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1. 发明申请

US20060292627A1 PB39, a gene dysregulated in prostate cancer, and uses thereof 审中-公开
标题翻译： PB39，前列腺癌失调的基因及其用途
公开(公告)号：US20060292627A1
公开(公告)日：2006-12-28
申请号：US11511259
申请日：2006-08-29
申请人： Rodrigo Chuaqui , Kristina Cole , Lance Liotta , Michael Emmert-Buck
发明人： Rodrigo Chuaqui , Kristina Cole , Lance Liotta , Michael Emmert-Buck
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K16/30 , C07K14/82
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/112
摘要： A novel gene, PB39, that is up-regulated, or over-expressed, in prostate cancer has been identified. The gene has been identified by means of its cDNA obtained by reverse transcription of the corresponding mRNA. Microdissection of prostate glands that had been surgically removed from prostate cancer patients revealed a novel up-regulated transcript in an aggressive prostate carcinoma. Differential analysis for the presence of this gene was carried out from the same glands by comparing tanscription in microdissected normal prostatic epithelium versus that in microdissected invasive tumor. The transcript was over-expressed in 5 of 10 prostate carcinomas examined. A variant transcript was over-expressed in 4 of 4 prostate carcinomas, and was found in 1 of 4 normal samples. The invention provides a purified and isolated nucleic acid that includes the sequence of PB39 or its complement, the sequence of a variant of PB39 or its complement, and a primer or probe, that includes a sequence that is a fragment of these sequences. Additionally, the polypeptide encoded by these genes, an antibody to the polypeptide, and methods of detection of PB39 or its gene product are provided.
摘要翻译：已经鉴定出在前列腺癌中上调或过度表达的新基因PB39。该基因已通过其相应mRNA的逆转录获得的cDNA鉴定。从前列腺癌患者手术切除的前列腺的显微解剖显示在侵袭性前列腺癌中有一种新的上调的转录物。通过比较显微解剖正常前列腺上皮与显微解剖浸润性肿瘤中的变体，从同一腺体进行该基因存在的差异分析。在检查的10个前列腺癌中的5个中，转录物过表达。在4个前列腺癌中的4个中，变体转录物过表达，并且在4个正常样品中的1个中发现。本发明提供了纯化和分离的核酸，其包括PB39或其互补序列，PB39或其互补序列变体的序列，以及引物或探针，其包括作为这些序列的片段的序列。另外，提供了由这些基因编码的多肽，多肽的抗体，以及检测PB39或其基因产物的方法。

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