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1. 发明授权

US07384952B2 Pyrazolopyrimidine compound and a process for preparing the same 失效
标题翻译：吡唑并嘧啶化合物及其制备方法
公开(公告)号：US07384952B2
公开(公告)日：2008-06-10
申请号：US10542081
申请日：2004-01-23
申请人： Iwao Takamuro , Yasuo Sekine , Yasunori Tsuboi , Kouji Nogi , Hiroyuki Taniguchi
发明人： Iwao Takamuro , Yasuo Sekine , Yasunori Tsuboi , Kouji Nogi , Hiroyuki Taniguchi
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519
CPC分类号： C07D487/04
摘要： The present invention provides a novel pyrazolopyrimidine compound of the formula [I]: wherein R′ is (A) a substituted aryl group, (B) an optionally substituted nitrogen-containing aliphatic heteromonocyclic group, (C) a substituted cyclo-lower alkyl group, (D) an optionally substituted amino group, or (E) a substituted heteroaryl group, R2 is (a) an optionally substituted heteroaryl group or (b) an optionally substituted aryl group, Y is a single bond, a lower alkylene group or a lower alkenylene group, Z is a group of the formula: —CO—, —CH2-, —SO2- or a group of the formula [II]: Q is a lower alkylene group, and q is an integer of 0 or 1 or a pharmaceutically acceptable sait thereof, which has a small conductance potassium channel (SK channel) blocking activity and is useful as a medicament and a process for preparing the same
摘要翻译：本发明提供式[I]的新型吡唑并嘧啶化合物：其中R'为（A）取代芳基，（B）任选取代的含氮脂族杂单环基团，（C）取代的环低级烷基，（D）任选取代的氨基或（E）取代的杂芳基，R 2是（a）任选取代的杂芳基或（b）任选取代的芳基，Y是单键，低级亚烷基或低级亚烯基，Z为下式基团：-CO - ， - CH 2 - ， - SO 2 - 或式[II]基团：Q为低级亚烷基， q是0或1的整数或其药学上可接受的sait，其具有小的电导钾通道（SK通道）阻断活性，并且可用作药物及其制备方法

2. 发明申请

US20060135525A1 Pyrazolopyrimidine compound and a process for preparing the same 失效
标题翻译：吡唑并嘧啶化合物及其制备方法
公开(公告)号：US20060135525A1
公开(公告)日：2006-06-22
申请号：US10542081
申请日：2004-01-23
申请人： Iwao Takamuro , Yasuo Sekine , Yasunori Tsuboi , Kouji Nogi , Hiroyuki Taniguchi
发明人： Iwao Takamuro , Yasuo Sekine , Yasunori Tsuboi , Kouji Nogi , Hiroyuki Taniguchi
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention provides a novel pyrazolopyrimidine compound of the formula [I]: wherein R′ is (A) a substituted aryl group, (B) an optionally substituted nitrogen-containing aliphatic heteromonocyclic group, (C) a substituted cyclo-lower alkyl group, (D) an optionally substituted amino group, or (E) a substituted heteroaryl group, R2 is (a) an optionally substituted heteroaryl group or (b) an optionally substituted aryl group, Y is a single bond, a lower alkylene group or a lower alkenylene group, Z is a group of the formula: —CO—, —CH2-, S02- or a group of the formula [II]: Q is a lower alkylene group, and q is an integer of 0 or 1 or a pharmaceutically acceptable sait thereof, which has a small conductance potassium channel (SK channel) blocking activity and is useful as a medicament and a process for preparing the same.
摘要翻译：本发明提供式[I]的新型吡唑并嘧啶化合物：其中R'为（A）取代芳基，（B）任选取代的含氮脂族杂单环基团，（C）取代的环低级烷基，（D）任选取代的氨基或（E）取代的杂芳基，R 2是（a）任选取代的杂芳基或（b）任选取代的芳基，Y是单键，低级亚烷基或低级亚烯基，Z为下式基团：-CO-，-CH 2 - ，SO 2 - 或式[II]基团：Q为低级亚烷基，q为是0或1的整数或其药学上可接受的sait，其具有小的电导钾通道（SK通道）阻断活性，并且可用作药物及其制备方法。

3. 发明申请

US20080081817A1 Nitrogenous Fused Bicyclic Compound 审中-公开
标题翻译：含氮双环化合物
公开(公告)号：US20080081817A1
公开(公告)日：2008-04-03
申请号：US11632725
申请日：2005-07-22
申请人： Iwao Takamuro , Saburo Kawanami , Yasunori Tsuboi , Toshiyuki Himiyama , Yuko Hasegawa , Hideki Mochida , Kouji Nogi
发明人： Iwao Takamuro , Saburo Kawanami , Yasunori Tsuboi , Toshiyuki Himiyama , Yuko Hasegawa , Hideki Mochida , Kouji Nogi
IPC分类号： A61K31/497 , A61K31/519 , A61P43/00 , C07D401/00 , C07D487/00
CPC分类号： C07D471/04 , C07D487/04
摘要： A novel nitrogenous fused bicyclic compound represented by the following general formula [1] or a pharmacologically acceptable salt of the compound. They have excellent SK channel blocking activity and are useful as a medicine. [I] (In the formula, R0 represents hydrogen, halogeno, etc.; R1 represents a group represented by the formula (a) or (b); A represents a group represented by the formula (X) or (Y); D1, D2 and D3 each represents N or CH; R2 represents halogeno or optionally halogenated lower alkyl, etc.; R3 represents hydrogen or lower alkyl; and Q represents lower alkylene.)
摘要翻译：由以下通式[1]表示的新型含氮稠合双环化合物或该化合物的药理学上可接受的盐。它们具有优异的SK通道阻断活性，可用作药物。 [I]（式中，R 0表示氢，卤素等; R 1表示由式（a）或（b）表示的基团; A 表示由式（X）或（Y）表示的基团; D 1，D 2和D 3各自表示N或CH; R 2表示卤代或任选卤代的低级烷基等; R 3表示氢或低级烷基; Q表示低级亚烷基。）

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