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1. 发明申请

US20090328239A1 BLOOD VESSEL IMAGING AND USES THEREFOR 审中-公开
标题翻译：血管成像及其使用
公开(公告)号：US20090328239A1
公开(公告)日：2009-12-31
申请号：US12363283
申请日：2009-01-30
申请人： Raul A. Brauner , John Heymach , George Naumov , Kongbin Kang
发明人： Raul A. Brauner , John Heymach , George Naumov , Kongbin Kang
IPC分类号： A61K49/00 , G01N33/00 , C12Q1/00 , A61P43/00
CPC分类号： A61B6/032 , A61B6/037 , A61B6/508
摘要： Methods are disclosed for analyzing representations of one or more structures in the body of a subject (e.g., a human subject or other animal subject) to glean information about the health of the subject or to evaluate the subject's response to a therapy or other condition. Aspects of the invention relate to obtaining structural information from casts (e.g., vascular casts from animal models) and using the information as a reference for evaluating structures in the body of a subject. Methods are disclosed for diagnosing, staging, grading, and monitoring diseases. Methods also are disclosed for targeting treatments, monitoring the effectiveness of therapies, and/or screening or validating therapies based analyzing structures (e.g., vascular structures) in a subject and comparing them to reference structures observed in casts obtained from models (e.g., animal models) of related diseases or conditions.
摘要翻译：公开了用于分析受试者（例如，人类受试者或其他动物受试者）体内的一种或多种结构的表现以收集关于受试者健康的信息或评估受试者对治疗或其他状况的反应的方法。本发明的方面涉及从铸件（例如，来自动物模型的血管形态）获得结构信息，并且使用该信息作为评估受试者体内的结构的参考。公开了用于诊断，分期，分级和监测疾病的方法。公开了用于靶向治疗，监测疗法的有效性和/或筛选或验证基于对象的分析结构（例如，血管结构）的治疗方法并将其与从模型（例如动物模型）获得的模型中观察到的参考结构进行比较的方法）相关疾病或病症。

2. 发明申请

US20120150048A1 VASCULAR ANALYSIS METHODS AND APPARATUS 审中-公开
标题翻译：血管分析方法和装置
公开(公告)号：US20120150048A1
公开(公告)日：2012-06-14
申请号：US13254913
申请日：2010-03-06
申请人： Kongbin Kang , Raul A. Brauner , Yanchun Wu , Joao Cruz
发明人： Kongbin Kang , Raul A. Brauner , Yanchun Wu , Joao Cruz
IPC分类号： A61B5/02
CPC分类号： G06T7/0016 , A61B6/508 , G06T7/11 , G06T7/13 , G06T7/149 , G06T7/155 , G06T2207/10072 , G06T2207/20021 , G06T2207/20036 , G06T2207/20112 , G06T2207/30101 , G06T2207/30172
摘要： According to some aspects, a method of identifying a boundary of a portion of a vasculature is provided, the vasculature comprising a geometric representation of a plurality of vessels. The method comprises logically dividing the geometric representation into a plurality of regions, determining at least one feature within each of the plurality of regions, and defining the boundary of the portion of the vasculature based, at least in part, on the at least one feature determined within each of the plurality of regions, wherein the boundary forms a volume defining a separation between inside and outside of the portion of the vasculature. According to some aspects, a method of performing vascular analysis using a geometric representation of a plurality of vessels of the vasculature is provided. The method comprises computing a boundary of a portion of the vasculature based on the geometric representation, logically dividing the geometric representation within the boundary into a plurality of regions, and analyzing at least one feature for each of the plurality of regions within the boundary.
摘要翻译：根据一些方面，提供了一种识别脉管系统的一部分的边界的方法，所述脉管系统包括多个血管的几何表示。所述方法包括将所述几何表示逻辑地划分成多个区域，确定所述多个区域中的每一个区域内的至少一个特征，以及至少部分地基于所述至少一个特征限定所述脉管系统的所述部分的边界在所述多个区域的每一个内确定，其中所述边界形成限定所述脉管系统部分的内部和外部之间的间隔的体积。根据一些方面，提供使用脉管系统的多个血管的几何表示进行血管分析的方法。所述方法包括基于所述几何表示计算所述脉管系统的一部分的边界，将所述边界内的几何表示逻辑地划分为多个区域，以及分析所述边界内的所述多个区域中的每一个的至少一个特征。

3. 发明申请

US20120114214A1 METHODS AND APPARATUS FOR IDENTIFYING SUBJECT MATTER IN VIEW DATA 有权
标题翻译：用于识别数据中的主题的方法和装置
公开(公告)号：US20120114214A1
公开(公告)日：2012-05-10
申请号：US13154787
申请日：2011-06-07
申请人： Joseph L. Mundy , Benjamin Kimia , Philip Nathan Klein , Kongbin Kang , Huseyin Can Aras
发明人： Joseph L. Mundy , Benjamin Kimia , Philip Nathan Klein , Kongbin Kang , Huseyin Can Aras
IPC分类号： G06K9/00
CPC分类号： G06K9/0055 , A61B5/489 , A61B6/03 , A61B6/032 , A61B6/12 , A61B6/5217 , C07D401/14 , G06K9/00503 , G06T5/001 , G06T7/194 , G06T11/008 , G06T17/10 , G06T2200/04 , G06T2207/10116 , G06T2207/20024
摘要： In one aspect, a method and apparatus for detecting subject matter of interest in view data obtained by scanning an object including generating a filter adapted to respond to the subject matter of interest, splatting the filter onto a portion of the view data to provide a filter splat, and performing at least one operation on the portion of the view data using the filter splat to facilitate determining whether the subject matter of interest is present in the portion of the view data.
摘要翻译：一方面，一种用于检测通过扫描对象获得的观看数据中感兴趣的主题的方法和装置，包括生成适于响应感兴趣主题的滤波器，将滤波器分解成视图数据的一部分以提供滤波器并且使用过滤器分片对视图数据的一部分执行至少一个操作，以便于确定感兴趣的主题是否存在于视图数据的部分中。

4. 发明授权

US08515145B2 Methods and apparatus for identifying subject matter in view data 有权
标题翻译：用于识别视图数据中的主题的方法和装置
公开(公告)号：US08515145B2
公开(公告)日：2013-08-20
申请号：US13154787
申请日：2011-06-07
申请人： Joseph L. Mundy , Benjamin Kimia , Philip Nathan Klein , Kongbin Kang , Huseyin Can Aras
发明人： Joseph L. Mundy , Benjamin Kimia , Philip Nathan Klein , Kongbin Kang , Huseyin Can Aras
IPC分类号： G06K9/00
CPC分类号： G06K9/0055 , A61B5/489 , A61B6/03 , A61B6/032 , A61B6/12 , A61B6/5217 , C07D401/14 , G06K9/00503 , G06T5/001 , G06T7/194 , G06T11/008 , G06T17/10 , G06T2200/04 , G06T2207/10116 , G06T2207/20024
摘要： In one aspect, a method and apparatus for detecting subject matter of interest in view data obtained by scanning an object including generating a filter adapted to respond to the subject matter of interest, splatting the filter onto a portion of the view data to provide a filter splat, and performing at least one operation on the portion of the view data using the filter splat to facilitate determining whether the subject matter of interest is present in the portion of the view data.
摘要翻译：一方面，一种用于检测通过扫描对象获得的观看数据中感兴趣的主题的方法和装置，包括生成适于响应感兴趣主题的滤波器，将滤波器分解成视图数据的一部分以提供滤波器并且使用过滤器分片对视图数据的一部分执行至少一个操作，以便于确定感兴趣的主题是否存在于视图数据的部分中。

5. 发明申请

US20110103657A1 METHODS OF OBTAINING GEOMETRY FROM IMAGES 有权
标题翻译：从图像中获取几何的方法
公开(公告)号：US20110103657A1
公开(公告)日：2011-05-05
申请号：US12811537
申请日：2009-01-02
申请人： Kongbin Kang , Raul A. Brauner , Yanchun Wu , Joao Cruz
发明人： Kongbin Kang , Raul A. Brauner , Yanchun Wu , Joao Cruz
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , A61B5/02007 , A61B5/055 , A61B5/107 , A61B5/489 , A61B6/504 , A61B6/508 , A61B2576/02 , G06K9/4609 , G06K9/4638 , G06K9/6215 , G06T7/20 , G06T7/60 , G06T7/62 , G06T7/74 , G06T15/08 , G06T2207/10028 , G06T2207/10072 , G06T2207/10116 , G06T2207/20004 , G06T2207/30101 , G06T2207/30172 , G06T2211/404
摘要： In one aspect, a method of detecting at least on feature associated with a blood vessel in at least one image of at least one blood vessel using a matched filter adapted to respond to the at least one feature is provided. The method comprises applying a scale detection filter to selected voxels in the at least one image to determine a scale for the matched filter at each of the selected voxels, determining an orientation for the matched filter at each of the selected voxels, wherein determining the orientation is assisted by using the scale determined at each of the selected voxels, applying the matched filter at each of the selected voxels at the scale and the orientation determined at each of the selected voxels to obtain a filter response at each of the selected voxels, and analyzing the filter response at each of the selected voxels to determine if the respective voxel corresponds to the at least one feature.
摘要翻译：在一个方面，提供一种使用适于响应于至少一个特征的匹配滤波器来检测至少一个血管的至少一个图像中的至少与血管相关联的特征的方法。所述方法包括对所述至少一个图像中的选定体素应用比例检测滤波器以确定每个所选择的体素处的匹配滤波器的比例，确定每个所选择的体素处的匹配滤波器的取向，其中确定取向通过使用在每个所选择的体素中确定的比例来辅助，在每个所选择的体素处以每个所选择的体素应用匹配滤波器，并且在每个所选择的体素处确定取向以在每个所选择的体素处获得滤波器响应，以及分析每个所选择的体素处的过滤器响应，以确定相应的体素是否对应于所述至少一个特征。

6. 发明授权

US08761466B2 Methods of obtaining geometry from images 有权
标题翻译：从图像获取几何的方法
公开(公告)号：US08761466B2
公开(公告)日：2014-06-24
申请号：US12811537
申请日：2009-01-02
申请人： Kongbin Kang , Raul A. Brauner , Yanchun Wu , Joao Cruz
发明人： Kongbin Kang , Raul A. Brauner , Yanchun Wu , Joao Cruz
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , A61B5/02007 , A61B5/055 , A61B5/107 , A61B5/489 , A61B6/504 , A61B6/508 , A61B2576/02 , G06K9/4609 , G06K9/4638 , G06K9/6215 , G06T7/20 , G06T7/60 , G06T7/62 , G06T7/74 , G06T15/08 , G06T2207/10028 , G06T2207/10072 , G06T2207/10116 , G06T2207/20004 , G06T2207/30101 , G06T2207/30172 , G06T2211/404
摘要： In one aspect, a method of detecting at least on feature associated with a blood vessel in at least one image of at least one blood vessel using a matched filter adapted to respond to the at least one feature is provided. The method comprises applying a scale detection filter to selected voxels in the at least one image to determine a scale for the matched filter at each of the selected voxels, determining an orientation for the matched filter at each of the selected voxels, wherein determining the orientation is assisted by using the scale determined at each of the selected voxels, applying the matched filter at each of the selected voxels at the scale and the orientation determined at each of the selected voxels to obtain a filter response at each of the selected voxels, and analyzing the filter response at each of the selected voxels to determine if the respective voxel corresponds to the at least one feature.
摘要翻译：在一个方面，提供一种使用适于响应于至少一个特征的匹配滤波器来检测至少一个血管的至少一个图像中的至少与血管相关联的特征的方法。所述方法包括对所述至少一个图像中的选定体素应用比例检测滤波器以确定每个所选择的体素处的匹配滤波器的比例，确定每个所选择的体素处的匹配滤波器的取向，其中确定取向通过使用在每个所选择的体素中确定的比例来辅助，在每个所选择的体素处以每个所选择的体素应用匹配滤波器，并且在每个所选择的体素处确定取向以在每个所选择的体素处获得滤波器响应，以及分析每个所选择的体素处的过滤器响应，以确定相应的体素是否对应于所述至少一个特征。

7. 发明授权

US07978887B2 Methods and apparatus for identifying subject matter in view data 有权
标题翻译：用于识别视图数据中的主题的方法和装置
公开(公告)号：US07978887B2
公开(公告)日：2011-07-12
申请号：US11299558
申请日：2005-12-09
申请人： Joseph L. Mundy , Benjamin Kimia , Philip Nathan Klein , Kongbin Kang , Huseyin Can Aras
发明人： Joseph L. Mundy , Benjamin Kimia , Philip Nathan Klein , Kongbin Kang , Huseyin Can Aras
IPC分类号： G06K9/00
CPC分类号： G06K9/0055 , A61B5/489 , A61B6/03 , A61B6/032 , A61B6/12 , A61B6/5217 , C07D401/14 , G06K9/00503 , G06T5/001 , G06T7/194 , G06T11/008 , G06T17/10 , G06T2200/04 , G06T2207/10116 , G06T2207/20024
摘要： In one aspect, a method and apparatus for detecting subject matter of interest in view data obtained by scanning an object including generating a filter adapted to respond to the subject matter of interest, splatting the filter onto a portion of the view data to provide a filter splat, and performing at least one operation on the portion of the view data using the filter splat to facilitate determining whether the subject matter of interest is present in the portion of the view data.
摘要翻译：一方面，一种用于检测通过扫描对象获得的观看数据中感兴趣的主题的方法和装置，包括生成适于响应感兴趣主题的滤波器，将滤波器分解成视图数据的一部分以提供滤波器并且使用过滤器分片对视图数据的一部分执行至少一个操作，以便于确定感兴趣的主题是否存在于视图数据的部分中。

8. 发明申请

US20060182327A1 Methods and apparatus for identifying subject matter in view data 有权
公开(公告)号：US20060182327A1
公开(公告)日：2006-08-17
申请号：US11299558
申请日：2005-12-09
申请人： Joseph Mundy , Benjamin Kimia , Philip Klein , Kongbin Kang , Huseyin Aras
发明人： Joseph Mundy , Benjamin Kimia , Philip Klein , Kongbin Kang , Huseyin Aras
IPC分类号： G06K9/00
CPC分类号： G06K9/0055 , A61B5/489 , A61B6/03 , A61B6/032 , A61B6/12 , A61B6/5217 , C07D401/14 , G06K9/00503 , G06T5/001 , G06T7/194 , G06T11/008 , G06T17/10 , G06T2200/04 , G06T2207/10116 , G06T2207/20024
摘要： In one aspect, a method and apparatus for detecting subject matter of interest in view data obtained by scanning an object including generating a filter adapted to respond to the subject matter of interest, splatting the filter onto a portion of the view data to provide a filter splat, and performing at least one operation on the portion of the view data using the filter splat to facilitate determining whether the subject matter of interest is present in the portion of the view data.

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