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1. 发明申请

US20110125141A1 Cryotherapy Methods for Treating Vessel Dissections and Side Branch Occlusion 审中-公开
标题翻译：用于治疗血管解剖和侧支阻塞的冷冻治疗方法
公开(公告)号：US20110125141A1
公开(公告)日：2011-05-26
申请号：US12980662
申请日：2010-12-29
申请人： James Joye , Kristine Tatsutani
发明人： James Joye , Kristine Tatsutani
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22062 , A61B2018/00023 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention provides cryotherapy treatment of dissections in a blood vessel of a patient. The present invention further provides cryotherapy treatment of side branch occlusion in a bifurcated blood vessel. One method for treating potential or existing dissections in a blood vessel comprises cooling the blood vessel to a temperature and for a time sufficient to remodel the blood vessel such that dissections of the blood vessel are reduced. Another method for treating side branch occlusion in a bifurcated blood vessel, the bifurcated blood vessel having a side branch and a main branch, the main branch having plaque disposed thereon, comprises cooling an inner surface of the main branch to a temperature and for a time sufficient to inhibit plaque shift from the main branch into the side branch.
摘要翻译：本发明提供对患者血管中的解剖的冷冻治疗。本发明还提供了在分叉血管中的侧分支闭塞的冷冻治疗。用于治疗血管中的潜在或现有解剖的一种方法包括将血管冷却到足以改造血管的温度和时间，使得血管的解剖减小。用于治疗分叉血管中的侧分支闭塞的另一种方法，具有侧分支和主分支的分叉血管，其中设置有斑块的主分支包括将主支路的内表面冷却至一段温度和一段时间足以抑制从主分支到侧枝的斑块偏移。

2. 发明授权

US07780608B2 Cryotherapy method for detecting and treating vulnerable plaque 有权
标题翻译：用于检测和治疗易损斑块的冷冻治疗方法
公开(公告)号：US07780608B2
公开(公告)日：2010-08-24
申请号：US11228691
申请日：2005-09-16
申请人： James Joye , Kristine Tatsutani , Joseph J. Williams
发明人： James Joye , Kristine Tatsutani , Joseph J. Williams
IPC分类号： A61B5/01 , A61B18/02
CPC分类号： A61B1/128 , A61B1/00082 , A61B1/12 , A61B1/3137 , A61B5/01 , A61B5/015 , A61B5/6853 , A61B18/02 , A61B2017/00084 , A61B2017/00101 , A61B2017/22001 , A61B2017/22002 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： Methods, apparatus, and kits detect and/or treat vulnerable plaque of a blood vessel. A temperature differential can be sensed along a lumen surface with temperature sensors on a balloon filled with warm gas. Treatment methods include controlled and safe cryogenic cooling of vulnerable plaque to inhibit release of retained fluid within the vulnerable plaque so as to inhibit acute coronary syndrome and to help maintain patency of a body lumen.
摘要翻译：方法，装置和试剂盒检测和/或治疗血管易损斑块。温度差可以沿着管腔表面检测，温度传感器在充满暖气的气球上。治疗方法包括易受伤害的斑块的受控和安全的低温冷却，以抑制残留的流体在易损斑块内的释放，以便抑制急性冠状动脉综合征并帮助维持体腔通畅。

3. 发明授权

US06602246B1 Cryotherapy method for detecting and treating vulnerable plaque 有权
标题翻译：用于检测和治疗易损斑块的冷冻治疗方法
公开(公告)号：US06602246B1
公开(公告)日：2003-08-05
申请号：US09641462
申请日：2000-08-18
申请人： James Joye , Kristine Tatsutani
发明人： James Joye , Kristine Tatsutani
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B5/01 , A61B5/6853 , A61B2017/00101 , A61B2017/22001 , A61B2017/22002 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention provides methods, apparatus, and kits for detection and/or treatment of vulnerable plaque of a blood vessel having a lumen surface. Detection methods include sensing a temperature differential along a lumen surface with temperature sensors that thermally couple the lumen surface. Treatment methods include controlled and safe cryogenic cooling of vulnerable plaque to inhibit release of retained fluid within the vulnerable plaque so as to inhibit acute coronary syndrome and to help maintain patency of a body lumen. Treatment methods may include additional treatments, such as primary treatments or passivation.
摘要翻译：本发明提供了用于检测和/或治疗具有内腔表面的血管的易损斑块的方法，装置和试剂盒。检测方法包括使用热耦合管腔表面的温度传感器感测沿着管腔表面的温度差。治疗方法包括易受伤害的斑块的受控和安全的低温冷却，以抑制残留的流体在易损斑块内的释放，以便抑制急性冠状动脉综合征并帮助维持体腔通畅。治疗方法可以包括额外的治疗，例如初级治疗或钝化。

4. 发明申请

US20080312644A1 CRYOGENIC BALLOON ABLATION INSTRUMENTS AND SYSTEMS 审中-公开
标题翻译：低温气泡吸收仪器和系统
公开(公告)号：US20080312644A1
公开(公告)日：2008-12-18
申请号：US11763372
申请日：2007-06-14
申请人： Michael Fourkas , Steven Walak , Kurt Geitz , Kristine Tatsutani
发明人： Michael Fourkas , Steven Walak , Kurt Geitz , Kristine Tatsutani
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B90/39 , A61B2017/00084 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2090/3937
摘要： Cryogenic tissue ablation instruments for treating body tissue include an elongate flexible body with a proximal supply port for coupling with a pressurized coolant (e.g., liquid N2O), a supply lumen in fluid communication with the proximal supply port, and an expandable cryogenic balloon carried on a distal portion of the elongate body, the balloon having a wall defining an interior of the balloon. A dispersion member coupled to or otherwise formed out of a distal end portion of the elongate body has an interior lumen in fluid communication with or otherwise comprising a portion of the supply lumen, the dispersion member having one or more coolant dispersion apertures in fluid communication with the balloon interior and sized and located with respect to the balloon wall such that a pressurized flowable coolant in the supply lumen will enter the balloon interior through the one or more apertures in the form of a liquid spray that contacts and provides (through rapid evaporation) substantially uniform cooling of an interior wall surface of a treatment region of the balloon.
摘要翻译：用于治疗身体组织的低温组织消融装置包括细长的柔性体，其具有用于与加压的冷却剂（例如，液体N2O）结合的近侧供应口，与近侧供应口流体连通的供应管腔和承载在其上的可膨胀低温球囊细长体的远端部分，气囊具有限定球囊内部的壁。与细长体的远端部分连接或以其它方式形成的分散体具有与供应内腔流体连通或以其他方式包含供应内腔的一部分的内腔，该分散体具有一个或多个冷却剂分散孔，其与气囊内部并且相对于球囊壁定尺寸和定位，使得供应内腔中的加压可流动的冷却剂将通过接触并提供（通过快速蒸发）的液体喷雾形式的一个或多个孔进入气囊内部，对气囊的治疗区域的内壁表面进行大致均匀的冷却。

5. 发明授权

US06955174B2 Cryotherapy method for detecting and treating vulnerable plaque 有权
标题翻译：用于检测和治疗易损斑块的冷冻治疗方法
公开(公告)号：US06955174B2
公开(公告)日：2005-10-18
申请号：US10387347
申请日：2003-03-11
申请人： James Joye , Kristine Tatsutani , Joseph J. Williams
发明人： James Joye , Kristine Tatsutani , Joseph J. Williams
IPC分类号： A61B20060101 , A61B1/12 , A61B5/00 , A61B17/00 , A61B17/22 , A61B18/02 , A61B18/18
CPC分类号： A61B1/128 , A61B1/00082 , A61B1/12 , A61B1/3137 , A61B5/01 , A61B5/015 , A61B5/6853 , A61B18/02 , A61B2017/00084 , A61B2017/00101 , A61B2017/22001 , A61B2017/22002 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： Methods, apparatus, and kits detect and/or treat vulnerable plaque of a blood vessel. A temperature differential can be sensed along a lumen surface with temperature sensors on a balloon filled with warm gas. Treatment methods include controlled and safe cryogenic cooling of vulnerable plaque to inhibit release of retained fluid within the vulnerable plaque so as to inhibit acute coronary syndrome and to help maintain patency of a body lumen.
摘要翻译：方法，装置和试剂盒检测和/或治疗血管易损斑块。温度差可以沿着管腔表面检测，温度传感器在充满暖气的气球上。治疗方法包括易受伤害的斑块的受控和安全的低温冷却，以抑制残留的流体在易损斑块内的释放，以便抑制急性冠状动脉综合征并帮助维持体腔通畅。

6. 发明授权

US09039688B2 Method for reducing hyperdynamic facial wrinkles 有权
标题翻译：减少高动力面部皱纹的方法
公开(公告)号：US09039688B2
公开(公告)日：2015-05-26
申请号：US13325004
申请日：2011-12-13
申请人： Francis R. Palmer, III , Michael Hsu , Kristine Tatsutani
发明人： Francis R. Palmer, III , Michael Hsu , Kristine Tatsutani
IPC分类号： A61B18/02 , A61B18/00
CPC分类号： A61B18/02 , A61B2018/00434 , A61B2018/00458 , A61B2018/0047 , A61B2018/0293
摘要： A method for cryogenically treating a target tissue comprises providing a cryogenic device having one or more tissue penetrating needle probes, and advancing the one or more tissue penetrating needle probes through skin disposed above the target tissue into the target tissue. The target tissue comprises a motor nerve. The method also includes cooling the target tissue with the one or more tissue penetrating needle probes, and temporarily disrupting signal conduction from the motor nerve thereby preventing contraction of a muscle operably coupled to the motor nerve. This reduces or eliminates hyperdynamic wrinkles of a patient's face.
摘要翻译：用于低温处理靶组织的方法包括提供具有一个或多个组织穿刺针探针的低温装置，以及使一个或多个组织穿刺针探针穿过设置在靶组织上方的皮肤进入靶组织。目标组织包括运动神经。该方法还包括用一个或多个组织穿刺针探针冷却目标组织，并暂时扰乱来自运动神经的信号传导，从而防止可操作地耦合到运动神经的肌肉的收缩。这减少或消除了患者脸部的高动态皱纹。

7. 发明申请

US20100318075A1 CRYOTHERAPY METHOD FOR DETECTING AND TREATING VULNERABLE PLAQUE 有权
标题翻译：用于检测和处理易受伤害的PLAQUE的CRYOTHERAPY方法
公开(公告)号：US20100318075A1
公开(公告)日：2010-12-16
申请号：US12862485
申请日：2010-08-24
申请人： JAMES JOYE , KRISTINE TATSUTANI , JOSEPH J. WILLIAMS
发明人： JAMES JOYE , KRISTINE TATSUTANI , JOSEPH J. WILLIAMS
IPC分类号： A61B18/02
CPC分类号： A61B1/128 , A61B1/00082 , A61B1/12 , A61B1/3137 , A61B5/01 , A61B5/015 , A61B5/6853 , A61B18/02 , A61B2017/00084 , A61B2017/00101 , A61B2017/22001 , A61B2017/22002 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： Methods, apparatus, and kits detect and/or treat vulnerable plaque of a blood vessel. A temperature differential can be sensed along a lumen surface with temperature sensors on a balloon filled with warm gas. Treatment methods include controlled and safe cryogenic cooling of vulnerable plaque to inhibit release of retained fluid within the vulnerable plaque so as to inhibit acute coronary syndrome and to help maintain patency of a body lumen.
摘要翻译：方法，装置和试剂盒检测和/或治疗血管易损斑块。温度差可以沿着管腔表面检测，温度传感器在充满暖气的气球上。治疗方法包括易受伤害的斑块的受控和安全的低温冷却，以抑制残留的流体在易损斑块内的释放，以便抑制急性冠状动脉综合征并帮助维持体腔通畅。

8. 发明申请

US20120310226A1 CRYOGENIC BALLOON ABLATION INSTRUMENTS AND SYSTEMS 有权
标题翻译：低温气泡吸收仪器和系统
公开(公告)号：US20120310226A1
公开(公告)日：2012-12-06
申请号：US13562150
申请日：2012-07-30
申请人： Michael Fourkas , Steven Walak , Kurt Geitz , Kristine Tatsutani
发明人： Michael Fourkas , Steven Walak , Kurt Geitz , Kristine Tatsutani
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B19/54 , A61B90/39 , A61B2017/00084 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2019/5437 , A61B2090/3937
摘要： A cryogenic tissue ablation instrument includes an elongate flexible body with a proximal supply port for coupling with a pressurized coolant, a supply lumen in communication with the proximal supply port, and an expandable balloon carried on the elongate body. A dispersion member coupled to the elongate body has an interior lumen in communication with the supply lumen, the dispersion member having one or more coolant dispersion apertures sized and located such that a pressurized flowable coolant will enter the balloon interior in the form of a liquid spray that contacts and provides substantially uniform cooling of the balloon.
摘要翻译：低温组织消融器具包括细长的柔性体，其具有用于与加压的冷却剂联接的近端供应口，与近端供应口连通的供应腔，以及承载在细长体上的可膨胀气囊。耦合到细长主体的分散部件具有与供应内腔连通的内腔，分散部件具有一个或多个冷却剂分配孔，其尺寸和位置使得加压的可流动的冷却剂将以液体喷雾的形式进入气囊内部其接触并提供气囊的基本上均匀的冷却。

9. 发明申请

US20120265187A1 Method for Reducing Hyperdynamic Facial Wrinkles 有权
标题翻译：减少超动力面部皱纹的方法
公开(公告)号：US20120265187A1
公开(公告)日：2012-10-18
申请号：US13325004
申请日：2011-12-13
申请人： Francis R. Palmer, III , Michael Hsu , Kristine Tatsutani
发明人： Francis R. Palmer, III , Michael Hsu , Kristine Tatsutani
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/00434 , A61B2018/00458 , A61B2018/0047 , A61B2018/0293
摘要： A method for cryogenically treating a target tissue comprises providing a cryogenic device having one or more tissue penetrating needle probes, and advancing the one or more tissue penetrating needle probes through skin disposed above the target tissue into the target tissue. The target tissue comprises a motor nerve. The method also includes cooling the target tissue with the one or more tissue penetrating needle probes, and temporarily disrupting signal conduction from the motor nerve thereby preventing contraction of a muscle operably coupled to the motor nerve. This reduces or eliminates hyperdynamic wrinkles of a patient's face.
摘要翻译：用于低温处理靶组织的方法包括提供具有一个或多个组织穿刺针探针的低温装置，以及使一个或多个组织穿刺针探针穿过设置在靶组织上方的皮肤进入靶组织。目标组织包括运动神经。该方法还包括用一个或多个组织穿刺针探针冷却目标组织，并暂时扰乱来自运动神经的信号传导，从而防止可操作地耦合到运动神经的肌肉的收缩。这减少或消除了患者脸部的高动态皱纹。

10. 发明授权

US07862557B2 Cryotherapy methods for treating vessel dissections and side branch occlusion 有权
标题翻译：用于治疗血管解剖和侧支闭塞的冷冻治疗方法
公开(公告)号：US07862557B2
公开(公告)日：2011-01-04
申请号：US10867986
申请日：2004-06-14
申请人： James Joye , Kristine Tatsutani
发明人： James Joye , Kristine Tatsutani
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22062 , A61B2018/00023 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention provides cryotherapy treatment of dissections in a blood vessel of a patient. The present invention further provides cryotherapy treatment of side branch occlusion in a bifurcated blood vessel. One method for treating potential or existing dissections in a blood vessel comprises cooling the blood vessel to a temperature and for a time sufficient to remodel the blood vessel such that dissections of the blood vessel are reduced. Another method for treating side branch occlusion in a bifurcated blood vessel, the bifurcated blood vessel having a side branch and a main branch, the main branch having plaque disposed thereon, comprises cooling an inner surface of the main branch to a temperature and for a time sufficient to inhibit plaque shift from the main branch into the side branch.
摘要翻译：本发明提供对患者血管中的解剖的冷冻治疗。本发明还提供了在分叉血管中的侧分支闭塞的冷冻治疗。用于治疗血管中的潜在或现有解剖的一种方法包括将血管冷却到足以改造血管的温度和时间，使得血管的解剖减小。用于治疗分叉血管中的侧分支闭塞的另一种方法，具有侧分支和主分支的分叉血管，其中设置有斑块的主分支包括将主支路的内表面冷却至一段温度和一段时间足以抑制从主分支到侧枝的斑块偏移。

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