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1. 发明申请

US20130287739A1 SERCA2 THERAPEUTIC COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： SERCA2治疗组合物及其使用方法
公开(公告)号：US20130287739A1
公开(公告)日：2013-10-31
申请号：US13929509
申请日：2013-06-27
申请人： Roger J. Hajjar , Yoshlaki Kawase , Dennis Ladage , Krisztina Zsebo
发明人： Roger J. Hajjar , Yoshlaki Kawase , Dennis Ladage , Krisztina Zsebo
IPC分类号： A61K38/46
CPC分类号： A61K38/46 , A61K48/005 , C12N9/14 , C12N2799/025 , C12N2799/04
摘要： The present invention provides methods for treating pulmonary hypertension in a subject by delivering a therapeutic adeno-associated virus (AAV)-SERCA2 composition to a subject in need thereof.
摘要翻译：本发明提供了通过将治疗性腺相关病毒（AAV）-SERCA2组合物递送至有需要的受试者来治疗受试者的肺动脉高压的方法。

2. 发明授权

US06407221B1 Chimeric chains for receptor-associated signal transduction pathways 失效
标题翻译：用于受体相关信号转导途径的嵌合链
公开(公告)号：US06407221B1
公开(公告)日：2002-06-18
申请号：US08475442
申请日：1995-06-07
申请人： Daniel J. Capon , Arthur Weiss , Brian A. Irving , Margo R. Roberts , Krisztina Zsebo
发明人： Daniel J. Capon , Arthur Weiss , Brian A. Irving , Margo R. Roberts , Krisztina Zsebo
IPC分类号： C07H2104
CPC分类号： C07K14/70514 , C07K14/7051 , C07K14/70535 , C07K2319/00
摘要： Chimeric proteins and DNA encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.
摘要翻译：提供嵌合蛋白和编码嵌合蛋白的DNA，其中嵌合蛋白的特征在于能够以非MHC限制性方式结合配体的细胞外结构域，能够激活信号通路的跨膜结构域和胞质结构域。细胞外结构域和细胞质结构域不是天生地共同发现的。配体与细胞外结构域的结合导致信号的转导和信号通路在细胞中的激活，由此可诱导细胞进行与信号通路相关的各种功能。可以使用多种细胞外结构域作为受体，其中这些结构域可以是天然存在的或合成的。嵌合DNA可用于修饰淋巴细胞以及造血干细胞作为许多重要细胞类型的前体。

3. 发明申请

US20070071714A1 Stem cell factor 审中-公开
标题翻译：干细胞因子
公开(公告)号：US20070071714A1
公开(公告)日：2007-03-29
申请号：US11517619
申请日：2006-09-07
申请人： Krisztina Zsebo , Robert Bosselman , Sidney Suggs , Francis Martin
发明人： Krisztina Zsebo , Robert Bosselman , Sidney Suggs , Francis Martin
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K14/475 , C12N5/08
CPC分类号： C07K16/22
摘要： Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.
摘要翻译：公开了新型干细胞因子，编码它们的寡核苷酸和生产方法。还公开了治疗涉及血细胞的疾病的药物组合物和方法。

4. 发明申请

US20050080250A1 Methods of stimulating growth of stromal cells in a human 审中-公开
标题翻译：刺激人类基质细胞生长的方法
公开(公告)号：US20050080250A1
公开(公告)日：2005-04-14
申请号：US10620642
申请日：2003-07-16
申请人： Krisztina Zsebo , Robert Bosselman , Sidney Suggs , Francis Martin
发明人： Krisztina Zsebo , Robert Bosselman , Sidney Suggs , Francis Martin
IPC分类号： A61K38/00 , C07K14/475 , C07K16/22 , C12N5/08 , C07H21/04
CPC分类号： C07K16/22 , A61K38/00 , C07K14/475
摘要： Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.
摘要翻译：公开了新型干细胞因子，编码它们的寡核苷酸和生产方法。还公开了治疗涉及血细胞的疾病的药物组合物和方法。

5. 发明授权

US5359046A Chimeric chains for receptor-associated signal transduction pathways 失效
标题翻译：用于受体相关信号转导途径的嵌合链
公开(公告)号：US5359046A
公开(公告)日：1994-10-25
申请号：US988194
申请日：1992-12-09
申请人： Daniel J. Capon , Arthur Weiss , Brian A. Irving , Margo R. Roberts , Krisztina Zsebo
发明人： Daniel J. Capon , Arthur Weiss , Brian A. Irving , Margo R. Roberts , Krisztina Zsebo
IPC分类号： A61K39/395 , C07K14/00 , C07K14/705 , C07K14/725 , C07K14/73 , C07K14/735 , C07K16/00 , C07K19/00 , C12N5/10 , C12N15/09 , C12Q1/68 , C07H17/00 , A61K35/14 , C07K3/00 , C12P21/00
CPC分类号： C07K14/70535 , C07K14/7051 , C07K14/70514 , C07K2319/00 , C07K2319/02 , C07K2319/32
摘要： Chimeric proteins and DNA sequence encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA sequences may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.
摘要翻译：提供嵌合蛋白和编码嵌合蛋白的DNA序列，其中嵌合蛋白的特征在于能够以非MHC限制性方式结合配体的细胞外结构域，能够激活信号通路的跨膜结构域和胞质结构域。细胞外结构域和细胞质结构域不是天生地共同发现的。配体与细胞外结构域的结合导致信号的转导和信号通路在细胞中的激活，由此可诱导细胞进行与信号通路相关的各种功能。可以使用多种细胞外结构域作为受体，其中这些结构域可以是天然存在的或合成的。嵌合DNA序列可用于修饰淋巴细胞以及造血干细胞，作为许多重要细胞类型的前体。

6. 发明申请

US20080076730A1 EXTENDED ANTEGRADE EPICARDIAL CORONARY INFUSION OF ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY 审中-公开
标题翻译：用于基因治疗的ADENO相关病毒载体的扩大ANTEGRADE EPICARDIAL冠状动脉灌注
公开(公告)号：US20080076730A1
公开(公告)日：2008-03-27
申请号：US11778900
申请日：2007-07-17
申请人： Krisztina Zsebo
发明人： Krisztina Zsebo
IPC分类号： A61K31/7052 , A61P9/00
CPC分类号： A61K48/0075 , A61K31/7052
摘要： The present invention relates to therapies for the treatment of cardiovascular diseases, particularly the delivery of therapeutic agents to heart tissue by direct infusion into the coronary circulation. A preferred embodiment of the invention is a method of treating or preventing a cardiovascular disease by transfecting cardiac cells of a large mammal, the method comprising, identifying an mammal in need of treatment or prevention of a cardiovascular disease, infusing a therapeutic polynucleotide into a blood vessel of the coronary circulation in vivo, where the therapeutic polynucleotide is infused into the blood vessel over a period of at least about three minutes, where the coronary circulation is not isolated or substantially isolated from the systemic circulation of the mammal; and where the therapeutic polynucleotide transfects cardiac cells of the animal resulting in the treatment or prevention of the cardiovascular disease.
摘要翻译：本发明涉及用于治疗心血管疾病的治疗，特别是通过直接输注到冠状动脉循环中将治疗剂递送至心脏组织。本发明的优选实施方案是通过转染大型哺乳动物的心脏细胞来治疗或预防心血管疾病的方法，所述方法包括：鉴定需要治疗或预防心血管疾病的哺乳动物，将治疗性多核苷酸注入血液中体内冠状动脉循环的血管，其中治疗性多核苷酸在至少约三分钟的时间内输注到血管中，其中冠状动脉循环未分离或基本上与哺乳动物的全身循环分离; 并且其中治疗性多核苷酸转染动物的心脏细胞导致心血管疾病的治疗或预防。

7. 发明授权

US06319494B1 Chimeric chains for receptor-associated signal transduction pathways 失效
标题翻译：用于受体相关信号转导途径的嵌合链
公开(公告)号：US06319494B1
公开(公告)日：2001-11-20
申请号：US08479737
申请日：1995-06-07
申请人： Daniel J. Capon , Arthur Weiss , Brian A. Irving , Margo R. Roberts , Krisztina Zsebo
发明人： Daniel J. Capon , Arthur Weiss , Brian A. Irving , Margo R. Roberts , Krisztina Zsebo
IPC分类号： C12N1500
CPC分类号： C07K14/70514 , C07K14/7051 , C07K14/70535 , C07K2319/00
摘要： Chimeric proteins and DNA encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.
摘要翻译：提供嵌合蛋白和编码嵌合蛋白的DNA，其中嵌合蛋白的特征在于能够以非MHC限制性方式结合配体的细胞外结构域，能够激活信号通路的跨膜结构域和胞质结构域。细胞外结构域和细胞质结构域不是天生地共同发现的。配体与细胞外结构域的结合导致信号的转导和信号通路在细胞中的激活，由此可诱导细胞进行与信号通路相关的各种功能。可以使用多种细胞外结构域作为受体，其中这些结构域可以是天然存在的或合成的。嵌合DNA可用于修饰淋巴细胞以及造血干细胞作为许多重要细胞类型的前体。

8. 发明申请

US20110256101A1 SERCA2 THERAPEUTIC COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： SERCA2治疗组合物及其使用方法
公开(公告)号：US20110256101A1
公开(公告)日：2011-10-20
申请号：US13086829
申请日：2011-04-14
申请人： Roger J. Hajjar , Yoshiaki Kawase , Dennis Ladage , Krisztina Zsebo
发明人： Roger J. Hajjar , Yoshiaki Kawase , Dennis Ladage , Krisztina Zsebo
IPC分类号： A61K35/76 , A61P11/00
CPC分类号： A61K38/46 , A61K48/00 , C12N7/00 , C12N9/14 , C12N15/86 , C12N2750/14143 , C12N2799/025 , C12N2799/04 , C12Y306/01003
摘要： The present invention provides methods for treating pulmonary hypertension in a subject by delivering a therapeutic adeno-associated virus (AAV)-SERCA2 composition to a subject in need thereof.
摘要翻译：本发明提供了通过将治疗性腺相关病毒（AAV）-SERCA2组合物递送至有需要的受试者来治疗受试者的肺动脉高压的方法。

9. 发明申请

US20050261175A1 SCF antibody compositions and methods of using the same 失效
标题翻译： SCF抗体组合物及其使用方法
公开(公告)号：US20050261175A1
公开(公告)日：2005-11-24
申请号：US10353783
申请日：2003-01-28
申请人： Krisztina Zsebo , Robert Bosselman , Sidney Suggs , Francis Martin
发明人： Krisztina Zsebo , Robert Bosselman , Sidney Suggs , Francis Martin
IPC分类号： A61K38/18 , C07K14/475 , C07K16/22 , C12N5/06 , C12P21/02 , C12Q1/68
CPC分类号： C07K16/22
摘要： Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.
摘要翻译：公开了新型干细胞因子，编码它们的寡核苷酸和生产方法。还公开了治疗涉及血细胞的疾病的药物组合物和方法。

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