细胞具有选择性的抗癌作用，从而最大化治疗效果并使化疗的副作用最小化。

6. 发明申请

US20100222538A1 NOVEL PHOTOSENSITIZER BASED ON POLYMER DERIVATIVES-PHOTOSENSITIZER CONJUGATES FOR PHOTODYNAMIC THERAPY 有权
标题翻译：基于聚合物衍生物的新型光敏剂 - 光致变色治疗光敏剂
公开(公告)号：US20100222538A1
公开(公告)日：2010-09-02
申请号：US12595103
申请日：2008-04-23
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Jong-Ho Kim , Kyeong-Soon Park
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Jong-Ho Kim , Kyeong-Soon Park
IPC分类号： C08F251/00
CPC分类号： A61K41/0071 , A61K47/61 , A61K47/6929
摘要： Disclosed is a novel photosensitizer based on polymer derivatives-photosensitizer conjugates for photodynamic therapy capable of being selectively accumulated in cancerous tissues and producing singlet oxygen or free radical by laser irradiation. The polymer derivatives-photosensitizer conjugates for photodynamic therapy are prepared as nano-sized particles, and have excellent selection and accumulation ratio for cancerous tissues. The photosensitizer conjugates can produce singlet oxygen or free radical by a specific laser wavelength. Owing to the excellent selection and accumulation ratio for cancerous tissues, the conjugates minimizes photo-cytotoxicity of the conventional photosensitizer having a low molecular amount. Accordingly, the conjugates are very useful as a photosensitizes for photodynamic therapy with reduced side effects and excellent therapeutic effectiveness.
摘要翻译：公开了一种基于用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物的新型光敏剂，其能够选择性地积累在癌组织中并通过激光照射产生单线态氧或自由基。用于光动力学治疗的聚合物衍生物 - 光敏剂共轭物制备为纳米尺寸颗粒，并且对于癌组织具有优异的选择和积累比。光敏剂共轭物可以通过特定的激光波长产生单线态氧或自由基。由于癌组织的优异的选择和积累比，共轭物使具有低分子量的常规光敏剂的光细胞毒性最小化。因此，缀合物对于具有降低的副作用和优异治疗有效性的光动力疗法的光敏剂是非常有用的。

7. 发明授权

US08841085B2 Nanoparticle sensor for measuring protease activity and method for manufacturing the same 有权
标题翻译：用于测量蛋白酶活性的纳米粒子传感器及其制造方法
公开(公告)号：US08841085B2
公开(公告)日：2014-09-23
申请号：US13060902
申请日：2009-08-27
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park , Dae-Hyuk Moon , Dae-Yoon Chi , Seung-Jin Lee , Seung-Jae Myung
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park , Dae-Hyuk Moon , Dae-Yoon Chi , Seung-Jin Lee , Seung-Jae Myung
IPC分类号： C12Q1/34 , C12Q1/37 , G01N33/543 , C12Q1/04 , C12Q1/06
CPC分类号： C12Q1/37 , G01N33/54346 , Y10S977/773 , Y10S977/774 , Y10S977/807 , Y10S977/811 , Y10S977/953
摘要： Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and a quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis and dementia.
摘要翻译：公开了用于测定蛋白酶活性的蛋白酶成像用纳米粒子传感器及其制备方法。更具体地，本发明涉及用于测量蛋白酶活性的纳米颗粒传感器，其中荧光团和猝灭剂缀合的肽底物与生物相容性聚合物纳米颗粒缀合。肽底物被蛋白酶特异性裂解。根据本发明的传感器能够抑制荧光材料上猝灭剂具有高灭绝活性的荧光发射。但是如果肽底物被特异性蛋白酶裂解，则强荧光是特异性发射的。因此，该传感器作为筛选新型药物如蛋白酶过表达抑制剂的方法，以及早期诊断不治之症以及各种疾病，如自身免疫性疾病，包括癌症，骨关节炎，类风湿性关节炎和痴呆症，都是特别有用的。

8. 发明授权

US08551727B2 Gold nanoparticle based protease imaging probes and use thereof 有权
标题翻译：基于金纳米颗粒的蛋白酶成像探针及其用途
公开(公告)号：US08551727B2
公开(公告)日：2013-10-08
申请号：US12595078
申请日：2008-04-10
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , Cheol-Hee Ahn , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , Cheol-Hee Ahn , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park
IPC分类号： C12Q1/37 , C12Q1/34 , B82B3/00 , C12N11/14 , C12N11/18
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0065 , A61K49/0093 , C12Q1/37
摘要： Disclosed are a metal nanoparticle onto which a peptide substrate specifically degraded by protease and fluorophore are chemically modified for selectively imaging protease expressed in cell and in tissue in a human body, and the use thereof. Also, a quantitative analysis method of protease using the metal nanoparticle, a cell imaging method and a drug screening method of inhibiting a protease overexpression are provided. In detail, the present invention is directed to a metal nanoparticle having a peptide substrate and fluorophore coupled thereto, the peptide substrate and the fluorophore being specifically degraded by due to a protease activated in various ways in cell and in a human body to exhibit fluorescence. Hence, the metal nanoparticle can be used to rapidly screen activation and inhibition of the protease in the imaging manner. Also, the metal nanoparticle is capable of being selectively absorbed into a cell and a tissue so as to be possibly used as a sensor for real-time cell imaging and early diagnosis of non-invasive diseases.
摘要翻译：公开了一种金属纳米颗粒，其上通过蛋白酶和荧光团特异性降解的肽底物被化学修饰以选择性地成像在细胞和人体组织中表达的蛋白酶及其用途。另外，提供了使用金属纳米粒子的蛋白酶的定量分析方法，细胞成像方法和抑制蛋白酶过表达的药物筛选方法。详细地说，本发明涉及一种具有肽底物和与其连接的荧光团的金属纳米颗粒，肽底物和荧光团由于在细胞和人体中以各种方式活化的蛋白酶而被特异性地降解以显示出荧光。因此，金属纳米颗粒可用于以成像方式快速筛选蛋白酶的活化和抑制。此外，金属纳米粒子能够被选择性地吸收到细胞和组织中，以便可能用作用于实时细胞成像和非侵入性疾病的早期诊断的传感器。

9. 发明申请

US20130253606A1 PERIPHERAL NERVE INTERFACE SYSTEM AND METHOD FOR PROSTHETIC HAND CONTROL 有权
标题翻译：外围神经接口系统和前置控制方法
公开(公告)号：US20130253606A1
公开(公告)日：2013-09-26
申请号：US13676598
申请日：2012-11-14
申请人： In Chan Youn , Kui Won Choi , Jun-Kyo Francis Suh , Kwang Meyung Kim , Jun Uk Chu , Sung Min Han , Kang Il Song , Heui Chang Lee , Jong Woong Park
发明人： In Chan Youn , Kui Won Choi , Jun-Kyo Francis Suh , Kwang Meyung Kim , Jun Uk Chu , Sung Min Han , Kang Il Song , Heui Chang Lee , Jong Woong Park
IPC分类号： A61N1/36
CPC分类号： A61N1/36003 , A61B5/04001 , A61B5/4041 , A61B5/6877 , A61F2/583 , A61F2/72 , A61F2002/704 , A61F2002/705 , A61N1/0551
摘要： The present disclosure relates to peripheral nerve interface system and method for prosthetic hand control, which may measure, analyze and control efferent motor nerve signals and afferent sensory nerve signals by regenerating a peripheral nerve and control an artificial prosthetic hand by means of the measurement, analysis and control of the signals. For this, the peripheral nerve interface system according to an embodiment of the present disclosure includes: a nerve conduit connected to a terminal of a damaged peripheral nerve at a cut body portion; a prosthesis for substituting for the cut body portion; and a peripheral nerve interface unit electrically connected to the nerve conduit and the prosthesis to restore a function of the damaged peripheral nerve and control operations of the prosthesis by transmitting and receiving signals of the damaged peripheral nerve.
摘要翻译：本公开涉及用于假肢手部控制的周围神经接口系统和方法，其可以通过再生周围神经并通过测量，分析来控制人造假手来测量，分析和控制传出的运动神经信号和传入感觉神经信号并控制信号。为此，根据本公开的实施方式的周围神经接口系统包括：连接到切割体部分的损伤的周围神经的末端的神经导管; 用于代替切割体部分的假体; 以及外周神经接口单元，其电连接到神经导管和假体，以通过发送和接收损伤的周围神经的信号来恢复损伤的周围神经的功能和假体的控制操作。

10. 发明申请

US20100124757A1 GOLD NANOPARTICLE BASED PROTEASE IMAGING PROBES AND USE THEREOF 有权
标题翻译：基于金纳米粒子的蛋白成像探针及其应用
公开(公告)号：US20100124757A1
公开(公告)日：2010-05-20
申请号：US12595078
申请日：2008-04-10
申请人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , Cheol-Hee Ahn , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park
发明人： Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyung Kim , Cheol-Hee Ahn , In-Chan Youn , Seul-Ki Lee , Kyeong-Soon Park
IPC分类号： C12Q1/37 , C07K2/00
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0065 , A61K49/0093 , C12Q1/37
摘要： Disclosed are a metal nanoparticle onto which a peptide substrate specifically degraded by protease and fluorophore are chemically modified for selectively imaging protease expressed in cell and in tissue in a human body, and the use thereof. Also, a quantitative analysis method of protease using the metal nanoparticle, a cell imaging method and a drug screening method of inhibiting a protease overexpression are provided. In detail, the present invention is directed to a metal nanoparticle having a peptide substrate and fluorophore coupled thereto, the peptide substrate and the fluorophore being specifically degraded by due to a protease activated in various ways in cell and in a human body to exhibit fluorescence. Hence, the metal nanoparticle can be used to rapidly screen activation and inhibition of the protease in the imaging manner. Also, the metal nanoparticle is capable of being selectively absorbed into a cell and a tissue so as to be possibly used as a sensor for real-time cell imaging and early diagnosis of non-invasive diseases.
摘要翻译：公开了一种金属纳米颗粒，其上通过蛋白酶和荧光团特异性降解的肽底物被化学修饰以选择性地成像在细胞和人体组织中表达的蛋白酶及其用途。另外，提供了使用金属纳米粒子的蛋白酶的定量分析方法，细胞成像方法和抑制蛋白酶过表达的药物筛选方法。详细地说，本发明涉及一种具有肽底物和与其连接的荧光团的金属纳米颗粒，肽底物和荧光团由于在细胞和人体中以各种方式活化的蛋白酶而被特异性地降解以显示出荧光。因此，金属纳米颗粒可用于以成像方式快速筛选蛋白酶的活化和抑制。此外，金属纳米粒子能够被选择性地吸收到细胞和组织中，以便可能用作用于实时细胞成像和非侵入性疾病的早期诊断的传感器。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式