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1. 发明申请

US20080122372A1 Organic electroluminescent display device and method of fabricating the same 有权
标题翻译：有机电致发光显示装置及其制造方法
公开(公告)号：US20080122372A1
公开(公告)日：2008-05-29
申请号：US11819286
申请日：2007-06-26
申请人： Choong-Keun Yoo , Kong-Ju Lee
发明人： Choong-Keun Yoo , Kong-Ju Lee
IPC分类号： G09G3/10 , H01J9/00
CPC分类号： H01L27/3251 , H01L27/3223 , H01L51/0011
摘要： An organic electroluminescent display (OELD) device comprises a first electrode on a first substrate having an active region and a non-active region at periphery of the active region, the active region including a plurality of pixel regions and the non-active region including a power supply region; an organic luminescent layer on the first electrode in the plurality of pixel regions; a first organic layer on the first electrode in the power supply region; a second organic layer on the first substrate in an outer region of the power supply region; a second electrode on the organic luminescent layer; a driving thin film transistor connected to the second electrode and formed on a second substrate; and a power supply terminal connected to the first organic layer and formed on the second substrate, wherein the first organic layer has substantially the same shape as the organic luminescent layer, and the second organic layer has substantially a different shape from the organic luminescent layer.
摘要翻译：有机电致发光显示器（OELD）器件包括在有源区周边的第一衬底上的第一电极和位于有源区周边的非有源区，所述有源区包括多个像素区，并且所述非有源区包括电源区; 在所述多个像素区域中的所述第一电极上的有机发光层; 电源区域中的第一电极上的第一有机层; 在所述电源区域的外部区域中的所述第一基板上的第二有机层; 有机发光层上的第二电极; 连接到第二电极并形成在第二基板上的驱动薄膜晶体管; 以及连接到所述第一有机层并形成在所述第二基板上的电源端子，其中所述第一有机层具有与所述有机发光层基本相同的形状，并且所述第二有机层具有与所述有机发光层基本上不同的形状。

2. 发明申请

US20100256073A1 THERAPEUTIC AGENT COMPRISING LIPOCALIN 2 AGAINST CANCER METASTASIS, AND METHODS OF EARLY DIAGNOSIS AND INHIBITION OF CANCER METASTASIS USING LIPOCALIN 2 审中-公开
标题翻译：包含LOCOCALIN 2抗癌剂的治疗药物，以及早期诊断方法和使用LIPOCALIN 2抑制癌症METASTASIS
公开(公告)号：US20100256073A1
公开(公告)日：2010-10-07
申请号：US12779911
申请日：2010-05-13
申请人： Eun-kyoung Lee , Ho-jeong Lee , Kong-ju Lee , Jang-seong Kim , Doo-hong Park , Yeup Yoon , Hyun-jun Kim , In-hwan Lim
发明人： Eun-kyoung Lee , Ho-jeong Lee , Kong-ju Lee , Jang-seong Kim , Doo-hong Park , Yeup Yoon , Hyun-jun Kim , In-hwan Lim
IPC分类号： A61K38/16 , A61P35/00 , A61P35/04
CPC分类号： A61K38/1709 , A61K48/00 , C12N15/86 , C12N2740/15043
摘要： The present invention relates to a pharmaceutical composition for the inhibition of cancer metastasis, more precisely, a novel pharmaceutical composition against cancer metastasis comprising lipocalin 2 protein, a gene encoding the protein, an expression vector containing the gene or cells transfected with the expression vector as an effective ingredient, a method for the inhibition of cancer metastasis using the composition, a diagnostic kit for the prediction of cancer metastasis, a method for the selection of a metastasis risk group using the kit, a novel pharmaceutical composition for the inhibition of cancer growth and a method for the inhibition of cancer growth using the same. The pharmaceutical composition of the present invention specifically inhibits cancer metastasis, so that it can improve the effect of cancer treatment dramatically. And, the diagnostic kit and the method for the selection of a metastasis risk group using the kit enable the selection of a metastasis risk group by measuring the level of lipocalin 2 in tumor tissues or in body fluid. Therefore, the kit and the method can contribute to the effective clinical control of a cancer patient. Further, the composition of the invention can be effectively used for the treatment of liver cancer owing to its liver cancer growth inhibitory effect.
摘要翻译：本发明涉及用于抑制癌症转移的药物组合物，更准确地说，涉及一种抗癌转移的新型药物组合物，其包含脂质运载蛋白2蛋白，编码该蛋白质的基因，含有表达载体转染的基因或表达载体的表达载体有效成分，使用该组合物抑制癌症转移的方法，用于预测癌症转移的诊断试剂盒，使用试剂盒选择转移风险组的方法，用于抑制癌症生长的新型药物组合物以及使用其抑制癌症生长的方法。本发明的药物组合物特异性地抑制癌症转移，从而可以显着地改善癌症治疗的效果。并且，使用该试剂盒的诊断试剂盒和选择转移风险组的方法能够通过测量肿瘤组织或体液中脂笼蛋白2的水平来选择转移风险组。因此，试剂盒和方法可以有助于癌症患者的有效临床控制。此外，本发明的组合物由于其肝癌生长抑制作用，可以有效地用于治疗肝癌。

3. 发明申请

US20100003742A1 METHOD FOR REDUCING FUCOSE CONTENTS OF RECOMBINANT PROTEINS 审中-公开
标题翻译：减少重组蛋白质内含物的方法
公开(公告)号：US20100003742A1
公开(公告)日：2010-01-07
申请号：US12351239
申请日：2009-01-09
申请人： Jung-Seob KIM , Jae-Hoon MOON , Mee Sook OH , Kong Ju LEE , Yeup YOON
发明人： Jung-Seob KIM , Jae-Hoon MOON , Mee Sook OH , Kong Ju LEE , Yeup YOON
IPC分类号： C07K1/14
CPC分类号： C07K16/00 , C07K2317/41 , C07K2317/732 , C07K2317/734 , C07K2319/05 , C12N9/1051 , C12Y204/01068 , C12Y302/01051
摘要： The present invention relates to a method for reducing the fucose content of a recombinant protein, which comprises expressing in an animal cell the recombinant protein and FUCA1, an FUCA1 mutant, FUCA2, or a fragment of FUT8 localization domain; or with a fusion protein of a fragment of FUT8 localization domain and a fragment of FUCA1, a FUCA1 mutant or FUCA2. Therefore, the antibody expressed according to the method of the present invention exhibits a reduced fucose content in their Fc regions, which leads to the improvement in the therapeutic effect thereof.
摘要翻译：本发明涉及一种降低重组蛋白的岩藻糖含量的方法，其包括在动物细胞中表达重组蛋白和FUCA1，FUCA1突变体，FUCA2或FUT8定位结构域的片段; 或与FUT8定位结构域的片段和FUCA1，FUCA1突变体或FUCA2的片段的融合蛋白。因此，根据本发明的方法表达的抗体在其Fc区显示出降低的岩藻糖含量，这导致其治疗效果的改善。

4. 发明授权

US07710021B2 Organic electroluminescent display device and method of fabricating the same 有权
标题翻译：有机电致发光显示装置及其制造方法
公开(公告)号：US07710021B2
公开(公告)日：2010-05-04
申请号：US11819286
申请日：2007-06-26
申请人： Choong-Keun Yoo , Kong-Ju Lee
发明人： Choong-Keun Yoo , Kong-Ju Lee
IPC分类号： H01L51/00
CPC分类号： H01L27/3251 , H01L27/3223 , H01L51/0011
摘要： An organic electroluminescent display (OELD) device comprises a first electrode on a first substrate having an active region and a non-active region at periphery of the active region, the active region including a plurality of pixel regions and the non-active region including a power supply region; an organic luminescent layer on the first electrode in the plurality of pixel regions; a first organic layer on the first electrode in the power supply region; a second organic layer on the first substrate in an outer region of the power supply region; a second electrode on the organic luminescent layer; a driving thin film transistor connected to the second electrode and formed on a second substrate; and a power supply terminal connected to the first organic layer and formed on the second substrate, wherein the first organic layer has substantially the same shape as the organic luminescent layer, and the second organic layer has substantially a different shape from the organic luminescent layer.
摘要翻译：有机电致发光显示器（OELD）器件包括在有源区周边的第一衬底上的第一电极和位于有源区周边的非有源区，所述有源区包括多个像素区，并且所述非有源区包括电源区; 在所述多个像素区域中的所述第一电极上的有机发光层; 电源区域中的第一电极上的第一有机层; 在所述电源区域的外部区域中的所述第一基板上的第二有机层; 有机发光层上的第二电极; 连接到第二电极并形成在第二基板上的驱动薄膜晶体管; 以及连接到所述第一有机层并形成在所述第二基板上的电源端子，其中所述第一有机层具有与所述有机发光层基本相同的形状，并且所述第二有机层具有与所述有机发光层基本上不同的形状。

5. 发明申请

US20090311224A1 THERAPEUTIC AGENT COMPRISING LIPOCALIN 2 AGAINST CANCER METASTASIS, AND METHODS OF EARLY DIAGNOSIS AND INHIBITION OF CANCER METASTASIS USING LIPOCALIN 2 审中-公开
标题翻译：包含LOCOCALIN 2抗癌剂的治疗药物，以及早期诊断方法和使用LIPOCALIN 2抑制癌症METASTASIS
公开(公告)号：US20090311224A1
公开(公告)日：2009-12-17
申请号：US11815088
申请日：2006-02-24
申请人： Eun-kyoung Lee , Ho-jeong Lee , Kong-ju Lee , Jang-seong Kim , Doo-bong Park , Yeup Yoon , Hyun-jun Kim , In-hwan Lim
发明人： Eun-kyoung Lee , Ho-jeong Lee , Kong-ju Lee , Jang-seong Kim , Doo-bong Park , Yeup Yoon , Hyun-jun Kim , In-hwan Lim
IPC分类号： A61K35/12 , C07H21/00 , C12N15/63 , C12N5/00 , A61K31/7052 , C07K14/00 , A61K38/16 , C07K16/00 , A61P35/00 , C12Q1/68
CPC分类号： A61K38/1709 , A61K48/00 , C12N15/86 , C12N2740/15043
摘要： The present invention relates to a pharmaceutical composition for the inhibition of cancer metastasis, more precisely, a novel pharmaceutical composition against cancer metastasis comprising lipocalin 2 protein, a gene encoding the protein, an expression vector containing the gene or cells transfected with the expression vector as an effective ingredient, a method for the inhibition of cancer metastasis using the composition, a diagnostic kit for the prediction of cancer metastasis, a method for the selection of a metastasis risk group using the kit, a novel pharmaceutical composition for the inhibition of cancer growth and a method for the inhibition of cancer growth using the same. The pharmaceutical composition of the present invention specifically inhibits cancer metastasis, so that it can improve the effect of cancer treatment dramatically. And, the diagnostic kit and the method for the selection of a metastasis risk group using the kit enable the selection of a metastasis risk group by measuring the level of lipocalin 2 in tumor tissues or in body fluid. Therefore, the kit and the method can contribute to the effective clinical control of a cancer patient. Further, the composition of the invention can be effectively used for the treatment of liver cancer owing to its liver cancer growth inhibitory effect.
摘要翻译：本发明涉及用于抑制癌症转移的药物组合物，更准确地说，涉及一种抗癌转移的新型药物组合物，其包含脂质运载蛋白2蛋白，编码该蛋白质的基因，含有表达载体转染的基因或表达载体的表达载体有效成分，使用该组合物抑制癌症转移的方法，用于预测癌症转移的诊断试剂盒，使用试剂盒选择转移风险组的方法，用于抑制癌症生长的新型药物组合物以及使用其抑制癌症生长的方法。本发明的药物组合物特异性地抑制癌症转移，从而可以显着地改善癌症治疗的效果。并且，使用该试剂盒的诊断试剂盒和选择转移风险组的方法能够通过测量肿瘤组织或体液中脂笼蛋白2的水平来选择转移风险组。因此，试剂盒和方法可以有助于癌症患者的有效临床控制。此外，本发明的组合物由于其肝癌生长抑制作用，可以有效地用于治疗肝癌。

6. 发明授权

US06692735B1 Variant of C6 &bgr;-chemokine leukotactin-1(shLkn-1) with enhanced biological activity 失效
标题翻译：具有增强的生物活性的C6β趋化因子白细胞生成素-1（shLkn-1）的变体
公开(公告)号：US06692735B1
公开(公告)日：2004-02-17
申请号：US09355193
申请日：1999-07-21
申请人： Byoung S. Kwon , Byung S. Youn , Soo-Il Chung , Doo-Hong Park , Seung Jae Baek , Eun-Kyoung Lee , Ju-Hyung Ahn , Kong-Ju Lee
发明人： Byoung S. Kwon , Byung S. Youn , Soo-Il Chung , Doo-Hong Park , Seung Jae Baek , Eun-Kyoung Lee , Ju-Hyung Ahn , Kong-Ju Lee
IPC分类号： C07K1452
CPC分类号： C07K14/523 , A61K38/00
摘要： The present invention relates to a variant of Lkn-1(shLkn-1) with enhanced biological activity, which is a truncated form of Lkn-1, a process for preparing a recombinant shLkn-1 by employing expression vector therefor and pharmaceutical application of the said protein. shLkn-1 is generated by missing 26 amino acid residues from the amino terminus of Lkn-1 to contain 66 amino acids. Recombinant shLkn-1 inhibits colony formation and cell proliferation in vivo, which suggests that it can be used as a potential drug for the antibody production, the treatment during HIV-1 infection, the protection of bone marrow stem cells during chemotherapy or radiotherapy, and the inhibition of leukemia.
摘要翻译：本发明涉及具有增强的生物活性的Lkn-1（shLkn-1）的变体，其是截短形式的Lkn-1，通过使用其表达载体制备重组shLkn-1的方法和药物应用说蛋白质。通过从Lkn-1的氨基末端缺失26个氨基酸残基来产生shLkn-1，以含有66个氨基酸。重组shLkn-1在体内抑制集落形成和细胞增殖，这表明它可以用作抗体生产的潜在药物，HIV-1感染期间的治疗，化疗或放疗期间对骨髓干细胞的保护，以及抑制白血病。

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