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1. 发明授权

US07456162B2 Benzofuran derivatives, their production and use 失效
标题翻译：苯并呋喃衍生物，其生产和使用
公开(公告)号：US07456162B2
公开(公告)日：2008-11-25
申请号：US11081615
申请日：2005-03-17
申请人： Shigenori Ohkawa , Yasuyoshi Arikawa , Kouki Kato , Masahiro Okura , Masaki Setoh
发明人： Shigenori Ohkawa , Yasuyoshi Arikawa , Kouki Kato , Masahiro Okura , Masaki Setoh
IPC分类号： A61K31/33 , C07D405/00 , C07D411/00 , C07D209/00
CPC分类号： C07D307/79 , C07D405/04 , C07D407/06 , C07D407/12 , C07D409/06
摘要： Compounds represented by the formula: wherein R1 and R2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R1 and R2 may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates a group represented by the formula: wherein R4 indicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, R5 is hydrogen atom, a C1-6 alkyl, or an acyl group, R3 indicates a C6-14 aryl group, or salts thereof. The compounds have an excellent action to inhibit neurodegeneration as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as drugs for nerve degenerative diseases.
摘要翻译：由下式表示的化合物：其中R 1和R 2是氢原子，烃基或杂环基，或R 1和R 2 可以与相邻的碳原子一起形成3-至8-元的杂环或杂环，W表示由下式表示的基团：其中R 4表示（1）可以被芳族基团取代的脂族烃基，或（2）含有芳基的酰基，R 5是氢原子，C 1-6 烷基或酰基，R 3表示C 6-14芳基或其盐。该化合物具有抑制神经变性以及优异的脑渗透性的优异作用，毒性低，因此可用作神经退行性疾病的药物。

2. 发明申请

US20050187238A1 Benzofuran derivatives, their production and use 失效
标题翻译：苯并呋喃衍生物，其生产和使用
公开(公告)号：US20050187238A1
公开(公告)日：2005-08-25
申请号：US11081615
申请日：2005-03-17
申请人： Shigenori Ohkawa , Yasuyoshi Arikawa , Kouki Kato , Masahiro Okura , Masaki Setoh
发明人： Shigenori Ohkawa , Yasuyoshi Arikawa , Kouki Kato , Masahiro Okura , Masaki Setoh
IPC分类号： A61P25/28 , C07D307/79 , C07D405/04 , C07D407/06 , C07D407/12 , C07D409/06 , C07D491/056 , C07D491/107 , A61K31/4747 , C07D493/04
CPC分类号： C07D307/79 , C07D405/04 , C07D407/06 , C07D407/12 , C07D409/06
摘要： Compounds represented by the formula: wherein R1 and R2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R1 and R2 may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates (i) a group represented by the formula: wherein ring B indicates a 5- to 7-membered ring, or (ii) a group represented by the formula: wherein R4 indicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, R5 is hydrogen atom, a C1-6 alkyl, or an acyl group, provided that, when W is Wa, R3 is hydrogen atom, a hydrocarbon group or a heterocyclic group, when W is Wb, R3 indicates a C6-14 aryl group, or salts thereof or prodrugs thereof have an excellent action to inhibit neurodegeneration and the like as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as prophylactic or therapeutic drugs for nerve degenerative diseases and the like.
摘要翻译：由下式表示的化合物：其中R 1和R 2是氢原子，烃基或杂环基，或R 1和R 2 可以与相邻的碳原子一起形成3-至8-元的杂环或杂环，W表示（i）由下式表示的基团：其中环B表示5-至或（ii）由下式表示的基团：其中R 4表示（1）可被芳基取代的脂族烃基，或（2）酰基含有芳基的基团R 5是氢原子，C 1-6烷基或酰基，条件是当W是Wa时，R“ 当W为Wb时，R 3为氢原子，烃基或杂环基，R 3为C 6-14芳基，或其盐或其前药具有抑制神经变性等优异的作用以及优异的脑渗透性，并且l 因此可用作神经变性疾病等的预防或治疗药物。

3. 发明授权

US07101867B2 Benzofuran derivatives, their production and use 失效
标题翻译：苯并呋喃衍生物，其生产和使用
公开(公告)号：US07101867B2
公开(公告)日：2006-09-05
申请号：US10120102
申请日：2002-04-11
申请人： Shigenori Ohkawa , Yasuyoshi Arikawa , Kouki Kato , Masahiro Okura , Masaki Setoh
发明人： Shigenori Ohkawa , Yasuyoshi Arikawa , Kouki Kato , Masahiro Okura , Masaki Setoh
IPC分类号： A61K31/33 , A61K31/40 , C07D405/00 , C07D411/00 , C07D209/00
CPC分类号： C07D307/79 , C07D405/04 , C07D407/06 , C07D407/12 , C07D409/06
摘要： Compounds represented by the formula: wherein R1 and R2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R1 and R2 may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates (i) a group represented by the formula: wherein ring B indicates a 5- to 7-membered ring, or (ii) a group represented by the formula: wherein R4 indicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, R5 is hydrogen atom, a C1-6 alkyl, or an acyl group, provided that, when W is Wa, R3 is hydrogen atom, a hydrocarbon group or a heterocyclic group, when W is Wb, R3 indicates a C6-14 aryl group, or salts thereof or prodrugs thereof have an excellent action to inhibit neurodegeneration and the like as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as prophylactic or therapeutic drugs for nerve degenerative diseases and the like.
摘要翻译：由下式表示的化合物：其中R 1和R 2是氢原子，烃基或杂环基，或R 1和R 2 可以与相邻的碳原子一起形成3-至8-元的杂环或杂环，W表示（i）由下式表示的基团：其中环B表示5-至或（ii）由下式表示的基团：其中R 4表示（1）可被芳基取代的脂族烃基，或（2）酰基含有芳基的基团R 5是氢原子，C 1-6烷基或酰基，条件是当W是Wa时，R“ 当W为Wb时，R 3为氢原子，烃基或杂环基，R 3为C 6-14芳基，或其盐或其前药具有抑制神经变性等优异的作用以及优异的脑渗透性，并且l 因此可用作神经变性疾病等的预防或治疗药物。

4. 发明授权

US06479536B1 Benzofuran derivatives, process for the preparation of the same and uses thereof 有权
标题翻译：苯并呋喃衍生物，其制备方法及其用途
公开(公告)号：US06479536B1
公开(公告)日：2002-11-12
申请号：US09857293
申请日：2001-06-01
申请人： Shigenori Ohkawa , Yasuyoshi Arikawa , Kouki Kato , Masahiro Okura , Masaki Setoh
发明人： Shigenori Ohkawa , Yasuyoshi Arikawa , Kouki Kato , Masahiro Okura , Masaki Setoh
IPC分类号： A61K3140
CPC分类号： C07D307/79 , C07D405/04 , C07D407/06 , C07D407/12 , C07D409/06
摘要： Compounds represented by the formula: wherein R1 and R2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R1 and R2 may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates (i) a group represented by the formula: wherein ring B indicates a 5- to 7-membered ring, or (ii) a group represented by the formula: wherein R4 indicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, R5 is hydrogen atom, a C1-6 alkyl, or an acyl group, provided that, when W is Wa, R3 is hydrogen atom, a hydrocarbon group or a heterocyclic group, when W is Wb, R3 indicates a C6-14 aryl group, or salts thereof or prodrugs thereof have an excellent action to inhibit neurodegeneration and the like as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as prophylactic or therapeutic drugs for nerve degenerative diseases and the like.
摘要翻译：由下式表示的化合物：其中R 1和R 2是氢原子，烃基或杂环基，或者R 1和R 2可以与相邻的碳原子一起形成3至8元的杂环或杂环，W表示（i）由下式表示的基团：其中环B表示5-至7-元环，或（ii）由下式表示的基团：其中R4表示（1）脂族烃基，其可以被芳香基，或（2）含芳基的酰基，R5为氢原子，C1-6烷基或酰基，条件是当W为Wa时，R3为氢原子，烃基或杂环基，当W为Wb时，R 3表示C 6-14芳基，或其盐或其前药具有抑制神经变性等优异的作用以及优异的脑渗透性，毒性低，因此有用作为神经退行性疾病的预防或治疗药物类似。

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